Jun-Lin Guan , PHD

~~Dr. Jun-Lin Guan received his education at the University of Science and Technology in China (B.S. 1982) and the University of California at San Diego (Ph.D. 1987). After postdoctoral training at the Center for Cancer Research at MIT, Dr. Guan joined Cornell University faculty as an Assistant Professor in 1991. He rose through the ranks to become a full Professor in 2001 and was director of graduate studies and professor of molecular medicine at Cornell University and also a member of the Cornell Nanobiotechnology Center. In 2006, he moved to the University of Michigan Medical School as a professor of internal medicine in the division of molecular medicine and genetics and of cell and developmental biology. In 2014, he joined University of Cincinnati College of Medicine as the Francis Brunning Endowed Chair and professor of cancer biology, associate director for research of the University of Cincinnati Cancer Institute (UCCI) and co-leader of molecular and cellular basis of cancer of the Cincinnati Cancer Center (CCC).
    Dr. Guan’s research centers on the mechanisms of cell signaling in biological processes and how disruption of the normal signaling pathways leads to cancer and other diseases. He is world renowned for his work on focal adhesion kinase (FAK), an important cytoplasmic signaling enzyme that impacts a wide range of normal physiology and pathology. His pioneering studies on the induction of tyrosine phosphorylation of an 120 kDa protein (pp120) upon cell adhesion and the identification of pp120 as a novel tyrosine kinase FAK that is controlled by both cell adhesion and oncogenic transformation helped to open up a new research field on signal transduction by integrins in the early 1990’s. His laboratory has made major contributions in the discovery and characterization of other signaling molecules and pathways in the regulation of cell migration, survival and proliferation by intergrin signaling through FAK. In recent years, Dr. Guan’s group have developed sophisticated mouse models with conditional FAK knockout and mutant knockin to demonstrate critical functions of FAK signaling in tumor development, metastasis, cancer stem cells, and angiogenesis. Dr. Guan’s laboratory is also at the forefront in deciphering the role of autophagy in biological and disease processes. His work in the early 2000’s identified and characterized a key protein FIP200 (FAK-family Interacting Protein of 200 Kd) that was subsequently shown as a component of a complex essential for autophagy induction in mammalian cells. Dr. Guan’s lab was the first to demonstrate a positive role for autophagy in promoting cancer development and progression in animal models with intact immune system. His current work continues to investigate the role of autophagy in cancer stem cells, dormancy, drug resistance, relapse and metastasis as well as in neural stem cells.
    Dr. Guan received many awards and honors, including Kuo Mu-Rao Award (1982), Anna Fuller Cancer Fund fellowship (1987), SmithKline Beecham Award for Research Excellence at Cornell University (1993), the Established Investigator Award from American Heart Association (1998), and League of Research Excellence at University of Michigan Medical School (2011). He has received continuous grants from the National Institutes of Health since 1992. He has mentored a large number of graduate students and postdoctoral fellows, who have become independent investigators. Dr. Guan is the author of more than 140 scientific papers, many of which are landmark contributions to his research fields. He was editor of Signaling Through Cell Adhesion Molecules (1999) and Cell Migration: Developmental Methods and Protocols (2005). He has served on the editorial boards of several journals including the Journal of Biological Chemistry, Molecular and Cellular Pharmacology and the Journal of Breast Cancer: Targets and Therapy. He also has

Bachelor's Degree: University of Science and Technology of China Hefei, CN, 1982 (Biology)

Doctoral Degree: University of California San Diego La Jolla, CT, 1987 (Biology)

Research: Massachusetts Institute of Technology Cambridge, MA, 1991 (Cancer Research)

• Tyrosine kinase signaling
• Autophagy
• Breast cancer
• Angiogenesis and vascular tumors
• Neural stem cells and neurogenesis
• Neurodegenerative diseases

04-19-1991 -1997 Assistant Professor, Department of Molecular Medicine, Cornell University,

1997 -2001 Associate Professor, Department of Molecular Medicine, , Cornell University,

11-19-1998 -05-19-1999 Visiting Professor, Sabbatical leave from Cornell University, Department of Bioengineering, University of California, San Diego, CA

09-20-2002 -09-20-2006 Member Nanobiotechnology Center, Cornell University,

07-20-2005 -09-20-2006 Director of Graduate Studies (Field of Pharmacology), Cornell University,

09-20-2006 -12-20-2013 Professor, Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School,

09-20-2006 -12-20-2013 Professor, Department of Cell and Developmental Biology, University of Michigan Medical School,

09-20-2006 -12-20-2013 Member, University of Michigan Comprehensive Cancer Center,

Grant: #3003077923 / R01CA125577 Investigators:Guan, Jun-lin 01-01-2014 -11-30-2018 National Cancer Institute ROLE OF CCN6 (WISP3) IN THE PROGRESSION AND METASTASIS OF BREAST CANCER. Role:PI $17,520.00 Awarded Level:Federal

Grant: #R01 HL073394 Investigators:Guan, Jun-lin 04-01-2014 -03-31-2017 National Heart, Lung and Blood Institute Analysis of intracellular signaling in angiogenesis Role:PI $395,625.00 Active Level:Federal

Grant: #7R01CA163493-03 Investigators:Guan, Jun-lin 04-01-2014 -03-31-2017 National Cancer Institute Genetic Analysis of FAK kinase and scaffold functions in breast cancer Role:PI $319,021.00 Awarded Level:Federal

Grant: #3003154652 / R01 AR062030 Investigators:Guan, Jun-lin 06-01-2014 -08-31-2017 National Institute of Arthritis, Musculoskeletal and Skin Disease THE MECHANISMS OF BONE MASS REGULATION BY FIP200 Role:PI $10,188.00 Active Level:Federal

Grant: #R01CA150926 Investigators:Guan, Jun-lin 09-11-2014 -12-31-2014 National Cancer Institute Molecular Analysis of Signal Transduction in Cancer Development and Progression Role:PI $81,887.00 Awarded Level:Federal

Grant: #NS094144-01 Investigators:Guan, Jun-lin 09-01-2015 -08-31-2020 National Institute of Neurological Disorders and Stroke Mechanisms of Neural Stem Cells Regulation by Autophagy Role:PI $345,625.00 Awarded Level:Federal

Grant: #R03NS097887 Investigators:Guan, Jun-lin; Wang, Chenran 07-01-2016 -06-30-2018 National Institute of Neurological Disorders and Stroke Mechanisms of autophagy in TSC1-deficient neural stem cells Role:Collaborator $79,000.00 Awarded Level:Federal

Grant: #mTORC1 Investigators:Guan, Jun-lin 08-01-2016 -07-31-2017 Angiosarcoma Awareness Inc. Therapeutic targeting of mTORC1 for lymphangiosarcoma using a novel mouse model Role:PI $43,200.00 Active Level:Private Non-Profit

Grant: #R01CA211066 Investigators:Guan, Jun-lin 06-15-2017 -05-31-2022 National Cancer Institute Mechanisms of FIP200 regulation of breast cancer through its autophagy and non-autophagy functions Role:PI $364,571.00 Active Level:Federal

Grant: #VA Billing Agreement - Brian Hunt Investigators:Guan, Jun-lin; Hunt, Brian 07-01-2017 -06-30-2019 Department of Veterans Affairs VA Contract - Brian Hunt Role:Collaborator $65,237.40 Awarded Level:Federal

Grant: #R01NS103981 Investigators:Guan, Jun-lin; Wang, Chenran 07-15-2018 -06-30-2023 National Institute of Neurological Disorders and Stroke Regulation of lipid catabolism by autophagy in neural stem cell of tuberous sclerosis complex Role:Collaborator $350,000.00 Active Level:Federal

Grant: #R01 HL073394 Investigators:Guan, Jun-lin 09-01-2018 -07-31-2022 National Heart, Lung and Blood Institute Autophagy and mTORC1 signaling in lymphatic malformation and lymphangiosarcoma Role:PI $416,946.00 Active Level:Federal

Grant: #OK St. Univ / R01AI141399 Investigators:Guan, Jun-lin 11-15-2018 -10-31-2023 National Institute of Allergy and Infectious Diseases Role of FIP200 in RIG-I-mediated innate immunity Role:PI $19,328.00 Awarded Level:Federal

Grant: #R01GM128216 Investigators:Czyzyk-Krzeska, Maria; Greis, Kenneth; Guan, Jun-lin; Meller, Jaroslaw 09-12-2019 -08-31-2023 National Institute of General Medical Sciences Mechanisms of selective autophagy Role:Collaborator $314,708.00 Awarded Level:Federal

Grant: #TUL-HSC-557767_ R01AI141399 Investigators:Guan, Jun-lin 11-01-2019 -10-31-2023 National Institute of Allergy and Infectious Diseases Role of FIP200 in RIG-I-mediated innate immunity Role:PI $20,266.85 Awarded Level:Federal

Grant: #R01NS094144 Investigators:Guan, Jun-lin; Wang, Chenran 09-01-2020 -06-30-2025 National Institute of Neurological Disorders and Stroke Regulation of neural stem cells and neurogenesis by autophagy genes Role:PI $396,034.00 Awarded Level:Federal

