Gary Gudelsky , PHD

The primary research projects being undertaken in the lab involve those that focus on the mechanisms and consequences of MDMA (Ecstasy)-induced serotonin neurotoxicity. With regard to MDMA neurotoxicity, it is our hypothesis that long term depletion of brain 5-HT occurs as a result of oxidative and/or bioenergetic stress induced by this drug of abuse. Moreover, such long term depletions of brain 5-HT are accompanied by functional consequences evident in disruptions of 5-HT neurotransmission. An additional area of interest is the neuropharmacology of second generation atypical antipsychotic agents. Current investigations focus on the differences in interactions of typical and atypical antipsychotics with glutamatergic neurotransmission.

BA Chemistry: Kalamazoo College

PhD in Pharmacology: Michigan State University

Neuropharmacology of amphetamines

Investigators:GA Gudelsky ,NIDA, Conditioned place preference to amphetamine following prenatal immune activation Role:Co-PI

Investigators:GA Gudelsky ,NIDA, Methamphetamine and cortiocstriatal glutamate Role:Co-PI

Investigators:GA Gudelsky ,NIDA, Determinants and Consequences of MDMA-Induced 5-HT Neurotoxicity Role:PI

Grant: #R01 DA007427 Investigators:Gudelsky, Gary 08-15-2006 -04-30-2012 National Institute on Drug Abuse Determinants and Consequences of MDMA Neurotoxicity Role:PI $1,514,953.00 Closed Level:Federal

Grant: #5-R01-DA-007427-11-A0-S0-E0 Investigators:Gudelsky, Gary 04-01-2000 -08-14-2006 National Institute on Drug Abuse Determinants and Consequences of MDMA Neurotoxicity Role:PI $1,265,196.00 Closed Level:Federal

Grant: #5-R44-DA-13300-04-A0-S0-E0 Investigators:Gudelsky, Gary 04-15-2002 -02-28-2005 National Institute on Drug Abuse Neurotoxin Discovery Platform Role:PI $198,022.00 Closed Level:Federal

Grant: #1-R44-DA-013300-01-A0-S0-E0 Investigators:Gudelsky, Gary 06-01-2000 -05-31-2001 National Institute on Drug Abuse Neurotoxin Discovery Platform - Drugs of Abuse Role:PI $32,453.00 Closed Level:Federal

Grant: #RIS-USA-T286-01-A0-S0-E0 Investigators:Gudelsky, Gary 12-01-2001 -11-30-2002 Janssen Pharmaceutica Research Foundation RIS-USA-T286 Effect of Antipsychotic Drugs on Acetylcholine Release Role:PI $21,468.00 Closed Level:Industry

Grant: #5-R01-DA-07427-06-A0-S0-E0 Investigators:Gudelsky, Gary 04-10-1997 -03-31-2000 National Institute on Drug Abuse Microdialysis Studies on MDMA-Induced Neurotoxicity Role:PI $443,354.00 Closed Level:Federal

Grant: #SRS 005803 Investigators:Gudelsky, Gary; Richtand, Neil 08-29-2008 -08-31-2011 Ortho-McNeil Janssen Scientific Affairs LLC Paliperidone and Glutamate in a Developmental Primary Prevention Model Role:Collaborator $160,076.00 Active Level:Industry

Grant: #1R21MH083192-01A1 Investigators:Benoit, Stephen; Gudelsky, Gary; Herman, James; Richtand, Neil; Stern, Javier 08-20-2008 -07-31-2011 National Institute of Mental Health Antipsychotics, Hypoglycemia, Glutamate and Cognition Role:Collaborator $386,100.00 Closed Level:Federal

Grant: #R21DA031876 Investigators:Benoit, Stephen; Gudelsky, Gary; Richtand, Neil 07-15-2012 -03-31-2014 National Institute on Drug Abuse Conditioned Place Preference to Amphetamine Following Prenatal Immune Activation Role:Collaborator $417,871.00 Active Level:Federal

Grant: #N2013-9 \ R01DA007606 Investigators:Gudelsky, Gary 07-01-2012 -04-30-2014 National Institute on Drug Abuse Methamphetamine Toxicity and Corticostriatal Glutamate Role:PI $37,158.00 Active Level:Federal

