Tolly E G Epstein , MD

Bachelor's Degree: Indiana University 1998 (Biology & Spanish (English Minor))

Medical Degree: Indiana University School of Medicine 2003

Master's Degree: University of Cincinnati College of Medicine 2010 (Clinical Research/Molecular Epidemiology)

Resident : Barnes-Jewish Hospital/Washington University 2006 (Internal Medicine )

Fellowship : University of Cincinnati College of Medicine 2010 (Allergy & Immunology )

American Board of Allergy and Immunology (Certification Date: 10-08-2010 )

American Board of Internal Medicine (Certification Date: 09-01-2006 )

Research interests:  Allergen immunotherapy, Asthma in Older Adults, Impact of Air pollutants on Asthma and Allergic Diseases

Practice interests:   A wide range of allergic disorders including asthma, rhinitis, food allergy, hives/angioedema, and contact dermatitis, as well as immunologic disorders including immune deficiencies

2010 -To Present Assistant Professor, Division of Allergy, Immunology, & Rheumatology, University of Cincinnati, Cincinnati, OH

2010 -To Present Attending Physician, Allergy & Immunology, Cincinnati VA Medical Center, Cincinnati, OH

2006 -2007 Hospitalist Attending, Barnes-Jewish Hospital, St. Louis, MO

1998 -1999 V.I.S.T.A. (Volunteers in Service to America) Coordinator of America Reads Literacy Programs, Pueblo Family Center, Pueblo, CO

1998 - Clinical Research Assistant, Allergy, Asthma, & Clinical Immunology Associates, Indianapolis, IN

Grant: #1008820 04-01-2011 -03-31-2013 University of Cincinnati KL2 Grant Program Air Pollutants, Anti-Oxidant Genes, and Asthma Severity in Older Adults Role:PI $140,672

04-2010 -03-2011 University of Cincinnati Center for Environmental Genetics Pilot Projects Program Grant Air Pollutants, Anti-Oxidant Genes, and Asthma Severity in Older Adults Role:PI

01-2010 -01-2011 University of Cincinnati Center for Environmental Genetics New Investigator Scholars Grant Air Pollutants, Anti-Oxidant Genes, and Asthma Severity in Older Adults

12-2008 -12-2009 University of Cincinnati/Cincinnati Children's Hospital Center for Environmental Genetics New Investigator Scholars Grant SPRR2B Polymorphisms and Eczema

07-2008 -07-2010 University of Cincinnati - Cincinnati Childhood Asthma & Air Pollution Study Atopic Dermatitis and Environmental Exposures

Grant: #OHHHU0027-14 Investigators:Epstein, Tolly; Grinshpun, Sergey; Reponen, Tiina 11-28-2014 -11-30-2017 Department of Housing and Urban Development Efficiency of HEPA air purification in reducing traffic-related particle exposures Role:Collaborator $688,261.00 Awarded Level:Federal

Peer Reviewed Publications

Epstein, Tolly; Bernstein, David I (2026. ) Immunotherapy in Allergic and Mixed Rhinitis.Immunology and allergy clinics of North America, , 46 (1 ) ,111-124 More Information

Epstein, Tolly G; Berendts, Karen; Bernstein, David I (2026. ) Impact of Dose Adjustment After Gaps in Subcutaneous Immunotherapy: Update From the North American Immunotherapy Surveillance Study (2008-2023).The journal of allergy and clinical immunology. In practice, , 14 (1 ) ,253-259.e2 More Information

Epstein, Tolly E G; Rorie, Andrew C; Ramon, German D; Keswani, Anjeni; Bernstein, Jonathan; Codina, Rosa; Codispoti, Christopher; Craig, Timothy; Dykewicz, Mark; Ferastraoaru, Denisa; Katz, Daniel; Kim, Jean; Larenas-Linnemann, Désirée; Nanda, Anil; Nguyen, Anh; Anand, Mahesh Padukudru; Patterson, Amber; Ponda, Punita; Toskala, Elina; Wasan, Anita N (2025. ) Impact of climate change on aerobiology, rhinitis, and allergen immunotherapy: Work Group Report from the Aerobiology, Rhinitis, Rhinosinusitis & Ocular Allergy, and Immunotherapy, Allergen Standardization & Allergy Diagnostics Committees of the American Academy of Allergy, Asthma & Immunology.The Journal of allergy and clinical immunology, , 155 (6 ) ,1767-1782.e2 More Information

Bernstein, David I; Khan, Najeeb; Epstein, Tolly G (2023. ) Reply to "Does hydroxychloroquine work for chronic spontaneous urticaria?".The journal of allergy and clinical immunology. In practice, , 11 (6 ) ,1983-1984 More Information

Larenas-Linnemann, Désirée; Ponda, Punita; Creticos, Peter; Bernstein, David; Epstein, Tolly; Williams, Paul (2023. ) Dose Adjustment After Gaps in Administration of Subcutaneous Immunotherapy From a Past Survey: Work Group Report of the AAAAI Allergen Standardization and Allergy Diagnostics Committee.The journal of allergy and clinical immunology. In practice, , 11 (1 ) ,145-148.e4 More Information

