Rulang Jiang , PhD

Bachelor's Degree: Nanjing Normal University

Master's Degree: Chinese Academy of Sciences (Genetics)

Doctoral Degree: Wesleyan University

Molecular developmental biology.

Peer Reviewed Publications

Jia, Shihai; Kwon, Hyuk-Jae Edward; Lan, Yu; Zhou, Jing; Liu, Han; Jiang, Rulang (2016. ) Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.Developmental biology, , 420 (1 ) ,110-119 More Information

Xu, Jingyue; Liu, Han; Chai, Ok Hee; Lan, Yu; Jiang, Rulang (2016. ) Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis.PloS one, , 11 (7 ) ,e0159597 More Information

Lan, Yu; Zhang, Nian; Liu, Han; Xu, Jingyue; Jiang, Rulang (2016. ) Golgb1 regulates protein glycosylation and is crucial for mammalian palate development.Development (Cambridge, England), , 143 (13 ) ,2344-55 More Information

Xu, Jingyue; Liu, Han; Lan, Yu; Aronow, Bruce J; Kalinichenko, Vladimir V; Jiang, Rulang (2016. ) A Shh-Foxf-Fgf18-Shh Molecular Circuit Regulating Palate Development.PLoS genetics, , 12 (1 ) ,e1005769 More Information

Dyment, Nathaniel A; Breidenbach, Andrew P; Schwartz, Andrea G; Russell, Ryan P; Aschbacher-Smith, Lindsey; Liu, Han; Hagiwara, Yusuke; Jiang, Rulang; Thomopoulos, Stavros; Butler, David L; Rowe, David W (2015. ) Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis.Developmental biology, , 405 (1 ) ,96-107 More Information

Breidenbach, Andrew P; Aschbacher-Smith, Lindsey; Lu, Yinhui; Dyment, Nathaniel A; Liu, Chia-Feng; Liu, Han; Wylie, Chris; Rao, Marepalli; Shearn, Jason T; Rowe, David W; Kadler, Karl E; Jiang, Rulang; Butler, David L (2015. ) Ablating hedgehog signaling in tenocytes during development impairs biomechanics and matrix organization of the adult murine patellar tendon enthesis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, , 33 (8 ) ,1142-51 More Information

Liu, Han; Xu, Jingyue; Liu, Chia-Feng; Lan, Yu; Wylie, Christopher; Jiang, Rulang (2015. ) Whole transcriptome expression profiling of mouse limb tendon development by using RNA-seq.Journal of orthopaedic research : official publication of the Orthopaedic Research Society, , 33 (6 ) ,840-8 More Information

Lan, Yu; Xu, Jingyue; Jiang, Rulang (2015. ) Cellular and Molecular Mechanisms of Palatogenesis.Current topics in developmental biology, , 115 ,59-84 More Information

Xu, Jingyue; Liu, Han; Park, Joo-Seop; Lan, Yu; Jiang, Rulang (2014. ) Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis.Development (Cambridge, England), , 141 (7 ) ,1442-52 More Information

Zhou, Hao; Zou, Shujuan; Lan, Yu; Fei, Wei; Jiang, Rulang; Hu, Jing (2014. ) Smad7 modulates TGF? signaling during cranial suture development to maintain suture patency.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, , 29 (3 ) ,716-24 More Information

Lan, Yu; Jia, Shihai; Jiang, Rulang Molecular patterning of the mammalian dentition.Seminars in cell & developmental biology, , 25-26 ,61-70 More Information

Zhou, Jing; Gao, Yang; Lan, Yu; Jia, Shihai; Jiang, Rulang (2013. ) Pax9 regulates a molecular network involving Bmp4, Fgf10, Shh signaling and the Osr2 transcription factor to control palate morphogenesis.Development (Cambridge, England), , 140 (23 ) ,4709-18 More Information

Liu, Han; Lan, Yu; Xu, Jingyue; Chang, Ching-Fang; Brugmann, Samantha A; Jiang, Rulang (2013. ) Odd-skipped related-1 controls neural crest chondrogenesis during tongue development.Proceedings of the National Academy of Sciences of the United States of America, , 110 (46 ) ,18555-60 More Information

Zhu, Songsong; Chen, Kan; Lan, Yu; Zhang, Nan; Jiang, Rulang; Hu, Jing (2013. ) Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats.Bone, , 53 (2 ) ,340-9 More Information