Investigators:Guan, Jun-lin 07-01-2022 -06-30-2026 National Heart, Lung and Blood Institute Mechanisms of progression of vascular malformation to lymphangiosarcoma Role:PI 487993.00 Awarded Level:Federal

Grant: #R01CA211066 Investigators:Guan, Jun-lin; Yeo, Syn 06-01-2023 -05-31-2028 National Cancer Institute Intersection of autophagy and vesicle trafficking in Her2-positive breast cancer Role:PI 407632.50 Hold Level:Federal

Grant: #R01CA273586 Investigators:Guan, Jun-lin; Wang, Chenran 04-01-2023 -03-31-2028 National Cancer Institute Roles of Glial Autophagy in Breast Cancer Brain Metastasis Role:Collaborator 402424.00 Awarded Level:Federal

Grant: #AAES Fndn Investigators:Guan, Jun-lin; Holm, Tammy 07-01-2023 -06-30-2024 American Association of Endocrine Surgeons Foundation Targeting Autophagy in the Pathogenesis of Anaplastic Thyroid Cancer Role:Collaborator 20000.00 Hold Level:Non Profit

Peer Reviewed Publications

Terasawa, Kazue; Kato, Yuji; Ikami, Yuta; Sakamoto, Kensaku; Ohtake, Kazumasa; Kusano, Seisuke; Tomabechi, Yuri; Kukimoto-Niino, Mutsuko; Shirouzu, Mikako; Guan, Jun-Lin; Kobayashi, Toshihide; Iwata, Takanori; Watabe, Tetsuro; Yokoyama, Shigeyuki; Hara-Yokoyama, Miki (2021. ) Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells.Autophagy, , 1-19 More Information

Hao, Mingang; Yeo, Syn Kok; Guan, Jun-Lin (2021. ) Autophagy inhibition perturbs ERBB2 trafficking and abolishes tumorigenesis in ERBB2-driven breast cancer.Autophagy, , 17 (4 ) ,1059-1060 More Information

Wang, Chenran; Haas, Michael A; Yeo, Syn Kok; Paul, Ritama; Yang, Fuchun; Vallabhapurapu, Subrahmanya; Qi, Xiaoyang; Plas, David R; Guan, Jun-Lin (2021. ) Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis.British journal of cancer, , 124 ,1711–1723 More Information

Yang, Yongguang; Leonard, Marissa; Luo, Zhenhua; Yeo, Syn; Bick, Gregory; Hao, Mingang; Cai, Chunmiao; Charif, Mahmoud; Wang, Jiang; Guan, Jun-Lin; Lower, Elyse E; Zhang, Xiaoting (2021. ) Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer.Cell reports, , 34 (10 ) ,108822 More Information

Hao, Mingang; Yeo, Syn Kok; Turner, Kevin; Harold, Alexis; Yang, Yongguang; Zhang, Xiaoting; Guan, Jun-Lin (2021. ) Autophagy Blockade Limits HER2+ Breast Cancer Tumorigenesis by Perturbing HER2 Trafficking and Promoting Release Via Small Extracellular Vesicles.Developmental cell, , 56 (3 ) ,341-355.e5 More Information

Fang, Hongbao; Geng, Shanshan; Hao, Mingang; Chen, Qixin; Liu, Minglun; Liu, Chunyan; Tian, Zhiqi; Wang, Chengjun; Takebe, Takanori; Guan, Jun-Lin; Chen, Yuncong; Guo, Zijian; He, Weijiang; Diao, Jiajie (2021. ) Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells.Nature communications, , 12 (1 ) ,109 More Information

Bischoff, Megan E; Zang, Yuanwei; Chu, Johnson; Price, Adam D; Ehmer, Birgit; Talbot, Nicholas J; Newbold, Michael J; Paul, Anurag; Guan, Jun-Lin; Plas, David R; Meller, Jarek; Czyzyk-Krzeska, Maria F (2021. ) Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide.The Journal of cell biology, , 220 (7 ) , More Information

Yi, Fei; Zhang, Ying; Wang, Zhijun; Wang, Zhuo; Li, Ziwei; Zhou, Tingting; Xu, Hongde; Liu, Jingwei; Jiang, Bo; Li, Xiaoman; Wang, Liang; Bai, Ning; Guo, Qiqiang; Guan, Yi; Feng, Yanling; Mao, Zhiyong; Fan, Guangjian; Zhang, Shengping; Wang, Chuangui; Cao, Longyue; O'Rourke, Brian P; Wang, Yang; Wu, Yanmei; Wu, Boquan; You, Shilong; Zhang, Naijin; Guan, Junlin; Song, Xiaoyu; Sun, Yingxian; Wei, Shi; Cao, Liu (2021. ) The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis.Science advances, , 7 (9 ) , More Information

Zachari, Maria; Gudmundsson, Sigurdur R; Li, Ziyue; Manifava, Maria; Cugliandolo, Fiorella; Shah, Ronak; Smith, Matthew; Stronge, James; Karanasios, Eleftherios; Piunti, Caterina; Kishi-Itakura, Chieko; Vihinen, Helena; Jokitalo, Eija; Guan, Jun-Lin; Buss, Folma; Smith, Andrew M; Walker, Simon A; Eskelinen, Eeva-Liisa; Ktistakis, Nicholas T (2020. ) Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.Developmental cell, , 55 (2 ) ,251 More Information

Morishita, Hideaki; Kanda, Yuki; Kaizuka, Takeshi; Chino, Haruka; Nakao, Kazuki; Miki, Yoshimi; Taketomi, Yoshitaka; Guan, Jun-Lin; Murakami, Makoto; Aiba, Atsu; Mizushima, Noboru (2020. ) Autophagy Is Required for Maturation of Surfactant-Containing Lamellar Bodies in the Lung and Swim Bladder.Cell reports, , 33 (10 ) ,108477 More Information

Xia, Houjun; Li, Shasha; Li, Xiong; Wang, Weichao; Bian, Yingjie; Wei, Shuang; Grove, Sara; Wang, Weimin; Vatan, Linda; Liu, J Rebecca; McLean, Karen; Rattan, Ramandeep; Munkarah, Adnan; Guan, Jun-Lin; Kryczek, Ilona; Zou, Weiping (2020. ) Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis.JCI insight, , 5 (18 ) , More Information

Huang, Huilin; Weng, Hengyou; Sun, Wenju; Qin, Xi; Shi, Hailing; Wu, Huizhe; Zhao, Boxuan Simen; Mesquita, Ana; Liu, Chang; Yuan, Celvie L; Hu, Yueh-Chiang; Hüttelmaier, Stefan; Skibbe, Jennifer R; Su, Rui; Deng, Xiaolan; Dong, Lei; Sun, Miao; Li, Chenying; Nachtergaele, Sigrid; Wang, Yungui; Hu, Chao; Ferchen, Kyle; Greis, Kenneth D; Jiang, Xi; Wei, Minjie; Qu, Lianghu; Guan, Jun-Lin; He, Chuan; Yang, Jianhua; Chen, Jianjun (2020. ) Publisher Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.Nature cell biology, , More Information

Yeo, Syn Kok; Zhu, Xiaoting; Okamoto, Takako; Hao, Mingang; Wang, Cailian; Lu, Peixin; Lu, Long Jason; Guan, Jun-Lin (2020. ) Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer.eLife, , 9 , More Information

Yeo, Syn Kok; Guan, Jun-Lin (2020. ) Regulation of immune checkpoint blockade efficacy in breast cancer by FIP200: A canonical-autophagy-independent function.Cell stress, , 4 (8 ) ,216-217 More Information

Ogawa, Michinaga; Takada, Naoki; Shizukuishi, Sayaka; Tomokiyo, Mikado; Chang, Bin; Yoshida, Mitsutaka; Kakuta, Soichiro; Tanida, Isei; Ryo, Akihide; Guan, Jun-Lin; Takeyama, Haruko; Ohnishi, Makoto (2020. ) Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAPosome-like vesicles via NDP52-delocalization.Communications biology, , 3 (1 ) ,25 More Information

Wu, Hsin-Jung; Hao, Mingang; Yeo, Syn Kok; Guan, Jun-Lin (2020. ) FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication.Oncogene, , More Information

Deng, Shan; Essandoh, Kobina; Wang, Xiaohong; Li, Yutian; Huang, Wei; Chen, Jing; Peng, Jiangtong; Jiang, Ding-Sheng; Mu, Xingjiang; Wang, Chenran; Peng, Tianqing; Guan, Jun-Lin; Wang, Yigang; Jegga, Anil; Huang, Kai; Fan, Guo-Chang (2020. ) Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.Redox biology, , 101453 More Information

Chen, Qixin; Shao, Xintian; Hao, Mingang; Fang, Hongbao; Guan, Ruilin; Tian, Zhiqi; Li, Miaoling; Wang, Chenran; Ji, Liangnian; Chao, Hui; Guan, Jun-Lin; Diao, Jiajie (2020. ) Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy.Biomaterials, , 250 ,120059 More Information

Yang, Fuchun; Sun, Shaogang; Wang, Chenran; Haas, Michael; Yeo, Syn; Guan, Jun-Lin (2020. ) Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation.British journal of cancer, , More Information

