Margaret Hostetter , MD

Dr. Margaret K. Hostetter, the Albert B. Sabin Professor of Pediatrics, is a board-certified specialist in pediatric infectious diseases whose research focuses on the yeast Candida albicans, a cause of vaginal colonization in pregnant women and of potentially fatal bloodstream infections in premature infants and other hosts.  Current extramural funding comes from the NIH, the Bill & Melinda Gates Foundation, and the Global Alliance to Prevent Prematurity and Stillbirth.

An Ohio native, Dr. Hostetter earned her M.D. from Baylor College of Medicine in Houston, Texas, and completed her pediatric residency and fellowship in pediatric infectious diseases at Children's Hospital Boston. She has served as the American Legion Heart Research Professor in Pediatrics at the University of Minnesota and as the Jean McLean Wallace Professor of Pediatrics and Chair of the Department of Pediatrics at Yale before coming to Cincinnati Children’s Hospital in 2010 as the Albert B. Sabin Professor.

Dr. Hostetter's honors include the American Academy of Pediatrics Award for Excellence in Research, the Samuel Rosenthal Award for contributions to academic pediatrics, the E. Mead Johnson Award for Pediatric Research from the Society for Pediatric Research, and the Maxwell Finland Lecture from the Infectious Diseases Society of America. She is a member of the Institute of Medicine of the National Academy of Sciences. 

Bachelor's Degree: Denison University Granville, OH, 1970 (English)

Medical Degree: Baylor College of Medicine Houston, TX, 1975 (Medicine)

Residency: Boston Children's (Harvard) Boston, MA, 1978 (Pediatrics)

Fellowship: Boston Children's (Harvard) Boston, MA, 1980 (Pediatric Infectious Diseases )

Research Interests: pathogenesis of infections caused by Candida albicans; fungal pathogenesis; biofilm formation; role of candidal vaginal colonization in pre-term birth

Clinical Interests: pediatric infectious diseases

Grant: #GAPPS2012 Investigators:Margaret Hostetter 10-01-2012 -09-30-2015 Global Alliance to Prevent Prematurity and Stillbirth Balance of Th17 Cells and Regulatory T Cells in Candida albicans Vaginal Colonization in vitro and in vivo. Role:PI $1,000,000 Active Type:Grant Level:International

Grant: #K12HD0000850-29 Investigators:Margaret Hostetter, Program Director 07-01-1986 -06-30-2017 NICHD Pediatric Scientist Development Program Role:PI $10,000,000 Active Type:Grant Level:National

Peer Reviewed Publications

Green, Julianne V; Orsborn, Kris I; Zhang, Minlu; Tan, Queenie K G; Greis, Kenneth D; Porollo, Alexey; Andes, David R; Long Lu, Jason; Hostetter, Margaret K (2013. ) Heparin-binding motifs and biofilm formation by Candida albicans.The Journal of infectious diseases, , 208 (10 ) ,1695-704 More Information

Hostetter, Margaret K (2012. ) Success for the physician-scientist in a resource-limited environment.The Journal of pediatrics, , 161 (1 ) ,1-2.e1 More Information

Hostetter, Margaret Kendrick (2012. ) What we don't see.The New England journal of medicine, , 366 (14 ) ,1328-34 More Information

Liu, Geoffrey; Vellucci, Vincent F; Kyc, Stephanie; Hostetter, Margaret K (2009. ) Simvastatin inhibits Candida albicans biofilm in vitro.Pediatric research, , 66 (6 ) ,600-4 More Information

Devore-Carter, Denise; Kar, Sujata; Vellucci, Vincent; Bhattacherjee, Vasker; Domanski, Paul; Hostetter, Margaret K (2008. ) Superantigen-like effects of a Candida albicans polypeptide.The Journal of infectious diseases, , 197 (7 ) ,981-9 More Information

Vellucci, Vincent F; Gygax, Scott E; Hostetter, Margaret K (2007. ) Involvement of Candida albicans pyruvate dehydrogenase complex protein X (Pdx1) in filamentation.Fungal genetics and biology : FG & B, , 44 (10 ) ,979-90 More Information