Jia, Shihai; Zhou, Jing; Gao, Yang; Baek, Jin-A; Martin, James F; Lan, Yu; Jiang, Rulang (2013. ) Roles of Bmp4 during tooth morphogenesis and sequential tooth formation.Development (Cambridge, England), , 140 (2 ) ,423-32 More Information

Anderson, Douglas M; George, Rajani; Noyes, Marcus B; Rowton, Megan; Liu, Wenjin; Jiang, Rulang; Wolfe, Scot A; Wilson-Rawls, Jeanne; Rawls, Alan (2012. ) Characterization of the DNA-binding properties of the Mohawk homeobox transcription factor.The Journal of biological chemistry, , 287 (42 ) ,35351-9 More Information

Yu, Cheng-Tai; Tang, Ke; Suh, Jae Mi; Jiang, Rulang; Tsai, Sophia Y; Tsai, Ming-Jer (2012. ) COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival.Development (Cambridge, England), , 139 (13 ) ,2330-9 More Information

Bush, Jeffrey O; Jiang, Rulang (2012. ) Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development.Development (Cambridge, England), , 139 (2 ) ,231-43 More Information

Guillot, Nicolas; Kollins, Dmitrij; Gilbert, Victoria; Xavier, Sandhya; Chen, Jun; Gentle, Madeleine; Reddy, Anand; Bottinger, Erwin; Jiang, Rulang; Rastaldi, Maria Pia; Corbelli, Alessandro; Schlondorff, Detlef (2012. ) BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGF? signaling.PloS one, , 7 (6 ) ,e39406 More Information

Kim, Tak-Heun; Lee, Ju-Yeon; Baek, Jin-A; Lee, Jeong-Chae; Yang, Xiao; Taketo, Makoto M; Jiang, Rulang; Cho, Eui-Sic (2011. ) Constitutive stabilization of ß-catenin in the dental mesenchyme leads to excessive dentin and cementum formation.Biochemical and biophysical research communications, , 412 (4 ) ,549-55 More Information

Zhou, Jing; Gao, Yang; Zhang, Zunyi; Zhang, Yuan; Maltby, Kathleen M; Liu, Zhaoyang; Lan, Yu; Jiang, Rulang (2011. ) Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmental field.Developmental biology, , 353 (2 ) ,344-53 More Information

Li, Jingyuan; Huang, Xiaofeng; Xu, Xun; Mayo, Julie; Bringas, Pablo; Jiang, Rulang; Wang, Songling; Chai, Yang (2011. ) SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis.Development (Cambridge, England), , 138 (10 ) ,1977-89 More Information

Lan, Yu; Liu, Han; Ovitt, Catherine E; Jiang, Rulang (2011. ) Generation of Osr1 conditional mutant mice.Genesis (New York, N.Y. : 2000), , 49 (5 ) ,419-22 More Information

Gao, Yang; Lan, Yu; Liu, Han; Jiang, Rulang (2011. ) The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation.Developmental biology, , 352 (1 ) ,83-91 More Information

Baek, Jin-A; Lan, Yu; Liu, Han; Maltby, Kathleen M; Mishina, Yuji; Jiang, Rulang (2011. ) Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation.Developmental biology, , 350 (2 ) ,520-31 More Information

Xie, Rong; Jiang, Rulang; Chen, Di (2011. ) Generation of Axin1 conditional mutant mice.Genesis (New York, N.Y. : 2000), , 49 (2 ) ,98-102 More Information

Liu, Wenjin; Watson, Spencer S; Lan, Yu; Keene, Douglas R; Ovitt, Catherine E; Liu, Han; Schweitzer, Ronen; Jiang, Rulang (2010. ) The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis.Molecular and cellular biology, , 30 (20 ) ,4797-807 More Information

Chen, Jianquan; Lan, Yu; Baek, Jin-A; Gao, Yang; Jiang, Rulang (2009. ) Wnt/beta-catenin signaling plays an essential role in activation of odontogenic mesenchyme during early tooth development.Developmental biology, , 334 (1 ) ,174-85 More Information

Richardson, Rebecca J; Dixon, Jill; Jiang, Rulang; Dixon, Michael J (2009. ) Integration of IRF6 and Jagged2 signalling is essential for controlling palatal adhesion and fusion competence.Human molecular genetics, , 18 (14 ) ,2632-42 More Information

Xiong, Wei; He, Fenglei; Morikawa, Yuka; Yu, Xueyan; Zhang, Zunyi; Lan, Yu; Jiang, Rulang; Cserjesi, Peter; Chen, Yiping (2009. ) Hand2 is required in the epithelium for palatogenesis in mice.Developmental biology, , 330 (1 ) ,131-41 More Information

