Wei Huang, PhD

My laboratory (www.huangwelab.com) has a long-standing research focus aimed at unraveling the cellular and molecular mechanisms underlying cardiovascular diseases triggered by stress or disease, encompassing conditions such as coronary artery disease, diabetic cardiomyopathy, and septic cardiomyopathy. Our overarching objective is to develop therapeutic strategies aimed at controlling cardiac remodeling and redirecting the adult heart to a regenerative state. Specifically, our research delves into two primary areas:

1. Mitochondrial nucleoid in cardiac homeostasis: bidirectional signaling of mitochondria and nucleus in cardiac diseases;
2. Epigenetic mechanisms implicated in inflammation activation and cardiac dysfunction.

Lab Website
www.huangwelab.com/

Grant: #20CDA35310176 Investigators:Huang, Wei 07-01-2020 -06-30-2023 American Heart Association - National Chapter Rescue mitochondria dysfunction in failing heart by DNA methylation of miR-128 enhancer. Role:PI $77,000.00

Grant: #R01HL163148 Investigators:Huang, Wei 01-12-2023 -12-31-2027 National Heart, Lung and Blood Institute Mitochondrial R-loop in sepsis-induced cardiomyopathy. Role:PI $445,156.00

Grant: #Pathology Research Pilot Award 03-28-2022 -03-28-2023 University of Cincinnati College of Medicine Mitochondrial R-loop in heart failure. Role:PI $10,000.00

Grant: #Research Innovation/Pilot Grant Program Investigators:Huang, Wei; Wang, Jiang 07-01-2022 -12-31-2023 University of Cincinnati College of Medicine The 3D genome in transcriptional regulation and heart failure therapy. Role:PI $26,000.00

Grant: #Pathology Research Pilot Award 01-01-2021 -12-30-2021 University of Cincinnati College of Medicine Targeting mitochondria-located miR-128 alleviates human cardiomyocyte hypertrophy. Role:PI $10,000.00

Grant: #R01HL168464 Investigators:Huang, Wei; Wang, Yi-Gang 12-15-2023 -11-30-2027 National Heart, Lung and Blood Institute A novel strategy for heart failure therapeutics Role:PI $487,918.00

Peer Reviewed Publications

For updated list of publications, please go to NIH https://www.ncbi.nlm.nih.gov/myncbi/14Ah47wG69FQ1/bibliography/public/ .

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08-2024 -08-2026 Brodie STEM Funds University of Cincinnati Office of the Provost

-PMM-8082 METHODS BOMED RES Methods in Biomedical Research Level:Graduate

-GNTD-8003 CAREER OPP BIOM SCI Career Opportunities in Biomedical Sciences Level:Graduate

Academic - CVC Room 3938
231 Albert Sabin Way
Cincinnati  Ohio, 45267
Phone: 5135582444
huangwe@ucmail.uc.edu