Guo-Chang Fan , PhD

Guo-Chang Fan, PhD
Professor
Department of Pharmacology, Physiology, and Neurobiology
University of Cincinnati College of Medicine
231 Albert Sabin Way
Cincinnati, OH, 45267-0575
Tel: 513-558-2340
Office: CVC #5923
Lab: CARE#5872, #5881

Research Summary:

Fan laboratory is dedicated to performing cardiovascular research that involves:  1) dissecting the molecular/cellular mechanisms underlying ischemia/reperfusion-induced cardiac remodeling; 2) elucidating how infection/inflammation (i.e., sepsis) causes vascular leakage and heart failure; and 3) defining the role of macrophages in disease-induced cardiovascular dysfunction. Fan lab primarily uses in vivo transgenic and knockout animal models as well as in vitro primary cell culture.  In addition, multiple state-of-art techniques (i.e., CRISPR-Cas9, single-cell sequencing, RNA sequencing, cell sorting, flow cytometry, Co-IP, Co-immunostaining, and bioinformatics) are employed to analyze the molecular/cellular mechanisms. 

Notably, his research team was the first to show that miRNAs were involved in the ischemia/reperfusion (I/R)-induced cardiovascular damage (Circulation, 2009 & 2010; J Biol Chem., 2016 & 2019).  Recent years, Dr. Fan's lab has been focusing on a new research direction toward understanding the roles of exosomes/extracellular vesicles and macrophages in cardiovascular patho-physiology (Mol. Ther. 2021; Cardiovasc. Res. 2021, 2023; JCI Insigh, 2024).  Because of his outstanding achievement in the field of exosome/miRNA research, Dr. Fan was awarded “Established Investigator” by American Heart Association in 2016. Currently, Dr. Fan serves as editorial board member for multiple academic journals (i.e., Shock, Cells, Front. Immunol.), and grant proposal reviewer for NIH and AHA.
 

Bachelor's Degree: Nanjing Normal University 1993 (Biology)

Master's Degree: Chinese Academy of Sciences 1995 (Microbiology)

Doctoral Degree: Zhejiang University 1998 (Molecular Cell Biology)

Postdoctoral : Beijing Institute of Radiation Medicine Beijing, China, 2000

Postdoctoral Fellowship: University of Cincinnati Cincinnati, OH, 2001 (Immunology)

Postdoctoral Research : University of Cincinnati College of Medicine Cincinnati, OH, 2005 (Pharmacology and Cell Biophysics)

Fan laboratory is dedicated to performing cardiovascular research that involves:  1) dissecting the molecular/cellular mechanisms underlying ischemia/reperfusion-induced cardiac remodeling; 2) elucidating how infection/inflammation (i.e., sepsis) causes vascular leakage and heart failure; and 3) defining the role of macrophages in disease-triggered cardiovascular dysfunction. 

01-01-2006 -12-30-2008 Research Instructor, Dept. of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH

01-01-2009 -09-30-2009 Research Assistant Professor, University of Cincinnati College of Medicine, Cincinnati, OH

10-01-2009 -06-01-2014 Assistant Professor , University of Cincinnati College of Medicine, Cincinnati, OH

06-01-2014 -08-31-2018 Associate Professor, University of Cincinnati College of Medicine,

09-01-2018 - Professor, Department of Pharmacology and Systems Physiology, , University of Cincinnati College of Medicine, Cincinnati, OH

Grant: #R01 GM112930 Investigators:Guochang Fan 12-01-2014 -11-30-2019 NIH Duplex miR-223 and Exosomes in Sepsis Role:PI $1,250,000 Pending Type:Grant Level:National

Grant: #R01 HL087861 Investigators:Fan, Guochang 04-18-2007 -01-31-2013 National Heart, Lung and Blood Institute Physiological and Pathophysiological Roles of Hsp20 in the Heart Role:PI $1,950,000.00 Closed Level:Federal

Grant: #3 R01 HL087861-03S1 Investigators:Fan, Guochang 07-01-2009 -06-30-2011 National Heart, Lung and Blood Institute Physiological and Pathophysiological Roles of Hsp20 in the Heart Role:PI $267,314.00 Closed Level:Federal

Grant: #R01HL087861 Investigators:Fan, Guochang; Narmoneva, Daria 07-01-2013 -06-30-2018 National Heart, Lung and Blood Institute Roles of Hsp20-Exosomes in Myocardial Angiogenesis Role:PI $393,270.00 Active Level:Federal

Grant: #AHA 0730076N Investigators: Fan, Guochang 01-01-2007 -04-15-2007 American Heart Association - National Chapter Cardioprotection of Hsp20 and Its Mechanisms Role:PI $65,000.00

Grant: #1 R01 GM112930 Investigators:Caldwell, Charles; Fan, Guochang 01-01-2015 -12-31-2018 National Institute of General Medical Sciences Duplex miR-223 and Exosomes in Sepsis Role:PI $307,928.00 Awarded Level:Federal

Grant: #17EIA33400063 Investigators:Fan, Guochang 01-01-2017 -12-31-2021 American Heart Association - National Chapter Exosomes and Their Content Reprogramming in Heart Failure Role:PI $80,000.00 Active Level:Private Non-Profit

Grant: #R01GM126061 Investigators:Fan, Guochang 12-10-2017 -11-30-2021 National Institute of General Medical Sciences Tsg101 and endosomes in cardiac surgery-induced injury Role:PI $303,446.00 Awarded Level:Federal

Grant: #18PRE33960576 Investigators:Fan, Guochang; Li, Yutian 07-01-2018 -06-30-2020 American Heart Association - National Chapter Role of Sectm1a in Diabetes-Induced Cardiac Dysfunction Role:Collaborator $53,688.00 Active Level:Private Non-Profit

Grant: #18PRE34030123 Investigators:Essandoh, Kobina; Fan, Guochang 07-01-2018 -06-30-2020 American Heart Association - National Chapter Role of Tsg101 in endosomal translocation of Glut-4 in ischemic hearts Role:Collaborator $53,688.00 Active Level:Private Non-Profit

Grant: #R01 HL143490 Investigators:Fan, Guochang; Rubinstein, Jack; Sadayappan, Sakthivel; Wang, Yi-Gang; Xu, Meifeng 04-01-2019 -03-31-2023 National Institute of Allergy and Infectious Diseases IGF-2R is a new therapeutic target for cardiac ischemia-reperfusion injury Role:Collaborator $411,432.00 Awarded Level:Federal

Grant: #R01-GM-132149 Investigators:Caldwell, Charles; Fan, Guochang 04-01-2019 -03-31-2023 National Institutes of Health Roles of Sectm1a in macrophages and cardiac function during sepsis Role:PI $304,713.00 Awarded Level:Federal

Grant: #R01HL157456 Investigators:Fan, Guochang; Liang, Jialiang; Wang, Hongsheng; Wang, Yi-Gang 04-01-2021 -03-31-2025 National Heart, Lung and Blood Institute CRISPR-induced cardiovascular progenitor cells to repair myocardial infarction Role:Collaborator $623,215.00 Awarded Level:Federal

Grant: #2 R01 HL064018 Investigators:Fan, Guochang; Kranias, Evangelia 01-01-2014 -12-31-2018 National Heart, Lung and Blood Institute Cardiac Sarcoplasmic Reticulum Calcium Cycling Proteins Role:Collaborator $1,575,940.00 Closed Level:Federal

Grant: #S10OD030402 Investigators:Closson, Chet; Fan, Guochang; Hong, Christian; Luo, Yu; Sadayappan, Sakthivel; Wang, Hongsheng; Weiss, Alison; Zhang, Yuhang 09-01-2021 -08-31-2022 Office of the Director, National Institutes of Health Leica Stellaris 8 Confocal Microscope Role:Collaborator 598148.00 Awarded Level:Federal

Grant: #R01HL160811 Investigators:Fan, Guochang; Wang, Yi-Gang 12-01-2021 -11-30-2025 National Heart, Lung and Blood Institute Lcn10 in Sepsis-Induced Vascular Leakage and Heart Failure Role:PI 698487.00 Awarded Level:Federal

Grant: #R01HL163148 Investigators:Fan, Guochang; Huang, Wei 01-12-2023 -12-31-2027 National Heart, Lung and Blood Institute Mitochondrial R-loop in sepsis-induced cardiomyopathy Role:Collaborator 445156.00 Awarded Level:Federal

Grant: #R35GM149538 Investigators:Fan, Guochang 06-01-2023 -03-31-2028 National Institute of General Medical Sciences Novel regulators of macrophage function to repair sterile inflammation-induced heart injury Role:PI 445500.00 Hold Level:Federal

