David Gius , MD,PHD

M.D.: Loyola University of Chicago Stritch School of Medicine Maywood, Illinois, 1992

Ph.D. : The University of Chicago Chicago, Illinois, 1989

B.S.: University of Illinois Chicago, Illinois, 1983 (Chemistry)

American Board of Radiology (Radiation Oncology) (Certification Date: 11-03-1997 ) - (Recertification Date: to 01-01-2018 )

Lung Cancer

Radiation Oncology

Radiation Oncology

Grant: #7R01CA257148-06 Investigators:Gius, David -07-15-2027 National Cancer Institute Lineage Plasticity, due to Disruption of MnSOD Biology, drives resistance to Ionizing Radiation / Androgen Deprivation Therapy Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Maity S.; Venkatesan M.; Chidambaram A.; Uthayabalan S.; Faat Lai L.T.; Clark N.D.; Lakkureddi A.; Ramachandran K.; Bentz K.; Ramalingam R.; Sen S.; Akram M.; Weintraub S.T.; Singh B.B.; Gius D.; Baur J.A.; Theiss A.L.; Caplan J.; Matthies D.; Stathopulos P.B.; Madesh M. (09-22-2026. ) Prohibitin controls MRS2-Mediated mitochondrial Mg2+ uptake to Shape bioenergetics.Cell Reports, , 45 (9 ) , More Information

Khan M.A.; Koniyan S.; Ahir M.; Jegga A.G.; Mayes M.D.; Gius D.; Leung J.; Bonnen M.D.; Montesi S.B.; Ghebre Y.T. (01-01-2026. ) Esomeprazole inhibits proliferation of scleroderma fibroblasts via cell cycle regulation.Frontiers in Pharmacology, , 16 , More Information

Chocron S.S.; Zhang D.; Sumawi B.; Schell J.; Cruz D.; Li G.; Sreenivas P.; Jiang H.; Dong F.F.; Munkácsy E.; Zhao S.; Porras M.A.G.; Gius D. (01-01-2026. ) ?3-adrenergic receptor agonist causes acute thermogenic metabolic crisis in ACSS1-K635Q knock-in mic.International Journal of Biological Sciences, , 22 (3 ) ,1070-1081 More Information

Leung J.W.; Gius D. (11-17-2025. ) GSK3? guides chromosomal repair pathway selection to support BRCA1-independent PARP inhibitor sensit.Journal of Clinical Investigation, , 135 (22 ) ,1-3 More Information

Wei S.J.; Schell J.; Qian W.; Silguero M.; Baseviciene A.; Chen W.H.; Trevino R.; Chocron E.S.; Ogle M.M.; Varmazyad M.; Martinez G.M.; Cruz D.; Lorenzana B.; Dong F.F.; Jiang H.; Nazarullah A.; Beardsley R.A.; Sharma K.; Chang J.; Munkácsy E.; Horikoshi N.; Gius D. (08-26-2025. ) Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative str.Cell Reports, , 44 (8 ) , More Information

Xu G.; Schell J.; Quan S.; Gao Y.; Wei S.J.; Pan M.; Han X.; Li G.; Zhou D.; Jiang H.; Dong F.F.; Munkácsy E.; Horikoshi N.; Gius D. (05-01-2025. ) Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered liver lipid metabolism on a ketog.Free Radical Biology and Medicine, , 232 ,260-268 More Information

Schell J.R.; Wei S.J.; Zhang J.; Trevino R.; Chen W.H.; Aguilar L.; Qian W.; Corbett C.W.; Jiang H.; Dong F.F.; Chocron E.S.; Nazarullah A.; Chang J.; Flanagan M.E.; Glatt V.; Dikalov S.; Munkácsy E.; Horikoshi N.; Gius D. (03-01-2025. ) MnSOD non-acetylation mimic knock-in mice exhibit dilated cardiomyopathy.Free Radical Biology and Medicine, , 229 ,58-67 More Information

Xu G.; Quan S.; Schell J.; Gao Y.; Varmazyad M.; Sreenivas P.; Cruz D.; Jiang H.; Pan M.; Han X.; Palavicini J.P.; Zhao P.; Sun X.; Marchant E.D.; Rasmussen B.B.; Li G.; Katsumura S.; Morita M.; Munkácsy E.; Horikoshi N.; Sandra Chocron E.; Gius D. (05-17-2024. ) Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and .Science Advances, , 10 (20 ) , More Information

Wei S.J.; Schell J.R.; Chocron E.S.; Varmazyad M.; Xu G.; Chen W.H.; Martinez G.M.; Dong F.F.; Sreenivas P.; Trevino R.; Jiang H.; Du Y.; Saliba A.; Qian W.; Lorenzana B.; Nazarullah A.; Chang J.; Sharma K.; Munkácsy E.; Horikoshi N.; Gius D. (05-17-2024. ) Ketogenic diet induces p53-dependent cellular senescence in multiple organs.Science Advances, , 10 (20 ) , More Information

Ogle M.M.; Trevino R.; Schell J.; Varmazyad M.; Horikoshi N.; Gius D. (04-01-2022. ) Manganese Superoxide Dismutase Acetylation and Regulation of Protein Structure in Breast Cancer Biol.Antioxidants, , 11 (4 ) , More Information

Prasanna P.G.; Citrin D.E.; Hildesheim J.; Ahmed M.M.; Venkatachalam S.; Riscuta G.; Xi D.; Zheng G.; Deursen J.v.; Goronzy J.; Kron S.J.; Anscher M.S.; Sharpless N.E.; Campisi J.; Brown S.L.; Niedernhofer L.J.; O'loghlen A.; Georgakilas A.G.; Paris F.; Gius D.; Gewirtz D.A.; Schmitt C.A.; Abazeed M.E.; Kirkland J.L.; Richmond A.; Romesser P.B.; Lowe S.W.; Gil J.; Mendonca M.S.; Burma S.; Zhou D.; Coleman C.N. (10-01-2021. ) Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy.Journal of the National Cancer Institute, , 113 (10 ) ,1285-1298 More Information

Cheresh P.; Kim S.J.; Jablonski R.; Watanabe S.; Lu Z.; Chi M.; Helmin K.A.; Gius D.; Scott Budinger G.R.; Kamp D.W. (07-01-2021. ) SIRT3 overexpression ameliorates asbestos-induced pulmonary fibrosis, mt-DNA damage and lung fibroge.International Journal of Molecular Sciences, , 22 (13 ) , More Information