Frank, Charlotte F; Hostetter, Margaret K (2007. ) Cleavage of E-cadherin: a mechanism for disruption of the intestinal epithelial barrier by Candida albicans.Translational research : the journal of laboratory and clinical medicine, , 149 (4 ) ,211-22 More Information

Hostetter, Margaret K (2004. ) A piece of my mind. Stitches.JAMA : the journal of the American Medical Association, , 291 (3 ) ,282 More Information

McDonough, Justin A; Bhattacherjee, Vasker; Sadlon, Tania; Hostetter, Margaret K (2002. ) Involvement of Candida albicans NADH dehydrogenase complex I in filamentation.Fungal genetics and biology : FG & B, , 36 (2 ) ,117-27 More Information

Hostetter, Margaret K (2002. ) Career development for physician-scientists: the model of the Pediatric Scientist Development Program.The Journal of pediatrics, , 140 (2 ) ,143-4 More Information

Zhang, Y; Masi, A W; Barniak, V; Mountzouros, K; Hostetter, M K; Green, B A (2001. ) Recombinant PhpA protein, a unique histidine motif-containing protein from Streptococcus pneumoniae, protects mice against intranasal pneumococcal challenge.Infection and immunity, , 69 (6 ) ,3827-36 More Information

Hostetter, M K (2000. ) RGD-mediated adhesion in fungal pathogens of humans, plants and insects. Current opinion in microbiology, , 3 (4 ) ,344-8

Smith, B L; Hostetter, M K (2000. ) C3 as substrate for adhesion of Streptococcus pneumoniae.The Journal of infectious diseases, , 182 (2 ) ,497-508 More Information

Cheng, Q; Finkel, D; Hostetter, M K (2000. ) Novel purification scheme and functions for a C3-binding protein from Streptococcus pneumoniae. Biochemistry, , 39 (18 ) ,5450-7

Madsen, M; Lebenthal, Y; Cheng, Q; Smith, B L; Hostetter, M K (2000. ) A pneumococcal protein that elicits interleukin-8 from pulmonary epithelial cells.The Journal of infectious diseases, , 181 (4 ) ,1330-6 More Information

San-Blas, G; Travassos, L R; Fries, B C; Goldman, D L; Casadevall, A; Carmona, A K; Barros, T F; Puccia, R; Hostetter, M K; Shanks, S G; Copping, V M; Knox, Y; Gow, N A (2000. ) Fungal morphogenesis and virulence. Medical mycology, , 38 Suppl 1 ,79-86

Hostetter, M K (1999. ) Integrin-like proteins in Candida spp. and other microorganisms.Fungal genetics and biology : FG & B, , 28 (3 ) ,135-45 More Information

Kinneberg, K M; Bendel, C M; Jechorek, R P; Cebelinski, E A; Gale, C A; Berman, J G; Erlandsen, S L; Hostetter, M K; Wells, C L (1999. ) Effect of INT1 gene on Candida albicans murine intestinal colonization.The Journal of surgical research, , 87 (2 ) ,245-51 More Information

Bendel, C M; Kinneberg, K M; Jechorek, R P; Gale, C A; Erlandsen, S L; Hostetter, M K; Wells, C L (1999. ) Systemic infection following intravenous inoculation of mice with Candida albicans int1 mutant strains.Molecular genetics and metabolism, , 67 (4 ) ,343-51 More Information

Hostetter, M K (1999. ) Opsonic and nonopsonic interactions of C3 with Streptococcus pneumoniae. Microbial drug resistance (Larchmont, N.Y.), , 5 (2 ) ,85-9

Hostetter, M K (1999. ) Epidemiology of travel-related morbidity and mortality in children. Pediatrics in review / American Academy of Pediatrics, , 20 (7 ) ,228-33

Hostetter, M K (1999. ) Infectious diseases in internationally adopted children: findings in children from China, Russia, and eastern Europe. Advances in pediatric infectious diseases, , 14 ,147-61

Hostetter, M K (1998. ) Linkage of adhesion, morphogenesis, and virulence in Candida albicans. The Journal of laboratory and clinical medicine, , 132 (4 ) ,258-63

Hostetter, M K (1998. ) Infectious diseases in internationally adopted children: the past five years. The Pediatric infectious disease journal, , 17 (6 ) ,517-8