Grant: #08818-01-311642 / R21 DA031876 Investigators:Benoit, Stephen; Gudelsky, Gary 07-01-2013 -03-31-2014 National Institute on Drug Abuse Conditioned Place Preference to Amphetamine following Prenatal Immune Activation Role:PI $57,086.00 Awarded Level:Federal

Grant: #R15NS088384 Investigators:Gudelsky, Gary; Hao, Jiukuan 04-01-2015 -03-31-2018 National Institute of Neurological Disorders and Stroke Targeting the Blood-Brain Barrier in Ischemic Stroke Role:Collaborator $487,203.00 Awarded Level:Federal

Grant: #R01NS100947 Investigators:Gudelsky, Gary; Jiang, Jianxiong 12-01-2017 -11-30-2022 National Institute of Neurological Disorders and Stroke Inflammatory regulation of neurotrophin signaling in epileptogenesis Role:Collaborator $349,396.00 Awarded Level:Federal

Grant: #R61NS128232 Investigators:Desai, Pankaj; Gudelsky, Gary; Phoenix, Timothy; Plas, David; Rodenberg, Cynthia; Sengupta, Soma; Wise-Draper, Trisha 08-01-2022 -07-31-2025 National Institute of Neurological Disorders and Stroke Translational Studies to facilitate Rational Therapeutic Combinations of Letrozole for the Treatment of Glioblastoma Role:Collaborator 389244.00 Awarded Level:Federal

Grant: #NINDS; 1R01NS137887-01 Investigators:Gudelsky, Gary; Ngwenya, Laura; Robson, Matthew -06-30-2029 National Institute of Neurological Disorders and Stroke No REST for 5-HT Neurons Following Traumatic Brain Injury Role:Collaborator 0.00 Hold Level:Federal

Peer Reviewed Publications

Anneken, John H; Cunningham, Jacobi I; Collins, Stuart A; Yamamoto, Bryan K; Gudelsky, Gary A (2013. ) MDMA Increases Glutamate Release and Reduces Parvalbumin-Positive GABAergic Cells in the Dorsal Hippocampus of the Rat: Role of Cyclooxygenase.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, , 8 (1 ) ,58-65 More Information

Isom, Amanda M; Gudelsky, Gary A; Benoit, Stephen C; Richtand, Neil M (2013. ) Antipsychotic medications, glutamate, and cell death: A hidden, but common medication side effect?.Medical hypotheses, , 80 (3 ) ,252-8 More Information

Huff, Courtney; Bhide, Nirmal; Schroering, Allen; Yamamoto, Bryan K; Gudelsky, Gary A (2013. ) Effect of repeated exposure to MDMA on the function of the 5-HT transporter as assessed by synaptosomal 5-HT uptake.Brain research bulletin, , 91 ,52-7 More Information

Anneken, John H; Gudelsky, Gary A (2012. ) MDMA produces a delayed and sustained increase in the extracellular concentration of glutamate in the rat hippocampus.Neuropharmacology, , 63 (6 ) ,1022-7 More Information

Roenker, Nicole L; Gudelsky, Gary A; Ahlbrand, Rebecca; Horn, Paul S; Richtand, Neil M (2012. ) Evidence for involvement of nitric oxide and GABA(B) receptors in MK-801- stimulated release of glutamate in rat prefrontal cortex.Neuropharmacology, , 63 (4 ) ,575-81 More Information

Schaefer, Tori L; Grace, Curtis E; Skelton, Matthew R; Graham, Devon L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2012. ) Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats.ACS chemical neuroscience, , 3 (1 ) ,12-21 More Information

Darvesh, Altaf S; Carroll, Richard T; Geldenhuys, Werner J; Gudelsky, Gary A; Klein, Jochen; Meshul, Charles K; Van der Schyf, Cornelis J (2011. ) In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery.Expert opinion on drug discovery, , 6 (2 ) ,109-127 More Information

Roenker, NL, Gudelsky, GA, Ahlbrand, R, Bronson, SL, Kern,JR, Waterman, H and Richtand, NM (2011. ) Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801 .Neuroscience Letters, , 500 ,575-581