Epstein, Tolly E G; Calabria, Christopher W (2022. ) Is immunotherapy safe for treatment of severe asthma.Current opinion in allergy and clinical immunology, , 22 (6 ) ,396-401 More Information

Khan, Najeeb; Epstein, Tolly G; DuBuske, Ilona; Strobel, Maria; Bernstein, David I (2022. ) Effectiveness of Hydroxychloroquine and Omalizumab in Chronic Spontaneous Urticaria: A Real-World Study.The journal of allergy and clinical immunology. In practice, , 10 (12 ) ,3300-3305 More Information

Chow, Timothy G; Palka, Jayme M; Stone, Brian; Trojan, Timothy; Epstein, Tolly G; Khan, David A (2022. ) Safety of subcutaneous immunotherapy in patients with severe asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 129 (5 ) ,585-591.e3 More Information

Bernstein, David I; Epstein, Tolly G (2022. ) Managing risk of anaphylaxis in patients receiving allergen immunotherapy: Assessing benefit versus risk.The Journal of allergy and clinical immunology, , 149 (3 ) ,884-886 More Information

Dhamija, Yashu; Epstein, Tolly E G; Bernstein, David I (2022. ) Systemic Allergic Reactions and Anaphylaxis Associated with Allergen Immunotherapy.Immunology and allergy clinics of North America, , 42 (1 ) ,105-119 More Information

Epstein, Tolly G; Murphy-Berendts, Karen; Liss, Gary M; Bernstein, David I (2021. ) Risk factors for fatal and nonfatal reactions to immunotherapy (2008-2018): postinjection monitoring and severe asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 127 (1 ) ,64-69.e1 More Information

Larenas-Linnemann, Désirée Erlinda; Epstein, Tolly; Ponda, Punita; Bernstein, David; Williams, Paul; Creticos, Peter (2020. ) Gaps in allergen immunotherapy administration and subcutaneous allergen immunotherapy dose adjustment schedules: Need for prospective data.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 125 (5 ) ,505-506.e2 More Information

Epstein, Tolly G; Liss, Gary M; Berendts, Karen Murphy; Bernstein, David I (2019. ) AAAAI/ACAAI Subcutaneous Immunotherapy Surveillance Study (2013-2017): Fatalities, Infections, Delayed Reactions, and Use of Epinephrine Autoinjectors.The journal of allergy and clinical immunology. In practice, , 7 (6 ) ,1996-2003.e1 More Information

Epstein, Tolly E; Tankersley, Mike S (2017. ) Are Allergen Immunotherapy Dose Adjustments Needed for Local Reactions, Peaks of Season, or Gaps in Treatment?.The journal of allergy and clinical immunology. In practice, , 5 (5 ) ,1227-1233 More Information

Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I (2017. ) Evaluation of the risk of infection associated with subcutaneous allergen immunotherapy: American Academy of Allergy, Asthma, and Immunology and American College of Allergy, Asthma, and Immunology National Surveillance Study on Allergen Immunotherapy, 2014-2015.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 118 (4 ) ,511-512 More Information

Epstein, Tolly G; Calabria, Christopher; Cox, Linda S; Dreborg, Sten (2017. ) Current Evidence on Safety and Practical Considerations for Administration of Sublingual Allergen Immunotherapy (SLIT) in the United States.The journal of allergy and clinical immunology. In practice, , 5 (1 ) ,34-40.e2 More Information

Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I (2016. ) Risk factors for fatal and nonfatal reactions to subcutaneous immunotherapy: National surveillance study on allergen immunotherapy (2008-2013).Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 116 (4 ) ,354-359.e2 More Information

Davis, Benjamin P; Epstein, Tolly; Kottyan, Leah; Amin, Priyal; Martin, Lisa J; Maddox, Avery; Collins, Margaret H; Sherrill, Joseph D; Abonia, J Pablo; Rothenberg, Marc E (2016. ) Association of eosinophilic esophagitis and hypertrophic cardiomyopathy.The Journal of allergy and clinical immunology, , 137 (3 ) ,934-6.e5 More Information

Kannan, Jennifer A; Bernstein, David I; Bernstein, Cheryl K; Ryan, Patrick H; Bernstein, Jonathan A; Villareal, Manuel S; Smith, Andrew M; Lenz, Peter H; Epstein, Tolly G (2015. ) Significant predictors of poor quality of life in older asthmatics.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 115 (3 ) ,198-204 More Information

Amin, Priyal; Levin, Linda; Epstein, Tolly; Ryan, Pat; LeMasters, Grace; Khurana Hershey, Gurjit; Reponen, Tina; Villareal, Manuel; Lockey, James; Bernstein, David I (2014. ) Optimum predictors of childhood asthma: persistent wheeze or the Asthma Predictive Index?.The journal of allergy and clinical immunology. In practice, , 2 (6 ) ,709-15 More Information

