Raphael Kopan, Ph.D. , PhD

Peer Reviewed Publications

Kopan, Raphael; Chen, Shuang; Liu, Zhenyi (2014. ) Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy.Pediatric nephrology (Berlin, Germany), , 29 (4 ) ,651-7 More Information

Kopan, Raphael; Chen, Shuang; Little, Melissa (2014. ) Nephron progenitor cells: shifting the balance of self-renewal and differentiation.Current topics in developmental biology, , 107 ,293-331 More Information

Boyle, Scott C; Liu, Zhenyi; Kopan, Raphael (2014. ) Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development.Development (Cambridge, England), , 141 (2 ) ,346-54 More Information

Ilagan, Ma Xenia G; Kopan, Raphael (2014. ) Monitoring Notch activation in cultured mammalian cells: luciferase complementation imaging assays.Methods in molecular biology (Clifton, N.J.), , 1187 ,155-68 More Information

Ilagan, Ma Xenia G; Kopan, Raphael (2014. ) Monitoring Notch activation in cultured mammalian cells: transcriptional reporter assays.Methods in molecular biology (Clifton, N.J.), , 1187 ,143-54 More Information

Yockey, Laura J; Demehri, Shadmehr; Turkoz, Mustafa; Turkoz, Ahu; Ahern, Philip P; Jassim, Omar; Manivasagam, Sindhu; Kearney, John F; Gordon, Jeffrey I; Kopan, Raphael (2013. ) The absence of a microbiota enhances TSLP expression in mice with defective skin barrier but does not affect the severity of their allergic inflammation.The Journal of investigative dermatology, , 133 (12 ) ,2714-21 More Information

Chillakuri, Chandramouli R; Sheppard, Devon; Ilagan, Ma Xenia G; Holt, Laurie R; Abbott, Felicity; Liang, Shaoyan; Kopan, Raphael; Handford, Penny A; Lea, Susan M (2013. ) Structural analysis uncovers lipid-binding properties of Notch ligands.Cell reports, , 5 (4 ) ,861-7 More Information

Zhao, Zhong-Qiu; Huo, Fu-Quan; Jeffry, Joseph; Hampton, Lori; Demehri, Shadmehr; Kim, Seungil; Liu, Xian-Yu; Barry, Devin M; Wan, Li; Liu, Zhong-Chun; Li, Hui; Turkoz, Ahu; Ma, Kaijie; Cornelius, Lynn A; Kopan, Raphael; Battey, James F; Zhong, Jian; Chen, Zhou-Feng (2013. ) Chronic itch development in sensory neurons requires BRAF signaling pathways.The Journal of clinical investigation, , 123 (11 ) ,4769-80 More Information

Groot, Arjan J; Cobzaru, Cristina; Weber, Silvio; Saftig, Paul; Blobel, Carl P; Kopan, Raphael; Vooijs, Marc; Franzke, Claus-Werner (2013. ) Epidermal ADAM17 is dispensable for notch activation.The Journal of investigative dermatology, , 133 (9 ) ,2286-8 More Information

Satpathy, Ansuman T; Briseño, Carlos G; Lee, Jacob S; Ng, Dennis; Manieri, Nicholas A; Kc, Wumesh; Wu, Xiaodi; Thomas, Stephanie R; Lee, Wan-Ling; Turkoz, Mustafa; McDonald, Keely G; Meredith, Matthew M; Song, Christina; Guidos, Cynthia J; Newberry, Rodney D; Ouyang, Wenjun; Murphy, Theresa L; Stappenbeck, Thaddeus S; Gommerman, Jennifer L; Nussenzweig, Michel C; Colonna, Marco; Kopan, Raphael; Murphy, Kenneth M (2013. ) Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.Nature immunology, , 14 (9 ) ,937-48 More Information

Liu, Zhenyi; Chen, Shuang; Boyle, Scott; Zhu, Yu; Zhang, Andrew; Piwnica-Worms, David R; Ilagan, Ma Xenia G; Kopan, Raphael (2013. ) The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development.Developmental cell, , 25 (6 ) ,585-98 More Information