Grant: #1R011HL168464-01 Investigators:Fan, Guochang; Huang, Wei; Kanisicak, Onur; Sadayappan, Sakthivel; Wang, Yi-Gang; Xu, Meifeng 12-15-2023 -11-30-2027 National Heart, Lung and Blood Institute A novel strategy for heart failure therapeutics Role:Collaborator 487918.00 Awarded Level:Federal

Peer Reviewed Publications

Mu, Xingjiang; Wang, Xiaohong; Huang, Wei; Wang, Rui-Tao; Essandoh, Kobina; Li, Yutian; Pugh, Amanda M; Peng, Jiangtong; Deng, Shan; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Yu, Kai-Jiang; Fan, Guo-Chang (2017. ) Circulating Exosomes Isolated from Septic Mice Induce Cardiovascular Hyperpermeability Through Promoting Podosome Cluster Formation.Shock (Augusta, Ga.), , More Information

Li, Shengcun; Zhang, Lulu; Ni, Rui; Cao, Ting; Zheng, Dong; Xiong, Sidong; Greer, Peter A; Fan, Guo-Chang; Peng, Tianqing (2016. ) Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress.Biochimica et biophysica acta, , 1862 (11 ) ,2023-2033 More Information

Wang, Xiaohong; Gu, Haitao; Huang, Wei; Peng, Jiangtong; Li, Yutian; Yang, Liwang; Qin, Dongze; Essandoh, Kobina; Wang, Yigang; Peng, Tianqing; Fan, Guo-Chang (2016. ) Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice.Diabetes, , 65 (10 ) ,3111-28 More Information

Qin, Dongze; Wang, Xiaohong; Li, Yutian; Yang, Liwang; Wang, Ruitao; Peng, Jiangtong; Essandoh, Kobina; Mu, Xingjiang; Peng, Tianqing; Han, Qinghua; Yu, Kai-Jiang; Fan, Guo-Chang (2016. ) MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts.The Journal of biological chemistry, , 291 (38 ) ,20247-59 More Information

Hu, Jing; Al-Waili, Daniah; Hassan, Aishlin; Fan, Guo-Chang; Xin, Mei; Hao, Jiukuan (2016. ) Inhibition of cerebral vascular inflammation by brain endothelium-targeted oligodeoxynucleotide complex.Neuroscience, , 329 ,30-42 More Information

Liu, Zhi-Feng; Zheng, Dong; Fan, Guo-Chang; Peng, Tianqing; Su, Lei (2016. ) Heat stress prevents lipopolysaccharide-induced apoptosis in pulmonary microvascular endothelial cells by blocking calpain/p38 MAPK signalling.Apoptosis : an international journal on programmed cell death, , 21 (8 ) ,896-904 More Information

Essandoh, Kobina; Li, Yutian; Huo, Jiuzhou; Fan, Guo-Chang (2016. ) MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response.Shock (Augusta, Ga.), , 46 (2 ) ,122-31 More Information

Yang, Liwang; Li, Yutian; Wang, Xiaohong; Mu, Xingjiang; Qin, Dongze; Huang, Wei; Alshahrani, Saeed; Nieman, Michelle; Peng, Jiangtong; Essandoh, Kobina; Peng, Tianqing; Wang, Yigang; Lorenz, John; Soleimani, Manoocher; Zhao, Zhi-Qing; Fan, Guo-Chang (2016. ) Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy.The Journal of biological chemistry, , 291 (30 ) ,15700-13 More Information

Zheng, Dong; Yu, Yong; Li, Minghui; Wang, Grace; Chen, Ruizhen; Fan, Guo-Chang; Martin, Claudio; Xiong, Sidong; Peng, Tianqing (2016. ) Inhibition of MicroRNA 195 Prevents Apoptosis and Multiple-Organ Injury in Mouse Models of Sepsis.The Journal of infectious diseases, , 213 (10 ) ,1661-70 More Information

Ni, Rui; Zheng, Dong; Xiong, Sidong; Hill, David J; Sun, Tao; Gardiner, Richard B; Fan, Guo-Chang; Lu, Yanrong; Abel, E Dale; Greer, Peter A; Peng, Tianqing (2016. ) Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.Diabetes, , 65 (1 ) ,255-68 More Information

Ni, Rui; Cao, Ting; Xiong, Sidong; Ma, Jian; Fan, Guo-Chang; Lacefield, James C; Lu, Yanrong; Le Tissier, Sydney; Peng, Tianqing (2016. ) Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy.Free radical biology & medicine, , 90 ,12-23 More Information

Essandoh, Kobina; Yang, Liwang; Wang, Xiaohong; Huang, Wei; Qin, Dongze; Hao, Jiukuan; Wang, Yigang; Zingarelli, Basilia; Peng, Tianqing; Fan, Guo-Chang (2015. ) Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction.Biochimica et biophysica acta, , 1852 (11 ) ,2362-71 More Information

Wang, Xiaohong; Gu, Haitao; Qin, Dongze; Yang, Liwang; Huang, Wei; Essandoh, Kobina; Wang, Yigang; Caldwell, Charles C; Peng, Tianqing; Zingarelli, Basilia; Fan, Guo-Chang (2015. ) Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis.Scientific reports, , 5 ,13721 More Information

Ni, Rui; Zheng, Dong; Wang, Qiang; Yu, Yong; Chen, Ruizhen; Sun, Tao; Wang, Wang; Fan, Guo-Chang; Greer, Peter A; Gardiner, Richard B; Peng, Tianqing (2015. ) Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.Circulation. Heart failure, , 8 (5 ) ,988-96 More Information

Zheng, Dong; Ma, Jian; Yu, Yong; Li, Minghui; Ni, Rui; Wang, Grace; Chen, Ruizhen; Li, Jianmin; Fan, Guo-Chang; Lacefield, James C; Peng, Tianqing (2015. ) Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice.Diabetologia, , 58 (8 ) ,1949-58 More Information

Cai, Wen-Feng; Liu, Guan-Sheng; Lam, Chi Keung; Florea, Stela; Qian, Jiang; Zhao, Wen; Pritchard, Tracy; Haghighi, Kobra; Lebeche, Djamel; Lu, Long Jason; Deng, Jingyuan; Fan, Guo-Chang; Hajjar, Roger J; Kranias, Evangelia G (2015. ) Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility.European journal of heart failure, , 17 (8 ) ,782-93 More Information

Zheng, Dong; Wang, Grace; Li, Shuai; Fan, Guo-Chang; Peng, Tianqing (2015. ) Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation.Biochimica et biophysica acta, , 1852 (5 ) ,882-92 More Information

Ailawadi, Shaina; Wang, Xiaohong; Gu, Haitao; Fan, Guo-Chang (2015. ) Pathologic function and therapeutic potential of exosomes in cardiovascular disease.Biochimica et biophysica acta, , 1852 (1 ) ,1-11 More Information

Fan, Guo-Chang (2014. ) Hypoxic exosomes promote angiogenesis.Blood, , 124 (25 ) ,3669-70 More Information

Li, Shang-Ze; Zhang, Hui-Hui; Liang, Jun-Bo; Song, Yang; Jin, Bing-Xue; Xing, Na-Na; Fan, Guo-Chang; Du, Run-Lei; Zhang, Xiao-Dong (2014. ) Nemo-like kinase (NLK) negatively regulates NF-kappa B activity through disrupting the interaction of TAK1 with IKK?.Biochimica et biophysica acta, , 1843 (7 ) ,1365-72 More Information

Wang, Xiaohong; Huang, Wei; Liu, Guansheng; Cai, Wenfeng; Millard, Ronald W; Wang, Yigang; Chang, Jiang; Peng, Tianqing; Fan, Guo-Chang (2014. ) Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells.Journal of molecular and cellular cardiology, , More Information

Essandoh, Kobina; Fan, Guo-Chang (2014. ) Role of extracellular and intracellular microRNAs in sepsis.Biochimica et biophysica acta, , 1842 (11 ) ,2155-2162 More Information

Wen, Zhili; Huang, Wei; Feng, Yuliang; Cai, Wenfeng; Wang, Yuhua; Wang, Xiaohong; Liang, Jialiang; Wani, Mashhood; Chen, Jing; Zhu, Pin; Chen, Ji-Mei; Millard, Ronald W; Fan, Guo-Chang; Wang, Yigang (2014. ) MicroRNA-377 Regulates Mesenchymal Stem Cell-Induced Angiogenesis in Ischemic Hearts by Targeting VEGF.PloS one, , 9 (9 ) ,e104666 More Information

Yue, X; Yang, X; Lin, X; Yang, T; Yi, X; Dai, Y; Guo, J; Li, T; Shi, J; Wei, L; Fan, G-C; Chen, C; Chang, J (2014. ) Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.Cell death & disease, , 5 ,e1284 More Information