Yamamoto, Bryan K; Moszczynska, Anna; Gudelsky, Gary A (2010. ) Amphetamine toxicities: classical and emerging mechanisms.Annals of the New York Academy of Sciences, , 1187 ,101-21 More Information

Schaefer, T L; Grace, C E; Gudelsky, G A; Vorhees, C V; Williams, M T (2010. ) Effects on plasma corticosterone levels and brain serotonin from interference with methamphetamine-induced corticosterone release in neonatal rats.Stress (Amsterdam, Netherlands), , 13 (6 ) ,469-80 More Information

Pachmerhiwala, Rashida; Bhide, Nirmal; Straiko, Megan; Gudelsky, Gary A (2010. ) Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain.European journal of pharmacology, , 644 (1-3 ) ,67-72 More Information

Herring, Nicole R; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2010. ) (+)-Methamphetamine-induced monoamine reductions and impaired egocentric learning in adrenalectomized rats is independent of hyperthermia.Synapse (New York, N.Y.), , 64 (10 ) ,773-85 More Information

Bhide, Nirmal S; Lipton, Jack W; Cunningham, Jacobi I; Yamamoto, Bryan K; Gudelsky, Gary A (2009. ) Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain.Brain research, , 1286 ,32-41 More Information

Skelton, Matthew R; Able, Jessica A; Grace, Curtis E; Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2008. ) (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks.Neuropharmacology, , 55 (7 ) ,1121-30 More Information

Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2008. ) Effect of +-methamphetamine on path integration learning, novel object recognition, and neurotoxicity in rats.Psychopharmacology, , 199 (4 ) ,637-50 More Information

Herring, Nicole R; Schaefer, Tori L; Tang, Peter H; Skelton, Matthew R; Lucot, James P; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2008. ) Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats.BMC neuroscience, , 9 (2 ) ,49-59 More Information

Apparaju, Sandhya Kiran; Gudelsky, Gary A; Desai, Pankaj B (2008. ) Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis.Cancer chemotherapy and pharmacology, , 61 (2 ) ,223-9 More Information

Gudelsky, GA and Yamamoto, BK (2008. ) Actions of 3,4methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons. Pharmacology, Biochemistry and Behavior, , 90 ,198-207

Schaefer, TL, Skelton, MR, Herring, NR, Gudelsky, GA, Vorhees, CV, Williams, MT (2008. ) Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment. J. Neurochemistry, , 104 ,1674-1685

Straiko, MM, Gudelsky, GA and Coolen, LM (2007. ) Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats .Behavioral Neuroscience, , 121 (3 ) ,58-593

Straiko, MM, Coolen, LM, Zemlan, FP and Gudelsky, GA (2007. ) The effect of amphetamine analogs on cleaved microtubule associated protein-tau formation in the rat brain .Neuroscience, , 144 ,223-231

Schaefer, Tori L; Ehrman, Lisa A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2006. ) Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat.Journal of neurochemistry, , 98 (5 ) ,1369-78 More Information

Able, Jessica A; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2006. ) 3,4-Methylenedioxymethamphetamine in adult rats produces deficits in path integration and spatial reference memory.Biological psychiatry, , 59 (12 ) ,1219-26 More Information

Nair, S G; Gudelsky, G A (2006. ) Effect of a serotonin depleting regimen of 3,4-methylenedioxymethamphetamine (MDMA) on the subsequent stimulation of acetylcholine release in the rat prefrontal cortex.Brain research bulletin, , 69 (4 ) ,382-7 More Information

Nair, Sunila G; Gudelsky, Gary A (2006. ) 3,4-Methylenedioxymethamphetamine enhances the release of acetylcholine in the prefrontal cortex and dorsal hippocampus of the rat.Psychopharmacology, , 184 (2 ) ,182-9 More Information

Darvesh, Altaf S; Gudelsky, Gary A (2005. ) Evidence for a role of energy dysregulation in the MDMA-induced depletion of brain 5-HT.Brain research, , 1056 (2 ) ,168-75 More Information

Nair, SG and Gudelsky, GA (2005. ) 3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex .Synapse, , 58 ,229-235