Liu, Zhiyong; Liu, Zhenyi; Walters, Bradley J; Owen, Thomas; Kopan, Raphael; Zuo, Jian (2013. ) In vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea.PloS one, , 8 (5 ) ,e64903 More Information

Ilagan, Ma Xenia G; Kopan, Raphael (2013. ) Selective blockade of transport via SERCA inhibition: the answer for oncogenic forms of Notch?.Cancer cell, , 23 (3 ) ,267-9 More Information

Morimoto, Mitsuru; Nishinakamura, Ryuichi; Saga, Yumiko; Kopan, Raphael (2012. ) Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells.Development (Cambridge, England), , 139 (23 ) ,4365-73 More Information

Demehri, Shadmehr; Turkoz, Ahu; Manivasagam, Sindhu; Yockey, Laura J; Turkoz, Mustafa; Kopan, Raphael (2012. ) Elevated epidermal thymic stromal lymphopoietin levels establish an antitumor environment in the skin.Cancer cell, , 22 (4 ) ,494-505 More Information

Kopan, Raphael (2012. ) Notch signaling.Cold Spring Harbor perspectives in biology, , 4 (10 ) , More Information

Barak, Hila; Huh, Sung-Ho; Chen, Shuang; Jeanpierre, Cécile; Martinovic, Jelena; Parisot, Mélanie; Bole-Feysot, Christine; Nitschké, Patrick; Salomon, Rémi; Antignac, Corinne; Ornitz, David M; Kopan, Raphael (2012. ) FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.Developmental cell, , 22 (6 ) ,1191-207 More Information

Zheng, Jin; Watanabe, Hirotaka; Wines-Samuelson, Mary; Zhao, Huailong; Gridley, Thomas; Kopan, Raphael; Shen, Jie (2012. ) Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins.The Journal of biological chemistry, , 287 (24 ) ,20356-68 More Information

Mascia, Francesca; Denning, Mitchell; Kopan, Raphael; Yuspa, Stuart H (2012. ) The black box illuminated: signals and signaling.The Journal of investigative dermatology, , 132 (3 Pt 2 ) ,811-9 More Information

Tu, Xiaolin; Chen, Jianquan; Lim, Joohyun; Karner, Courtney M; Lee, Seung-Yon; Heisig, Julia; Wiese, Cornelia; Surendran, Kameswaran; Kopan, Raphael; Gessler, Manfred; Long, Fanxin (2012. ) Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.PLoS genetics, , 8 (3 ) ,e1002577 More Information

Sato, Chihiro; Turkoz, Mustafa; Dearborn, Joshua T; Wozniak, David F; Kopan, Raphael; Hass, Matthew R (2012. ) Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice.PloS one, , 7 (10 ) ,e48180 More Information

Lee, Jacob S; Cella, Marina; McDonald, Keely G; Garlanda, Cecilia; Kennedy, Gregory D; Nukaya, Manabu; Mantovani, Alberto; Kopan, Raphael; Bradfield, Christopher A; Newberry, Rodney D; Colonna, Marco (2012. ) AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch.Nature immunology, , 13 (2 ) ,144-51 More Information

Boyle, Scott C; Kim, Mijin; Valerius, M Todd; McMahon, Andrew P; Kopan, Raphael (2011. ) Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells.Development (Cambridge, England), , 138 (19 ) ,4245-54 More Information

Vooijs, Marc; Liu, Zhenyi; Kopan, Raphael (2011. ) Notch: architect, landscaper, and guardian of the intestine.Gastroenterology, , 141 (2 ) ,448-59 More Information

Ilagan, Ma Xenia G; Lim, Sora; Fulbright, Mary; Piwnica-Worms, David; Kopan, Raphael (2011. ) Real-time imaging of notch activation with a luciferase complementation-based reporter.Science signaling, , 4 (181 ) ,rs7 More Information