Gao Y.; Zhu Y.; Tran E.L.; Tokars V.; Dean A.E.; Quan S.; Gius D. (01-01-2021. ) Mnsod lysine 68 acetylation leads to cisplatin and doxorubicin resistance due to aberrant mitochondr.International Journal of Biological Sciences, , 17 (5 ) ,1203-1216 More Information

Vidimar V.; Beilhartz G.L.; Park M.; Biancucci M.; Kieffer M.B.; Gius D.R.; Melnyk R.A.; Satchell K.J.F. (07-21-2020. ) An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth.Proceedings of the National Academy of Sciences of the United States of America, , 117 (29 ) ,16938-16948 More Information

Zhou Z.; Song X.; Chi J.(.; Gius D.R.; Huang Y.; Cristofanilli M.; Wan Y. (06-01-2020. ) Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance.Cellular Signalling, , 70 , More Information

Zhu Y.; Zou X.; Dean A.E.; Brien J.O.; Gao Y.; Tran E.L.; Park S.H.; Liu G.; Kieffer M.B.; Jiang H.; Stauffer M.E.; Hart R.; Quan S.; Satchell K.J.F.; Horikoshi N.; Bonini M.; Gius D. (12-01-2019. ) Lysine 68 acetylation directs MnSOD as a tetrameric detoxification complex versus a monomeric tumor .Nature Communications, , 10 (1 ) , More Information

Zhang S.; Weinberg S.; DeBerge M.; Gainullina A.; Schipma M.; Kinchen J.M.; Ben-Sahra I.; Gius D.R.; Yvan-Charvet L.; Chandel N.S.; Schumacker P.T.; Thorp E.B. (02-05-2019. ) Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polariz.Cell Metabolism, , 29 (2 ) ,443-456.e5 More Information

Kosciuczuk E.M.; Mehrotra S.; Saleiro D.; Kroczynska B.; Majchrzak-Kita B.; Lisowski P.; Driehaus C.; Rogalska A.; Turner A.; Lienhoop T.; Gius D.; Fish E.N.; Vassilopoulos A.; Platanias L.C. (01-18-2019. ) Sirtuin 2–mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I int.Journal of Biological Chemistry, , 294 (3 ) ,827-837 More Information

Gius D.; Zhu Y. (01-01-2019. ) Homeostatic roles of STING in cell proliferation and chromosomal instability.Cancer Research, , 79 (7 ) ,1295-1296 More Information

He C.; Danes J.M.; Hart P.C.; Zhu Y.; Huang Y.; de Abreu A.L.; O’Brien J.; Mathison A.J.; Tang B.; Frasor J.M.; Wakefield L.M.; Ganini D.; Stauder E.; Zielonka J.; Gantner B.N.; Urrutia R.A.; Gius D.; Bonini M.G. (01-01-2019. ) SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer.Proceedings of the National Academy of Sciences of the United States of America, , 116 (47 ) ,23534-23541 More Information

Quan S.; Principe D.R.; Dean A.E.; Park S.H.; Grippo P.J.; Gius D.; Horikoshi N. (12-01-2018. ) Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induc.Scientific Reports, , 8 (1 ) , More Information

Lantier L.; Williams A.S.; Hughey C.C.; Bracy D.P.; James F.D.; Ansari M.A.; Gius D.; Wasserman D.H. (12-01-2018. ) SIRT2 knockout exacerbates insulin resistance in high fat-fed mice.Plos One, , 13 (12 ) , More Information

Kibria G.; Ramos E.K.; Wan Y.; Gius D.R.; Liu H. (09-04-2018. ) Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges.Molecular Pharmaceutics, , 15 (9 ) ,3625-3633 More Information

Zhu Y.; Dean A.E.; Horikoshi N.; Heer C.; Spitz D.R.; Gius D. (08-31-2018. ) Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy.Journal of Clinical Investigation, , 128 (9 ) ,3682-3691 More Information

Vassilopoulos A.; Wang R.H.; Gius D. (04-25-2018. ) Mammalian Sirtuins, Cellular Energy Regulation, and Metabolism, and Carcinogenesis.Introductory Review on Sirtuins in Biology Aging and Disease, , 141-154 More Information

Zhu Y.; Gius D. (04-01-2018. ) Glycogen phosphorylase: A novel biomarker in doxorubicin-induced cardiac injury.Clinical Cancer Research, , 24 (7 ) ,1516-1517 More Information

Song H.Y.; Rellinger E.J.; Park S.H.; Paul P.; Qiao J.; Vasilopoulos A.; Ozden O.; Gius D.; Chung D.H. (02-01-2018. ) Inhibition of sirtuin 6 induces neuroblastoma differentiation.Anticancer Research, , 38 (2 ) ,647-654 More Information

Traver G.; Mont S.; Gius D.; Lawson W.E.; Ding G.X.; Sekhar K.R.; Freeman M.L. (11-01-2017. ) Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung.Free Radical Biology and Medicine, , 112 ,578-586 More Information

Zou X.; Ratti B.A.; O’Brien J.G.; Lautenschlager S.O.; Gius D.R.; Bonini M.G.; Zhu Y. (08-01-2017. ) Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox sign.Journal of Bioenergetics and Biomembranes, , 49 (4 ) ,325-333 More Information

Zou X.; Zhu Y.; Park S.H.; Liu G.; O'Brien J.; Jiang H.; Gius D. (08-01-2017. ) SIRT3-mediated dimerization of IDH2 directs cancer cell metabolism and tumor growth.Cancer Research, , 77 (15 ) ,3990-3999 More Information

Traba J.; Geiger S.S.; Kwarteng-Siaw M.; Han K.; Ra O.H.; Siegel R.M.; Gius D.; Sack M.N. (07-21-2017. ) Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-medi.Journal of Biological Chemistry, , 292 (29 ) ,12153-12164 More Information

Jablonski R.P.; Kim S.J.; Cheresh P.; Williams D.B.; Morales-Nebreda L.; Cheng Y.; Yeldandi A.; Bhorade S.; Pardo A.; Selman M.; Ridge K.; Gius D.; Budinger G.R.S.; Kamp D.W. (06-01-2017. ) SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA dam.FASEB Journal, , 31 (6 ) ,2520-2532 More Information