Gale, C A; Bendel, C M; McClellan, M; Hauser, M; Becker, J M; Berman, J; Hostetter, M K (1998. ) Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1. Science (New York, N.Y.), , 279 (5355 ) ,1355-8

Albers, L H; Johnson, D E; Hostetter, M K; Iverson, S; Miller, L C (1997. ) Health of children adopted from the former Soviet Union and Eastern Europe. Comparison with preadoptive medical records. JAMA : the journal of the American Medical Association, , 278 (11 ) ,922-4

Hostetter, M K (1996. ) Steadfast in the 'steady state'. Archives of pediatrics & adolescent medicine, , 150 (9 ) ,897-8

Salazar, J C; Bloom, K E; Hostetter, M K; Leonardi, C L (1996. ) Drug-resistant tuberculosis verrucosa cutis in a Southeast Asian teenager. The Pediatric infectious disease journal, , 15 (9 ) ,834-6

DeMuri, G P; Hostetter, M K (1996. ) Evidence for a beta 1 integrin fibronectin receptor in Candida tropicalis. The Journal of infectious diseases, , 174 (1 ) ,127-32

Hostetter, M K (1996. ) An integrin-like protein in Candida albicans: implications for pathogenesis.Trends in microbiology, , 4 (6 ) ,242-6 More Information

Hostetter, M K (1996. ) Adhesion and morphogenesis in Candida albicans.Pediatric research, , 39 (4 Pt 1 ) ,569-73 More Information

Hostetter, M K; Johnson, D (1996. ) Medical examination of the internationally adopted child: screening for infectious diseases and developmental delay. Postgraduate medicine, , 99 (4 ) ,70-2, 75-7, 81-2

Hostetter, M K (1996. ) New insights into candidal infections. Advances in pediatrics, , 43 ,209-30

Faix, R G; Finkel, D J; Andersen, R D; Hostetter, M K (1995. ) Genotypic analysis of a cluster of systemic Candida albicans infections in a neonatal intensive care unit. The Pediatric infectious disease journal, , 14 (12 ) ,1063-8

Hostetter, M K; Tao, N J; Gale, C; Herman, D J; McClellan, M; Sharp, R L; Kendrick, K E (1995. ) Antigenic and functional conservation of an integrin I-domain in Saccharomyces cerevisiae. Biochemical and molecular medicine, , 55 (2 ) ,122-30

Bendel, C M; St Sauver, J; Carlson, S; Hostetter, M K (1995. ) Epithelial adhesion in yeast species: correlation with surface expression of the integrin analog. The Journal of infectious diseases, , 171 (6 ) ,1660-3

DeMuri, G P; Hostetter, M K (1995. ) Resistance to antifungal agents. Pediatric clinics of North America, , 42 (3 ) ,665-85

Michael, E J; McClellan, M; Huebner, H; Hostetter, M K (1995. ) Expression of CD21 and synthesis of its ligands by HeLa cells after growth in serum-free medium. The Journal of laboratory and clinical medicine, , 125 (1 ) ,102-12

Hostetter, M K (1994. ) Society for Pediatric Research presidential address 1994: yeast as metaphor.Pediatric research, , 36 (6 ) ,692-8 More Information

Angel, C S; Ruzek, M; Hostetter, M K (1994. ) Degradation of C3 by Streptococcus pneumoniae. The Journal of infectious diseases, , 170 (3 ) ,600-8

Hostetter, M K (1994. ) Adhesins and ligands involved in the interaction of Candida spp. with epithelial and endothelial surfaces. Clinical microbiology reviews, , 7 (1 ) ,29-42

Hostetter, M K (1993. ) The third component of complement: new functions for an old friend. The Journal of laboratory and clinical medicine, , 122 (5 ) ,491-6

Bendel, C M; Hostetter, M K (1993. ) Distinct mechanisms of epithelial adhesion for Candida albicans and Candida tropicalis. Identification of the participating ligands and development of inhibitory peptides.The Journal of clinical investigation, , 92 (4 ) ,1840-9 More Information

Johnson, D E; Miller, L C; Iverson, S; Thomas, W; Franchino, B; Dole, K; Kiernan, M T; Georgieff, M K; Hostetter, M K The health of children adopted from Romania. JAMA : the journal of the American Medical Association, , 268 (24 ) ,3446-51