Darvesh, A, Yamamoto, BK and Gudelsky, GA. (2005. ) Evidence for the involvement of nitric oxide in 3,4-methyeledioxymethamphetamine-induced serotonin depletion in the rat brain .J. Pharmacol. Exp. Ther, , 312 ,694-701

Skelton, Matthew R; Blankenmeyer, Tracy L; Gudelsky, Gary A; Brown-Strittholt, Carrie A; Vorhees, Charles V; Williams, Michael T (2004. ) Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats.Synapse (New York, N.Y.), , 54 (4 ) ,214-22 More Information

Nair, Sunila G; Gudelsky, Gary A (2004. ) Protein kinase C inhibition differentially affects 3,4-methylenedioxymethamphetamine-induced dopamine release in the striatum and prefrontal cortex of the rat.Brain research, , 1013 (2 ) ,168-73 More Information

Williams, Michael T; Blankenmeyer, Tracy L; Schaefer, Tori L; Brown, Carrie A; Gudelsky, Gary A; Vorhees, Charles V (2003. ) Long-term effects of neonatal methamphetamine exposure in rats on spatial learning in the Barnes maze and on cliff avoidance, corticosterone release, and neurotoxicity in adulthood. Brain research. Developmental brain research, , 147 (1-2 ) ,163-75

Darvesh, Altaf S; Gudelsky, Gary A (2003. ) Activation of 5-HT2 receptors induces glycogenolysis in the rat brain. European journal of pharmacology, , 464 (2-3 ) ,135-40

Gudelsky, Gary A; Yamamoto, Bryan K (2003. ) Neuropharmacology and neurotoxicity of 3,4-methylenedioxymethamphetamine. Methods in molecular medicine, , 79 ,55-73

Darvesh, Altaf S; Shankaran, Mahalakshmi; Gudelsky, Gary A (2002. ) 3,4-Methylenedioxymethamphetamine produces glycogenolysis and increases the extracellular concentration of glucose in the rat brain. The Journal of pharmacology and experimental therapeutics, , 301 (1 ) ,138-44

Wallace, T L; Vorhees, C V; Gudelsky, G A (2001. ) Effects of lubeluzole on the methamphetamine-induced increase in extracellular glutamate and the long-term depletion of striatal dopamine.Synapse (New York, N.Y.), , 40 (2 ) ,95-101 More Information

Shankaran, M; Yamamoto, B K; Gudelsky, G A (2001. ) Ascorbic acid prevents 3,4-methylenedioxymethamphetamine (MDMA)-induced hydroxyl radical formation and the behavioral and neurochemical consequences of the depletion of brain 5-HT.Synapse (New York, N.Y.), , 40 (1 ) ,55-64 More Information

Huff, Courtney L; Morano, Rachel L; Herman, James P; Yamamoto, Bryan K; Gudelsky, Gary A (2016. ) MDMA decreases glutamic acid decarboxylase (GAD) 67-immunoreactive neurons in the hippocampus and increases seizure susceptibility: Role for glutamate.Neurotoxicology, , 57 ,282-290 More Information

Collins, Stuart A; Huff, Courtney; Chiaia, Nicolas; Gudelsky, Gary A; Yamamoto, Bryan K (2016. ) 3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5HT2A receptor-induced PGE2 signaling.Journal of neurochemistry, , 136 (5 ) ,1074-84 More Information

Collins, Stuart A; Gudelsky, Gary A; Yamamoto, Bryan K (2015. ) MDMA-induced loss of parvalbumin interneurons within the dentate gyrus is mediated by 5HT2A and NMDA receptors.European journal of pharmacology, , 761 ,95-100 More Information

Dave, Nimita; Chow, Lionel M L; Gudelsky, Gary A; LaSance, Kathleen; Qi, Xiaoyang; Desai, Pankaj B (2015. ) Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas.Molecular cancer therapeutics, , 14 (4 ) ,857-64 More Information

Krishan, Mansi; Gudelsky, Gary A; Desai, Pankaj B; Genter, Mary Beth (2014. ) Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain.Drug delivery, , 21 (1 ) ,8-16 More Information

Weber, Georg F; Johnson, Bethann N; Yamamoto, Bryan K; Gudelsky, Gary A (2014. ) Effects of stress and MDMA on hippocampal gene expression.BioMed research international, , 2014 ,141396 More Information