Jiang, Ding-Sheng; Wei, Xiang; Zhang, Xiao-Fei; Liu, Yu; Zhang, Yan; Chen, Ke; Gao, Lu; Zhou, Heng; Zhu, Xue-Hai; Liu, Peter P; Bond Lau, Wayne; Ma, Xinliang; Zou, Yunzeng; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang (2014. ) IRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling.Nature communications, , 5 ,3303 More Information

Zhang, Yan; Liu, Yu; Zhu, Xue-Hai; Zhang, Xiao-Dong; Jiang, Ding-Sheng; Bian, Zhou-Yan; Zhang, Xiao-Fei; Chen, Ke; Wei, Xiang; Gao, Lu; Zhu, Li-Hua; Yang, Qinglin; Fan, Guo-Chang; Lau, Wayne B; Ma, Xinliang; Li, Hongliang (2014. ) Dickkopf-3 attenuates pressure overload-induced cardiac remodelling.Cardiovascular research, , More Information

Zhang, Yan; Zhang, Xiao-Fei; Gao, Lu; Liu, Yu; Jiang, Ding-Sheng; Chen, Ke; Yang, Qinglin; Fan, Guo-Chang; Zhang, Xiao-Dong; Huang, Congxin (2014. ) Growth/differentiation factor 1 alleviates pressure overload-induced cardiac hypertrophy and dysfunction.Biochimica et biophysica acta, , 1842 (2 ) ,232-44 More Information

Wang, Xiaohong; Huang, Wei; Yang, Yang; Wang, Yigang; Peng, Tianqing; Chang, Jiang; Caldwell, Charles C; Zingarelli, Basilia; Fan, Guo-Chang (2014. ) Loss of duplexmiR-223 (5p and 3p) aggravates myocardial depression and mortality in polymicrobial sepsis.Biochimica et biophysica acta, , 1842 (5 ) ,701-711 More Information

Jiang, Ding-Sheng; Liu, Yu; Zhou, Heng; Zhang, Yan; Zhang, Xiao-Dong; Zhang, Xiao-Fei; Chen, Ke; Gao, Lu; Peng, Juan; Gong, Hui; Chen, Yingjie; Yang, Qinglin; Liu, Peter P; Fan, Guo-Chang; Zou, Yunzeng; Li, Hongliang (2014. ) Interferon Regulatory Factor 7 Functions as a Novel Negative Regulator of Pathological Cardiac Hypertrophy.Hypertension, , More Information

Liu, Yi; Jiang, Xiao-Li; Liu, Yu; Jiang, Ding-Sheng; Zhang, Yan; Zhang, Rui; Chen, Yingjie; Yang, Qinglin; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang (2014. ) Toll-interacting protein (Tollip) negatively regulates pressure overload-induced ventricular hypertrophy in mice.Cardiovascular research, , 101 (1 ) ,87-96 More Information

Lu, Yan-Yun; Li, Zuo-Zhi; Jiang, Ding-Sheng; Wang, Lang; Zhang, Yan; Chen, Ke; Zhang, Xiao-Fei; Liu, Yi; Fan, Guo-Chang; Chen, Yingjie; Yang, Qinglin; Zhou, Yan; Zhang, Xiao-Dong; Liu, De-Pei; Li, Hongliang (2013. ) TRAF1 is a critical regulator of cerebral ischaemia-reperfusion injury and neuronal death.Nature communications, , 4 ,2852 More Information

Jiang, Ding-Sheng; Luo, Yu-Xuan; Zhang, Ran; Zhang, Xiao-Dong; Chen, Hou-Zao; Zhang, Yan; Chen, Ke; Zhang, Shu-Min; Fan, Guo-Chang; Liu, Peter P; Liu, De-Pei; Li, Hongliang (2013. ) Interferon Regulatory Factor 9 Protects Against Cardiac Hypertrophy by Targeting Myocardin.Hypertension, , More Information

Jiang, Ding-Sheng; Zhang, Xiao-Fei; Gao, Lu; Zong, Jing; Zhou, Heng; Liu, Yu; Zhang, Yan; Bian, Zhou-Yan; Zhu, Li-Hua; Fan, Guo-Chang; Zhang, Xiao-Dong; Li, Hongliang (2013. ) Signal Regulatory Protein-? Protects Against Cardiac Hypertrophy Via the Disruption of Toll-Like Receptor 4 Signaling.Hypertension, , More Information

Li, Qi; Guo, Junli; Lin, Xi; Yang, Xiangsheng; Ma, Yanlin; Fan, Guo-Chang; Chang, Jiang (2013. ) An Intragenic SRF-Dependent Regulatory Motif Directs Cardiac-Specific microRNA-1-1/133a-2 Expression.PloS one, , 8 (9 ) ,e75470 More Information

Jiang, Ding-Sheng; Bian, Zhou-Yan; Zhang, Yan; Zhang, Shu-Min; Liu, Yi; Zhang, Rui; Chen, Yingjie; Yang, Qinglin; Zhang, Xiao-Dong; Fan, Guo-Chang; Li, Hongliang (2013. ) Role of interferon regulatory factor 4 in the regulation of pathological cardiac hypertrophy.Hypertension, , 61 (6 ) ,1193-202 More Information

Zhu, Hongyan; Fan, Guo-Chang (2013. ) Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction.Journal of biomarkers in drug development, , 1 (1 ) , More Information

Ribeiro, Mara Fernandes; Zhu, Hongyan; Millard, Ronald W; Fan, Guo-Chang (2013. ) Exosomes Function in Pro- and Anti-Angiogenesis.Current angiogenesis, , 2 (1 ) ,54-59 More Information

Ma, Jian; Wei, Meng; Wang, Qiang; Li, Jianmin; Wang, Hao; Liu, Weihua; Lacefield, James C; Greer, Peter A; Karmazyn, Morris; Fan, Guo-Chang; Peng, Tianqing (2012. ) Deficiency of Capn4 gene inhibits nuclear factor-?B (NF-?B) protein signaling/inflammation and reduces remodeling after myocardial infarction.The Journal of biological chemistry, , 287 (33 ) ,27480-9 More Information

Wang, Xiaohong; Zhu, Hongyan; Zhang, Xiaowei; Liu, Yong; Chen, Jing; Medvedovic, Mario; Li, Hongliang; Weiss, Mitchell J; Ren, Xiaoping; Fan, Guo-Chang (2012. ) Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1.Cardiovascular research, , 94 (2 ) ,379-90 More Information

Zhu, Hongyan; Fan, Guo-Chang (2012. ) Role of microRNAs in the reperfused myocardium towards post-infarct remodelling.Cardiovascular research, , 94 (2 ) ,284-92 More Information

Huang, Wei; Wang, Tao; Zhang, Dongsheng; Zhao, Tiemin; Dai, Bo; Ashraf, Atif; Wang, Xiaohong; Xu, Meifeng; Millard, Ronald W; Fan, Guo-Chang; Ashraf, Muhammad; Yu, Xi-Yong; Wang, Yigang (2012. ) Mesenchymal stem cells overexpressing CXCR4 attenuate remodeling of postmyocardial infarction by releasing matrix metalloproteinase-9.Stem cells and development, , 21 (5 ) ,778-89 More Information

Haghighi, Kobra; Pritchard, Tracy; Bossuyt, Julie; Waggoner, Jason R; Yuan, Qunying; Fan, Guo-Chang; Osinska, Hanna; Anjak, Ahmad; Rubinstein, Jack; Robbins, Jeffrey; Bers, Donald M; Kranias, Evangelia G (2012. ) The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase.Journal of molecular and cellular cardiology, , 52 (3 ) ,773-82 More Information

Zuo, Shi; Jones, W Keith; Li, Hongxia; He, Zhisong; Pasha, Zeeshan; Yang, Yueting; Wang, Yigang; Fan, Guo-Chang; Ashraf, Muhammad; Xu, Meifeng (2012. ) Paracrine effect of Wnt11-overexpressing mesenchymal stem cells on ischemic injury.Stem cells and development, , 21 (4 ) ,598-608 More Information

Zhang, Xiaowei; Wang, Xiaohong; Zhu, Hongyan; Kranias, Evangelia G; Tang, Yaoliang; Peng, Tianqing; Chang, Jiang; Fan, Guo-Chang (2012. ) Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2.PloS one, , 7 (3 ) ,e32765 More Information

Fan, Guo-Chang (2012. ) Role of heat shock proteins in stem cell behavior.Progress in molecular biology and translational science, , 111 ,305-22 More Information

Ma, Yonggang; Zhang, Xiaowei; Bao, Huayan; Mi, Su; Cai, Wenfeng; Yan, Huimin; Wang, Qingqing; Wang, Ziyan; Yan, Jun; Fan, Guo-Chang; Fan, Guochang; Lindsey, Merry L; Hu, Zhuowei (2012. ) Toll-like receptor (TLR) 2 and TLR4 differentially regulate doxorubicin induced cardiomyopathy in mice.PloS one, , 7 (7 ) ,e40763 More Information