Liu G.; Park S.H.; Imbesi M.; Nathan W.J.; Zou X.; Zhu Y.; Jiang H.; Parisiadou L.; Gius D. (05-20-2017. ) Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dys.Antioxidants and Redox Signaling, , 26 (15 ) ,846-863 More Information

Shi H.; Deng H.X.; Gius D.; Schumacker P.T.; Surmeier D.J.; Ma Y.C. (05-15-2017. ) Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress.Human Molecular Genetics, , 26 (10 ) ,1915-1926 More Information

Yang X.; Park S.H.; Chang H.C.; Shapiro J.S.; Vassilopoulos A.; Sawicki K.T.; Chen C.; Shang M.; Burridge P.W.; Epting C.L.; Wilsbacher L.D.; Jenkitkasemwong S.; Knutson M.; Gius D.; Ardehali H. (04-03-2017. ) Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.Journal of Clinical Investigation, , 127 (4 ) ,1505-1516 More Information

Vidimar V.; Gius D.; Chakravarti D.; Bulun S.E.; Wei J.J.; Kim J.J. (11-01-2016. ) Dysfunctional MnSOD leads to redox dysregulation and activation of prosurvival AKT signaling in uter.Science Advances, , 2 (11 ) , More Information

Zou X.; Santa-Maria C.A.; O'Brien J.; Gius D.; Zhu Y. (08-20-2016. ) Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote.Antioxidants and Redox Signaling, , 25 (6 ) ,326-336 More Information

Park S.H.; Ozden O.; Liu G.; Song H.Y.; Zhu Y.; Yan Y.; Zou X.; Kang H.J.; Jiang H.; Principe D.R.; Cha Y.I.; Roh M.; Vassilopoulos A.; Gius D. (07-01-2016. ) SIRT2-mediated deacetylation and tetramerization of pyruvate kinase directs glycolysis and tumor gro.Cancer Research, , 76 (13 ) ,3802-3812 More Information

Wang X.X.; Edelstein M.H.; Gafter U.; Qiu L.; Luo Y.; Dobrinskikh E.; Lucia S.; Adorini L.; D'Agati V.D.; Levi J.; Rosenberg A.; Kopp J.B.; Gius D.R.; Saleem M.A.; Levi M. (05-01-2016. ) G protein-coupled bile acid receptor TGR5 activation inhibits kidney disease in obesity and diabetes.Journal of the American Society of Nephrology, , 27 (5 ) ,1362-1378 More Information

Zhang H.; Head P.S.E.; Daddacha W.; Park S.H.; Li X.; Pan Y.; Madden M.Z.; Duong D.M.; Xie M.; Yu B.; Warren M.D.; Liu E.A.; Dhere V.R.; Li C.; Pradilla I.; Torres M.A.; Wang Y.; Dynan W.S.; Doetsch P.W.; Deng X.; Seyfried N.T.; Gius D.; Yu D.S. (02-16-2016. ) ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.Cell Reports, , 14 (6 ) ,1435-1447 More Information

Song H.Y.; Biancucci M.; Kang H.J.; O'Callaghan C.; Park S.H.; Principe D.R.; Jiang H.; Yan Y.; Satchell K.F.; Raparia K.; Gius D.; Vassilopoulos A. (01-01-2016. ) SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.Oncotarget, , 7 (49 ) ,80336-80349 More Information

Zhu Y.; Paul P.; Lee S.; Craig B.T.; Rellinger E.J.; Qiao J.; Gius D.R.; Chung D.H. (09-01-2015. ) Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma.Surgery United States, , 158 (3 ) ,827-836 More Information

Lantier L.; Williams A.S.; Williams I.M.; Yang K.K.; Bracy D.P.; Goelzer M.; James F.D.; Gius D.; Wasserman D.H. (09-01-2015. ) SIRT3 is crucial for maintaining skeletal muscle insulin action and protects against severe insulin .Diabetes, , 64 (9 ) ,3081-3092 More Information

Liu R.; Fan M.; Candas D.; Qin L.; Zhang X.; Eldridge A.; Zou J.X.; Zhang T.; Juma S.; Jin C.; Li R.F.; Perks J.; Sun L.Q.; Vaughan A.T.M.; Hai C.X.; Gius D.R.; Li J.J. (09-01-2015. ) CDK1-mediated SIRT3 activation enhances mitochondrial function and tumor radioresistance.Molecular Cancer Therapeutics, , 14 (9 ) ,2090-2102 More Information

Antic I.; Biancucci M.; Zhu Y.; Gius D.R.; Satchell K.J.F. (06-08-2015. ) Site-specific processing of Ras and Rap1 Switch i by a MARTX toxin effector domain.Nature Communications, , 6 , More Information

Vassilopoulos A.; Tominaga Y.; Kim H.S.; Lahusen T.; Li B.; Yu H.; Gius D.; Deng C.X. (06-04-2015. ) WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carc.Oncogene, , 34 (23 ) ,3023-3035 More Information

Pillai V.B.; Samant S.; Sundaresan N.R.; Raghuraman H.; Kim G.; Bonner M.Y.; Arbiser J.L.; Walker D.I.; Jones D.P.; Gius D.; Gupta M.P. (04-14-2015. ) Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.Nature Communications, , 6 , More Information

Agarwal S.; Zhu Y.; Gius D.R.; Satchell K.J.F. (01-01-2015. ) The Makes Caterpillars Floppy (MCF)-like domain of Vibrio vulnificus induces mitochondrion-mediated .Infection and Immunity, , 83 (11 ) ,4392-4403 More Information

Tao R.; Leclerc J.; Yildiz K.; Park S.H.; Jung B.; Gius D.; Özden Ö. (01-01-2015. ) Changes in gene expression in SIRT3 knockout liver cells.Turkish Journal of Biology, , 39 (3 ) ,380-387 More Information

Vassilopoulos A.; Pennington J.D.; Andresson T.; Rees D.M.; Bosley A.D.; Fearnley I.M.; Ham A.; Flynn C.R.; Hill S.; Rose K.L.; Kim H.S.; Deng C.X.; Walker J.E.; Gius D. (08-01-2014. ) SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient-and exercise-induced str.Antioxidants and Redox Signaling, , 21 (4 ) ,551-564 More Information

Xu Y.; Gao X.D.; Lee J.H.; Huang H.; Tan H.; Ahn J.; Reinke L.M.; Peter M.E.; Feng Y.; Gius D.; Siziopikou K.P.; Peng J.; Xiao X.; Cheng C. (06-01-2014. ) Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative.Genes and Development, , 28 (11 ) ,1191-1203 More Information