Dave, Nimita; Gudelsky, Gary A; Desai, Pankaj B (2013. ) The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis.Cancer chemotherapy and pharmacology, , 72 (2 ) ,349-57 More Information

Grace, Curtis E; Schaefer, Tori L; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V Neonatal methamphetamine-induced corticosterone release in rats is inhibited by adrenal autotransplantation without altering the effect of the drug on hippocampal serotonin.Neurotoxicology and teratology, , 32 (3 ) ,356-61 More Information

Grace, Curtis E; Schaefer, Tori L; Herring, Nicole R; Graham, Devon L; Skelton, Matthew R; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice.Neurotoxicology and teratology, , 32 (3 ) ,346-55 More Information

Gudelsky, Gary A; Yamamoto, Bryan K (2008. ) Actions of 3,4-methylenedioxymethamphetamine (MDMA) on cerebral dopaminergic, serotonergic and cholinergic neurons.Pharmacology, biochemistry, and behavior, , 90 (2 ) ,198-207 More Information

Schaefer, Tori L; Skelton, Matthew R; Herring, Nicole R; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T (2008. ) Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment.Journal of neurochemistry, , 104 (6 ) ,1674-85 More Information

Straiko, Megan M W; Gudelsky, Gary A; Coolen, Lique M (2007. ) Treatment with a serotonin-depleting regimen of MDMA prevents conditioned place preference to sex in male rats.Behavioral neuroscience, , 121 (3 ) ,586-93 More Information

Straiko, M M W; Coolen, L M; Zemlan, F P; Gudelsky, G A (2007. ) The effect of amphetamine analogs on cleaved microtubule-associated protein-tau formation in the rat brain.Neuroscience, , 144 (1 ) ,223-31 More Information

Nair, Sunila G; Gudelsky, Gary A (2005. ) 3,4-Methylenedioxymethamphetamine (MDMA) enhances the release of acetylcholine by 5-HT4 and D1 receptor mechanisms in the rat prefrontal cortex.Synapse (New York, N.Y.), , 58 (4 ) ,229-35 More Information

Williams, Michael T; Schaefer, Tori L; Ehrman, Lisa A; Able, Jessica A; Gudelsky, Gary A; Sah, Renu; Vorhees, Charles V (2005. ) 3,4-Methylenedioxymethamphetamine administration on postnatal day 11 in rats increases pituitary-adrenal output and reduces striatal and hippocampal serotonin without altering SERT activity.Brain research, , 1039 (1-2 ) ,97-107 More Information

Darvesh, Altaf S; Yamamoto, Bryan K; Gudelsky, Gary A (2005. ) Evidence for the involvement of nitric oxide in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in the rat brain.The Journal of pharmacology and experimental therapeutics, , 312 (2 ) ,694-701 More Information

Nair, Sunila G; Gudelsky, Gary A (2004. ) Activation of 5-HT2 receptors enhances the release of acetylcholine in the prefrontal cortex and hippocampus of the rat.Synapse (New York, N.Y.), , 53 (4 ) ,202-7 More Information

Darvesh, Altaf S; Gudelsky, Gary A The relationship between hyperthermia and glycogenolysis in 3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats.Neurotoxicology and teratology, , 26 (4 ) ,571-7 More Information

Wallace, T L; Vorhees, C V; Zemlan, F P; Gudelsky, G A (2003. ) Methamphetamine enhances the cleavage of the cytoskeletal protein tau in the rat brain. Neuroscience, , 116 (4 ) ,1063-8

Wallace, T L; Gudelsky, G A; Vorhees, C V (2001. ) Alterations in diurnal and nocturnal locomotor activity in rats treated with a monoamine-depleting regimen of methamphetamine or 3,4-methylenedioxymethamphetamine. Psychopharmacology, , 153 (3 ) ,321-6

Wallace, T L; Gudelsky, G A; Vorhees, C V (2001. ) Neurotoxic regimen of methamphetamine produces evidence of behavioral sensitization in the rat.Synapse (New York, N.Y.), , 39 (1 ) ,1-7 More Information