Surendran, Kameswaran; Kopan, Raphael (2011. ) Chromatin-based mechanisms of renal epithelial differentiation.Journal of the American Society of Nephrology : JASN, , 22 (7 ) ,1208-12 More Information

Raphael, Kopan (2011. ) Deuterium reveals the dynamics of notch activation.Structure (London, England : 1993), , 19 (4 ) ,443-4 More Information

Pellegrinet, Luca; Rodilla, Veronica; Liu, Zhenyi; Chen, Shuang; Koch, Ute; Espinosa, Lluis; Kaestner, Klaus H; Kopan, Raphael; Lewis, Julian; Radtke, Freddy (2011. ) Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells.Gastroenterology, , 140 (4 ) ,1230-1240.e1-7 More Information

Liu, Zhenyi; Turkoz, Ahu; Jackson, Erin N; Corbo, Joseph C; Engelbach, John A; Garbow, Joel R; Piwnica-Worms, David R; Kopan, Raphael (2011. ) Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.The Journal of clinical investigation, , 121 (2 ) ,800-8 More Information

Arnett, Kelly L; Hass, Matthew; McArthur, Debbie G; Ilagan, Ma Xenia G; Aster, Jon C; Kopan, Raphael; Blacklow, Stephen C (2010. ) Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes.Nature structural & molecular biology, , 17 (11 ) ,1312-7 More Information

Liu, Zhenyi; Schneider, Daniel L; Kornfeld, Kerry; Kopan, Raphael (2010. ) Simple copy number determination with reference query pyrosequencing (RQPS). Cold Spring Harbor protocols, , 2010 (9 ) ,pdb.prot5491

Tong, Youren; Yamaguchi, Hiroo; Giaime, Emilie; Boyle, Scott; Kopan, Raphael; Kelleher, Raymond J; Shen, Jie (2010. ) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice.Proceedings of the National Academy of Sciences of the United States of America, , 107 (21 ) ,9879-84 More Information

Costantini, Frank; Kopan, Raphael (2010. ) Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.Developmental cell, , 18 (5 ) ,698-712 More Information

Surendran, Kameswaran; Selassie, Meron; Liapis, Helen; Krigman, Hannah; Kopan, Raphael (2010. ) Reduced Notch signaling leads to renal cysts and papillary microadenomas.Journal of the American Society of Nephrology : JASN, , 21 (5 ) ,819-32 More Information

Johnson, Scott E; Ilagan, M Xenia G; Kopan, Raphael; Barrick, Doug (2010. ) Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2.The Journal of biological chemistry, , 285 (9 ) ,6681-92 More Information

Dumortier, Alexis; Durham, André-Dante; Di Piazza, Matteo; Vauclair, Sophie; Koch, Ute; Ferrand, Gisèle; Ferrero, Isabel; Demehri, Shadmehr; Song, Lynda Li; Farr, Andrew G; Leonard, Warren J; Kopan, Raphael; Miele, Lucio; Hohl, Daniel; Finke, Daniela; Radtke, Freddy (2010. ) Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.PloS one, , 5 (2 ) ,e9258 More Information

Zhao, Guojun; Liu, Zhenyi; Ilagan, Ma Xenia G; Kopan, Raphael (2010. ) Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 30 (5 ) ,1648-56 More Information

Surendran, Kameswaran; Boyle, Scott; Barak, Hila; Kim, Mijin; Stomberski, Colin; McCright, Brent; Kopan, Raphael (2010. ) The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.Developmental biology, , 337 (2 ) ,386-95 More Information

Morimoto, Mitsuru; Liu, Zhenyi; Cheng, Hui-Teng; Winters, Niki; Bader, David; Kopan, Raphael (2010. ) Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate.Journal of cell science, , 123 (Pt 2 ) ,213-24 More Information