Cheng, G; Smith, A M; Levin, L; Epstein, T; Ryan, P H; LeMasters, G K; Khurana Hershey, G K; Reponen, T; Villareal, M; Lockey, J; Bernstein, D I (2014. ) Duration of day care attendance during infancy predicts asthma at the age of seven: the Cincinnati Childhood Allergy and Air Pollution Study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , 44 (10 ) ,1274-81 More Information

Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I (2014. ) AAAAI/ACAAI surveillance study of subcutaneous immunotherapy, years 2008-2012: an update on fatal and nonfatal systemic allergic reactions.The journal of allergy and clinical immunology. In practice, , 2 (2 ) ,161-7 More Information

Epstein, Tolly G; Kesavalu, Banurekha; Bernstein, Cheryl K; Ryan, Patrick H; Bernstein, Jonathan A; Zimmermann, Nives; Lummus, Zana; Villareal, Manuel S; Smith, Andrew M; Lenz, Peter H; Bernstein, David I (2013. ) Chronic traffic pollution exposure is associated with eosinophilic, but not neutrophilic inflammation in older adult asthmatics.The Journal of asthma : official journal of the Association for the Care of Asthma, , 50 (9 ) ,983-9 More Information

Kannan, Jennifer A; Epstein, Tolly G (2013. ) Immunotherapy safety: what have we learned from surveillance surveys?.Current allergy and asthma reports, , 13 (4 ) ,381-8 More Information

Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I (2013. ) AAAAI and ACAAI surveillance study of subcutaneous immunotherapy, Year 3: what practices modify the risk of systemic reactions?.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 110 (4 ) ,274-8, 278.e1 More Information

Epstein, Tolly G; Ryan, Patrick H; LeMasters, Grace K; Bernstein, Cheryl K; Levin, Linda S; Bernstein, Jonathan A; Villareal, Manuel S; Bernstein, David I (2012. ) Poor asthma control and exposure to traffic pollutants and obesity in older adults.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 108 (6 ) ,423-428.e2 More Information

Epstein, Tolly G; LeMasters, Grace K; Bernstein, David I; Ericksen, Mark B; Martin, Lisa J; Ryan, Patrick H; Biagini Myers, Jocelyn M; Butsch Kovacic, Melinda S; Lindsey, Mark A; He, Hua; Reponen, Tiina; Villareal, Manuel S; Lockey, James E; Bernstein, Cheryl K; Khurana Hershey, Gurjit K (2012. ) Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 108 (3 ) ,145-50 More Information

Epstein, Tolly G; Liss, Gary M; Murphy-Berendts, Karen; Bernstein, David I (2011. ) Immediate and delayed-onset systemic reactions after subcutaneous immunotherapy injections: ACAAI/AAAAI surveillance study of subcutaneous immunotherapy: year 2.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 107 (5 ) ,426-431.e1 More Information

Bernstein, David I; Epstein, Tolly (2011. ) Systemic reactions to subcutaneous allergen immunotherapy.Immunology and allergy clinics of North America, , 31 (2 ) ,241-9, viii-ix More Information

Epstein, Tolly G; Bernstein, David I; Levin, Linda; Khurana Hershey, Gurjit K; Ryan, Patrick H; Reponen, Tiina; Villareal, Manuel; Lockey, James E; Lemasters, Grace K (2011. ) Opposing effects of cat and dog ownership and allergic sensitization on eczema in an atopic birth cohort.The Journal of pediatrics, , 158 (2 ) ,265-71.e1-5 More Information

Bernstein, David I; Epstein, Tolly; Murphy-Berendts, Karen; Liss, Gary M (2010. ) Surveillance of systemic reactions to subcutaneous immunotherapy injections: year 1 outcomes of the ACAAI and AAAAI collaborative study.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, , 104 (6 ) ,530-5 More Information

Biagini Myers, Jocelyn M; Wang, Ning; LeMasters, Grace K; Bernstein, David I; Epstein, Tolly G; Lindsey, Mark A; Ericksen, Mark B; Chakraborty, Ranajit; Ryan, Patrick H; Villareal, Manuel S; Burkle, Jeff W; Lockey, James E; Reponen, Tiina; Khurana Hershey, Gurjit K (2010. ) Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.The Journal of investigative dermatology, , 130 (2 ) ,430-7 More Information

Epstein, Tolly G; Bernstein, Jonathan A (2008. ) Current and emerging management options for hereditary angioedema in the US.Drugs, , 68 (18 ) ,2561-73 More Information

2010 Featured Research Poster American Academy of Allergy, Asthma, & Immunology

2009 First Place, Internal Medicine Trainee's Research Grand Rounds

2006 Elected Teaching Resident

1999 -2000 Mariellen Dentino Scholarship (for outstanding academic performance)

1998 Graduated with Highest Distinction (Top 3% in Biological Sciences & Arts)

1998 Phi Beta Kappa

1996 Golden Key Honor Society

1995 Phi Eta Sigma

1995 -1998 Dean's List

Allergy

Academic - Health Professions Building
3255 Eden Avenue
Cincinnati  Ohio, 45267
Phone: 513) 558-4701
Fax: (513) 558-3799
epsteite@ucmail.uc.edu