Zhu, Hongyan; Fan, Guo-Chang (2011. ) Extracellular/circulating microRNAs and their potential role in cardiovascular disease. American journal of cardiovascular disease, , 1 (2 ) ,138-149

Qian, Jiang; Vafiadaki, Elizabeth; Florea, Stela M; Singh, Vivek P; Song, Weizhong; Lam, Chi Kung; Wang, Yigang; Yuan, Qunying; Pritchard, Tracy J; Cai, Wenfeng; Haghighi, Kobra; Rodriguez, Patricia; Wang, Hong-Sheng; Sanoudou, Despina; Fan, Guo-Chang; Kranias, Evangelia G (2011. ) Small heat shock protein 20 interacts with protein phosphatase-1 and enhances sarcoplasmic reticulum calcium cycling.Circulation research, , 108 (12 ) ,1429-38 More Information

Zhang, Xiaowei; Wang, Xiaohong; Zhu, Hongyan; Zhu, Cheng; Wang, Yigang; Pu, William T; Jegga, Anil G; Fan, Guo-Chang (2010. ) Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death.Journal of molecular and cellular cardiology, , 49 (5 ) ,841-50 More Information

Fan, Guo-Chang; Kranias, Evangelia G (2010. ) Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure.Journal of molecular and cellular cardiology, , More Information

Wang, Xiaohong; Zhang, Xiaowei; Ren, Xiao-Ping; Chen, Jing; Liu, Hongzhu; Yang, Junqi; Medvedovic, Mario; Hu, Zhuowei; Fan, Guo-Chang (2010. ) MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury.Circulation, , 122 (13 ) ,1308-18 More Information

Chen, Guoli; Zhou, Xiaoyang; Florea, Stela; Qian, Jiang; Cai, Wenfeng; Zhang, Zhiguo; Fan, Guo-Chang; Lorenz, John; Hajjar, Roger J; Kranias, Evangelia G (2010. ) Expression of active protein phosphatase 1 inhibitor-1 attenuates chronic beta-agonist-induced cardiac apoptosis.Basic research in cardiology, , 105 (5 ) ,573-81 More Information

Huang, Wei; Zhang, Dongsheng; Millard, Ronald W; Wang, Tao; Zhao, Tiemin; Fan, Guo-Chang; Ashraf, Atif; Xu, Meifeng; Ashraf, Muhammad; Wang, Yigang (2010. ) Gene manipulated peritoneal cell patch repairs infarcted myocardium.Journal of molecular and cellular cardiology, , 48 (4 ) ,702-12 More Information

Qian, Jiang; Ren, Xiaoping; Wang, Xiaohong; Zhang, Pengyuan; Jones, W Keith; Molkentin, Jeffery D; Fan, Guo-Chang; Kranias, Evangelia G (2009. ) Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.Circulation research, , 105 (12 ) ,1223-31 More Information

Wang, Xiaohong; Zhao, Tiemin; Huang, Wei; Wang, Tao; Qian, Jiang; Xu, Meifeng; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang (2009. ) Hsp20-engineered mesenchymal stem cells are resistant to oxidative stress via enhanced activation of Akt and increased secretion of growth factors.Stem cells (Dayton, Ohio), , 27 (12 ) ,3021-31 More Information

Jones, W Keith; Fan, Guo-Chang; Liao, Siyun; Zhang, Jun-Ming; Wang, Yang; Weintraub, Neal L; Kranias, Evangelia G; Schultz, Jo El; Lorenz, John; Ren, Xiaoping (2009. ) Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling.Circulation, , 120 (11 Suppl ) ,S1-9 More Information

Wang, Xiaohong; Zingarelli, Basilia; O'Connor, Michael; Zhang, Pengyuan; Adeyemo, Adeola; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang (2009. ) Overexpression of Hsp20 prevents endotoxin-induced myocardial dysfunction and apoptosis via inhibition of NF-kappaB activation.Journal of molecular and cellular cardiology, , 47 (3 ) ,382-90 More Information

Zhao, Wen; Fan, Guo-Chang; Zhang, Zhi-Guo; Bandyopadhyay, Arun; Zhou, Xiaoyang; Kranias, Evangelia G (2009. ) Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis.Basic research in cardiology, , 104 (4 ) ,377-89 More Information

Ren, Xiao-Ping; Wu, Jinghai; Wang, Xiaohong; Sartor, Maureen A; Qian, Jiang; Jones, Keith; Nicolaou, Persoulla; Pritchard, Tracy J; Fan, Guo-Chang (2009. ) MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20.Circulation, , 119 (17 ) ,2357-66 More Information

Jones, W Keith; Fan, Guo-Chang; Liao, Siyun; Zhang, Jun-Ming; Wang, Yang; Weintraub, Neal L; Kranias, Evangelia G; Schultz, Jo El; Lorenz, John; Ren, Xiaoping (2009. ) Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling.Circulation, , 120 (11 Suppl ) ,S1-9 More Information

Nicolaou, Persoulla; Knöll, Ralph; Haghighi, Kobra; Fan, Guo-Chang; Dorn, Gerald W; Hasenfub, Gerd; Kranias, Evangelia G (2008. ) Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects.The Journal of biological chemistry, , 283 (48 ) ,33465-71 More Information

Fan, Guo-Chang; Zhou, Xiaoyang; Wang, Xiaohong; Song, Guojie; Qian, Jiang; Nicolaou, Persoulla; Chen, Guoli; Ren, Xiaoping; Kranias, Evangelia G (2008. ) Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.Circulation research, , 103 (11 ) ,1270-9 More Information

Chen, Guoli; Zhou, Xiaoyang; Nicolaou, Persoulla; Rodriguez, Patricia; Song, Guojie; Mitton, Bryan; Pathak, Anand; Zachariah, Amit; Fan, Guo-Chang; Dorn, Gerald W; Kranias, Evangelia G (2008. ) A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation.The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 22 (6 ) ,1790-6 More Information

Haghighi, Kobra; Chen, Guoli; Sato, Yoji; Fan, Guo-Chang; He, Suiwen; Kolokathis, Fotis; Pater, Luke; Paraskevaidis, Ioannis; Jones, W Keith; Dorn, Gerald W; Kremastinos, Dimitrios Th; Kranias, Evangelia G (2008. ) A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids.Human mutation, , 29 (5 ) ,640-7 More Information

Zhang, Dongsheng; Fan, Guo-Chang; Zhou, Xiaoyang; Zhao, Tiemin; Pasha, Zeeshan; Xu, Meifeng; Zhu, Yi; Ashraf, Muhammad; Wang, Yigang (2008. ) Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium.Journal of molecular and cellular cardiology, , 44 (2 ) ,281-92 More Information

Fan, Guo-Chang; Yuan, Qunying; Kranias, Evangelia G (2008. ) Regulatory roles of junctin in sarcoplasmic reticulum calcium cycling and myocardial function.Trends in cardiovascular medicine, , 18 (1 ) ,1-5 More Information

Arvanitis, Demetrios A; Vafiadaki, Elizabeth; Fan, Guo-Chang; Mitton, Bryan A; Gregory, Kimberly N; Del Monte, Federica; Kontrogianni-Konstantopoulos, Aikaterini; Sanoudou, Despina; Kranias, Evangelia G (2007. ) Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase.American journal of physiology. Heart and circulatory physiology, , 293 (3 ) ,H1581-9 More Information

Zhou, Xiaoyang; Fan, Guo-Chang; Ren, Xiaoping; Waggoner, Jason R; Gregory, Kimberly N; Chen, Guoli; Jones, W Keith; Kranias, Evangelia G (2007. ) Overexpression of histidine-rich Ca-binding protein protects against ischemia/reperfusion-induced cardiac injury.Cardiovascular research, , 75 (3 ) ,487-97 More Information

Yuan, Qunying; Fan, Guo-Chang; Dong, Min; Altschafl, Beth; Diwan, Abhinav; Ren, Xiaoping; Hahn, Harvey H; Zhao, Wen; Waggoner, Jason R; Jones, Larry R; Jones, W Keith; Bers, Donald M; Dorn, Gerald W; Wang, Hong-Sheng; Valdivia, Héctor H; Chu, Guoxiang; Kranias, Evangelia G (2007. ) Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity.Circulation, , 115 (3 ) ,300-9 More Information

Fan, Guo-Chang; Yuan, Qunying; Zhao, Wen; Chu, Guoxiang; Kranias, Evangelia G (2007. ) Junctin is a prominent regulator of contractility in cardiomyocytes.Biochemical and biophysical research communications, , 352 (3 ) ,617-22 More Information