Tao R.; Vassilopoulos A.; Parisiadou L.; Yan Y.; Gius D. (04-01-2014. ) Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling netwo.Antioxidants and Redox Signaling, , 20 (10 ) ,1646-1654 More Information

Coleman M.C.; Olivier A.K.; Jacobus J.A.; Mapuskar K.A.; Mao G.; Martin S.M.; Riley D.P.; Gius D.; Spitz D.R. (03-20-2014. ) Superoxide mediates acute liver injury in irradiated mice lacking Sirtuin 3.Antioxidants and Redox Signaling, , 20 (9 ) ,1423-1435 More Information

Nottingham L.K.; Yan C.H.; Yang X.; Si H.; Coupar J.; Bian Y.; Cheng T.F.; Allen C.; Arun P.; Gius D.; Dang L.; Van Waes C.; Chen Z. (02-27-2014. ) Aberrant IKK? and IKK? cooperatively activate NF-?B and induce EGFR/AP1 signaling to promote surviva.Oncogene, , 33 (9 ) ,1135-1147 More Information

Desouki M.M.; Doubinskaia I.; Gius D.; Abdulkadir S.A. (01-01-2014. ) Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor out.Human Pathology, , 45 (5 ) ,1071-1077 More Information

Ozden O.; Park S.H.; Wagner B.A.; Song H.Y.; Zhu Y.; Vassilopoulos A.; Jung B.; Buettner G.R.; Gius D. (01-01-2014. ) SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.Free Radical Biology and Medicine, , 76 ,163-172 More Information

Chi A.; Nguyen N.P.; Welsh J.S.; Tse W.; Monga M.; Oduntan O.; Almubarak M.; Rogers J.; Remick S.C.; Gius D. (01-01-2014. ) Strategies of dose escalation in the treatment of locally advanced non-small cell lung cancer: Image.Frontiers in Oncology, , 4 JUN , More Information

Zhu Y.; Yan Y.; Gius D.; Vassilopoulos A. (11-01-2013. ) Metabolic regulation of Sirtuins upon fasting and the implication for cancer.Current Opinion in Oncology, , 25 (6 ) ,630-636 More Information

Horn L.; Eisenberg R.; Gius D.; Kimmelshue K.; Massion P.; Putnam J.; Robinson C.; Carbone D. (10-22-2013. ) Cancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer.Abeloff S Clinical Oncology Fifth Edition, , 1143-1192 More Information

Liang Q.; Benavides G.A.; Vassilopoulos A.; Gius D.; Darley-Usmar V.; Zhang J. (09-01-2013. ) Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic .Biochemical Journal, , 454 (2 ) ,249-257 More Information

Zhang H.; Park S.H.; Pantazides B.G.; Karpiuk O.; Warren M.D.; Hardy C.W.; Duong D.M.; Park S.J.; Kim H.S.; Vassilopoulos A.; Seyfried N.T.; Johnsen S.A.; Gius D.; Yu D.S. (08-13-2013. ) SIRT2 directs the replication stress response through CDK9 deacetylation.Proceedings of the National Academy of Sciences of the United States of America, , 110 (33 ) ,13546-13551 More Information

Jacobus J.A.; Duda C.G.; Coleman M.C.; Martin S.M.; Mapuskar K.; Mao G.; Smith B.J.; Aykin-Burns N.; Guida P.; Gius D.; Domann F.E.; Knudson C.M.; Spitz D.R. (08-01-2013. ) Low-dose radiation-induced enhancement of thymic lymphomagenesis in lck-bax mice is dependent on LET.Radiation Research, , 180 (2 ) ,156-165 More Information

Shankavaram U.; Fliedner S.; Elkahloun A.; Barb J.; Munson P.; Huynh T.; Matro J.; Turkova H.; Marston Linehan W.; Timmers H.; Tischler A.; Powers J.; de Krijger R.; Baysal B.; Takacova M.; Pastorekova S.; Gius D.; Lehnert H.; Camphausen K.; Pacak K. (01-01-2013. ) Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragan.Neoplasia United States, , 15 (4 ) ,435-447 More Information

Peek C.B.; Affinati A.H.; Ramsey K.M.; Kuo H.Y.; Yu W.; Sena L.A.; Ilkayeva O.; Marcheva B.; Kobayashi Y.; Omura C.; Levine D.C.; Bacsik D.J.; Gius D.; Newgard C.B.; Goetzman E.; Chandel N.S.; Denu J.M.; Mrksich M.; Bass J. (01-01-2013. ) Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice.Science, , 342 (6158 ) , More Information

Zhu Y.; Park S.H.; Ozden O.; Kim H.S.; Jiang H.; Vassilopoulos A.; Spitz D.R.; Gius D. (08-15-2012. ) Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation stat.Free Radical Biology and Medicine, , 53 (4 ) ,828-833 More Information

Park S.H.; Zhu Y.; Ozden O.; Kim H.S.; Jiang H.; Deng C.X.; Gius D.; Vassilopoulos A. (06-01-2012. ) SIRT2 is a tumor suppressor that connects aging, acetylome, cell cycle signaling, and carcinogenesis.Translational Cancer Research, , 1 (1 ) ,15-21 More Information

Haigis M.C.; Deng C.X.; Finley L.W.S.; Kim H.S.; Gius D. (05-15-2012. ) SIRT3 is a mitochondrial tumor suppressor: A scientific tale that connects aberrant cellular ROS, th.Cancer Research, , 72 (10 ) ,2468-2472 More Information

Wang J.; Anderson P.D.; Luo W.; Gius D.; Roh M.; Abdulkadir S.A. (04-05-2012. ) Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells.Oncogene, , 31 (14 ) ,1794-1803 More Information

Scarbrough P.M.; Mapuskar K.A.; Mattson D.M.; Gius D.; Watson W.H.; Spitz D.R. (01-15-2012. ) Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potenti.Free Radical Biology and Medicine, , 52 (2 ) ,436-443 More Information

Spitz D.R.; Dornfeld K.J.; Krishnan K.; Gius D. (01-01-2012. ) Oxidative stress in cancer biology and therapy.Oxidative Stress in Cancer Biology and Therapy, , 1-460 More Information