Nath, K A; Salahudeen, A K; Clark, E C; Hostetter, M K; Hostetter, T H (1992. ) Role of cellular metabolites in progressive renal injury. Kidney international. Supplement, , 38 ,S109-13

Henwick, S; Hetherington, S V; Hostetter, M K (1992. ) Specificity of three anti-complement factor 3 monoclonal antibodies. Journal of immunological methods, , 153 (1-2 ) ,173-84

Clark, E C; Nath, K A; Hostetter, T H; Hostetter, M K (1992. ) Hyperosmolality impairs ammonia-mediated inflammation: implications for the renal medulla. The American journal of physiology, , 263 (1 Pt 2 ) ,R148-55

Zach, T L; Hill, L D; Herrman, V A; Leuschen, M P; Hostetter, M K (1992. ) Effect of glucocorticoids on C3 gene expression by the A549 human pulmonary epithelial cell line. Journal of immunology (Baltimore, Md. : 1950), , 148 (12 ) ,3964-9

Hostetter, M K; Iverson, S; Thomas, W; McKenzie, D; Dole, K; Johnson, D E (1991. ) Medical evaluation of internationally adopted children.The New England journal of medicine, , 325 (7 ) ,479-85 More Information

Nath, K A; Hostetter, M K; Hostetter, T H (1991. ) Increased ammoniagenesis as a determinant of progressive renal injury. American journal of kidney diseases : the official journal of the National Kidney Foundation, , 17 (6 ) ,654-7

Gustafson, K S; Vercellotti, G M; Bendel, C M; Hostetter, M K (1991. ) Molecular mimicry in Candida albicans. Role of an integrin analogue in adhesion of the yeast to human endothelium.The Journal of clinical investigation, , 87 (6 ) ,1896-902 More Information

Clark, E C; Nath, K A; Hostetter, M K; Hostetter, T H (1991. ) Role of ammonia in progressive interstitial nephritis. American journal of kidney diseases : the official journal of the National Kidney Foundation, , 17 (5 Suppl 1 ) ,15-9

Nath, K A; Hostetter, M K; Hostetter, T H (1991. ) The role of ammonia in progressive renal injury. Contributions to nephrology, , 92 ,78-82

Lugenbill, C; Clark, R B; Fagnant, R J; Hostetter, M K; Hill, W C (1990. ) Comparison of the cervicovaginal gram stain and rapid latex agglutination slide test for identification of group B streptococci. Journal of perinatology : official journal of the California Perinatal Association, , 10 (4 ) ,403-5

Hostetter, M K; Lorenz, J S; Preus, L; Kendrick, K E (1990. ) The iC3b receptor on Candida albicans: subcellular localization and modulation of receptor expression by glucose. The Journal of infectious diseases, , 161 (4 ) ,761-8

Hostetter, M K (1990. ) Handicaps to host defense. Effects of hyperglycemia on C3 and Candida albicans. Diabetes, , 39 (3 ) ,271-5

Moy, J N; Nelson, R D; Richards, K L; Hostetter, M K (1990. ) Identification of an IgA inhibitor of neutrophil chemotaxis and its membrane target for the metabolic burst. Immunology, , 69 (2 ) ,257-63

Clark, R B; Pakiz, C B; Hostetter, M K (1990. ) Synergistic activity of aminoglycoside-beta-lactam combinations against Pseudomonas aeruginosa with an unusual aminoglycoside antibiogram. Medical microbiology and immunology, , 179 (2 ) ,77-86

Clark, E C; Nath, K A; Hostetter, M K; Hostetter, T H (1990. ) Role of ammonia in tubulointerstitial injury. Mineral and electrolyte metabolism, , 16 (5 ) ,315-21

Nath, K A; Hostetter, M K; Hostetter, T H (1989. ) Ammonia-complement interaction in the pathogenesis of progressive renal injury. Kidney international. Supplement, , 27 ,S52-4

Hostetter, M K; Johnson, G M (1989. ) The erythrocyte as instigator of inflammation. Generation of amidated C3 by erythrocyte adenosine deaminase.The Journal of clinical investigation, , 84 (2 ) ,665-71 More Information