Gao, Yang; Lan, Yu; Ovitt, Catherine E; Jiang, Rulang (2009. ) Functional equivalence of the zinc finger transcription factors Osr1 and Osr2 in mouse development.Developmental biology, , 328 (2 ) ,200-9 More Information

Lan, Yu; Jiang, Rulang (2009. ) Sonic hedgehog signaling regulates reciprocal epithelial-mesenchymal interactions controlling palatal outgrowth.Development (Cambridge, England), , 136 (8 ) ,1387-96 More Information

Zhang, Zunyi; Lan, Yu; Chai, Yang; Jiang, Rulang (2009. ) Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row.Science (New York, N.Y.), , 323 (5918 ) ,1232-4 More Information

Liu, Wenjin; Lan, Yu; Pauws, Erwin; Meester-Smoor, Magda A; Stanier, Philip; Zwarthoff, Ellen C; Jiang, Rulang (2008. ) The Mn1 transcription factor acts upstream of Tbx22 and preferentially regulates posterior palate growth in mice.Development (Cambridge, England), , 135 (23 ) ,3959-68 More Information

Lan, Yu; Wang, Qingru; Ovitt, Catherine E; Jiang, Rulang (2007. ) A unique mouse strain expressing Cre recombinase for tissue-specific analysis of gene function in palate and kidney development.Genesis (New York, N.Y. : 2000), , 45 (10 ) ,618-24 More Information

Chen, Jianquan; Bush, Jeffrey O; Ovitt, Catherine E; Lan, Yu; Jiang, Rulang (2007. ) The TGF-beta pseudoreceptor gene Bambi is dispensable for mouse embryonic development and postnatal survival.Genesis (New York, N.Y. : 2000), , 45 (8 ) ,482-6 More Information

James, Richard G; Kamei, Caramai N; Wang, Qingru; Jiang, Rulang; Schultheiss, Thomas M (2006. ) Odd-skipped related 1 is required for development of the metanephric kidney and regulates formation and differentiation of kidney precursor cells.Development (Cambridge, England), , 133 (15 ) ,2995-3004 More Information

Liu, Han; Liu, Wenjin; Maltby, Kathleen M; Lan, Yu; Jiang, Rulang (2006. ) Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation.Gene expression patterns : GEP, , 6 (6 ) ,632-6 More Information

Casey, Liam M; Lan, Yu; Cho, Eui-Sic; Maltby, Kathleen M; Gridley, Thomas; Jiang, Rulang (2006. ) Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.Developmental dynamics : an official publication of the American Association of Anatomists, , 235 (7 ) ,1830-44 More Information

Lan, Yu; Ryan, Rosemary C; Zhang, Zunyi; Bullard, Steven A; Bush, Jeffrey O; Maltby, Kathleen M; Lidral, Andrew C; Jiang, Rulang (2006. ) Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.Developmental dynamics : an official publication of the American Association of Anatomists, , 235 (5 ) ,1448-54 More Information

Jiang, Rulang; Bush, Jeffrey O; Lidral, Andrew C (2006. ) Development of the upper lip: morphogenetic and molecular mechanisms.Developmental dynamics : an official publication of the American Association of Anatomists, , 235 (5 ) ,1152-66 More Information

Knight, Alexandra S; Schutte, Brian C; Jiang, Rulang; Dixon, Michael J (2006. ) Developmental expression analysis of the mouse and chick orthologues of IRF6: the gene mutated in Van der Woude syndrome.Developmental dynamics : an official publication of the American Association of Anatomists, , 235 (5 ) ,1441-7 More Information

Wang, Qingru; Lan, Yu; Cho, Eui-Sic; Maltby, Kathleen M; Jiang, Rulang (2005. ) Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development.Developmental biology, , 288 (2 ) ,582-94 More Information

Vieira, Alexandre R; Avila, Joseph R; Daack-Hirsch, Sandra; Dragan, Ecaterina; Félix, Têmis M; Rahimov, Fedik; Harrington, Jill; Schultz, Rebecca R; Watanabe, Yoriko; Johnson, Marla; Fang, Jennifer; O'Brien, Sarah E; Orioli, Iêda M; Castilla, Eduardo E; Fitzpatrick, David R; Jiang, Rulang; Marazita, Mary L; Murray, Jeffrey C (2005. ) Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.PLoS genetics, , 1 (6 ) ,e64 More Information