Park S.H.; Ozden O.; Jiang H.; Cha Y.I.; Pennington J.D.; Aykin-Burns N.; Spitz D.R.; Gius D.; Kim H.S. (09-01-2011. ) Sirt3, mitochondrial ROS, ageing, and carcinogenesis.International Journal of Molecular Sciences, , 12 (9 ) ,6226-6239 More Information

Kendrick A.A.; Choudhury M.; Rahman S.M.; McCurdy C.E.; Friederich M.; Van Hove J.L.K.; Watson P.A.; Birdsey N.; Bao J.; Gius D.; Sack M.N.; Jing E.; Kahn C.R.; Friedman J.E.; Jonscher K.R. (02-01-2011. ) Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation.Biochemical Journal, , 433 (3 ) ,505-514 More Information

Vassilopoulos A.; Fritz K.S.; Petersen D.R.; Gius D. (01-01-2011. ) The human sirtuin family: Evolutionary divergences and functions.Human Genomics, , 5 (5 ) ,485-496 More Information

Kamrava M.; Gius D.; Casagrande G.; Kohn E. (01-01-2011. ) Will targeting insulin growth factor help us or hurt us?: An oncologist's perspective.Ageing Research Reviews, , 10 (1 ) ,62-70 More Information

Ozden O.; Park S.H.; Kim H.S.; Jiang H.; Coleman M.C.; Spitz D.R.; Gius D. (01-01-2011. ) Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative .Aging, , 3 (2 ) ,102-107 More Information

Kim H.S.; Vassilopoulos A.; Wang R.H.; Lahusen T.; Xiao Z.; Xu X.; Li C.; Veenstra T.D.; Li B.; Yu H.; Ji J.; Wang X.W.; Park S.H.; Cha Y.I.; Gius D.; Deng C.X. (01-01-2011. ) SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity.Cancer Cell, , 20 (4 ) ,487-499 More Information

Tao R.; Coleman M.C.; Pennington J.D.; Ozden O.; Park S.H.; Jiang H.; Kim H.S.; Flynn C.R.; Hill S.; McDonald W.H.; Olivier A.K.; Spitz D.R.; Gius D. (12-22-2010. ) Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Resp.Molecular Cell, , 40 (6 ) ,893-904 More Information

Xiao C.; Kim H.S.; Lahusen T.; Wang R.H.; Xu X.; Gavrilova O.; Jou W.; Gius D.; Deng C.X. (11-19-2010. ) SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated gluco.Journal of Biological Chemistry, , 285 (47 ) ,36776-36784 More Information

Bao J.; Scott I.; Lu Z.; Pang L.; Dimond C.; Gius D.; Sack M. (10-01-2010. ) SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity.Free Radical Biology and Medicine, , 49 (7 ) ,1230-1237 More Information

Baur J.A.; Chen D.; Chini E.N.; Chua K.; Cohen H.Y.; De Cabo R.; Deng C.; Dimmeler S.; Gius D.; Guarente L.P.; Helfand S.L.; Imai S.I.; Itoh H.; Kadowaki T.; Koya D.; Leeuwenburgh C.; Mcburney M.; Nabeshima Y.O.I.; Neri C.; Oberdoerffer P.; Pestell R.G.; Rogina B.; Sadoshima J.; Sartorelli V.; Serrano M.; Sinclair D.A.; Steegborn C.; Tatar M.; Tissenbaum H.A.; Tong Q.; Tsubota K.; Vaquero A.; Verdin E. (08-27-2010. ) Dietary restriction: Standing up for sirtuins.Science, , 329 (5995 ) ,1012-1013 More Information

Van Waes C.; Allen C.T.; Citrin D.; Gius D.; Colevas A.D.; Harold N.A.; Rudy S.; Nottingham L.; Muir C.; Chen Z.; Singh A.K.; Dancey J.; Morris J.C. (06-01-2010. ) Molecular and Clinical Responses in a Pilot Study of Gefitinib With Paclitaxel and Radiation in Loca.International Journal of Radiation Oncology Biology Physics, , 77 (2 ) ,447-454 More Information

Bao J.; Lu Z.; Joseph J.J.; Carabenciov D.; Dimond C.C.; Pang L.; Samsel L.; McCoy J.P.; Leclerc J.; Nguyen P.M.; Gius D.; Sack M.N. (05-01-2010. ) Characterization of the murine SIRT3 mitochondrial localization sequence and comparison of mitochond.Journal of Cellular Biochemistry, , 110 (1 ) ,238-247 More Information

Kim H.S.; Patel K.; Muldoon-Jacobs K.; Bisht K.S.; Aykin-Burns N.; Pennington J.D.; van der Meer R.; Nguyen P.; Savage J.; Owens K.M.; Vassilopoulos A.; Ozden O.; Park S.H.; Singh K.K.; Abdulkadir S.A.; Spitz D.R.; Deng C.X.; Gius D. (01-19-2010. ) SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integri.Cancer Cell, , 17 (1 ) ,41-52 More Information

Kassis J.N.; Virador V.M.; Guancial E.A.; Kimm D.; Ho A.S.; Mishra M.; Chuang E.Y.; Cook J.; Gius D.; Kohn E.C. (08-01-2009. ) Genomic and phenotypic analysis reveals a key role for CCN1 (CYR61) in BAG3 - Modulated adhesion and.Journal of Pathology, , 218 (4 ) ,495-504 More Information

Simone N.L.; Soule B.P.; Ly D.; Saleh A.D.; Savage J.E.; DeGraff W.; Cook J.; Harris C.C.; Gius D.; Mitchell J.B. (07-27-2009. ) Ionizing radiation-induced oxidative stress alters miRNA expression.Plos One, , 4 (7 ) , More Information

Sharp H.; Morris J.C.; Van Waes C.; Gius D.; Cooley-Zgela T.; Singh A.K. (12-01-2008. ) High incidence of oral dysesthesias on a trial of gefitinib, paclitaxel, and concurrent external bea.American Journal of Clinical Oncology Cancer Clinical Trials, , 31 (6 ) ,557-560 More Information

Rader J.S.; Malone J.P.; Gross J.; Gilmore P.; Brooks R.A.; Nguyen L.; Crimmins D.L.; Feng S.; Wright J.D.; Taylor N.; Zighelboim I.; Funk M.C.; Huettner P.C.; Ledenson J.H.; Gius D.; Townsend R.R. (12-01-2008. ) A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to ident.Proteomics Clinical Applications, , 2 (12 ) ,1658-1669 More Information

