Recent advances in engineering and the enabling sciences provide an unprecedented opportunity for revolutionary developments in biological interface materials and technologies. Our Gen 3 Engineering Research Center for Revolutionizing Metallic Biomaterials is to transform current medical and surgical treatments by creating "smart" implants to improve treatments for orthopedic, craniofacial, neural and cardiovascular ailments, coupled with the development of a vibrant, diverse workforce well-prepared for the multidisciplinary and global challenges and opportunities of the new millennium. The major goal is to revolutionize metallic biomaterials (RMB) and smart coatings with built-in responsive biosensory capabilities which can adapt to biological changes, to create novel bio-functional Engineered Systems. The ERC lead institution is North Carolina A&T State University (NCAT) with core partner institutions, the University of Pittsburgh (Pitt) and the University of Cincinnati (UC), global research partner Hannover Medical School (MHH) and other global and national partners that include industry, innovators, and state and local government entrepreneurial networks. ore information is available at: http://erc.ncat.edu/.