Bazzi, Hisham; Demehri, Shadmehr; Potter, Christopher S; Barber, Alison G; Awgulewitsch, Alexander; Kopan, Raphael; Christiano, Angela M (2009. ) Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation.Differentiation; research in biological diversity, , 78 (5 ) ,292-300 More Information

van Tetering, Geert; van Diest, Paul; Verlaan, Ingrid; van der Wall, Elsken; Kopan, Raphael; Vooijs, Marc (2009. ) Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.The Journal of biological chemistry, , 284 (45 ) ,31018-27 More Information

Liu, Zhenyi; Obenauf, Anna C; Speicher, Michael R; Kopan, Raphael (2009. ) Rapid identification of homologous recombinants and determination of gene copy number with reference/query pyrosequencing (RQPS).Genome research, , 19 (11 ) ,2081-9 More Information

Riesenberg, Amy N; Liu, Zhenyi; Kopan, Raphael; Brown, Nadean L (2009. ) Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 29 (41 ) ,12865-77 More Information

Cras-Méneur, Corentin; Li, Lin; Kopan, Raphael; Permutt, M Alan (2009. ) Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.Genes & development, , 23 (17 ) ,2088-101 More Information

Demehri, Shadmehr; Turkoz, Ahu; Kopan, Raphael (2009. ) Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.Cancer cell, , 16 (1 ) ,55-66 More Information

Demehri, Shadmehr; Morimoto, Mitsuru; Holtzman, Michael J; Kopan, Raphael (2009. ) Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma.PLoS biology, , 7 (5 ) ,e1000067 More Information

Kopan, Raphael; Ilagan, Maria Xenia G (2009. ) The canonical Notch signaling pathway: unfolding the activation mechanism.Cell, , 137 (2 ) ,216-33 More Information

Hass, Matthew R; Sato, Chihiro; Kopan, Raphael; Zhao, Guojun (2009. ) Presenilin: RIP and beyond.Seminars in cell & developmental biology, , 20 (2 ) ,201-10 More Information

Demehri, Shadmehr; Kopan, Raphael (2009. ) Notch signaling in bulge stem cells is not required for selection of hair follicle fate.Development (Cambridge, England), , 136 (6 ) ,891-6 More Information

Cai, Jing; Lee, Jonghyeob; Kopan, Raphael; Ma, Liang (2009. ) Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation.Developmental biology, , 326 (2 ) ,420-30 More Information

Morimoto, Mitsuru; Kopan, Raphael (2009. ) rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse.Developmental biology, , 325 (1 ) ,171-8 More Information

Ong, Chin-Tong; Sedy, John R; Murphy, Kenneth M; Kopan, Raphael (2008. ) Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition.PloS one, , 3 (7 ) ,e2823 More Information

Demehri, Shadmehr; Liu, Zhenyi; Lee, Jonghyeob; Lin, Meei-Hua; Crosby, Seth D; Roberts, Christopher J; Grigsby, Perry W; Miner, Jeffrey H; Farr, Andrew G; Kopan, Raphael (2008. ) Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.PLoS biology, , 6 (5 ) ,e123 More Information

Bai, Shuting; Kopan, Raphael; Zou, Wei; Hilton, Matthew J; Ong, Chin-tong; Long, Fanxin; Ross, F Patrick; Teitelbaum, Steven L (2008. ) NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells.The Journal of biological chemistry, , 283 (10 ) ,6509-18 More Information

Hilton, Matthew J; Tu, Xiaolin; Wu, Ximei; Bai, Shuting; Zhao, Haibo; Kobayashi, Tatsuya; Kronenberg, Henry M; Teitelbaum, Steven L; Ross, F Patrick; Kopan, Raphael; Long, Fanxin (2008. ) Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.Nature medicine, , 14 (3 ) ,306-14 More Information

Lee, Jonghyeob; Wu, Wei; Kopan, Raphael (2008. ) Murine vibrissae cultured in serum-free medium reinitiate anagen.The Journal of investigative dermatology, , 128 (2 ) ,482-5 More Information

Khandelwal, Abha; Chandu, Dilip; Roe, Catherine M; Kopan, Raphael; Quatrano, Ralph S (2007. ) Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.Proceedings of the National Academy of Sciences of the United States of America, , 104 (33 ) ,13337-42 More Information