Nguyen P.; Bar-Sela G.; Sun L.; Bisht K.S.; Cui H.; Kohn E.; Feinberg A.P.; Gius D. (11-01-2008. ) BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expre.Molecular and Cellular Biology, , 28 (21 ) ,6720-6729 More Information

Jacobs K.M.; Pennington J.D.; Bisht K.S.; Aykin-Burns N.; Kim H.S.; Mishra M.; Sun L.; Nguyen P.; Ahn B.H.; Leclerc J.; Deng C.X.; Spitz D.R.; Gius D. (09-05-2008. ) SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a depe.International Journal of Biological Sciences, , 4 (5 ) ,291-299 More Information

Trimble E.L.; Harlan L.C.; Gius D.; Stevens J.; Schwartz S.M. (08-15-2008. ) Patterns of care for women with cervical cancer in the United States.Cancer, , 113 (4 ) ,743-749 More Information

Nguyen P.; Cui H.; Bisht K.S.; Sun L.; Patel K.; Lee R.S.; Kugoh H.; Oshimura M.; Feinberg A.P.; Gius D. (07-15-2008. ) CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the patern.Cancer Research, , 68 (14 ) ,5546-5551 More Information

Sun L.; Huang L.; Nguyen P.; Bisht K.S.; Bar-Sela G.; Ho A.S.; Bradbury C.M.; Yu W.; Cui H.; Lee S.; Trepel J.B.; Feinberg A.P.; Gius D. (04-15-2008. ) DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulati.Cancer Research, , 68 (8 ) ,2726-2735 More Information

Mishra M.V.; Bisht K.S.; Sun L.; Muldoon-Jacobs K.; Awwad R.; Kaushal A.; Nguyen P.; Huang L.; Pennington J.D.; Markovina S.; Bradbury C.M.; Gius D. (02-01-2008. ) DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells.Molecular Cancer Research, , 6 (2 ) ,243-249 More Information

Yu W.; Gius D.; Onyango P.; Muldoon-Jacobs K.; Karp J.; Feinberg A.P.; Cui H. (01-01-2008. ) Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA.Nature, , 451 (7175 ) ,202-206 More Information

Guo Z.; Tsai M.H.; Shiao Y.H.; Chen L.H.; Wei M.L.; Lv X.; Gius D.; Little J.B.; Mitchell J.B.; Chuang E.Y. (01-01-2008. ) DNA (cytosine-5)-methyltransferase 1 as a mediator of mutant p53-determined p16ink4A down-regulation.Journal of Biomedical Science, , 15 (2 ) ,163-168 More Information

Annunziata C.; Kleinberg L.; Davidson B.; Berner A.; Gius D.; Tchabo N.; Steinberg S.; Kohn E. (11-15-2007. ) BAG-4/SODD and associated antiapoptotic proteins are linked to aggressiveness of epithelial ovarian .Clinical Cancer Research, , 13 (22 ) ,6585-6592 More Information

Gius D.; Funk M.C.; Chuang E.Y.; Feng S.; Huettner P.C.; Nguyen L.; Bradbury C.M.; Mishra M.; Gao S.; Buttin B.M.; Cohn D.E.; Powell M.A.; Horowitz N.S.; Whitcomb B.P.; Rader J. (08-01-2007. ) Profiling microdissected epithelium and stroma to model genomic signatures for cervical carcinogenes.Cancer Research, , 67 (15 ) ,7113-7123 More Information

Bar-Sela G.; Jacobs K.M.; Gius D. (01-01-2007. ) Histone deacetylase inhibitor and demethylating agent chromatin compaction and the radiation respons.Cancer Journal, , 13 (1 ) ,65-69 More Information

Pennington J.D.; Jacobs K.M.; Sun L.; Bar-Sela G.; Mishra M.; Gius D. (01-01-2007. ) Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy.Current Pharmaceutical Design, , 13 (33 ) ,3368-3377 More Information

Fitzpatrick M.A.; Funk M.C.; Gius D.; Huettner P.C.; Zhang Z.; Bidder M.; Ma D.; Powell M.A.; Rader J.S. (11-01-2006. ) Identification of chromosomal alterations important in the development of cervical intraepithelial n.Gynecologic Oncology, , 103 (2 ) ,458-462 More Information

Gius D.; Spitz D.R. (07-01-2006. ) Redox signaling in cancer biology.Antioxidants and Redox Signaling, , 8 (7-8 ) ,1249-1252 More Information

Zhao W.; Chuang E.Y.; Mishra M.; Awwad R.; Bisht K.; Sun L.; Nguyen P.; Pennington J.D.; Wang T.J.C.; Bradbury C.M.; Huang L.; Chen Z.; Bar-Sela G.; Robbins M.E.C.; Gius D. (06-15-2006. ) Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene express.Clinical Cancer Research, , 12 (12 ) ,3823-3830 More Information

Nguyen P.; Awwad R.T.; Smart D.D.K.; Spitz D.R.; Gius D. (05-18-2006. ) Thioredoxin reductase as a novel molecular target for cancer therapy.Cancer Letters, , 236 (2 ) ,164-174 More Information

Barker C.; Burgan W.; Carter D.; Cerna D.; Gius D.; Hollingshead M.; Camphausen K.; Tofilon P. (05-01-2006. ) In vitro and in vivo radiosensitization induced by the ribonucleotide reductase inhibitor triapine (.Clinical Cancer Research, , 12 (9 ) ,2912-2918 More Information

Van Waes C.; Chang A.A.; Lebowitz P.F.; Druzgal C.H.; Chen Z.; Elsayed Y.A.; Sunwoo J.B.; Rudy S.F.; Morris J.C.; Mitchell J.B.; Camphausen K.; Gius D.; Adams J.; Sausville E.A.; Conley B.A. (12-01-2005. ) Inhibition of nuclear factor-?B and target genes during combined therapy with proteasome inhibitor b.International Journal of Radiation Oncology Biology Physics, , 63 (5 ) ,1400-1412 More Information

Stoyanovsky D.A.; Tyurina Y.Y.; Tyurin V.A.; Anand D.; Mandavia D.N.; Gius D.; Ivanova J.; Pitt B.; Billiar T.R.; Kagan V.E. (11-16-2005. ) Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitroso.Journal of the American Chemical Society, , 127 (45 ) ,15815-15823 More Information