Qi, Shuqun; Sun, Xiumei; Choi, Han Kyoung; Yao, Jinfeng; Wang, Li; Wu, Guomin; He, Yun; Pan, Jian; Guan, Jun-Lin; Liu, Fei (2020. ) FAK promotes early osteoprogenitor cell proliferation by enhancing mTORC1 signaling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, , More Information

Paul, Ritama; Luo, Ming; Mo, Xueying; Lu, Jason; Yeo, Syn Kok; Guan, Jun-Lin (2020. ) FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.Breast cancer research : BCR, , 22 (1 ) ,59 More Information

Qiu, Kangqiang; Du, Yang; Liu, Jiyan; Guan, Jun-Lin; Chao, Hui; Diao, Jiajie (2020. ) Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles.Theranostics, , 10 (13 ) ,6072-6081 More Information

Yeo, Syn Kok; Wang, Chenran; Guan, Jun-Lin (2020. ) Role of FIP200 in inflammatory processes beyond its canonical autophagy function.Biochemical Society transactions, , More Information

Paul, Ritama; Luo, Ming; Mo, Xueying; Lu, Jason; Yeo, Syn Kok; Guan, Jun-Lin (2020. ) Correction to: FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors.Breast cancer research : BCR, , 22 (1 ) ,71 More Information

Okamoto, Takako; Yeo, Syn Kok; Hao, Mingang; Copley, Mary Rose; Haas, Michael A; Chen, Song; Guan, Jun-Lin (2020. ) FIP200 suppresses immune checkpoint therapy responses in breast cancers by limiting AZI2/TBK1/IRF signaling independent of its canonical autophagy function.Cancer research, , More Information

Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin (2019. ) Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells.Nature metabolism, , 1 (11 ) ,1127-1140 More Information

Ho, Wan Yun; Tai, Yee Kit; Chang, Jer-Cherng; Liang, Jason; Tyan, Sheue-Houy; Chen, Song; Guan, Jun-Lin; Zhou, Huilin; Shen, Han-Ming; Koo, Edward; Ling, Shuo-Chien (2019. ) The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy.Autophagy, , 1-16 More Information

Jeong, Kyuho; Kim, Jung-Hyun; Murphy, James M; Park, Hyeonsoo; Kim, Su-Jeong; Rodriguez, Yelitza; Kong, Hyunkyung; Choi, Chungsik; Guan, Jun-Lin; Taylor, Joan M; Lincoln, Thomas M; Gerthoffer, William T; Kim, Jun-Sub; Ahn, Eun-Young Erin; Schlaepfer, David D; Lim, Ssang-Taek Steve (2019. ) Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription.Circulation research, , More Information

Gao, Chenxi; Chen, Guangming; Zhang, Dennis Han; Zhang, Judy; Kuan, Shih-Fan; Hu, Wenhuo; Esni, Farzad; Gao, Xuan; Guan, Jun-Lin; Chu, Edward; Hu, Jing (2019. ) PYK2 is involved in premalignant acinar cell reprogramming and pancreatic ductal adenocarcinoma maintenance by phosphorylating ?-cateninY654.Cellular and molecular gastroenterology and hepatology, , More Information

Zachari, Maria; Gudmundsson, Sigurdur R; Li, Ziyue; Manifava, Maria; Shah, Ronak; Smith, Matthew; Stronge, James; Karanasios, Eleftherios; Piunti, Caterina; Kishi-Itakura, Chieko; Vihinen, Helena; Jokitalo, Eija; Guan, Jun-Lin; Buss, Folma; Smith, Andrew M; Walker, Simon A; Eskelinen, Eeva-Liisa; Ktistakis, Nicholas T (2019. ) Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform.Developmental cell, , More Information

Thomas, Neil; Choi, Han Kyoung; Wei, Xiaoxi; Wang, Li; Mishina, Yuji; Guan, Jun-Lin; Liu, Fei (2019. ) Autophagy Regulates Craniofacial Bone Acquisition.Calcified tissue international, , More Information

Huang, Huilin; Weng, Hengyou; Zhou, Keren; Wu, Tong; Zhao, Boxuan Simen; Sun, Mingli; Chen, Zhenhua; Deng, Xiaolan; Xiao, Gang; Auer, Franziska; Klemm, Lars; Wu, Huizhe; Zuo, Zhixiang; Qin, Xi; Dong, Yunzhu; Zhou, Yile; Qin, Hanjun; Tao, Shu; Du, Juan; Liu, Jun; Lu, Zhike; Yin, Hang; Mesquita, Ana; Yuan, Celvie L; Hu, Yueh-Chiang; Sun, Wenju; Su, Rui; Dong, Lei; Shen, Chao; Li, Chenying; Qing, Ying; Jiang, Xi; Wu, Xiwei; Sun, Miao; Guan, Jun-Lin; Qu, Lianghu; Wei, Minjie; Müschen, Markus; Huang, Gang; He, Chuan; Yang, Jianhua; Chen, Jianjun (2019. ) Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally.Nature, , 567 (7748 ) ,414-419 More Information

Chen, Qixin; Jin, Chengzhi; Shao, Xintian; Guan, Ruilin; Tian, Zhiqi; Wang, Chenran; Liu, Fei; Ling, Peixue; Guan, Jun-Lin; Ji, Liangnian; Wang, Fengshan; Chao, Hui; Diao, Jiajie (2018. ) Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore.Small (Weinheim an der Bergstrasse, Germany), , 14 (41 ) ,e1802166 More Information

Liu, Bingjie; Du, Ruikai; Zhou, Lei; Xu, Jiahui; Chen, Song; Chen, Ji; Yang, Xiaoli; Liu, Dong-Xu; Shao, Zhi-Ming; Zhang, Lixing; Yu, Zuoren; Xie, Ni; Guan, Jun-Lin; Liu, Suling (2018. ) miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/?-Catenin Axis.Theranostics, , 8 (21 ) ,5801-5813 More Information

Ogawa, Michinaga; Matsuda, Ryuta; Takada, Naoki; Tomokiyo, Mikado; Yamamoto, Shouji; Shizukusihi, Sayaka; Yamaji, Toshiyuki; Yoshikawa, Yuko; Yoshida, Mitsutaka; Tanida, Isei; Koike, Masato; Murai, Miyo; Morita, Hidetoshi; Takeyama, Haruko; Ryo, Akihide; Guan, Jun-Lin; Yamamoto, Masahiro; Inoue, Jun-Ichiro; Yanagawa, Toru; Fukuda, Mitsunori; Kawabe, Hiroshi; Ohnishi, Makoto (2018. ) Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1 mediated K63-linked ubiquitination.Cellular microbiology, , e12846 More Information

Nwadike, Chinwendu; Williamson, Leon E; Gallagher, Laura E; Guan, Jun-Lin; Chan, Edmond Y W (2018. ) AMPK inhibits ULK1-dependent autophagosome formation and lysosomal acidification via distinct mechanisms.Molecular and cellular biology, , More Information

Huang, Huilin; Weng, Hengyou; Sun, Wenju; Qin, Xi; Shi, Hailing; Wu, Huizhe; Zhao, Boxuan Simen; Mesquita, Ana; Liu, Chang; Yuan, Celvie L; Hu, Yueh-Chiang; Hüttelmaier, Stefan; Skibbe, Jennifer R; Su, Rui; Deng, Xiaolan; Dong, Lei; Sun, Miao; Li, Chenying; Nachtergaele, Sigrid; Wang, Yungui; Hu, Chao; Ferchen, Kyle; Greis, Kenneth D; Jiang, Xi; Wei, Minjie; Qu, Lianghu; Guan, Jun-Lin; He, Chuan; Yang, Jianhua; Chen, Jianjun (2018. ) Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.Nature cell biology, , 20 (3 ) ,285-295 More Information

Thiagarajan, Praveena S; Sinyuk, Maksim; Turaga, Soumya M; Mulkearns-Hubert, Erin E; Hale, James S; Rao, Vinay; Demelash, Abeba; Saygin, Caner; China, Arnab; Alban, Tyler J; Hitomi, Masahiro; Torre-Healy, Luke A; Alvarado, Alvaro G; Jarrar, Awad; Wiechert, Andrew; Adorno-Cruz, Valery; Fox, Paul L; Calhoun, Benjamin C; Guan, Jun-Lin; Liu, Huiping; Reizes, Ofer; Lathia, Justin D (2018. ) Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase.Nature communications, , 9 (1 ) ,578 More Information

Sun, Shaogang; Wu, Hsin-Jung; Guan, Jun-Lin (2018. ) Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice.Scientific reports, , 8 (1 ) ,2550 More Information

Choi, Han Kyoung; Yuan, Hebao; Fang, Fang; Wei, Xiaoxi; Liu, Lu; Li, Qing; Guan, Jun-Lin; Liu, Fei (2018. ) Tsc1 regulates the balance between osteoblast and adipocyte differentiation through autophagy/Notch1/β-catenin cascade.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, , More Information

Yeo, Syn Kok; Paul, Ritama; Haas, Michael; Wang, Chenran; Guan, Jun-Lin (2018. ) Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.Autophagy, , More Information

Martin, E E; Huang, W; Anwar, T; Arellano-Garcia, C; Burman, B; Guan, J-L; Gonzalez, M E; Kleer, C G (2017. ) MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas.Oncogene, , 36 (16 ) ,2275-2285 More Information