Fan, Guo-Chang; Yuan, Qunying; Song, Guojie; Wang, Yigang; Chen, Guoli; Qian, Jiang; Zhou, Xiaoyang; Lee, Yong J; Ashraf, Muhammad; Kranias, Evangelia G (2006. ) Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1.Circulation research, , 99 (11 ) ,1233-42 More Information

Haghighi, Kobra; Kolokathis, Fotis; Gramolini, Anthony O; Waggoner, Jason R; Pater, Luke; Lynch, Roy A; Fan, Guo-Chang; Tsiapras, Dimitris; Parekh, Rohan R; Dorn, Gerald W; MacLennan, David H; Kremastinos, Dimitrios Th; Kranias, Evangelia G (2006. ) A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.Proceedings of the National Academy of Sciences of the United States of America, , 103 (5 ) ,1388-93 More Information

Fan, Guo-Chang; Chu, Guoxiang; Kranias, Evangelia G (2005. ) Hsp20 and its cardioprotection.Trends in cardiovascular medicine, , 15 (4 ) ,138-41 More Information

Fan, Guo-Chang; Ren, Xiaoping; Qian, Jiang; Yuan, Qunying; Nicolaou, Persoulla; Wang, Yang; Jones, W Keith; Chu, Guoxiang; Kranias, Evangelia G (2005. ) Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury.Circulation, , 111 (14 ) ,1792-9 More Information

Fan, Guo-Chang; Gregory, Kimberly N; Zhao, Wen; Park, Woo Jin; Kranias, Evangelia G (2004. ) Regulation of myocardial function by histidine-rich, calcium-binding protein.American journal of physiology. Heart and circulatory physiology, , 287 (4 ) ,H1705-11 More Information

Fan, Guo-Chang; Chu, Guoxiang; Mitton, Bryan; Song, Qiujing; Yuan, Qunying; Kranias, Evangelia G (2004. ) Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis.Circulation research, , 94 (11 ) ,1474-82 More Information

Chu, Guoxiang; Egnaczyk, Gregory F; Zhao, Wen; Jo, Su-Hyun; Fan, Guo-Chang; Maggio, John E; Xiao, Rui-Ping; Kranias, Evangelia G (2004. ) Phosphoproteome analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein p20.Circulation research, , 94 (2 ) ,184-93 More Information

Haghighi, Kobra; Kolokathis, Fotis; Pater, Luke; Lynch, Roy A; Asahi, Michio; Gramolini, Anthony O; Fan, Guo-Chang; Tsiapras, Dimitris; Hahn, Harvey S; Adamopoulos, Stamatis; Liggett, Stephen B; Dorn, Gerald W; MacLennan, David H; Kremastinos, Dimitrios T; Kranias, Evangelia G (2003. ) Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.The Journal of clinical investigation, , 111 (6 ) ,869-76 More Information

Fan, Guo-Chang; Singh, Ram Raj (2002. ) Vaccination with minigenes encoding V(H)-derived major histocompatibility complex class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus. The Journal of experimental medicine, , 196 (6 ) ,731-41

Hong, Guangliang; Zheng, Dong; Zhang, Lulu; Ni, Rui; Wang, Grace; Fan, Guo-Chang; Lu, Zhongqiu; Peng, Tianqing (2018. ) Administration of nicotinamide riboside prevents oxidative stress and organ injury in sepsis.Free radical biology & medicine, , 123 ,125-137 More Information

Peng, Jiangtong; Li, Yutian; Wang, Xiaohong; Deng, Shan; Holland, Jenna; Yates, Emily; Chen, Jing; Gu, Haitao; Essandoh, Kobina; Mu, Xingjiang; Wang, Boyu; McNamara, Robert K; Peng, Tianqing; Jegga, Anil G; Liu, Tiemin; Nakamura, Takahisa; Huang, Kai; Perez-Tilve, Diego; Fan, Guo-Chang (2018. ) An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPAR? Ubiquitination.Cell reports, , 23 (12 ) ,3607-3620 More Information

Chen, Yanfang; Tang, Yaoliang; Fan, Guo-Chang; Duan, Dayue Darrel (2018. ) Extracellular vesicles as novel biomarkers and pharmaceutic targets of diseases.Acta pharmacologica Sinica, , 39 (4 ) ,499-500 More Information

Yu, You-Jiang; Wang, Xiao-Hong; Fan, Guo-Chang (2018. ) Versatile effects of bacterium-released membrane vesicles on mammalian cells and infectious/inflammatory diseases.Acta pharmacologica Sinica, , 39 (4 ) ,514-533 More Information

Liu, Guan-Sheng; Zhu, Hongyan; Cai, Wen-Feng; Wang, Xiaohong; Jiang, Min; Essandoh, Kobina; Vafiadaki, Elizabeth; Haghighi, Kobra; Lam, Chi Keung; Gardner, George; Adly, George; Nicolaou, Persoulla; Sanoudou, Despina; Liang, Qiangrong; Rubinstein, Jack; Fan, Guo-Chang; Kranias, Evangelia G (2018. ) Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6S10F mutant.Autophagy, , 14 (1 ) ,80-97 More Information

Salem, Esam S B; Fan, Guo-Chang (2017. ) Pathological Effects of Exosomes in Mediating Diabetic Cardiomyopathy.Advances in experimental medicine and biology, , 998 ,113-138 More Information

Zheng, Dong; Cao, Ting; Zhang, Lu-Lu; Fan, Guo-Chang; Qiu, Jun; Peng, Tian-Qing (2020. ) Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury.Acta pharmacologica Sinica, , More Information

Mu, Xingjiang; Wang, Peng; Wang, Xiaohong; Li, Yutian; Zhao, Hongyan; Li, Qianqian; Essandoh, Kobina; Deng, Shan; Peng, Tianqing; Fan, Guo-Chang (2020. ) Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR.Journal of immunology (Baltimore, Md. : 1950), , 205 (6 ) ,1633-1643 More Information

Essandoh, Kobina; Deng, Shan; Wang, Xiaohong; Li, Yutian; Li, Qianqian; Mu, Xingjiang; Peng, Tianqing; Fan, Guo-Chang (2020. ) Tsg101 Is Involved in the Sorting and Re-Distribution of Glucose Transporter-4 to the Sarcolemma Membrane of Cardiac Myocytes.Cells, , 9 (9 ) , More Information

Li, Yutian; Li, Qianqian; Fan, Guo-Chang (2020. ) Macrophage Efferocytosis in Cardiac Pathophysiology and Repair.Shock (Augusta, Ga.), , More Information

Mu, Xingjiang; Li, Yutian; Fan, Guo-Chang (2020. ) Tissue-Resident Macrophages in the Control of Infection and Resolution of Inflammation.Shock (Augusta, Ga.), , More Information

Deng, Shan; Essandoh, Kobina; Wang, Xiaohong; Li, Yutian; Huang, Wei; Chen, Jing; Peng, Jiangtong; Jiang, Ding-Sheng; Mu, Xingjiang; Wang, Chenran; Peng, Tianqing; Guan, Jun-Lin; Wang, Yigang; Jegga, Anil; Huang, Kai; Fan, Guo-Chang (2020. ) Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.Redox biology, , 32 ,101453 More Information

Li, Yutian; Deng, Shan; Wang, Xiaohong; Huang, Wei; Chen, Jing; Robbins, Nathan; Mu, Xingjiang; Essandoh, Kobina; Peng, Tianqing; Jegga, Anil G; Rubinstein, Jack; Adams, David E; Wang, Yigang; Peng, Jiangtong; Fan, Guo-Chang (2020. ) Sectm1a Deficiency Aggravates Inflammation-Triggered Cardiac Dysfunction through Disruption of LXR? Signaling in Macrophages.Cardiovascular research, , More Information

Wang, Lu; Li, Yutian; Wang, Xiaohong; Wang, Peng; Essandoh, Kobina; Cui, Shunan; Huang, Wei; Mu, Xingjiang; Liu, Zhenling; Wang, Yigang; Peng, Tianqing; Fan, Guo-Chang (2020. ) GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype.Cells, , 9 (1 ) , More Information

Essandoh, Kobina; Wang, Xiaohong; Huang, Wei; Deng, Shan; Gardner, George; Mu, Xingjiang; Li, Yutian; Kranias, Evangelia G; Wang, Yigang; Fan, Guo-Chang (2019. ) Tumor susceptibility gene 101 ameliorates endotoxin-induced cardiac dysfunction by enhancing Parkin-mediated mitophagy.The Journal of biological chemistry, , 294 (48 ) ,18057-18068 More Information