Lee, Jonghyeob; Basak, Jacob M; Demehri, Shadmehr; Kopan, Raphael (2007. ) Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes.Development (Cambridge, England), , 134 (15 ) ,2795-806 More Information

Kopan, Raphael; Cheng, Hui-Teng; Surendran, Kameswaran (2007. ) Molecular insights into segmentation along the proximal-distal axis of the nephron.Journal of the American Society of Nephrology : JASN, , 18 (7 ) ,2014-20 More Information

Ilagan, Maria Xenia G; Kopan, Raphael (2007. ) SnapShot: notch signaling pathway.Cell, , 128 (6 ) ,1246 More Information

Cheng, Hui-Teng; Kim, Mijin; Valerius, M Todd; Surendran, Kameswaran; Schuster-Gossler, Karin; Gossler, Achim; McMahon, Andrew P; Kopan, Raphael (2007. ) Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.Development (Cambridge, England), , 134 (4 ) ,801-11 More Information

Vooijs, Marc; Ong, Chin-Tong; Hadland, Brandon; Huppert, Stacey; Liu, Zhenyi; Korving, Jeroen; van den Born, Maaike; Stappenbeck, Thaddeus; Wu, Yumei; Clevers, Hans; Kopan, Raphael (2007. ) Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.Development (Cambridge, England), , 134 (3 ) ,535-44 More Information

Lubman, Olga Y; Ilagan, Ma Xenia G; Kopan, Raphael; Barrick, Doug (2007. ) Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch.Journal of molecular biology, , 365 (3 ) ,577-89 More Information

Weinmaster, Gerry; Kopan, Raphael (2006. ) A garden of Notch-ly delights.Development (Cambridge, England), , 133 (17 ) ,3277-82 More Information

Ogura, Toshihiko; Mio, Kazuhiro; Hayashi, Ikuo; Miyashita, Hiroyuki; Fukuda, Rie; Kopan, Raphael; Kodama, Tatsuhiko; Hamakubo, Takao; Iwatsubo, Takeshi; Iwastubo, Takeshi; Tomita, Taisuke; Sato, Chikara (2006. ) Three-dimensional structure of the gamma-secretase complex.Biochemical and biophysical research communications, , 343 (2 ) ,525-34 More Information

Keller, Preston C; Tomita, Taisuke; Hayashi, Ikuo; Chandu, Dilip; Weber, Jason D; Cistola, David P; Kopan, Raphael (2006. ) A faster migrating variant masquerades as NICD when performing in vitro gamma-secretase assays with bacterially expressed Notch substrates.Biochemistry, , 45 (16 ) ,5351-8 More Information

Barrick, Doug; Kopan, Raphael (2006. ) The Notch transcription activation complex makes its move.Cell, , 124 (5 ) ,883-5 More Information

Ong, Chin-Tong; Cheng, Hui-Teng; Chang, Li-Wei; Ohtsuka, Toshiyuki; Kageyama, Ryoichiro; Stormo, Gary D; Kopan, Raphael (2006. ) Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability.The Journal of biological chemistry, , 281 (8 ) ,5106-19 More Information

Yang, Xudong; Tomita, Taisuke; Wines-Samuelson, Mary; Beglopoulos, Vassilios; Tansey, Malú G; Kopan, Raphael; Shen, Jie (2006. ) Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord.Developmental neuroscience, , 28 (1-2 ) ,102-17 More Information

Chandu, Dilip; Huppert, Stacey S; Kopan, Raphael (2006. ) Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase.Journal of neurochemistry, , 96 (1 ) ,228-35 More Information

Cheng, Hui-Teng; Kopan, Raphael (2005. ) The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney.Kidney international, , 68 (5 ) ,1951-2 More Information

Pan, Yonghua; Liu, Zhenyi; Shen, Jie; Kopan, Raphael (2005. ) Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis.Developmental biology, , 286 (2 ) ,472-82 More Information