Wang, Chenran; Yeo, Syn; Haas, Michael A; Guan, Jun-Lin (2017. ) Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.The Journal of cell biology, , 216 (8 ) ,2581-2596 More Information

He, Yun; Sun, Xiumei; Wang, Li; Mishina, Yuji; Guan, Jun-Lin; Liu, Fei (2017. ) Male germline recombination of a conditional allele by the widely used Dermo1-cre (Twist2-cre) transgene.Genesis (New York, N.Y. : 2000), , More Information

Wacker, Rahel; Eickel, Nina; Schmuckli-Maurer, Jacqueline; Annoura, Takeshi; Niklaus, Livia; Khan, Shahid M; Guan, Jun-Lin; Heussler, Volker T (2017. ) LC3-association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a noncanonical autophagy pathway.Cellular microbiology, , More Information

Chen, Xiaoyi; Clark, Jason; Wunderlich, Mark; Fan, Cuiqing; Davis, Ashley; Chen, Song; Guan, Jun-Lin; Mulloy, James C; Kumar, Ashish; Zheng, Yi (2017. ) Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine.Autophagy, , 13 (5 ) ,955-966 More Information

Ruiz-Torres, Sasha J; Benight, Nancy M; Karns, Rebekah A; Lower, Elyse E; Guan, Jun-Lin; Waltz, Susan E (2017. ) HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling.Oncotarget, , 8 (35 ) ,58918-58933 More Information

Xia, Houjun; Wang, Wei; Crespo, Joel; Kryczek, Ilona; Li, Wei; Wei, Shuang; Bian, Zhaoqun; Maj, Tomasz; He, Mingxiao; Liu, Rebecca J; He, Youwen; Rattan, Ramandeep; Munkarah, Adnan; Guan, Jun-Lin; Zou, Weiping (2017. ) Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity.Science immunology, , 2 (17 ) , More Information

Wang, Bo; Iyengar, Rekha; Li-Harms, Xiujie; Joo, Joung Hyuck; Wright, Christopher; Lavado, Alfonso; Horner, Linda; Yang, Mao; Guan, Jun-Lin; Frase, Sharon; Green, Douglas R; Cao, Xinwei; Kundu, Mondira (2017. ) The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway.Autophagy, , 1-16 More Information

Yeo, Syn Kok; Guan, Jun-Lin (2017. ) Breast Cancer: Multiple Subtypes within a Tumor?.Trends in cancer, , 3 (11 ) ,753-760 More Information

Park, Sunmin; Buck, Michael D; Desai, Chandni; Zhang, Xin; Loginicheva, Ekaterina; Martinez, Jennifer; Freeman, Michael L; Saitoh, Tatsuya; Akira, Shizuo; Guan, Jun-Lin; He, You-Wen; Blackman, Marcia A; Handley, Scott A; Levine, Beth; Green, Douglas R; Reese, Tiffany A; Artyomov, Maxim N; Virgin, Herbert W (2016. ) Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.Cell host & microbe, , 19 (1 ) ,91-101 More Information

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin (2016. ) Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.The Journal of cell biology, , 212 (7 ) ,879 More Information

Sun, Shaogang; Guan, Jun-Lin (2016. ) Modeling lymphangiosarcoma in mice.Cell cycle (Georgetown, Tex.), , 0 More Information

Chen, Song; Wang, Chenran; Yeo, Syn; Liang, Chun-Chi; Okamoto, Takako; Sun, Shaogang; Wen, Jian; Guan, Jun-Lin (2016. ) Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.Genes & development, , 30 (7 ) ,856-69 More Information

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin (2016. ) Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.The Journal of cell biology, , 212 (5 ) ,545-60 More Information

Sun, Chunhui; Yuan, Hebao; Wang, Li; Wei, Xiaoxi; Williams, Linford; Krebsbach, Paul H; Guan, Jun-Lin; Liu, Fei (2016. ) FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation By Enhancing Wnt Signaling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, , More Information

Wagener, Brant M; Hu, Meng; Zheng, Anni; Zhao, Xueke; Che, Pulin; Brandon, Angela; Anjum, Naseem; Snapper, Scott; Creighton, Judy; Guan, Jun-Lin; Han, Qimei; Cai, Guo-Qiang; Han, Xiaosi; Pittet, Jean-Francois; Ding, Qiang (2016. ) Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 30 (7 ) ,2557-69 More Information

Yeo, Syn Kok; Wen, Jian; Chen, Song; Guan, Jun-Lin (2016. ) Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling.Cancer research, , 76 (11 ) ,3397-410 More Information

Yeo, Syn Kok; Guan, Jun-Lin (2016. ) Hierarchical heterogeneity in mammary tumors and its regulation by autophagy.Autophagy, , 12 (10 ) ,1960-1961 More Information

Santeford, Andrea; Wiley, Luke A; Park, Sunmin; Bamba, Sonya; Nakamura, Rei; Gdoura, Abdelaziz; Ferguson, Thomas A; Rao, P Kumar; Guan, Jun-Lin; Saitoh, Tatsuya; Akira, Shizuo; Xavier, Ramnik; Virgin, Herbert W; Apte, Rajendra S (2016. ) Impaired autophagy in macrophages promotes inflammatory eye disease.Autophagy, , 12 (10 ) ,1876-1885 More Information

Wen, Jian; Yeo, Syn; Wang, Chenran; Chen, Song; Sun, Shaogang; Haas, Michael A; Tu, Wei; Jin, Feng; Guan, Jun-Lin (2015. ) Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis.Breast cancer research and treatment, , 149 (3 ) ,619-29 More Information

Fang, Fang; Sun, Shaogang; Wang, Li; Guan, Jun-Lin; Giovannini, Marco; Zhu, Yuan; Liu, Fei (2015. ) Neural Crest-Specific TSC1 Deletion in Mice Leads to Sclerotic Craniofacial Bone Lesion.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, , 30 (7 ) ,1195-205 More Information

Martinez, Jennifer; Malireddi, R K Subbarao; Lu, Qun; Cunha, Larissa Dias; Pelletier, Stephane; Gingras, Sebastien; Orchard, Robert; Guan, Jun-Lin; Tan, Haiyan; Peng, Junmin; Kanneganti, Thirumala-Devi; Virgin, Herbert W; Green, Douglas R (2015. ) Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins.Nature cell biology, , 17 (7 ) ,893-906 More Information

Yao, Jingyu; Jia, Lin; Khan, Naheed; Lin, Chengmao; Mitter, Sayak K; Boulton, Michael E; Dunaief, Joshua L; Klionsky, Daniel J; Guan, Jun-Lin; Thompson, Debra A; Zacks, David N (2015. ) Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.Autophagy, , 11 (6 ) ,939-53 More Information

Wei, Huijun; Guan, Jun-Lin (2015. ) Blocking tumor growth by targeting autophagy and SQSTM1 in vivo.Autophagy, , 11 (5 ) ,854-5 More Information

Tai, Yu-Ling; Chu, Pei-Yu; Lai, I-Rue; Wang, Ming-Yang; Tseng, Hui-Yuan; Guan, Jun-Lin; Liou, Jun-Yang; Shen, Tang-Long (2015. ) An EGFR/Src-dependent beta-4 integrin/FAK complex contributes to malignancy of breast cancer.Scientific reports, , 5 ,16408 More Information

Sun, Shaogang; Chen, Song; Liu, Fei; Wu, Haige; McHugh, Jonathan; Bergin, Ingrid L; Gupta, Anita; Adams, Denise; Guan, Jun-Lin (2015. ) Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling.Cancer cell, , 28 (6 ) ,758-72 More Information

Kim, Edward; Wang, Yuan; Kim, Sun-Jung; Bornhorst, Miriam; Jecrois, Emmanuelle S; Anthony, Todd E; Wang, Chenran; Li, Yi E; Guan, Jun-Lin; Murphy, Geoffrey G; Zhu, Yuan (2014. ) Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1.eLife, , 3 , More Information

Qu, Hong; Tu, Yizeng; Guan, Jun-Lin; Xiao, Guozhi; Wu, Chuanyue (2014. ) Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit.The Journal of biological chemistry, , 289 (45 ) ,31001-13 More Information

Wei, Huijun; Wang, Chenran; Croce, Carlo M; Guan, Jun-Lin (2014. ) p62/SQSTM1 synergizes with autophagy for tumor growth in vivo.Genes & development, , 28 (11 ) ,1204-16 More Information

Chen, Yongqiang; Wei, Huijun; Liu, Fei; Guan, Jun-Lin (2014. ) Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling.The Journal of biological chemistry, , 289 (2 ) ,1164-73 More Information

Seong, Jihye; Tajik, Arash; Sun, Jie; Guan, Jun-Lin; Humphries, Martin J; Craig, Susan E; Shekaran, Asha; García, Andrés J; Lu, Shaoying; Lin, Michael Z; Wang, Ning; Wang, Yingxiao (2013. ) Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins.Proceedings of the National Academy of Sciences of the United States of America, , 110 (48 ) ,19372-7 More Information

Hsieh, Yu-Hua; van der Heyde, Henri; Oh, Eok-Soo; Guan, Jun-Lin; Chang, Pi-Ling (2013. ) Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: An Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis.Molecular carcinogenesis, , 54 (5 ) ,379-92 More Information