Shankaran, M; Yamamoto, B K; Gudelsky, G A (1999. ) Involvement of the serotonin transporter in the formation of hydroxyl radicals induced by 3,4-methylenedioxymethamphetamine. European journal of pharmacology, , 385 (2-3 ) ,103-10

Shankaran, M; Gudelsky, G A (1999. ) A neurotoxic regimen of MDMA suppresses behavioral, thermal and neurochemical responses to subsequent MDMA administration. Psychopharmacology, , 147 (1 ) ,66-72

Wallace, T L; Gudelsky, G A; Vorhees, C V (1999. ) Methamphetamine-induced neurotoxicity alters locomotor activity, stereotypic behavior, and stimulated dopamine release in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience, , 19 (20 ) ,9141-8

Shankaran, M; Yamamoto, B K; Gudelsky, G A (1999. ) Mazindol attenuates the 3,4-methylenedioxymethamphetamine-induced formation of hydroxyl radicals and long-term depletion of serotonin in the striatum. Journal of neurochemistry, , 72 (6 ) ,2516-22

Shankaran, M; Gudelsky, G A (1998. ) Effect of 3,4-methylenedioxymethamphetamine (MDMA) on hippocampal dopamine and serotonin. Pharmacology, biochemistry, and behavior, , 61 (4 ) ,361-6

Gudelsky, G A (1996. ) Effect of ascorbate and cysteine on the 3,4-methylenedioxymethamphetamine-induced depletion of brain serotonin.Journal of neural transmission (Vienna, Austria : 1996), , 103 (12 ) ,1397-404 More Information

Gudelsky, G A; Nash, J F (1996. ) Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions. Journal of neurochemistry, , 66 (1 ) ,243-9

Gudelsky, G A; Nwajei, E E; Defife, K; Nash, J F (1992. ) Effects of amfonelic acid and GBR 12909 on the haloperidol- and clozapine-induced activation of dopamine neurons. Psychopharmacology bulletin, , 28 (3 ) ,275-9

Nash, J F; Meltzer, H Y; Gudelsky, G A (1988. ) Antagonism of serotonin receptor mediated neuroendocrine and temperature responses by atypical neuroleptics in the rat. European journal of pharmacology, , 151 (3 ) ,463-9

Pitzer, Emily M; Sugimoto, Chiho; Gudelsky, Gary A; Huff Adams, Courtney L; Williams, Michael T; Vorhees, Charles V (2019. ) Deltamethrin Exposure Daily From Postnatal Day 3-20 in Sprague-Dawley Rats Causes Long-term Cognitive and Behavioral Deficits.Toxicological sciences : an official journal of the Society of Toxicology, , 169 (2 ) ,511-523 More Information

Arora, Priyanka; Adams, Courtney Huff; Gudelsky, Gary; DasGupta, Biplab; Desai, Pankaj B (2019. ) Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats.Cancer chemotherapy and pharmacology, , 83 (1 ) ,81-89 More Information

Roenker, Nicole L; Gudelsky, Gary; Ahlbrand, Rebecca; Bronson, Stefanie L; Kern, Joseph R; Waterman, Heather; Richtand, Neil M (2011. ) Effect of paliperidone and risperidone on extracellular glutamate in the prefrontal cortex of rats exposed to prenatal immune activation or MK-801.Neuroscience letters, , 500 (3 ) ,167-71 More Information

Hui, Anna S; Striet, Justin B; Gudelsky, Gary; Soukhova, Galia K; Gozal, Evelyne; Beitner-Johnson, Dana; Guo, Shang-Z; Sachleben, Leroy R; Haycock, John W; Gozal, David; Czyzyk-Krzeska, Maria F (2003. ) Regulation of catecholamines by sustained and intermittent hypoxia in neuroendocrine cells and sympathetic neurons.Hypertension (Dallas, Tex. : 1979), , 42 (6 ) ,1130-6 More Information

Harold, C; Wallace, T; Friedman, R; Gudelsky, G; Yamamoto, B (2000. ) Methamphetamine selectively alters brain glutathione.European journal of pharmacology, , 400 (1 ) ,99-102 More Information