Zach, T L; Hostetter, M K (1989. ) Biochemical abnormalities of the third component of complement in neonates.Pediatric research, , 26 (2 ) ,116-20 More Information

Hostetter, M K; Iverson, S; Dole, K; Johnson, D (1989. ) Unsuspected infectious diseases and other medical diagnoses in the evaluation of internationally adopted children. Pediatrics, , 83 (4 ) ,559-64

Goldhagen, J; Alford, B A; Prewitt, L H; Thompson, L; Hostetter, M K (1988. ) Suppurative thrombophlebitis of the internal jugular vein: report of three cases and review of the pediatric literature. The Pediatric infectious disease journal, , 7 (6 ) ,410-4

Clark, R B; Sanders, C C; Pakiz, C B; Hostetter, M K (1988. ) Aminoglycoside resistance among Pseudomonas aeruginosa isolates with an unusual disk diffusion antibiogram. Antimicrobial agents and chemotherapy, , 32 (5 ) ,689-92

Gordon, D L; Rice, J; Finlay-Jones, J J; McDonald, P J; Hostetter, M K (1988. ) Analysis of C3 deposition and degradation on bacterial surfaces after opsonization. The Journal of infectious diseases, , 157 (4 ) ,697-704

Hostetter, T H; Nath, K A; Hostetter, M K (1988. ) Infection-related chronic interstitial nephropathy. Seminars in nephrology, , 8 (1 ) ,11-6

Gilmore, B J; Retsinas, E M; Lorenz, J S; Hostetter, M K (1988. ) An iC3b receptor on Candida albicans: structure, function, and correlates for pathogenicity. The Journal of infectious diseases, , 157 (1 ) ,38-46

Tolins, J P; Hostetter, M K; Hostetter, T H (1987. ) Hypokalemic nephropathy in the rat. Role of ammonia in chronic tubular injury.The Journal of clinical investigation, , 79 (5 ) ,1447-58 More Information

Gordon, D L; Johnson, G M; Hostetter, M K (1987. ) Characteristics of iC3b binding to human polymorphonuclear leucocytes. Immunology, , 60 (4 ) ,553-8

Hostetter, M K; Gordon, D L Biochemistry of C3 and related thiolester proteins in infection and inflammation. Reviews of infectious diseases, , 9 (1 ) ,97-109

Gordon, D L; Johnson, G M; Hostetter, M K (1986. ) Ligand-receptor interactions in the phagocytosis of virulent Streptococcus pneumoniae by polymorphonuclear leukocytes. The Journal of infectious diseases, , 154 (4 ) ,619-26

Gordon, D L; Hostetter, M K (1986. ) Complement and host defence against microorganisms. Pathology, , 18 (4 ) ,365-75

Hostetter, M K (1986. ) Serotypic variations among virulent pneumococci in deposition and degradation of covalently bound C3b: implications for phagocytosis and antibody production. The Journal of infectious diseases, , 153 (4 ) ,682-93

Nath, K A; Hostetter, M K; Hostetter, T H (1985. ) Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3.The Journal of clinical investigation, , 76 (2 ) ,667-75 More Information

Giebink, G S; Carlson, B A; Hetherington, S V; Hostetter, M K; Le, C T; Juhn, S K Bacterial and polymorphonuclear leukocyte contribution to middle ear inflammation in chronic otitis media with effusion. The Annals of otology, rhinology, and laryngology, , 94 (4 Pt 1 ) ,398-402

Gordon, D L; Krueger, R A; Quie, P G; Hostetter, M K (1985. ) Amidation of C3 at the thiolester site: stimulation of chemiluminescence and phagocytosis by a new inflammatory mediator. Journal of immunology (Baltimore, Md. : 1950), , 134 (5 ) ,3339-45

Hostetter, M K; Krueger, R A; Schmeling, D J (1984. ) The biochemistry of opsonization: central role of the reactive thiolester of the third component of complement. The Journal of infectious diseases, , 150 (5 ) ,653-61

Hostetter, M K; Levy, H L; Winter, H S; Knight, G J; Haddow, J E (1983. ) Evidence for liver disease preceding amino acid abnormalities in hereditary tyrosinemia.The New England journal of medicine, , 308 (21 ) ,1265-7 More Information