Jin, Yixin; Liu, Yang; Lin, Qiong; Li, Jieli; Druso, Joseph E; Antonyak, Marc A; Meininger, Cynthia J; Zhang, Shenyuan L; Dostal, David E; Guan, Jun-Lin; Cerione, Richard A; Peng, Xu (2013. ) Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis.Molecular and cellular biology, , 33 (21 ) ,4181-97 More Information

Fujita, Naonobu; Morita, Eiji; Itoh, Takashi; Tanaka, Atsushi; Nakaoka, Megumi; Osada, Yuki; Umemoto, Tetsuo; Saitoh, Tatsuya; Nakatogawa, Hitoshi; Kobayashi, Shouhei; Haraguchi, Tokuko; Guan, Jun-Lin; Iwai, Kazuhiro; Tokunaga, Fuminori; Saito, Kazunobu; Ishibashi, Koutaro; Akira, Shizuo; Fukuda, Mitsunori; Noda, Takeshi; Yoshimori, Tamotsu (2013. ) Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.The Journal of cell biology, , 203 (1 ) ,115-28 More Information

Peng, Xu; Lin, Qiong; Liu, Yang; Jin, Yixin; Druso, Joseph E; Antonyak, Marc A; Guan, Jun-Lin; Cerione, Richard A (2013. ) Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice.Protein & cell, , 4 (3 ) ,231-42 More Information

Monastyrska, Iryna; Ulasli, Mustafa; Rottier, Peter J M; Guan, Jun-Lin; Reggiori, Fulvio; de Haan, Cornelis A M (2013. ) An autophagy-independent role for LC3 in equine arteritis virus replication.Autophagy, , 9 (2 ) ,164-74 More Information

Patel, Khushbu K; Miyoshi, Hiroyuki; Beatty, Wandy L; Head, Richard D; Malvin, Nicole P; Cadwell, Ken; Guan, Jun-Lin; Saitoh, Tatsuya; Akira, Shizuo; Seglen, Per O; Dinauer, Mary C; Virgin, Herbert W; Stappenbeck, Thaddeus S (2013. ) Autophagy proteins control goblet cell function by potentiating reactive oxygen species production.The EMBO journal, , 32 (24 ) ,3130-44 More Information

Schmidt, Tracy Thennes; Tauseef, Mohammad; Yue, Lili; Bonini, Marcelo G; Gothert, Joachim; Shen, Tang-Long; Guan, Jun-Lin; Predescu, Sanda; Sadikot, Ruxana; Mehta, Dolly (2013. ) Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities.American journal of physiology. Lung cellular and molecular physiology, , 305 (4 ) ,L291-300 More Information

Chen, Song; Guan, Jun-Lin (2013. ) Tumor-promoting and -suppressive roles of autophagy in the same mouse model of BrafV600E-driven lung cancer.Cancer discovery, , 3 (11 ) ,1225-7 More Information

Liu, Fei; Fang, Fang; Yuan, Hebao; Yang, Dongye; Chen, Yongqiang; Williams, Linford; Goldstein, Steven A; Krebsbach, Paul H; Guan, Jun-Lin (2013. ) Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, , 28 (11 ) ,2414-30 More Information

Ma, Di; Molusky, Matthew M; Song, Jianrui; Hu, Chun-Rui; Fang, Fang; Rui, Crystal; Mathew, Anna V; Pennathur, Subramaniam; Liu, Fei; Cheng, Ji-Xin; Guan, Jun-Lin; Lin, Jiandie D (2013. ) Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD.Molecular endocrinology (Baltimore, Md.), , 27 (10 ) ,1643-54 More Information

Luo, Ming; Zhao, Xiaofeng; Chen, Song; Liu, Suling; Wicha, Max S; Guan, Jun-Lin (2013. ) Distinct FAK activities determine progenitor and mammary stem cell characteristics.Cancer research, , 73 (17 ) ,5591-602 More Information

Kim, Myungjin; Park, Hae Li; Park, Hwan-Woo; Ro, Seung-Hyun; Nam, Samuel G; Reed, John M; Guan, Jun-Lin; Lee, Jun Hee (2013. ) Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging.Autophagy, , 9 (8 ) ,1201-13 More Information

Guan, Jun-Lin; Simon, Anna Katharina; Prescott, Mark; Menendez, Javier A; Liu, Fei; Wang, Fen; Wang, Chenran; Wolvetang, Ernst; Vazquez-Martin, Alejandro; Zhang, Jue (2013. ) Autophagy in stem cells.Autophagy, , 9 (6 ) ,830-49 More Information

Wang, Chenran; Liang, Chun-Chi; Bian, Z Christine; Zhu, Yuan; Guan, Jun-Lin (2013. ) FIP200 is required for maintenance and differentiation of postnatal neural stem cells.Nature neuroscience, , 16 (5 ) ,532-42 More Information

Ritt, Michael; Guan, Jun Lin; Sivaramakrishnan, Sivaraj (2013. ) Visualizing and manipulating focal adhesion kinase regulation in live cells.The Journal of biological chemistry, , 288 (13 ) ,8875-86 More Information

Fan, Huaping; Zhao, Xiaofeng; Sun, Shaogang; Luo, Ming; Guan, Jun-Lin (2013. ) Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo.The Journal of biological chemistry, , 288 (5 ) ,3322-33 More Information

Wei, Huijun; Guan, Jun-Lin (2012. ) Pro-tumorigenic function of autophagy in mammary oncogenesis.Autophagy, , 8 (1 ) ,129-31 More Information

Cai, Guo-Qiang; Chou, Chu-Fang; Hu, Meng; Zheng, Anni; Reichardt, Louis F; Guan, Jun-Lin; Fang, Haotian; Luckhardt, Tracy R; Zhou, Yong; Thannickal, Victor J; Ding, Qiang (2012. ) Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of ?-smooth muscle actin filaments during myofibroblast differentiation.American journal of physiology. Lung cellular and molecular physiology, , 303 (8 ) ,L692-702 More Information

Chen, Xiao Lei; Nam, Ju-Ock; Jean, Christine; Lawson, Christine; Walsh, Colin T; Goka, Erik; Lim, Ssang-Taek; Tomar, Alok; Tancioni, Isabelle; Uryu, Sean; Guan, Jun-Lin; Acevedo, Lisette M; Weis, Sara M; Cheresh, David A; Schlaepfer, David D (2012. ) VEGF-induced vascular permeability is mediated by FAK.Developmental cell, , 22 (1 ) ,146-57 More Information

Chen, Xi; Li, Min; Chen, Daohong; Gao, Wentao; Guan, Jun-Lin; Komatsu, Massaki; Yin, Xiao-Ming (2012. ) Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis.PloS one, , 7 (12 ) ,e52347 More Information

Petridou, Nicoletta I; Stylianou, Panayiota; Christodoulou, Neophytos; Rhoads, Daniel; Guan, Jun-Lin; Skourides, Paris A (2012. ) Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos.PloS one, , 7 (8 ) ,e42577 More Information

Kageyama, Shun; Omori, Hiroko; Saitoh, Tatsuya; Sone, Takefumi; Guan, Jun-Lin; Akira, Shizuo; Imamoto, Fumio; Noda, Takeshi; Yoshimori, Tamotsu (2011. ) The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella.Molecular biology of the cell, , 22 (13 ) ,2290-300 More Information

Peng, Xu; Guan, Jun-Lin (2011. ) Focal adhesion kinase: from in vitro studies to functional analyses in vivo. Current protein & peptide science, , 12 (1 ) ,52-67

Wang, Dongyan; Olman, Mitchell A; Stewart, Jerry; Tipps, Russell; Huang, Ping; Sanders, Paul W; Toline, Eric; Prayson, Richard A; Lee, Jeongwu; Weil, Robert J; Palmer, Cheryl A; Gillespie, G Yancey; Liu, Wei Michael; Pieper, Russell O; Guan, Jun-Lin; Gladson, Candece L (2011. ) Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity.PloS one, , 6 (5 ) ,e19629 More Information

Li, Xiao-Yan; Zhou, Xiaoming; Rowe, R Grant; Hu, Yuexian; Schlaepfer, David D; Ili?, Dusko; Dressler, Gregory; Park, Ann; Guan, Jun-Lin; Weiss, Stephen J (2011. ) Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.The Journal of cell biology, , 195 (5 ) ,729-38 More Information

Bae, Heekyong; Guan, Jun-Lin (2011. ) Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents.Molecular cancer research : MCR, , 9 (9 ) ,1232-41 More Information

Zhao, Xiaofeng; Guan, Jun-Lin (2011. ) Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis.Advanced drug delivery reviews, , 63 (8 ) ,610-5 More Information

Wei, Huijun; Wei, Shuang; Gan, Boyi; Peng, Xu; Zou, Weiping; Guan, Jun-Lin (2011. ) Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis.Genes & development, , 25 (14 ) ,1510-27 More Information

Fan, Huaping; Guan, Jun-Lin (2011. ) Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity.The Journal of biological chemistry, , 286 (21 ) ,18573-82 More Information

Liu, Fei; Guan, Jun-Lin (2011. ) FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesis. Autophagy, , 7 (2 ) ,229-30

Seong, Jihye; Ouyang, Mingxing; Kim, Taejin; Sun, Jie; Wen, Po-Chao; Lu, Shaoying; Zhuo, Yue; Llewellyn, Nicholas M; Schlaepfer, David D; Guan, Jun-Lin; Chien, Shu; Wang, Yingxiao (2011. ) Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer.Nature communications, , 2 ,406 More Information