Liang, Liwen; Yuan, Wenyi; Qu, Lina; Li, Huili; Zhang, Lulu; Fan, Guo-Chang; Peng, Tianqing (2019. ) Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47phox phosphorylation, NADPH oxidase activation and MuRF1 expression.Journal of translational medicine, , 17 (1 ) ,279 More Information

Zheng, Dong; Zhang, Yi; Zheng, Ming; Cao, Ting; Wang, Grace; Zhang, Lulu; Ni, Rui; Brockman, Joseph; Zhong, Huiting; Fan, Guo-Chang; Peng, Tianqing (2019. ) Nicotinamide riboside promotes autolysosome clearance in preventing doxorubicin-induced cardiotoxicity.Clinical science (London, England : 1979), , 133 (13 ) ,1505-1521 More Information

Li, Yutian; Deng, Shan; Peng, Jiangtong; Wang, Xiaohong; Essandoh, Kobina; Mu, Xingjiang; Peng, Tianqing; Meng, Zhuo-Xian; Fan, Guo-Chang (2019. ) MicroRNA-223 is essential for maintaining functional ?-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways.The Journal of biological chemistry, , 294 (27 ) ,10438-10448 More Information

Essandoh, Kobina; Deng, Shan; Wang, Xiaohong; Jiang, Min; Mu, Xingjiang; Peng, Jiangtong; Li, Yutian; Peng, Tianqing; Wagner, Kay-Uwe; Rubinstein, Jack; Fan, Guo-Chang (2019. ) Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 33 (6 ) ,7451-7466 More Information

Teng, Xiaomei; Ji, Chen; Zhong, Huiting; Zheng, Dong; Ni, Rui; Hill, David J; Xiong, Sidong; Fan, Guo-Chang; Greer, Peter A; Shen, Zhenya; Peng, Tianqing (2019. ) Selective deletion of endothelial cell calpain in mice reduces diabetic cardiomyopathy by improving angiogenesis.Diabetologia, , 62 (5 ) ,860-872 More Information

Gardner, George T; Travers, Joshua G; Qian, Jiang; Liu, Guan-Sheng; Haghighi, Kobra; Robbins, Nathan; Jiang, Min; Li, Yutian; Fan, Guo-Chang; Rubinstein, Jack; Blaxall, Burns C; Kranias, Evangelia G (2019. ) Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure.JACC. Basic to translational science, , 4 (2 ) ,188-199 More Information

Zheng, Dong; Su, Zhaoliang; Zhang, Yi; Ni, Rui; Fan, Guo-Chang; Robbins, Jeffrey; Song, Long-Sheng; Li, Jianmin; Peng, Tianqing (2019. ) Calpain-2 promotes MKP-1 expression protecting cardiomyocytes in both in vitro and in vivo mouse models of doxorubicin-induced cardiotoxicity.Archives of toxicology, , 93 (4 ) ,1051-1065 More Information

Cao, Ting; Fan, Shuai; Zheng, Dong; Wang, Grace; Yu, Yong; Chen, Ruizhen; Song, Long-Sheng; Fan, Guo-Chang; Zhang, Zhuxu; Peng, Tianqing (2019. ) Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.Basic research in cardiology, , 114 (3 ) ,17 More Information

Ren, Xiaoping; Roessler, Anne E; Lynch, Thomas L; Haar, Lauren; Mallick, Faryal; Lui, Yong; Tranter, Michael; Ren, Michelle Huan; Xie, Wen Rui; Fan, Guo-Chang; Zhang, Jun-Ming; Kranias, Evangelia G; Anjak, Ahmad; Koch, Sheryl; Jiang, Min; Miao, Qing; Wang, Yang; Cohen, Albert; Rubinstein, Jack; Weintraub, Neal L; Jones, W Keith (2019. ) Cardioprotection via the skin: nociceptor-induced conditioning against cardiac MI in the NIC of time.American journal of physiology. Heart and circulatory physiology, , 316 (3 ) ,H543-H553 More Information

Li, S; Zhang, L; Ni, R; Cao, T; Zheng, D; Xiong, S; Greer, P A; Fan, G C; Peng, T (2017. ) Corrigendum to "Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress" [Biochim. Biophy.Acta 1862 (11): 2023-2033].Biochimica et biophysica acta. Molecular basis of disease, , 1863 (9 ) ,2409 More Information

Essandoh, Kobina; Fan, Guo-Chang (2014. ) Role of extracellular and intracellular microRNAs in sepsis.Biochimica et biophysica acta, , 1842 (11 ) ,2155-2162 More Information

Wen, Zhili; Huang, Wei; Feng, Yuliang; Cai, Wenfeng; Wang, Yuhua; Wang, Xiaohong; Liang, Jialiang; Wani, Mashhood; Chen, Jing; Zhu, Pin; Chen, Ji-Mei; Millard, Ronald W; Fan, Guo-Chang; Wang, Yigang (2014. ) MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF.PloS one, , 9 (9 ) ,e104666 More Information

Zhu, Hongyan; Fan, Guo-Chang (2013. ) Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction.Journal of biomarkers in drug development, , 1 (1 ) , More Information

Liang, Liwen; Li, Huili; Cao, Ting; Qu, Lina; Zhang, Lulu; Fan, Guo-Chang; Greer, Peter A; Li, Jianmin; Jones, Douglas L; Peng, Tianqing (2020. ) Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways.The Journal of biological chemistry, , 295 (49 ) ,16840-16851 More Information

Mu, Xingjiang; Fan, Hongkuan; Wang, Peng; Li, Yutian; Domenico, Karen; Li, Qianqian; Wang, Xiaohong; Essandoh, Kobina; Chen, Jing; Peng, Tianqing; Fan, Guo-Chang (2021. ) Sectm1a Facilitates Protection against Inflammation-Induced Organ Damage through Promoting TRM Self-Renewal.Molecular therapy : the journal of the American Society of Gene Therapy, , 29 (3 ) ,1294-1311 More Information

Zhao, Hongyan; Wang, Peng; Wang, Xiaohong; Du, Wa; Yang, Hui-Hui; Liu, Yueying; Cui, Shu-Nan; Huang, Wei; Peng, Tianqing; Chen, Jing; Gao, Chen; Wang, Yigang; Sadayappan, Sakthivel; Ma, Chengen; Fan, Yanbo; Wang, Chunting; Fan, Guo-Chang (2023. ) Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LRP2-Ssh1 signaling pathway.Cardiovascular research, , More Information

Wang, Peng; Mu, Xingjiang; Zhao, Hongyan; Li, Yutian; Wang, Lu; Wolfe, Vivian; Cui, Shu-Nan; Wang, Xiaohong; Peng, Tianqing; Zingarelli, Basilia; Wang, Chunting; Fan, Guo-Chang (2021. ) Administration of GDF3 Into Septic Mice Improves Survival via Enhancing LXR?-Mediated Macrophage Phagocytosis.Frontiers in immunology, , 12 ,647070 More Information

Wu, Zhichao; Huang, Wei; He, Xingyu; Dutta, Suchandrima; Paul, Christian; Fan, Guo-Chang; Kanisicak, Onur; Xu, Meifeng; Liang, Jialiang; Wang, Yigang (2023. ) Myocardial IGF2R is a critical mediator of inflammation and fibrosis after ischemia-reperfusion injury.bioRxiv : the preprint server for biology, , More Information

Cui, Shu-Nan; Tan, Hong-Yu; Fan, Guo-Chang (2021. ) Immunopathological Roles of Neutrophils in Virus Infection and COVID-19.Shock (Augusta, Ga.), , More Information

Yang, Hui-Hui; Wang, Xiaohong; Li, Siru; Liu, Yueying; Akbar, Rubab; Fan, Guo-Chang (2023. ) Lipocalin family proteins and their diverse roles in cardiovascular disease.Pharmacology & therapeutics, , 244 ,108385 More Information

Saas, Philippe; Fan, Guo-Chang (2023. ) Editorial: Hypoxia and inflammation: A two-way street.Frontiers in immunology, , 14 ,1171116 More Information

Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Wu, Shihong; Deng, Siwei; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim (2023. ) BRD9-SMAD2/3 orchestrates stemness and tumorigenesis in pancreatic ductal adenocarcinoma.bioRxiv : the preprint server for biology, , More Information

Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo (2023. ) Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice.iScience, , 26 (1 ) ,105769 More Information

Ji, Xiao-Yun; Zheng, Dong; Ni, Rui; Wang, Jin-Xi; Shao, Jian-Qiang; Vue, Zer; Hinton, Antentor; Song, Long-Sheng; Fan, Guo-Chang; Chakrabarti, Subrata; Su, Zhao-Liang; Peng, Tian-Qing (2022. ) Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy.Acta pharmacologica Sinica, , 43 (11 ) ,2873-2884 More Information