Burrows, K B; Gudelsky, G; Yamamoto, B K (2000. ) Rapid and transient inhibition of mitochondrial function following methamphetamine or 3,4-methylenedioxymethamphetamine administration.European journal of pharmacology, , 398 (1 ) ,11-8 More Information

Ackerman, G E; MacDonald, P C; Gudelsky, G; Mendelson, C R; Simpson, E R (1981. ) Potentiation of epinephrine-induced lipolysis by catechol estrogens and their methoxy derivatives.Endocrinology, , 109 (6 ) ,2084-8 More Information

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Dave,N; Gudelsky,G; Desai,P (2013. ) The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma assessed by intracerebral microdialysis .Cancer Chemother Pharmacol, , 72 (2 ) ,349

Pitzer, Emily M; Sugimoto, Chiho; Regan, Samantha L; Gudelsky, Gary A; Williams, Michael T; Vorhees, Charles V (2022. ) Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats.Current research in toxicology, , 3 ,100093 More Information

Karve, Aniruddha S; Desai, Janki M; Dave, Nimita; Wise-Draper, Trisha M; Gudelsky, Gary A; Phoenix, Timothy N; DasGupta, Biplab; Sengupta, Soma; Plas, David R; Desai, Pankaj B (2022. ) Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole.Cancer chemotherapy and pharmacology, , 90 (4 ) ,345-356 More Information

Desai, Janki M; Karve, Aniruddha S; Gudelsky, Gary A; Gawali, Mruniya V; Seibel, William; Sallans, Larry; DasGupta, Biplab; Desai, Pankaj B (2022. ) Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma.Investigational new drugs, , 40 (5 ) ,944-952 More Information

Collins, Sean M; O'Connell, Christopher J; Reeder, Evan L; Norman, Sophia V; Lungani, Kainat; Gopalan, Poornima; Gudelsky, Gary A; Robson, Matthew J (2022. ) Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance.Frontiers in pharmacology, , 13 ,930346 More Information

Rech R.; Gudelsky G. (01-01-1974. ) Interactions between Ro4 1284 and d amphetamine (dA) on shuttle box avoidance in rats .Pharmacologist, , 16 (2 ) ,

Gudelsky G.; Simpkins J.; Mueller G.; Meites J.; Moore K. (01-01-1976. ) Selective actions of prolactin on catecholamine turnover in the hypothalamus and on serum LH and FSH.Neuroendocrinology, , 22 (3 ) ,206-215 More Information

Annunziato L.; Gudelsky G.; Moore K. (01-01-1977. ) The effects of hypothalamic deafferentation on the haloperidol induced activation of tuberoinfundibu .Pharmacologist, , 19 (2 ) ,

Gudelsky G.; Annunziato L.; Ravitz A. (01-01-1977. ) Effects of estrogen on serum prolactin levels and dopamine turnover in nigrostriatal and tuberoinfun .Federation Proceedings, , 36 (3 ) ,

Nansel D.D.; Gudelsky G.A.; Porter J.C. (01-01-1979. ) Subcellular localization of dopamine in the anterior pituitary gland of the rat: Apparent associatio .Federation Proceedings, , 38 (3 II ) ,

Gudelsky G.A.; Porter J.C. (01-01-1979. ) Prolactin and haloperidol stimulation of hypothalamic secretion of dopamine into pituitary stalk blo .Federation Proceedings, , 38 (3 II ) ,

Porter J.C.; Dale Nansel D.; Gudelsky G.A.; Reymond M.J.; Pilotte N.S.; Foreman M.M.; Tilders F.J.H. (01-01-1980. ) Some aspects of hypothalamic and hypophysial secretion in aging rats.Peptides, , 1 (SUPPL. 1 ) ,135-139 More Information

Locatelli V.; Apud J.A.; Gudelsky G.A.; Cocchi D.; Masotto C.; Casanueva F.; Racagni G.; Müller E.E. (01-01-1985. ) Prolactin in cerebrospinal fluid increases the synthesis and release of hypothalamic ?-aminobutyric .Journal of Endocrinology, , 106 (3 ) ,323-328 More Information