Liu, Fei; Lee, Jae Y; Wei, Huijun; Tanabe, Osamu; Engel, James D; Morrison, Sean J; Guan, Jun-Lin (2010. ) FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells.Blood, , 116 (23 ) ,4806-14 More Information

Wang, Chenran; Yoo, Youngdong; Fan, Huaping; Kim, Eunjung; Guan, Kun-Liang; Guan, Jun-Lin (2010. ) Regulation of Integrin ? 1 recycling to lipid rafts by Rab1a to promote cell migration.The Journal of biological chemistry, , 285 (38 ) ,29398-405 More Information

Zhao, Xiaofeng; Peng, Xu; Sun, Shaogang; Park, Ann Y J; Guan, Jun-Lin (2010. ) Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development.The Journal of cell biology, , 189 (6 ) ,955-65 More Information

Guan, Jun-Lin (2010. ) Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer.IUBMB life, , 62 (4 ) ,268-76 More Information

Luo, Ming; Guan, Jun-Lin (2010. ) Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis.Cancer letters, , 289 (2 ) ,127-39 More Information

Ginestier, Christophe; Liu, Suling; Diebel, Mark E; Korkaya, Hasan; Luo, Ming; Brown, Marty; Wicinski, Julien; Cabaud, Olivier; Charafe-Jauffret, Emmanuelle; Birnbaum, Daniel; Guan, Jun-Lin; Dontu, Gabriela; Wicha, Max S (2010. ) CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.The Journal of clinical investigation, , 120 (2 ) ,485-97 More Information

Liang, Chun-Chi; Wang, Chenran; Peng, Xu; Gan, Boyi; Guan, Jun-Lin (2010. ) Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration.The Journal of biological chemistry, , 285 (5 ) ,3499-509 More Information

Yoo, Y; Ho, H J; Wang, C; Guan, J-L (2010. ) Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway.Oncogene, , 29 (2 ) ,263-72 More Information

Ma, Hong; Togawa, Akashi; Soda, Keita; Zhang, Junhui; Lee, Sik; Ma, Ming; Yu, Zhiheng; Ardito, Thomas; Czyzyk, Jan; Diggs, Lonnette; Joly, Dominique; Hatakeyama, Shinji; Kawahara, Eiji; Holzman, Lawrence; Guan, Jun Lin; Ishibe, Shuta (2010. ) Inhibition of podocyte FAK protects against proteinuria and foot process effacement.Journal of the American Society of Nephrology : JASN, , 21 (7 ) ,1145-56 More Information

Chu, Pei-Yu; Huang, Ling-Ya; Hsu, Chun-Hua; Liang, Chun-Chi; Guan, Jun-Lin; Hung, Ting-Hsuan; Shen, Tang-Long (2009. ) Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis.The Journal of biological chemistry, , 284 (30 ) ,20215-26 More Information

Zhao, Jihe; Guan, Jun-Lin (2009. ) Signal transduction by focal adhesion kinase in cancer.Cancer metastasis reviews, , 28 (1-2 ) ,35-49 More Information

Hosokawa, Nao; Hara, Taichi; Kaizuka, Takeshi; Kishi, Chieko; Takamura, Akito; Miura, Yutaka; Iemura, Shun-ichiro; Natsume, Tohru; Takehana, Kenji; Yamada, Naoyuki; Guan, Jun-Lin; Oshiro, Noriko; Mizushima, Noboru (2009. ) Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.Molecular biology of the cell, , 20 (7 ) ,1981-91 More Information

Park, Ann Y J; Shen, Tang-Long; Chien, Shu; Guan, Jun-Lin (2009. ) Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis.The Journal of biological chemistry, , 284 (14 ) ,9418-25 More Information

Wei, Huijun; Gan, Boyi; Wu, Xiaoyang; Guan, Jun-Lin (2009. ) Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models.The Journal of biological chemistry, , 284 (9 ) ,6004-13 More Information

Luo, Ming; Fan, Huaping; Nagy, Tamas; Wei, Huijun; Wang, Chenran; Liu, Suling; Wicha, Max S; Guan, Jun-Lin (2009. ) Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.Cancer research, , 69 (2 ) ,466-74 More Information

Xie, Jianjun; Allen, Krystal H; Marguet, Amelia; Berghorn, Kathie A; Bliss, Stuart P; Navratil, Amy M; Guan, Jun Lin; Roberson, Mark S (2008. ) Analysis of the calcium-dependent regulation of proline-rich tyrosine kinase 2 by gonadotropin-releasing hormone.Molecular endocrinology (Baltimore, Md.), , 22 (10 ) ,2322-35 More Information

Bechara, Ahmad; Nawabi, Homaira; Moret, Frédéric; Yaron, Avraham; Weaver, Eli; Bozon, Muriel; Abouzid, Karima; Guan, Jun-Lin; Tessier-Lavigne, Marc; Lemmon, Vance; Castellani, Valérie (2008. ) FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse.The EMBO journal, , 27 (11 ) ,1549-62 More Information

Peng, Xu; Wu, Xiaoyang; Druso, Joseph E; Wei, Huijun; Park, Ann Yong-Jin; Kraus, Marc S; Alcaraz, Ana; Chen, Ju; Chien, Shu; Cerione, Richard A; Guan, Jun-Lin (2008. ) Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice.Proceedings of the National Academy of Sciences of the United States of America, , 105 (18 ) ,6638-43 More Information

Hara, Taichi; Takamura, Akito; Kishi, Chieko; Iemura, Shun-Ichiro; Natsume, Tohru; Guan, Jun-Lin; Mizushima, Noboru (2008. ) FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells.The Journal of cell biology, , 181 (3 ) ,497-510 More Information

Gan, Boyi; Guan, Jun-Lin (2008. ) FIP200, a key signaling node to coordinately regulate various cellular processes.Cellular signalling, , 20 (5 ) ,787-94 More Information

Weis, Sara M; Lim, Ssang-Taek; Lutu-Fuga, Kimberly M; Barnes, Leo A; Chen, Xiao Lei; Göthert, Joachim R; Shen, Tang-Long; Guan, Jun-Lin; Schlaepfer, David D; Cheresh, David A (2008. ) Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.The Journal of cell biology, , 181 (1 ) ,43-50 More Information

Martin, Nadine; Schwamborn, Klaus; Urlaub, Henning; Gan, Boyi; Guan, Jun-Lin; Dejean, Anne (2008. ) Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity.Molecular and cellular biology, , 28 (8 ) ,2771-81 More Information

Rhoads, Daniel S; Guan, Jun-Lin (2007. ) Analysis of directional cell migration on defined FN gradients: role of intracellular signaling molecules.Experimental cell research, , 313 (18 ) ,3859-67 More Information

Nagy, Tamas; Wei, Huijun; Shen, Tang-Long; Peng, Xu; Liang, Chun-Chi; Gan, Boyi; Guan, Jun-Lin (2007. ) Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland.The Journal of biological chemistry, , 282 (43 ) ,31766-76 More Information

Yoo, Youngdong; Wu, Xiaoyang; Guan, Jun-Lin (2007. ) A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription.The Journal of biological chemistry, , 282 (10 ) ,7616-23 More Information

Liang, Chun-Chi; Park, Ann Y; Guan, Jun-Lin (2007. ) In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.Nature protocols, , 2 (2 ) ,329-33 More Information

Gan, Boyi; Yoo, Youngdong; Guan, Jun-Lin (2006. ) Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth.The Journal of biological chemistry, , 281 (49 ) ,37321-9 More Information

Gan, Boyi; Peng, Xu; Nagy, Tamas; Alcaraz, Ana; Gu, Hua; Guan, Jun-Lin (2006. ) Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways.The Journal of cell biology, , 175 (1 ) ,121-33 More Information

Feng, Qiyu; Baird, Dan; Peng, Xu; Wang, Jianbin; Ly, Thi; Guan, Jun-Lin; Cerione, Richard A (2006. ) Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth.Nature cell biology, , 8 (9 ) ,945-56 More Information

Wu, Xiaoyang; Yoo, Youngdong; Okuhama, Nataly N; Tucker, Philip W; Liu, Gang; Guan, Jun-Lin (2006. ) Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners.Nature cell biology, , 8 (7 ) ,756-63 More Information

Wei, Huijun; Wang, Xianhui; Gan, Boyi; Urvalek, Alison M; Melkoumian, Zara K; Guan, Jun-Lin; Zhao, Jihe (2006. ) Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation.The Journal of biological chemistry, , 281 (24 ) ,16664-71 More Information

Yoo, Youngdong; Wu, Xiaoyang; Egile, Coumaran; Li, Rong; Guan, Jun-Lin (2006. ) Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading.The Journal of biological chemistry, , 281 (22 ) ,15352-60 More Information

Peng, Xu; Kraus, Marc S; Wei, Huijun; Shen, Tang-Long; Pariaut, Romain; Alcaraz, Ana; Ji, Guangju; Cheng, Lihong; Yang, Qinglin; Kotlikoff, Michael I; Chen, Ju; Chien, Kenneth; Gu, Hua; Guan, Jun-Lin (2006. ) Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.The Journal of clinical investigation, , 116 (1 ) ,217-27 More Information