Kiernan, Amy E; Cordes, Ralf; Kopan, Raphael; Gossler, Achim; Gridley, Thomas (2005. ) The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear.Development (Cambridge, England), , 132 (19 ) ,4353-62 More Information

Huppert, Stacey S; Ilagan, Ma Xenia G; De Strooper, Bart; Kopan, Raphael (2005. ) Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.Developmental cell, , 8 (5 ) ,677-88 More Information

Lubman, Olga Y; Kopan, Raphael; Waksman, Gabriel; Korolev, Sergey (2005. ) The crystal structure of a partial mouse Notch-1 ankyrin domain: repeats 4 through 7 preserve an ankyrin fold.Protein science : a publication of the Protein Society, , 14 (5 ) ,1274-81 More Information

Vooijs, Marc; Schroeter, Eric H; Pan, Yonghua; Blandford, Mary; Kopan, Raphael (2004. ) Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization.The Journal of biological chemistry, , 279 (49 ) ,50864-73 More Information

Hadland, Brandon K; Huppert, Stacey S; Kanungo, Jyotshnabala; Xue, Yingzi; Jiang, Rulang; Gridley, Thomas; Conlon, Ronald A; Cheng, Alec M; Kopan, Raphael; Longmore, Gregory D (2004. ) A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development.Blood, , 104 (10 ) ,3097-105 More Information

Pan, Yonghua; Lin, Meei-Hua; Tian, Xiaolin; Cheng, Hui-Teng; Gridley, Thomas; Shen, Jie; Kopan, Raphael (2004. ) gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.Developmental cell, , 7 (5 ) ,731-43 More Information

Nichols, Amy M; Pan, Yonghua; Herreman, An; Hadland, Brandon K; De Strooper, Bart; Kopan, Raphael; Huppert, Stacey S (2004. ) Notch pathway is dispensable for adipocyte specification.Genesis (New York, N.Y. : 2000), , 40 (1 ) ,40-4 More Information

Wolfe, Michael S; Kopan, Raphael (2004. ) Intramembrane proteolysis: theme and variations.Science (New York, N.Y.), , 305 (5687 ) ,1119-23 More Information

Koo, Edward H; Kopan, Raphael (2004. ) Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.Nature medicine, , 10 Suppl ,S26-33 More Information

Kopan, Raphael; Ilagan, Ma Xenia G (2004. ) Gamma-secretase: proteasome of the membrane?.Nature reviews. Molecular cell biology, , 5 (6 ) ,499-504 More Information

Yang, Xudong; Klein, Rüdiger; Tian, Xiaolin; Cheng, Hui-Teng; Kopan, Raphael; Shen, Jie (2004. ) Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway.Developmental biology, , 269 (1 ) ,81-94 More Information

Lubman, Olga Y; Korolev, Sergey V; Kopan, Raphael (2004. ) Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Molecular cell, , 13 (5 ) ,619-26

Lin, Meei-Hua; Kopan, Raphael (2003. ) Long-range, nonautonomous effects of activated Notch1 on tissue homeostasis in the nail. Developmental biology, , 263 (2 ) ,343-59

Schroeter, Eric H; Ilagan, Ma Xenia G; Brunkan, Anne L; Hecimovic, Silva; Li, Yue-ming; Xu, Min; Lewis, Huw D; Saxena, Meera T; De Strooper, Bart; Coonrod, Archie; Tomita, Taisuke; Iwatsubo, Takeshi; Moore, Chad L; Goate, Alison; Wolfe, Michael S; Shearman, Mark; Kopan, Raphael (2003. ) A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.Proceedings of the National Academy of Sciences of the United States of America, , 100 (22 ) ,13075-80 More Information