Cao, Ting; Ni, Rui; Ding, Weimin; Ji, Xiaoyun; Li, Lan; Liao, Guangneng; Lu, Yanrong; Fan, Guo-Chang; Zhang, Zhuxu; Peng, Tianqing (2022. ) MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes.Cardiovascular diabetology, , 21 (1 ) ,165 More Information

Li, Huili; Cao, Ting; Ding, Weimin; Liang, Liwen; Fan, Guo-Chang; Qu, Lina; Peng, Tianqing (2022. ) Pharmacological inhibition of Rac1 attenuates myocardial abnormalities in tail-suspended mice.Journal of cardiovascular translational research, , 15 (4 ) ,805-815 More Information

Li, Qianqian; Li, Yutian; Huang, Wei; Wang, Xiaohong; Liu, Zhenling; Chen, Jing; Fan, Yanbo; Peng, Tianqing; Sadayappan, Sakthivel; Wang, Yigang; Fan, Guo-Chang (2022. ) Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages.Frontiers in immunology, , 13 ,930397 More Information

Feng, Yuliang; Cai, Liuyang; Hong, Wanzi; Zhang, Chunxiang; Tan, Ning; Wang, Mingyang; Wang, Cheng; Liu, Feng; Wang, Xiaohong; Ma, Jianyong; Gao, Chen; Kumar, Mohit; Mo, Yuanxi; Geng, Qingshan; Luo, Changjun; Lin, Yan; Chen, Haiyang; Wang, Shuang-Yin; Watson, Michael J; Jegga, Anil G; Pedersen, Roger A; Fu, Ji-Dong; Wang, Zhao V; Fan, Guo-Chang; Sadayappan, Sakthivel; Wang, Yigang; Pauklin, Siim; Huang, Feng; Huang, Wei; Jiang, Lei (2022. ) Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy.Circulation, , 145 (22 ) ,1663-1683 More Information

Zhang, Mengxiao; Zhong, Huiting; Cao, Ting; Huang, Yifan; Ji, Xiaoyun; Fan, Guo-Chang; Peng, Tianqing (2022. ) Gamma-Aminobutyrate Transaminase Protects against Lipid Overload-Triggered Cardiac Injury in Mice.International journal of molecular sciences, , 23 (4 ) , More Information

Jiang, Lin; Liang, Jialiang; Huang, Wei; Ma, Jianyong; Park, Ki Ho; Wu, Zhichao; Chen, Peng; Zhu, Hua; Ma, Jian-Jie; Cai, Wenfeng; Paul, Christian; Niu, Liang; Fan, Guo-Chang; Wang, Hong-Sheng; Kanisicak, Onur; Xu, Meifeng; Wang, Yigang (2022. ) CRISPR activation of endogenous genes reprograms fibroblasts into cardiovascular progenitor cells for myocardial infarction therapy.Molecular therapy : the journal of the American Society of Gene Therapy, , 30 (1 ) ,54-74 More Information

Liang, Liwen; Li, Huili; Cao, Ting; Qu, Lina; Zhang, Lulu; Fan, Guo-Chang; Greer, Peter A; Li, Jianmin; Jones, Douglas L; Peng, Tianqing (2020. ) Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways.The Journal of biological chemistry, , 295 (49 ) ,16840-16851 More Information

Liu, Benjamin D; Akbar, Rubab; Oliverio, Anna; Thapa, Kajol; Wang, Xiaohong; Fan, Guo-Chang (2023. ) Bacterial Extracellular Vesicles in the Regulation of Inflammatory Response and Host-Microbe Interactions.Shock (Augusta, Ga.), , More Information

Feng, Yuliang; Cai, Liuyang; Pook, Martin; Liu, Feng; Chang, Chao-Hui; Mouti, Mai Abdel; Nibhani, Reshma; Militi, Stefania; Dunford, James; Philpott, Martin; Fan, Yanbo; Fan, Guo-Chang; Liu, Qi; Qi, Jun; Wang, Cheng; Hong, Wanzi; Morgan, Hannah; Wang, Mingyang; Sadayappan, Sakthivel; Jegga, Anil G; Oppermann, Udo; Wang, Yigang; Huang, Wei; Jiang, Lei; Pauklin, Siim (2023. ) BRD9-SMAD2/3 Orchestrates Stemness and Tumorigenesis in Pancreatic Ductal Adenocarcinoma.Gastroenterology, , More Information

Wang, Xiaohong; Du, Wa; Li, Yutian; Yang, Hui-Hui; Zhang, Yu; Akbar, Rubab; Morgan, Hannah; Peng, Tianqing; Chen, Jing; Sadayappan, Sakthivel; Hu, Yueh-Chiang; Fan, Yanbo; Huang, Wei; Fan, Guo-Chang (2024. ) Macrophage-enriched Sectm1a promotes efficient efferocytosis to attenuate ischemia/reperfusion-induced cardiac injury.JCI insight, , 9 (5 ) , More Information

Cao, Ting; Ni, Rui; Ding, Weimin; Ji, Xiaoyun; Fan, Guo-Chang; Zhang, Zhuxu; Peng, Tianqing (2023. ) Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis.Journal of translational medicine, , 21 (1 ) ,883 More Information

Other Publications

Fan GC and Wu CT (2000. ) Transfer of p14ARF gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits cell proliferation and reduces doxorubicin resistance .Cancer lett., 158 (2 ) ,203-210

Fan GC, Singh RR (2002. ) Vaccination with minigenes encoding VH-derived MHC class I-binding epitopes activates cytotoxic T cells that ablate autoantibody-producing B cells and inhibit lupus .Exp. Med., 196 (6 ) ,731-741

22 Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, Fan GC, Tsiapras D, Hahn HS, Adamopoulos S, Liggett SB, Dorn GW 2nd, MacLennan DH, Kremastinos DT, Kranias EG (2003. ) Human Phospholamban Null Results in Lethal Dilated Cardiomyopathy: Critical Difference Between Mouse and Man .J. Clin. Invest., 111 ,869-876

Fan GC, Gregory KN, Zhao W, Park WJ, Kranias EG (2004. ) Regulation of Myocardial Function by Histidine-Rich Calcium Binding Protein .Am. J. Physiol., 287 (4 ) ,H1705-1711

Fan GC, Chu G, Mitton B, Song Q, Yuan Q, Kranias EG (2004. ) Small heat-shock protein Hsp20 phosphorylation inhibits beta-agonist-induced cardiac apoptosis .Circ. Res., 94 (11 ) ,1474-1482

21 Chu G, Egnaczyk GF, Zhao W, Jo SH, Fan GC, Maggio JE, Xaio RP, and Kranias EG (2004. ) Phosphoprotemoe analysis of cardiomyocytes subjected to beta-adrenergic stimulation: identification and characterization of a cardiac heat shock protein Hsp20 .Circ. Res., 94 (2 ) ,184-193

Fan GC, Chu G, Kranias EG (2005. ) Hsp20 and its cardioprotection .Trends Cardiovasc. Med., 15 (4 ) ,138-141

Fan GC, Ren X, Qian J, Yuan Q, Nicolaou P, Wang Y, Jones WK, Chu G, Kranias EG (2005. ) A novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury .Circulation, 111 (14 ) ,1792-1799

Fan GC, Yuan Q, Song G, Wang Y, Chen G, Qian J, Zhou X, Lee YJ, Ashraf M, Kranias EG (2006. ) Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase .Circ Res., 99 (11 ) ,1233-1242

Haghighi K, Kolokathis F, Gramolini AO, Waggoner J, Pater L, Lynch RA., Fan GC, Tsiapras D, Parekh RR, Dorn GW, MacLennan DH, Kremastinos DK, Kranias EG (2006. ) Human mutation in Phospholamban in the Human Phosphorylation gene, Deleting Arginine14, Results in Lethal Human Hereditary Cardiomyopathy .Proc. Natl. Acad. Sci., 103 (5 ) ,1388-1393

Arvanitis DA, Vafiadaki E, Fan GC, Mitton BA, Gregory KN, del Monte F, Kontrogianni-Konstantopoulos A, Sanoudou D, and Kranias EG (2007. ) The Histidine-Rich Calcium Binding Protein Interacts with Sarcoplasmic Reticulum Ca-ATPase .Am J Physiol., 293 ,H1581-H1589

Zhou X, Fan GC, Ren X, Waggoner J, Gregory K, Chen G, Jones WK, Kranias EG (2007. ) Overexpression of Histidine-Rich Ca-Binding Protein Protects Against Ischemia/Reperfusion-Induced Cardiac Injury .Cardiovascular Res., 75 (3 ) ,487-497

Yuan Q, Fan GC, Dong M, Altschafl M, Diwan A, Ren X, Zhao W, Waggoner JR, Jones LR, Jones WK, Bers DM, Dorn GW, Wang HS, Valdivia HH, Chu G, and Kranias EG (2007. ) Sarcoplasmic Reticulum Calcium Overloading in Junctin Deficiency Enhances Cardiac Contractility, but Increases Ventricular Automaticity .Circulation, 115 (3 ) ,300-309

Fan GC, Yuan Q, Zhao W, Chu G, Kranias EG (2007. ) Junctin Is a Prominent Regulator of Contractility in Cardiomyocytes .Biochem Biophys Res Commun., 352 (3 ) ,617-622

Wang X, Zingarelli B, Fan GC (2008. ) Hsp20 prevents endotoxin-induced cardiac injury through downregulation of NF-kB activity.