Alappat, Sylvia R; Zhang, Zunyi; Suzuki, Kentaro; Zhang, Xiaoyun; Liu, Hongbing; Jiang, Rulang; Yamada, Gen; Chen, YiPing (2005. ) The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice.Developmental biology, , 277 (1 ) ,102-13 More Information

Hadland, Brandon K; Huppert, Stacey S; Kanungo, Jyotshnabala; Xue, Yingzi; Jiang, Rulang; Gridley, Thomas; Conlon, Ronald A; Cheng, Alec M; Kopan, Raphael; Longmore, Gregory D (2004. ) A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development.Blood, , 104 (10 ) ,3097-105 More Information

Lan, Yu; Ovitt, Catherine E; Cho, Eui-Sic; Maltby, Kathleen M; Wang, Qingru; Jiang, Rulang (2004. ) Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis.Development (Cambridge, England), , 131 (13 ) ,3207-16 More Information

Bush, Jeffrey O; Lan, Yu; Jiang, Rulang (2004. ) The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene.Proceedings of the National Academy of Sciences of the United States of America, , 101 (18 ) ,7022-7 More Information

Bush, Jeffrey O; Maltby, Kathleen M; Cho, Eui-Sic; Jiang, Rulang (2003. ) The T-box gene Tbx10 exhibits a uniquely restricted expression pattern during mouse embryogenesis. Gene expression patterns : GEP, , 3 (4 ) ,533-8

Krebs, Luke T; Iwai, Naomi; Nonaka, Shigenori; Welsh, Ian C; Lan, Yu; Jiang, Rulang; Saijoh, Yukio; O'Brien, Timothy P; Hamada, Hiroshi; Gridley, Thomas (2003. ) Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.Genes & development, , 17 (10 ) ,1207-12 More Information

Bush, Jeffrey O; Lan, Yu; Maltby, Kathleen M; Jiang, Rulang (2002. ) Isolation and developmental expression analysis of Tbx22, the mouse homolog of the human X-linked cleft palate gene.Developmental dynamics : an official publication of the American Association of Anatomists, , 225 (3 ) ,322-6 More Information

Liu Z.;Li C.;Xu J.;Lan Y.;Liu H.;Li X.;Maire P.;Wang X.;Jiang R. (05-01-2019. ) Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.Journal of Dental Research, , 98 (5 ) ,572-579 More Information

Liu H.;Xu J.;Jiang R. (03-01-2019. ) Mkx-Deficient Mice Exhibit Hedgehog Signaling–Dependent Ectopic Ossification in the Achilles Tendons.Journal of Bone and Mineral Research, , 34 (3 ) ,557-569 More Information

Xu J.;Liu H.;Lan Y.;Adam M.;Clouthier D.E.;Potter S.;Jiang R. (01-14-2019. ) Hedgehog signaling patterns the oral-aboral axis of the mandibular arch.eLife, , 8 , More Information

Fu X.;Xu J.;Chaturvedi P.;Liu H.;Jiang R.;Lan Y. (11-01-2017. ) Identification of Osr2 Transcriptional Target Genes in Palate Development.Journal of Dental Research, , 96 (12 ) ,1451-1458 More Information

Li C.;Lan Y.;Jiang R. (10-01-2017. ) Molecular and Cellular Mechanisms of Palate Development.Journal of Dental Research, , 96 (11 ) ,1184-1191 More Information

Li C.;Lan Y.;Krumlauf R.;Jiang R. (10-01-2017. ) Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice.Journal of Dental Research, , 96 (11 ) ,1273-1281 More Information

Kwon H.J.E.;Jia S.;Lan Y.;Liu H.;Jiang R. (09-01-2017. ) Activin and Bmp4 Signaling Converge on Wnt Activation during Odontogenesis.Journal of Dental Research, , 96 (10 ) ,1145-1152 More Information

Han L.;Xu J.;Grigg E.;Slack M.;Chaturvedi P.;Jiang R.;Zorn A. (07-01-2017. ) Osr1 functions downstream of Hedgehog pathway to regulate foregut development.Developmental Biology, , 427 (1 ) ,72-83 More Information

Kwon H.;Park E.;Jia S.;Liu H.;Lan Y.;Jiang R. (01-01-2015. ) Deletion of Osr2 partially rescues tooth development in Runx2 mutant mice.Journal of Dental Research, , 94 (8 ) ,1113-1119 More Information

Bae C.H.;Lee J.Y.;Kim T.H.;Baek J.A.;Lee J.C.;Yang X.;Taketo M.M.;Jiang R.;Cho E.S. (08-01-2013. ) Excessive Wnt/?-catenin signaling disturbs tooth-root formation.Journal of Periodontal Research, , 48 (4 ) ,405-410 More Information