Hu, Qi-Dong; Ang, Beng-Ti; Karsak, Meliha; Hu, Wei-Ping; Cui, Xiao-Ying; Duka, Tanya; Takeda, Yasuo; Chia, Wendy; Sankar, Natesan; Ng, Yee-Kong; Ling, Eng-Ang; Maciag, Thomas; Small, Deena; Trifonova, Radianna; Kopan, Raphael; Okano, Hideyuki; Nakafuku, Masato; Chiba, Shigeru; Hirai, Hisamaru; Aster, Jon C; Schachner, Melitta; Pallen, Catherine J; Watanabe, Kazutada; Xiao, Zhi-Cheng (2003. ) F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell, , 115 (2 ) ,163-75

Cheng, Hui-Teng; Miner, Jeffrey H; Lin, MeeiHua; Tansey, Malú G; Roth, Kevin; Kopan, Raphael (2003. ) Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney.Development (Cambridge, England), , 130 (20 ) ,5031-42 More Information

Selkoe, Dennis; Kopan, Raphael (2003. ) Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.Annual review of neuroscience, , 26 ,565-97 More Information

Michelson, Alan; Kopan, Raphael (2002. ) Differentiation and gene regulation: toward a holistic understanding of animal development: intercellular communication and transcriptional regulation are two sides of the same coin. Current opinion in genetics & development, , 12 (5 ) ,499-502

Kopan, Raphael (2002. ) Notch: a membrane-bound transcription factor. Journal of cell science, , 115 (Pt 6 ) ,1095-7

Kopan, Raphael; Lee, Jonghyeob; Lin, Meei-Hua; Syder, Andrew J; Kesterson, John; Crutchfield, Neil; Li, Caroline R; Wu, Wei; Books, Jason; Gordon, Jeffrey I (2002. ) Genetic mosaic analysis indicates that the bulb region of coat hair follicles contains a resident population of several active multipotent epithelial lineage progenitors.Developmental biology, , 242 (1 ) ,44-57 More Information

Kopan, Raphael; Goate, Alison (2002. ) Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization. Neuron, , 33 (3 ) ,321-4

Liu, Zhenyi; Schneider, Daniel L; Kornfeld, Kerry; Kopan, Raphael (2015. ) Corrigendum: Simple Copy Number Determination with Reference Query Pyrosequencing (RQPS).Cold Spring Harbor protocols, , 2015 (10 ) ,pdb.corr090167 More Information

Hass, Matthew R; Liow, Hien-Haw; Chen, Xiaoting; Sharma, Ankur; Inoue, Yukiko U; Inoue, Takayoshi; Reeb, Ashley; Martens, Andrew; Fulbright, Mary; Raju, Saravanan; Stevens, Michael; Boyle, Scott; Park, Joo-Seop; Weirauch, Matthew T; Brent, Michael R; Kopan, Raphael (2015. ) SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers.Molecular cell, , 59 (4 ) ,685-97 More Information

Demitrack, Elise S; Gifford, Gail B; Keeley, Theresa M; Carulli, Alexis J; VanDussen, Kelli L; Thomas, Dafydd; Giordano, Thomas J; Liu, Zhenyi; Kopan, Raphael; Samuelson, Linda C (2015. ) Notch signaling regulates gastric antral LGR5 stem cell function.The EMBO journal, , 34 (20 ) ,2522-36 More Information

Liu, Zhenyi; Brunskill, Eric; Varnum-Finney, Barbara; Zhang, Chi; Zhang, Andrew; Jay, Patrick Y; Bernstein, Irv; Morimoto, Mitsuru; Kopan, Raphael (2015. ) The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis.Development (Cambridge, England), , 142 (14 ) ,2452-63 More Information

Liu, Zhenyi; Brunskill, Eric; Boyle, Scott; Chen, Shuang; Turkoz, Mustafa; Guo, Yuxuan; Grant, Rachel; Kopan, Raphael (2015. ) Second-generation Notch1 activity-trap mouse line (N1IP::CreHI) provides a more comprehensive map of cells experiencing Notch1 activity.Development (Cambridge, England), , 142 (6 ) ,1193-202 More Information

raphael.kopan@cchmc.org