Gudelsky G.A.; Nash J.F.; Koenig J.I.; Meltzer H.Y. (01-01-1987. ) Neuroendocrine effects of typical and atypical antipsychotics in the rat .Psychopharmacology Bulletin, , 23 (3 ) ,483-486

Wallace T.L.; Gudelsky G.A.; Vorhees C.V. (01-01-2001. ) Effect of chronic olanzapine treatment on striatal synaptic organization.Synapse, , 39 (1 ) ,8-15 More Information

Gudelsky G.; Moore K. (01-01-1976. ) Differential drug effects on the tuberoinfundibular, mesolimbic and nigrostriatal dopaminergic neuro .Pharmacologist, , 18 (2 ) ,

Gudelsky G.; Hippius H.; Meltzer H.; Naber D. (03-01-1989. ) Summary of discussions.Psychopharmacology, , 99 (1 Supplement ) , More Information

Yamamoto B.; Moszczynska A.; Gudelsky G. (01-01-2010. ) Amphetamine toxicities: Classical and emerging mechanisms.Annals of the New York Academy of Sciences, , 1187 ,101-121 More Information

Darvesh A.; Carroll R.; Geldenhuys W.; Gudelsky G.; Klein J.; Meshul C.; Van Der Schyf C. (02-01-2011. ) In vivo brain microdialysis: Advances in neuropsychopharmacology and drug discovery.Expert Opinion on Drug Discovery, , 6 (2 ) ,109-127 More Information

Schaefer T.; Grace C.; Skelton M.; Graham D.; Gudelsky G.; Vorhees C.; Williams M. (01-18-2012. ) Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats.ACS Chemical Neuroscience, , 3 (1 ) ,12-21 More Information

Anneken J.; Collins S.; Yamamoto B.; Gudelsky G. (04-15-2016. ) MDMA and Glutamate: Implications for Hippocampal Neurotoxicity.Neuropathology of Drug Addictions and Substance Misuse, , 2 ,406-414 More Information

Oatman N.; Dasgupta N.; Arora P.; Choi K.; Gawali M.V.; Gupta N.; Parameswaran S.; Salomone J.; Reisz J.A.; Lawler S.; Furnari F.; Brennan C.; Wu J.; Sallans L.; Gudelsky G.; Desai P.; Gebelein B.; Weirauch M.T.; D'Alessandro A.; Komurov K.; Dasgupta B. (02-10-2021. ) Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer.Science Advances, , 7 (7 ) , More Information

Arora P.; Gudelsky G.; Desai P.B. (04-01-2021. ) Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: A.PLoS ONE, , 16 (4 April ) , More Information

Anneken J.H.; Collins S.A.; Yamamoto B.K.; Gudelsky G.A. (01-01-2016. ) MDMA and Glutamate: Implications for Hippocampal Neurotoxicity.Neuropathology of Drug Addictions and Substance Misuse Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects, , 406-414 More Information

Collins S.M.; O’Connell C.J.; Reeder E.L.; Norman S.V.; Lungani K.; Gopalan P.; Gudelsky G.A.; Robson M.J. (07-15-2022. ) Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited .Frontiers in Pharmacology, , 13 , More Information

Pitzer E.M.; Sugimoto C.; Regan S.L.; Gudelsky G.A.; Williams M.T.; Vorhees C.V. (01-01-2022. ) Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats.Current Research in Toxicology, , 3 , More Information

O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J (2024. ) Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury.Experimental neurology, , 374 ,114695 More Information

O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J (2024. ) Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury.Experimental neurology, , 374 ,114695 More Information

O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J (2024. ) Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury.Experimental neurology, , 374 ,114695 More Information

O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J (2024. ) Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury.Experimental neurology, , 374 ,114695 More Information

Dopamine,Clozapine,Serotonin,Haloperidol,Pentazocine,Pcp Receptor,Drug Receptor,Microdialysis,Schizophrenia,Laboratory Rat,Neurochemistry,Corpus Striatum,Methamphetamine,Neurotransmitter,Neuropharmacology,Antipsychotic Agent,Stereotaxic Technique

MDMA

Academic - Phone: 513-558-5735
Gary.Gudelsky@uc.edu

Research - Gudelsky's Lab
231 Albert Sabin Way
Cincinnati  Ohio, 45229