Matthew Skelton , PhD

Creatine transporter deficiency (CTD) is the most prevalent form of Creatine Deficiency Syndromes (CDS) and the second most common cause of X-linked mental retardation.  The loss of the creatine transporter (CrT) prevents the uptake of Cr into the brain.  Patients affected by this disorder show a complete loss of brain creatine, intellectual disability, epilepsy and a lack of communicative ability.  To date, there is no known treatment for CTD.  The primary work of my lab is to understand how the loss of Cr leads to such profound deficits.  To do this, we have developed a mouse model of CTD, the CrT knockout (CrT-KO) mouse.   CrT-KO mice show significant learning and memory deficits, similar to that of human patients.  Using molecular, cellular and behavioral techniques, my lab works to identify the critical parameters that are necessary in order to further understand and develop treatments for this disorder.  

Doctoral Degree: University of Cincinnati 2006 (Molecular and Developmental Biology)

Bachelor's Degree: Bellarmine University 2000 (Biology)

Peer Reviewed Publications

Wong, Ann Chi Yan; Velamoor, Sailakshmi; Skelton, Matthew R; Thorne, Peter R; Vlajkovic, Srdjan M (2012. ) Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues.Histochemistry and cell biology, , 137 (5 ) ,599-613 More Information

Skelton, Matthew R; Schaefer, Tori L; Graham, Devon L; Degrauw, Ton J; Clark, Joseph F; Williams, Michael T; Vorhees, Charles V (2011. ) Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency.PloS one, , 6 (1 ) ,e16187 More Information

Skelton, Matthew R; Graham, Devon L; Schaefer, Tori L; Grace, Curtis E; Braun, Amanda A; Burns, Lindsey N; Amos-Kroohs, Robyn M; Williams, Michael T; Vorhees, Charles V (2012. ) Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats.The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), , 15 (6 ) ,811-24 More Information

Curran, Christine P; Nebert, Daniel W; Genter, Mary Beth; Patel, Krishna V; Schaefer, Tori L; Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V (2011. ) In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes.Environmental health perspectives, , 119 (9 ) ,1286-93 More Information

Sun, Ying; Liou, Benjamin; Ran, Huimin; Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V; Kitatani, Kazuyuki; Hannun, Yusuf A; Witte, David P; Xu, You-Hai; Grabowski, Gregory A (2010. ) Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits.Human molecular genetics, , 19 (6 ) ,1088-97 More Information

Sun, Ying; Ran, Huimin; Zamzow, Matt; Kitatani, Kazuyuki; Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V; Witte, David P; Hannun, Yusuf A; Grabowski, Gregory A (2010. ) Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse.Human molecular genetics, , 19 (4 ) ,634-47 More Information

Skelton, Matthew R; Schaefer, Tori L; Herring, Nicole R; Grace, Curtis E; Vorhees, Charles V; Williams, Michael T (2009. ) Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats.Psychopharmacology, , 204 (2 ) ,287-97 More Information

Skelton, Matthew R; Able, Jessica A; Grace, Curtis E; Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2008. ) (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks.Neuropharmacology, , 55 (7 ) ,1121-30 More Information

Sun, Ying; Witte, David P; Ran, Huimin; Zamzow, Matt; Barnes, Sonya; Cheng, Hua; Han, Xianlin; Williams, Michael T; Skelton, Matthew R; Vorhees, Charles V; Grabowski, Gregory A (2008. ) Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice.Human molecular genetics, , 17 (15 ) ,2345-56 More Information

Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V (2008. ) Developmental effects of 3,4-methylenedioxymethamphetamine: a review.Behavioural pharmacology, , 19 (2 ) ,91-111 More Information

Skelton, Matthew R; Williams, Michael T; Schaefer, Tori L; Vorhees, Charles V (2007. ) Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits.Psychoneuroendocrinology, , 32 (6 ) ,734-45 More Information

Skelton, Matthew R; Blankenmeyer, Tracy L; Gudelsky, Gary A; Brown-Strittholt, Carrie A; Vorhees, Charles V; Williams, Michael T (2004. ) Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats.Synapse (New York, N.Y.), , 54 (4 ) ,214-22 More Information

Skelton, Matthew R; Ponniah, Sathivel; Wang, Dennis Z-M; Doetschman, Thomas; Vorhees, Charles V; Pallen, Catherine J (2003. ) Protein tyrosine phosphatase alpha (PTP alpha) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety. Brain research, , 984 (1-2 ) ,1-10

Braun, Amanda A; Amos-Kroohs, Robyn M; Gutierrez, Arnold; Lundgren, Kerstin H; Seroogy, Kim B; Skelton, Matthew R; Vorhees, Charles V; Williams, Michael T (2015. ) Dopamine depletion in either the dorsomedial or dorsolateral striatum impairs egocentric Cincinnati water maze performance while sparing allocentric Morris water maze learning.Neurobiology of learning and memory, , 118 ,55-63 More Information

Vorhees, Charles V; Graham, Devon L; Braun, Amanda A; Schaefer, Tori L; Skelton, Matthew R; Richtand, Neil M; Williams, Michael T Prenatal immune challenge in rats: effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine.Neurotoxicology and teratology, , 47 ,54-65 More Information

Russell, Aaron P; Ghobrial, Lobna; Wright, Craig R; Lamon, Séverine; Brown, Erin L; Kon, Michihiro; Skelton, Matthew R; Snow, Rodney J (2014. ) Creatine transporter (SLC6A8) knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle.Frontiers in physiology, , 5 ,314 More Information

Hautman, Emily R; Kokenge, Amanda N; Udobi, Kenea C; Williams, Michael T; Vorhees, Charles V; Skelton, Matthew R (2014. ) Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits.Journal of inherited metabolic disease, , 37 (1 ) ,63-8 More Information

Vorhees, Charles V; Graham, Devon L; Amos-Kroohs, Robyn M; Braun, Amanda A; Grace, Curtis E; Schaefer, Tori L; Skelton, Matthew R; Erikson, Keith M; Aschner, Michael; Williams, Michael T (2014. ) Effects of developmental manganese, stress, and the combination of both on monoamines, growth, and corticosterone.Toxicology reports, , 1 ,1046-1061 More Information

Williams, Michael T; Skelton, Matthew R; Longacre, Ian D; Huggins, Kimberly N; Maple, Amanda M; Vorhees, Charles V; Brown, Russell W (2014. ) Neuronal reorganization in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine.Toxicology reports, , 1 ,699-706 More Information

Schaefer, Tori L; Grace, Curtis E; Braun, Amanda A; Amos-Kroohs, Robyn M; Graham, Devon L; Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V (2013. ) Cognitive impairments from developmental exposure to serotonergic drugs: citalopram and MDMA.The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), , 16 (6 ) ,1383-94 More Information

Academic - Cincinnati Children's Hospital Medical Center
Cincinnati  Ohio, 45229
Phone: 513-636-4222
matthew.skelton@cchmc.org