Hostetter, M K; Thomas, M L; Rosen, F S; Tack, B F (1982. ) Binding of C3b proceeds by a transesterification reaction at the thiolester site. Nature, , 298 (5869 ) ,72-5

Hostetter, M K; Schwartz, A L; Siber, G R; Schiffman, G (1981. ) Pneumococcal vaccine failure. American journal of diseases of children (1960), , 135 (12 ) ,1149-50

Mann, J; O'Brien, R; Hostetter, M K; Alper, C A; Rosen, F S; Babior, B M (1981. ) The third component of complement: covalent attachment of a radioactive sugar to the labile binding site of C3 via the alternative pathway. Journal of immunology (Baltimore, Md. : 1950), , 126 (6 ) ,2370-2

Burns, Audrea M; Moore, Daniel J; Forster, Catherine S; Powell, Weston; Thammasitboon, Satid; Hostetter, Margaret K; Weiss, Pnina; Boyer, Debra; Ward, Mark A; Blankenburg, Rebecca; Heyman, Melvin B; Rassbach, Caroline E; McPhillips, Heather; French, Anthony; Nguyen, Suong; Byrne, Bobbi J; Parsons, Donald Williams; Gonzalez, Fernando; Nowalk, Andrew J; Ho, Jacqueline; Kumar, Shelley; Orange, Jordan S; Ackerman, Kate G (2021. ) Physician-Scientist Training and Programming in Pediatric Residency Programs: A National Survey.The Journal of pediatrics, , More Information

Gordon, Catherine M; Hostetter, Margaret K; DeBaun, Michael R (2021. ) Academic pipeline initiatives in pediatrics.Pediatric research, , More Information

Barrett, Katherine J; Cooley, T Michelle; Schwartz, Alan L; Hostetter, Margaret K; Clapp, D Wade; Permar, Sallie R (2020. ) Addressing Gaps in Pediatric Scientist Development: The Department Chair View of 2 AMSPDC-Sponsored Programs.The Journal of pediatrics, , 222 ,7-12.e4 More Information

Hostetter, Margaret K (2020. ) Ensuring Equity in Compensation and Career Advancement for Female Physicians.Mayo Clinic proceedings, , 95 (1 ) ,3-5 More Information

Dermody, Terence S; Hirsch, Raphael; Hostetter, Margaret K; Orange, Jordan S; St Geme, Joseph W (2019. ) Expanding the Pipeline for Pediatric Physician-Scientists.The Journal of pediatrics, , 207 ,3-7.e1 More Information

Wikenheiser-Brokamp, Kathryn A; Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; DeWitt, Thomas G; Loch, Jill; Strauss, Arnold W; Muglia, Louis J; Hostetter, Margaret K (2017. ) Evaluation of Fellows' CrossTalk Effectiveness in Promoting Transdisciplinary Networking and Research.The Journal of pediatrics, , 181 ,5-6.e3 More Information

Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; Muglia, Louis J; Wikenheiser-Brokamp, Kathryn A; Loch, Jill; Hostetter, Margaret K; Strauss, Arnold W; DeWitt, Thomas G (2015. ) Enhancing Pediatric Fellows' Research Training: Development of an Office of Pediatric Clinical Fellowships.The Journal of pediatrics, , 167 (3 ) ,506-7.e1 More Information

Patel, Zubin H; Kottyan, Leah C; Lazaro, Sara; Williams, Marc S; Ledbetter, David H; Tromp, Hbgerard; Rupert, Andrew; Kohram, Mojtaba; Wagner, Michael; Husami, Ammar; Qian, Yaping; Valencia, C Alexander; Zhang, Kejian; Hostetter, Margaret K; Harley, John B; Kaufman, Kenneth M (2014. ) The struggle to find reliable results in exome sequencing data: filtering out Mendelian errors.Frontiers in genetics, , 5 ,16 More Information

Hostetter, Margaret K; Johnson, Dana (1996. ) Medical examination of the internationally adopted child.Postgraduate medicine, , 99 (4 ) ,70-82 More Information

Academic - Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue
Cincinnati  Ohio, 45229
Phone: 513-636-7839
Fax: 513-803-3224
margaret.hostetter@cchmc.org