Gius D.; Bradbury C.M.; Sun L.; Awwad R.T.; Huang L.; Smart D.D.K.; Bisht K.S.; Ho A.S.; Nguyen P. (10-26-2005. ) The epigenome as a molecular marker and target: Implications for cancer.Cancer, , 104 (9 ) ,1789-1793 More Information

Wang T.; Hui Y.C.; Dong S.; Fan M.; Tamae D.; Ozeki M.; Gao Q.; Gius D.; Jian J.L. (04-01-2005. ) Co-activation of ERK, NF-??, and GADD45? in response to ionizing radiation.Journal of Biological Chemistry, , 280 (13 ) ,12593-12601 More Information

Pennington J.; Wang T.; Nguyen P.; Sun L.; Bisht K.; Smart D.; Gius D. (01-01-2005. ) Redox-sensitive signaling factors as a novel molecular targets for cancer therapy.Drug Resistance Updates, , 8 (5 ) ,322-330 More Information

Bjornsson H.T.; Cui H.; Gius D.; Fallin M.D.; Feinberg A.P. (12-01-2004. ) The new field of epigenomics: Implications for cancer and other common disease research.Cold Spring Harbor Symposia on Quantitative Biology, , 69 ,447-456 More Information

Smart D.D.K.; Ortiz K.L.; Mattson D.; Bradbury C.M.; Bisht K.S.; Sieck L.K.; Brechbiel M.W.; Gius D. (09-15-2004. ) Thioredoxin reductase as a potential molecular target for anticancer agents that induce oxidative st.Cancer Research, , 64 (18 ) ,6716-6724 More Information

Spitz D.; Azzam E.; Li J.; Gius D. (08-01-2004. ) Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying con.Cancer and Metastasis Reviews, , 23 (3-4 ) ,311-322 More Information

Gius D.; Mattson D.; Bradbury C.M.; Smart D.K.; Spitz D.R. (03-01-2004. ) Thermal stress and the disruption of redox-sensitive signalling and transcription factor activation:.International Journal of Hyperthermia, , 20 (2 ) ,213-223 More Information

Lagunas L.; Bradbury C.; Laszlo A.; Hunt C.; Gius D. (01-23-2004. ) Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock respon.Biochemical and Biophysical Research Communications, , 313 (4 ) ,863-870 More Information

Gius D. (01-01-2004. ) Redox-sensitive signaling factors and antioxidants: How tumor cells respond to ionizing radiation.Journal of Nutrition, , 134 (11 ) , More Information

Cook J.A.; Gius D.; Wink D.A.; Krishna M.C.; Russo A.; Mitchell J.B. (01-01-2004. ) Oxidative stress, redox, and the tumor microenvironment.Seminars in Radiation Oncology, , 14 (3 ) ,259-266 More Information

Mattson D.; Bradbury C.M.; Bisht K.S.; Curry H.A.; Spitz D.R.; Gius D. (01-01-2004. ) Heat shock and the activation of AP-1 and inhibition of NF-?B DNA-binding activity: Possible role of.International Journal of Hyperthermia, , 20 (2 ) ,224-233 More Information

Mimnaugh E.G.; Xu W.; Vos M.; Yuan X.; Isaacs J.S.; Bisht K.S.; Gius D.; Neckers L. (01-01-2004. ) Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endopla.Molecular Cancer Therapeutics, , 3 (5 ) ,551-566 More Information

Gius D.; Cui H.; Bradbury C.M.; Cook J.; Smart D.D.K.; Zhao S.; Young L.; Brandenburg S.A.; Hu Y.; Bisht K.S.; Ho A.S.; Mattson D.; Sun L.; Munson P.J.; Chuang E.Y.; Mitchell J.B.; Feinberg A.P. (01-01-2004. ) Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome rev.Cancer Cell, , 6 (4 ) ,361-371 More Information

Bisht K.S.; Bradbury C.M.; Mattson D.; Kaushal A.; Sowers A.; Markovina S.; Ortiz K.L.; Sieck L.K.; Isaacs J.S.; Brechbiel M.W.; Mitchell J.B.; Neckers L.M.; Gius D. (12-15-2003. ) Geldanamycin and 17-Allylamino-17-demethoxygeldanamycin Potentiate the in Vitro and in Vivo Radiatio .Cancer Research, , 63 (24 ) ,8984-8995

Bisht K.; Bradbury C.; Zoberi I.; Curry H.; Kaushal A.; Roti Roti J.; Gius D. (11-01-2003. ) Inhibition of cyclooxygenase-2 with NS-398 and the prevention of radiation-induced transformation, m.International Journal of Radiation Biology, , 79 (11 ) ,879-888 More Information

Dewhirst M.W.; Sneed P.K.; Karimpour S.; Gius D. (10-01-2003. ) Those in gene therapy should pay closer attention to lessons from hyperthermia [5] (multiple letter).International Journal of Radiation Oncology Biology Physics, , 57 (2 ) ,597-599 More Information

Lin X.; Zhang F.; Bradbury C.M.; Kaushal A.; Li L.; Spitz D.R.; Aft R.L.; Gius D. (06-15-2003. ) 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disrupt .Cancer Research, , 63 (12 ) ,3413-3417

Karimpour S.; Gius D. (01-01-2003. ) The holy grail of radiation oncology: Lessons learned from hyperthermia.International Journal of Radiation Oncology Biology Physics, , 55 (1 ) ,3-4 More Information

Trimble E.; Schoenfeldt M.; Streicher H.; Gius D.; Cornelison T. (01-01-2003. ) Clinical Trials Referral Resource. Clinical trials in cervical cancer. Oncology Williston Park N Y, , 17 (1 ) ,84-89

Ohiro Y.; Usheva A.; Kobayashi S.; Duffy S.; Nantz R.; Gius D.; Horikoshi N. (01-01-2003. ) Inhibition of stress-inducible kinase pathways by tumorigenic mutant p53.Molecular and Cellular Biology, , 23 (1 ) ,322-334 More Information

Gius D.; Coleman C.N. (11-06-2002. ) Treatment of nasopharyngeal cancer: Raising the "Barr".Journal of the National Cancer Institute, , 94 (21 ) ,1594-1595 More Information

Ohiro Y.; Garkavtsev I.; Kobayashi S.; Sreekumar K.R.; Nantz R.; Higashikubo B.T.; Duffy S.L.; Higashikubo R.; Usheva A.; Gius D.; Kley N.; Horikoshi N. (07-31-2002. ) A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (.FEBS Letters, , 524 (1-3 ) ,163-171 More Information