Kim T.H.;Bae C.H.;Lee J.C.;Ko S.O.;Yang X.;Jiang R.;Cho E.S. (03-01-2013. ) ?-Catenin is required in odontoblasts for tooth root formation.Journal of Dental Research, , 92 (3 ) ,215-221 More Information

Baek J.A.;Lan Y.;Liu H.;Maltby K.M.;Mishina Y.;Jiang R. (02-15-2011. ) Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation.Developmental Biology, , 350 (2 ) ,520-531 More Information

Gao Y.;Lan Y.;Liu H.;Jiang R. (01-01-2011. ) The zinc finger transcription factors Osr1 and Osr2 control synovial joint formation.Developmental Biology, , 352 (1 ) ,83-91 More Information

Zhou J.;Gao Y.;Zhang Z.;Zhang Y.;Maltby K.;Liu Z.;Lan Y.;Jiang R. (01-01-2011. ) Osr2 acts downstream of Pax9 and interacts with both Msx1 and Pax9 to pattern the tooth developmenta.Developmental Biology, , 353 (2 ) ,344-353 More Information

Alappat S.;Zhang Z.;Suzuki K.;Zhang X.;Liu H.;Jiang R.;Yamada G.;Chen Y. (01-01-2005. ) The cellular and molecular etiology of the cleft secondary palate in Fgf10 mutant mice.Developmental Biology, , 277 (1 ) ,102-113 More Information

Carver E.;Jiang R.;Lan Y.;Oram K.;Gridley T. (11-22-2001. ) The mouse Snail gene encodes a key regulator of the epithelial-mesenchymal transition.Molecular and Cellular Biology, , 21 (23 ) ,8184-8188 More Information

McCright B.;Gao X.;Shen L.;Lozier J.;Lan Y.;Maguire M.;Herzlinger D.;Weinmaster G.;Jiang R.;Gridley T. (04-02-2001. ) Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic .Development, , 128 (4 ) ,491-502

Lan Y.;Kingsley P.;Cho E.;Jiang R. (01-01-2001. ) Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns durin.Mechanisms of Development, , 107 (1-2 ) ,175-179 More Information

Lanford P.;Lan Y.;Jiang R.;Lindsell C.;Weinmaster G.;Gridley T.;Kelley M. (03-01-1999. ) Notch signalling pathway mediates hair cell development in mammalian cochlea.Nature Genetics, , 21 (3 ) ,289-292 More Information

Jiang R.;Norton C.;Copeland N.;Gilbert D.;Jenkins N.;Gridley T. (11-26-1998. ) Genomic organization, expression and chromosomal localization of the mouse Slug (Slugh) gene.Biochimica et Biophysica Acta - Gene Structure and Expression, , 1443 (1-2 ) ,251-254 More Information

Bell S.;Lan Y.;Jiang R.;Gridley T. (09-15-1998. ) Exclusion of Jagged2 as a candidate for the legless gene.Mammalian Genome, , 9 (9 ) ,778-779 More Information

Jiang R.;Lan Y.;Norton C.;Sundberg J.;Gridley T. (06-15-1998. ) The slug gene is not essential for mesoderm or neural crest development in mice.Developmental Biology, , 198 (2 ) ,277-285 More Information

Jiang R.;Lan Y.;Chapman H.;Shawber C.;Norton C.;Serreze D.;Weinmaster G.;Gridley T. (04-01-1998. ) Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice.Genes and Development, , 12 (7 ) ,1046-1057 More Information

Lan Y.;Jiang R.;Shawber C.;Weinmaster G.;Gridley T. (11-15-1997. ) The Jagged2 gene maps to chromosome 12 and is a candidate for the igl and l sm mutations .Mammalian Genome, , 8 (11 ) ,875-876

Jiang R.;Copeland N.;Gilbert D.;Jenkins N.;Gridley T. (09-01-1997. ) Genomic organization and chromosomal localization of the mouse snail (Sna) gene.Mammalian Genome, , 8 (9 ) ,686-688 More Information

Jiang R.;Gridley T. (05-01-1997. ) Gene targeting: Things go better with Cre .Current Biology, , 7 (5 ) ,

Academic - Cincinnati Children's Hospital Medical Center
Division of Developmental Biology
Cincinnati  Ohio, 45229
Phone: 513-636-3212
rulang.jiang@cchmc.org