Cohen, Lee Ann; Guan, Jun-Lin (2005. ) Mechanisms of focal adhesion kinase regulation. Current cancer drug targets, , 5 (8 ) ,629-43

Pongchairerk, Urai; Guan, Jun-Lin; Leardkamolkarn, Vijittra (2005. ) Focal adhesion kinase and Src phosphorylations in HGF-induced proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1. World journal of gastroenterology : WJG, , 11 (37 ) ,5845-52

Melkoumian, Zara K; Peng, Xu; Gan, Boyi; Wu, Xiaoyang; Guan, Jun-Lin (2005. ) Mechanism of cell cycle regulation by FIP200 in human breast cancer cells.Cancer research, , 65 (15 ) ,6676-84 More Information

Wu, Xiaoyang; Gan, Boyi; Yoo, Youngdong; Guan, Jun-Lin (2005. ) FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation.Developmental cell, , 9 (2 ) ,185-96 More Information

Gan, Boyi; Melkoumian, Zara K; Wu, Xiaoyang; Guan, Kun-Liang; Guan, Jun-Lin (2005. ) Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control.The Journal of cell biology, , 170 (3 ) ,379-89 More Information

Shen, Tang-Long; Park, Ann Y-J; Alcaraz, Ana; Peng, Xu; Jang, Ihnkyung; Koni, Pandelakis; Flavell, Richard A; Gu, Hua; Guan, Jun-Lin (2005. ) Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis.The Journal of cell biology, , 169 (6 ) ,941-52 More Information

Moon, James J; Matsumoto, Melissa; Patel, Shyam; Lee, Luke; Guan, Jun-Lin; Li, Song (2005. ) Role of cell surface heparan sulfate proteoglycans in endothelial cell migration and mechanotransduction.Journal of cellular physiology, , 203 (1 ) ,166-76 More Information

Cohen, Lee Ann; Guan, Jun-Lin (2005. ) Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation.The Journal of biological chemistry, , 280 (9 ) ,8197-207 More Information

Ding, Qiang; Grammer, J Robert; Nelson, Mark A; Guan, Jun-Lin; Stewart, Jerry E; Gladson, Candece L (2005. ) p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain.The Journal of biological chemistry, , 280 (8 ) ,6802-15 More Information

Miao, Hui; Strebhardt, Klaus; Pasquale, Elena B; Shen, Tang-Long; Guan, Jun-Lin; Wang, Bingcheng (2005. ) Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases.The Journal of biological chemistry, , 280 (2 ) ,923-32 More Information

Li, Song; Guan, Jun-Lin; Chien, Shu (2005. ) Biochemistry and biomechanics of cell motility.Annual review of biomedical engineering, , 7 ,105-50 More Information

Rodriguez, Luis G; Guan, Jun-Lin (2005. ) 14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove.Journal of cellular physiology, , 202 (1 ) ,285-94 More Information

Rhoads, Daniel S; Nadkarni, Sharvari M; Song, Loling; Voeltz, Camilla; Bodenschatz, Eberhard; Guan, Jun-Lin (2005. ) Using microfluidic channel networks to generate gradients for studying cell migration. Methods in molecular biology (Clifton, N.J.), , 294 ,347-57

Rodriguez, Luis G; Wu, Xiaoyang; Guan, Jun-Lin (2005. ) Wound-healing assay. Methods in molecular biology (Clifton, N.J.), , 294 ,23-9

Peng, Xu; Ueda, Hiroki; Zhou, Hongming; Stokol, Tracy; Shen, Tang-Long; Alcaraz, Ana; Nagy, Tamas; Vassalli, Jean-Dominique; Guan, Jun-Lin (2004. ) Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice.Cardiovascular research, , 64 (3 ) ,421-30 More Information

Wu, Xiaoyang; Suetsugu, Shiro; Cooper, Lee Ann; Takenawa, Tadaomi; Guan, Jun-Lin (2004. ) Focal adhesion kinase regulation of N-WASP subcellular localization and function.The Journal of biological chemistry, , 279 (10 ) ,9565-76 More Information

Guan, Jun-Lin (2004. ) Cell biology. Integrins, rafts, Rac, and Rho.Science (New York, N.Y.), , 303 (5659 ) ,773-4 More Information

Shen, Tang-Long; Guan, Jun-Lin (2004. ) Grb7 in intracellular signaling and its role in cell regulation. Frontiers in bioscience : a journal and virtual library, , 9 ,192-200

Li, Weiquan; Lee, Jeeyong; Vikis, Haris G; Lee, Seung-Hee; Liu, Guofa; Aurandt, Jennifer; Shen, Tang-Long; Fearon, Eric R; Guan, Jun-Lin; Han, Min; Rao, Yi; Hong, Kyonsoo; Guan, Kun-Liang (2004. ) Activation of FAK and Src are receptor-proximal events required for netrin signaling.Nature neuroscience, , 7 (11 ) ,1213-21 More Information

Cooper, Lee Ann; Shen, Tang-Long; Guan, Jun-Lin (2003. ) Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Molecular and cellular biology, , 23 (22 ) ,8030-41

Zhao, Jihe; Bian, Z Christine; Yee, Kristine; Chen, Benjamin P C; Chien, Shu; Guan, Jun-Lin (2003. ) Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Molecular cell, , 11 (6 ) ,1503-15

Han, Dong Cho; Shen, Tang-Long; Miao, Hui; Wang, Bingcheng; Guan, Jun-Lin (2002. ) EphB1 associates with Grb7 and regulates cell migration.The Journal of biological chemistry, , 277 (47 ) ,45655-61 More Information

Abbi, Smita; Ueda, Hiroki; Zheng, Chuanhai; Cooper, Lee Ann; Zhao, Jihe; Christopher, Renee; Guan, Jun-Lin (2002. ) Regulation of focal adhesion kinase by a novel protein inhibitor FIP200.Molecular biology of the cell, , 13 (9 ) ,3178-91 More Information

Shen, Tang-Long; Han, Dong Cho; Guan, Jun-Lin (2002. ) Association of Grb7 with phosphoinositides and its role in the regulation of cell migration.The Journal of biological chemistry, , 277 (32 ) ,29069-77 More Information

Goicoechea, Silvia M; Tu, Yizeng; Hua, Yun; Chen, Ka; Shen, Tang-Long; Guan, Jun-Lin; Wu, Chuanyue (2002. ) Nck-2 interacts with focal adhesion kinase and modulates cell motility. The international journal of biochemistry & cell biology, , 34 (7 ) ,791-805

Li, Song; Butler, Peter; Wang, Yingxiao; Hu, Yingli; Han, Dong Cho; Usami, Shunichi; Guan, Jun-Lin; Chien, Shu (2002. ) The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells.Proceedings of the National Academy of Sciences of the United States of America, , 99 (6 ) ,3546-51 More Information

Wang, Chenran; Haas, Michael; Yeo, Syn Kok; Sebti, Salwa; Fernández, Álvaro F; Zou, Zhongju; Levine, Beth; Guan, Jun-Lin (2021. ) Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction.Autophagy, , 1-14 More Information

Wang, Chenran; Haas, Michael; Yeo, Syn Kok; Sebti, Salwa; Fernández, Álvaro F; Zou, Zhongju; Levine, Beth; Guan, Jun-Lin (2021. ) Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction.Autophagy, , 1-14 More Information

Turner, Kevin M; Yeo, Syn Kok; Holm, Tammy M; Shaughnessy, Elizabeth; Guan, Jun-Lin (2021. ) Heterogeneity Within Molecular Subtypes of Breast Cancer.American journal of physiology. Cell physiology, , More Information

Wang, Lingyan; Song, Kun; Hao, Wenzhuo; Wu, Yakun; Patil, Girish; Hua, Fang; Sun, Yiwen; Huang, Chaoqun; Ritchey, Jerry; Jones, Clinton; Liu, Lin; Guan, Jun-Lin; Li, Shitao (2021. ) FIP200 restricts RNA virus infection by facilitating RIG-I activation.Communications biology, , 4 (1 ) ,921 More Information

Poillet-Perez, Laura; Sharp, Daniel W; Yang, Yang; Laddha, Saurabh V; Ibrahim, Maria; Bommareddy, Praveen K; Sherrie Hu, Zhixian; Vieth, Joshua; Haas, Michael; Bosenberg, Marcus W; Rabinowitz, Joshua D; Cao, Jian; Guan, Jun-Lin; Ganesan, Shridar; Chan, Chang S; Mehnert, Janice M; Lattime, Edmund C; White, Eileen (2020. ) Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.Nature cancer, , 1 (9 ) ,923-934 More Information

Chen, Qixin; Hao, Mingang; Wang, Lei; Li, Linsen; Chen, Yang; Shao, Xintian; Tian, Zhiqi; Pfuetzner, Richard A; Zhong, Qing; Brunger, Axel T; Guan, Jun-Lin; Diao, Jiajie (2021. ) Prefused lysosomes cluster on autophagosomes regulated by VAMP8.Cell death & disease, , 12 (10 ) ,939 More Information

Holm, Tammy M; Bian, Z Christine; Manupati, Kanakaraju; Guan, Jun-Lin (2021. ) Inhibition of autophagy mitigates cell migration and invasion in thyroid cancer.Surgery, , More Information