Locke J.E.; Bradbury C.M.; Wei S.J.; Shah S.; Rene L.M.; Clemens R.A.; Roti J.R.; Horikoshi N.; Gius D. (07-04-2002. ) Indomethacin lowers the threshold thermal exposure for hyperthermic radiosensitization and heat-shoc.International Journal of Radiation Biology, , 78 (6 ) ,493-502 More Information

Sekhar K.; Spitz D.; Harris S.; Nguyen T.; Meredith M.; Holt J.; Gius D.; Marnett L.; Summar M.; Freeman M. (07-01-2002. ) Erratum: Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced express.Free Radical Biology and Medicine, , 33 (1 ) ,149 More Information

Sekhar K.R.; Spitz D.R.; Harris S.; Nguyen T.T.; Meredith M.J.; Holt J.T.; Guis D.; Marnett L.J.; Summar M.L.; Freeman M.L. (04-01-2002. ) Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of ?-.Free Radical Biology and Medicine, , 32 (7 ) ,650-662 More Information

Zoberi I.; Bradbury C.M.; Curry H.A.; Bisht K.S.; Goswami P.C.; Roti Roti J.L.; Gius D. (01-25-2002. ) Radiosensitizing and anti-proliferative effects of resveratrol in two human cervical tumor cell line.Cancer Letters, , 175 (2 ) ,165-173 More Information

Aft R.L.; Zhang F.W.; Gius D. (01-01-2002. ) Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: Mechanism of cell death.British Journal of Cancer, , 87 (7 ) ,805-812 More Information

Karimpour S.; Lou J.; Lin L.L.; Rene L.M.; Lagunas L.; Ma X.; Karra S.; Bradbury C.M.; Markovina S.; Goswami P.C.; Spitz D.R.; Hirota K.; Kalvakolanu D.V.; Yodoi J.; Gius D. (01-01-2002. ) Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active.Oncogene, , 21 (41 ) ,6317-6327 More Information

Markovina S.; Wei S.J.; Rene L.M.; Zoberi I.; Horikoshi N.; Bradbury C.M.; Gius D. (10-15-2001. ) Indomethacin-induced radiosensitization and inhibition of ionizing radiation-induced NF-?B activatio .Cancer Research, , 61 (20 ) ,7689-7696

Bradbury C.M.; Locke J.E.; Wei S.J.; Rene L.M.; Karimpour S.; Hunt C.; Spitz D.R.; Gius D. (04-15-2001. ) Increased activator protein 1 activity as well as resistance to heat-induced radiosensitization, hyd .Cancer Research, , 61 (8 ) ,3486-3492

Goswami P.C.; Sheren J.; Albee L.D.; Parsian A.; Sim J.E.; Ridnour L.A.; Higashikubo R.; Gius D.; Hunt C.R.; Spitz D.R. (12-08-2000. ) Cell cycle-coupled variation in topoisomerase II? mRNA is regulated by the 3?-untranslated region: P.Journal of Biological Chemistry, , 275 (49 ) ,38384-38392 More Information

Roti Roti J.; Gius D.; VanderWaal R.; Xu M. (12-01-2000. ) Rearrangement of chromatin domains in cancer and development .Journal of Cellular Biochemistry, , 80 (SUPPL. 35 ) ,54-60

Wei S.; Botero A.; Hirota K.; Bradbury C.; Markovina S.; Laszlo A.; Spitz D.; Goswami P.; Yodoi J.; Gius D. (12-01-2000. ) Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protei .Cancer Research, , 60 (23 ) ,6688-6695

Curry H.A.; Clemens R.A.; Shah S.; Bradbury C.M.; Botero A.; Goswami P.; Gius D. (08-13-1999. ) Heat shock inhibits radiation-induced activation of NF-?B via inhibition of I-?B kinase.Journal of Biological Chemistry, , 274 (33 ) ,23061-23067 More Information

Diamond D.A.; Parsian A.; Hunt C.R.; Lofgren S.; Spitz D.R.; Goswami P.C.; Gius D. (06-11-1999. ) Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat.Journal of Biological Chemistry, , 274 (24 ) ,16959-16964 More Information

Gius D.; Botero A.; Shah S.; Curry H.A. (06-01-1999. ) Intracellular oxidation/reduction status in the regulation of transcription factors NF-?B and AP-1.Toxicology Letters, , 106 (2-3 ) ,93-106 More Information

Gius D.R.; Ezhevsky S.A.; Becker-Hapak M.; Nagahara H.; Wei M.C.; Dowdy S.F. (06-01-1999. ) Transduced p16(INK4a) peptides inhibit hypophosphorylation of the retinoblastoma protein and cell cy .Cancer Research, , 59 (11 ) ,2577-2580

Ezhevsky S.A.; Nagahara H.; Vocero-Akbani A.M.; Gius D.R.; Wei M.C.; Dowdy S.F. (09-30-1997. ) Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in act.Proceedings of the National Academy of Sciences of the United States of America, , 94 (20 ) ,10699-10704 More Information

Hallahan D.E.; Gius D.; Kuchibhotla J.; Sukhatme V.; Kufe D.W.; Weichselbaum R.R. (03-05-1993. ) Radiation signaling mediated by jun activation following dissociation from a cell type-specific repr.Journal of Biological Chemistry, , 268 (7 ) ,4903-4907 More Information

Rim M.; Qureshi S.A.; Gius D.; Nho J.; Sukhatme V.P.; Foster D.A. (01-01-1992. ) Evidence that activation of the Egr-1 promoter by v-Raf involves serum response elements .Oncogene, , 7 (10 ) ,2069-2072

Gius D.; Cao X.; Rauscher F.; Cohen D.; Curran T.; Sukhatme V. (01-01-1990. ) Transcriptional activation and repression by fos are independent functions: The C terminus represses.Molecular and Cellular Biology, , 10 (8 ) ,4243-4255 More Information

Gius D.; Laimins L.A. (01-01-1989. ) Activation of human papillomavirus type 18 gene expression by herpes simplex virus type 1 viral tran.Journal of Virology, , 63 (2 ) ,555-563 More Information

Gius D.; Grossman S.; Bedell M.A.; Laimins L.A. (01-01-1988. ) Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18.Journal of Virology, , 62 (3 ) ,665-672 More Information