Wang X, Zhang D, Zhao T, Wang Y, Ashraf M, Kranias EG and Fan GC (2008. ) Bone-morrow stem cells modified with Hsp20 are resistant to oxidative stress and improve cardiac function via release of paracrine factors in the infarct heart .

Wu J, Ren X, Wang X, Sartor MA, Krainas EG, Jones WK, Fan GC (2008. ) MiR-320 is an ischemia-related microRNA by targeting Hsp20 .Proc. Natl. Acad. Sci,

Fan GC, Liao S, Wang Y, Zhang J, Kranias EG, Schultz JE, Lorenz J, Jones WK, and Ren X (2008. ) Neurogenic activation mediates remote non-ischemic cardioprotection via bradykinin receptor 2-dependent PKC signaling pathway .Circulation,

Zhao W, Fan GC, Bandyopadhyay A, Zhou X, Kranias EG (2008. ) Peroxiredoxin II protects cardiomyocytes from oxidative stress-induced cell death and apoptosis .Cardiovascular Res.,

Fan GC*, Zhou X, Song G, Qian J, Kranias EG (2008. ) Hsp20 Interacting With Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity .Circ Res.,

Chen G, Zhou X, Rodriguez P, Song G, Mitton B, Pathak A, Fan GC, Dorn GW II, Kranias EG (2008. ) A Human Polymorphism of Protein Phosphatase 1 Inhibitor 1 is Associated with Attenuated Cardiac Contractile Responses to Beta-adrenergic Stimulation .The FASEB Journal, 22 (6 ) ,1790-1796

Zhang D, Fan GC, Zhou X, Zhao T, Pasha Z, Xu M, Zhu Y, Ashraf M, Wang Y (2008. ) Overexpression of CXCR4 in mesenchymal stem cells improves cardiac repair following infarction .J Mol Cell Cardiol., 44 (2 ) ,281-292

Fan GC, Yuan Q, Kranias EG (2008. ) Regulatory Roles of Junctin in SR Ca Cycling and Myocardial Function .Trends Cardiovasc. Med., 18 (1 ) ,1-5

Haghighi K, Chen G, Sato Y, Fan GC, He S, Kolokathis F, Pater L, Paraskevaidis L, Jones KW, Kremastinos DT, and Kranias EG (2008. ) A Human Phospholamban Promoter Mutation in Dilated Cardiomyopathy Alters Transcriptional Regulation by Glucocorticoids .Human Mutation, 29 (5 ) ,640-647

Book Chapter

Guo-Chang Fan, Evangelia G. Kranias (2010 ) Small stress proteins in protecting the heart Small stress proteins and human diseases .(pp. 147-169).New York, Nova Science Publishers, Inc. (Author)

Hongyan Zhu, Guo-Chang Fan (04-09-2013 ) Intracellular and Extracellular MicroRNAs in Myocardial Angiogenesis Cardiovascular Diseases Nutritional and Therapeutic Interventions .(pp. 163-186).New York, CRC Press (Author)

Electronic Journal

Hongyan Zhu, Guo-Chang Fan (08-02-2012. ) Whether Circulating miRNAs or miRNA-Carriers Serve as Biomarkers for Acute Myocardial Infarction .Journal of Biomarkers in drug development, 1 (1 ) ,

Invited Presentations

Guo-Chang Fan (05-12-2013. ) Stress-Responsive Hsp20/miRs/Exosomes in Cardiovascular Disease .University of Mississippi Medical Center. Level:National

Guo-Chang Fan (07-15-2013. ) Roles of microRNAs and Exosomes in Ischemic Heart Disease .Center for Cardiovascular Research, University of Illinois at Chicago . Level:National

Guo-Chang Fan (10-08-2013. ) Hsp20 and Stem Cell-Derived Exosomes: Novel Regulators of Cardioprotection .Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine . Level:College

Guo-Chang Fan (03-04-2014. ) Roles of microRNAs and Exosomes in Myocardial Angiogenesis .Cardiovascular Center of Excellence, University of Cincinnati . Level:College

Guo-Chang Fan (04-08-2014. ) Exosomes in Cardiovascular Disease .Department of Molecular Genetics, Biochemistry & Microbiology University of Cincinnati . Level:College

2008 -2008 Outstanding Early-Career Investigator Award at the Basic Cardiovascular Sciences Conference 2008 Heart Failure: Molecular Mechanisms and Therapeutic Targets

2005 -2005 New Investigator Travel Award at the 2nd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences Targeting Heart Failure: New Science, New Tools, New Strategies

2003 -2003 Travel grant to the 7th Annual Scientific Meeting of the Heart Failure Society of America

1999 -1999 Distinguished Achievement Award, Beijing Institute of Radiation Medicine

1996 -1998 Graduate Scholarship for Ph.D., Zhejiang University, China

Kobina Essandoh (Master ) Supervisor Status:Completed 2013

Lam Chi (Doctoral ) Committee Member Status:Completed 2012

Tiffany Forde (Master ) Committee Member Status:Completed 2010

Kristin Luther (Doctoral ) Committee Member Status:In Progress

Guansheng Liu (Doctoral ) Co-Chair Status:In Progress

Jiang Qian (Doctoral ) Co-Chair Status:Completed 2009

Adeola Adeyemo (Doctoral ) Lab Rotation Preceptor Status:Completed 2007

Allyson Hamlin (Doctoral ) Lab Rotation Preceptor Status:Completed 2011

Yang Yang (Doctoral ) Lab Rotation Preceptor Status:Completed 2012

Liwang Yang (Doctoral ) Supervisor Status:In Progress

Dongze Qin (Doctoral ) Supervisor Status:In Progress

Haitao Gu (Postdoctoral ) Supervisor Status:In Progress

Xiaowei Zhang (Postdoctoral ) Supervisor Status:Completed 2013

Pengyuan Zhang (Postdoctoral ) Supervisor Status:Completed 2009

Hongyan Zhu (Postdoctoral ) Supervisor Status:Completed 2011

Department of Pharmacology and Cell Biophysics (Graduate Education Committee ) Committee Member Type:Departmental Service Level:Department 2013

Department of Pharmacology and Cell Biophysics (Research Committee ) Committee Member Type:Departmental Service Level:Department 2011

College of Medicine (Interviewed Flex PhD candidates ) Member Type:University/College Service Level:College 02-18-2010

University of Cincinnati and CCHMC (Poster judge at the Capstone Poster Session for undergraduates working in labs ) Member Type:University/College Service Level:University 08-05-2011

University of Cincinnati (CEG Pilot Project Review Committee ) Committee Member Type:University/College Service Level:College 2011

University of Cincinnati (Poster judge at the 2012 UC Graduate Poster Forum ) Member Type:University/College Service Level:University 03-02-2012

University of Cincinnati and CCHMC (judge for the Capstone Poster Session for undergraduates working in labs here at UC and CCHMC 2013 summer ) Member Type:University/College Service Level:University 08-02-2013

University of Cincinnati (judge for the 2014 graduate Poster Forum ) Member Type:University/College Service Level:University 02-28-2014

University of Cincinnati (judge for the Science Fair ) Member Type:Service to Professional Associations Level:Local 03-15-2014

University of Cincinnati (CEG Pilot Project Review Committee ) Member Type:University/College Service Level:University 05-20-2014

17th World Congress on Heart Disease, International Academy of Cardiology Annual Scientific Sessions 2012, Toronto, ON, Canada. (Scientific Advisory Board ) Member Type:Service to Professional Associations Level:International 2012

18th World Congress on Heart Disease, International Academy of Cardiology Annual Scientific Sessions (Scientific Advisory Board ) Member Type:Service to Professional Associations Level:International 2013

the American Heart Association’s annual Scientific Sessions conference (educational session ) Member Type:Service to Professional Associations Level:National 11-20-2013

19th World Congress on Heart Disease, Bonston, July 25-28, 2014. (Scientific Advisory Board ) Member Type:Service to Professional Associations Level:International 2014

Academic - Cardiovascular Center Building
Room 5923
Cincinnati  Ohio, 45267-0575
Phone: 513-558-2340
guochang.fan@uc.edu