Liu, Hang; Wang, Chenran; Yi, Fei; Yeo, Syn; Haas, Michael; Tang, Xin; Guan, Jun-Lin (2021. ) Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation.Scientific reports, , 11 (1 ) ,23907 More Information

Manupati, Kanakaraju; Paul, Ritama; Hao, Mingang; Haas, Michael; Bian, Zhaoqun Christine; Holm, Tammy M; Guan, Jun-Lin; Yeo, Syn Kok (2022. ) Biglycan Promotes Cancer Stem Cell Properties, NFĸB Signaling and Metastatic Potential in Breast Cancer Cells.Cancers, , 14 (2 ) , More Information

Poillet-Perez, Laura; Sharp, Daniel W; Yang, Yang; Laddha, Saurabh V; Ibrahim, Maria; Bommareddy, Praveen K; Hu, Zhixian Sherrie; Vieth, Joshua; Haas, Michael; Bosenberg, Marcus W; Rabinowitz, Joshua D; Cao, Jian; Guan, Jun-Lin; Ganesan, Shridar; Chan, Chang S; Mehnert, Janice M; Lattime, Edmund C; White, Eileen (2021. ) Publisher Correction: Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.Nature cancer, , 2 (9 ) ,994 More Information

Yang, Yang; Gomez, Maria; Marsh, Timothy; Poillet-Perez, Laura; Sawant, Akshada; Chen, Lei; Park, Noel R; Jackson, S RaElle; Hu, Zhixian; Alon, Noa; Liu, Chen; Debnath, Jayanta; Guan, Jun-Lin; Davidson, Shawn; Verzi, Michael; White, Eileen (2022. ) Autophagy in PDGFR?+ mesenchymal cells is essential for intestinal stem cell survival.Proceedings of the National Academy of Sciences of the United States of America, , 119 (21 ) ,e2202016119 More Information

Yang, Yi; Zhu, Yifu; Zhou, Shuai; Tang, Peipei; Xu, Ran; Zhang, Yuwei; Wei, Dongping; Wen, Jian; Thorne, Rick F; Zhang, Xu Dong; Guan, Jun-Lin; Liu, Lianxin; Wu, Mian; Chen, Song (2022. ) TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis.The EMBO journal, , e109777 More Information

Qiu, Kangqiang; Zou, Weiwei; Fang, Hongbao; Hao, Mingang; Mehta, Kritika; Tian, Zhiqi; Guan, Jun-Lin; Zhang, Kai; Huang, Taosheng; Diao, Jiajie (2022. ) Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts.Nature communications, , 13 (1 ) ,4303 More Information

Holm, Tammy M; Yeo, Syn; Turner, Kevin M; Guan, Jun-Lin (2022. ) Targeting Autophagy in Thyroid Cancer: EMT, Apoptosis, and Cancer Stem Cells.Frontiers in cell and developmental biology, , 10 ,821855 More Information

Fang, Hongbao; Hu, Lianting; Chen, Qixin; Geng, Shanshan; Qiu, Kangqiang; Wang, Chengjun; Hao, Mingang; Tian, Zhiqi; Chen, Huimin; Liu, Lei; Guan, Jun-Lin; Chen, Yuncong; Dong, Lei; Guo, Zijian; He, Weijiang; Diao, Jiajie (2023. ) An ER-targeted "reserve-release" fluorogen for topological quantification of reticulophagy.Biomaterials, , 292 ,121929 More Information

Yi, Fei; Cai, Chunmiao; Ruan, Banzhan; Hao, Mingang; Yeo, Syn Kok; Haas, Michael; Yang, Fuchun; Zhang, Xiaoting; Guan, Jun-Lin (2022. ) Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region.Autophagy, , 1-16 More Information

Shimanaka, Yuta; Matsumoto, Keiko; Tanaka, Yuki; Ishino, Yuki; Ni, Shenwei; Guan, Jun-Lin; Arai, Hiroyuki; Kono, Nozomu (2022. ) Supercritical fluid chromatography-mass spectrometry enables simultaneous measurement of all phosphoinositide regioisomers.Communications chemistry, , 5 (1 ) ,61 More Information

Huang, Huilin; Weng, Hengyou; Sun, Wenju; Qin, Xi; Shi, Hailing; Wu, Huizhe; Zhao, Boxuan Simen; Mesquita, Ana; Liu, Chang; Yuan, Celvie L; Hu, Yueh-Chiang; Hüttelmaier, Stefan; Skibbe, Jennifer R; Su, Rui; Deng, Xiaolan; Dong, Lei; Sun, Miao; Li, Chenying; Nachtergaele, Sigrid; Wang, Yungui; Hu, Chao; Ferchen, Kyle; Greis, Kenneth D; Jiang, Xi; Wei, Minjie; Qu, Lianghu; Guan, Jun-Lin; He, Chuan; Yang, Jianhua; Chen, Jianjun (2018. ) Author Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.Nature cell biology, , 20 (9 ) ,1098 More Information

Yang, Fuchun; Kalantari, Shiva; Ruan, Banzhan; Sun, Shaogang; Bian, Zhaoqun; Guan, Jun-Lin (2023. ) Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling.Nature communications, , 14 (1 ) ,978 More Information

Yang, Fuchun; Guan, Jun-Lin (2023. ) Autophagy-dependent expression of osteopontin and its downstream Stat3 signaling contributes to lymphatic malformation progression to lymphangiosarcoma.Autophagy, , 1-2 More Information

Zhang, Chengying; Tian, Zhiqi; Chen, Rui; Rowan, Fiona; Qiu, Kangqiang; Sun, Yujie; Guan, Jun-Lin; Diao, Jiajie (2023. ) Advanced imaging techniques for tracking drug dynamics at the subcellular level.Advanced drug delivery reviews, , 199 ,114978 More Information

Yeo, Syn Kok; Haas, Michael; Manupati, Kanakaraju; Hao, Mingang; Yang, Fuchun; Chen, Song; Guan, Jun-Lin (2023. ) AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer.Autophagy, , 1-16 More Information

Chen, Qixin; Liu, Liu-Yi; Tian, Zhiqi; Fang, Zhou; Wang, Kang-Nan; Shao, Xintian; Zhang, Chengying; Zou, Weiwei; Rowan, Fiona; Qiu, Kangqiang; Ji, Baohua; Guan, Jun-Lin; Li, Dechang; Mao, Zong-Wan; Diao, Jiajie (2023. ) Mitochondrial nucleoid condensates drive peripheral fission through high membrane curvature.Cell reports, , 42 (12 ) ,113472 More Information

Hao, Mingang; Lu, Peixin; Sotropa, Sarah; Manupati, Kanakaraju; Yeo, Syn Kok; Guan, Jun-Lin (2024. ) In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux.Cell reports, , 43 (2 ) ,113780 More Information

Sakuma, Chisato; Shizukuishi, Sayaka; Ogawa, Michinaga; Honjo, Yuko; Takeyama, Haruko; Guan, Jun-Lin; Weiser, Jeffery; Sasai, Miwa; Yamamoto, Masahiro; Ohnishi, Makoto; Akeda, Yukihiro (2024. ) Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition.Cell reports, , 43 (5 ) ,114131 More Information

Liu, Han; Su, Peihong; Li, Yuanyuan; Hoover, Alex; Hu, Sophie; King, Sarah A; Zhao, Jing; Guan, Jun-Lin; Chen, Shao-Yu; Zhao, Yingming; Tan, Minjia; Wu, Xiaoyang (2024. ) VAMP2 controls murine epidermal differentiation and carcinogenesis by regulation of nucleophagy.Developmental cell, , More Information

Manupati, Kanakaraju; Hao, Mingang; Haas, Michael; Yeo, Syn Kok; Guan, Jun-Lin (2024. ) Role of NuMA1 in breast cancer stem cells with implications for combination therapy of PIM1 and autophagy inhibition in triple negative breast cancer.Research square, , More Information

Sakuma, Chisato; Shizukuishi, Sayaka; Ogawa, Michinaga; Honjo, Yuko; Takeyama, Haruko; Guan, Jun-Lin; Weiser, Jeffery; Sasai, Miwa; Yamamoto, Masahiro; Ohnishi, Makoto; Akeda, Yukihiro (2024. ) Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition.Cell reports, , 43 (5 ) ,114131 More Information

Liu, Han; Su, Peihong; Li, Yuanyuan; Hoover, Alex; Hu, Sophie; King, Sarah A; Zhao, Jing; Guan, Jun-Lin; Chen, Shao-Yu; Zhao, Yingming; Tan, Minjia; Wu, Xiaoyang (2024. ) VAMP2 controls murine epidermal differentiation and carcinogenesis by regulation of nucleophagy.Developmental cell, , More Information

Manupati, Kanakaraju; Hao, Mingang; Haas, Michael; Yeo, Syn Kok; Guan, Jun-Lin (2024. ) Role of NuMA1 in breast cancer stem cells with implications for combination therapy of PIM1 and autophagy inhibition in triple negative breast cancer.Research square, , More Information

Academic - Vontz Center for Molecular Studies
Room 3326
Cincinnati  Ohio, 45267
Phone: 513-558-0114
Fax: 513-558-1190
jun-lin.guan@uc.edu