John N. Lorenz , PhD

Director, Murine Physiology Core Facility
Cardiovascular and renal physiology research
Director, Special Masters Program in Physiology
Course Director, Graduate Medical Physiology I & II

Bachelor's Degree: Thomas More College Crestview Hills, KY, 1982 (Biology)

Doctoral Degree: University of Kentucky Lexington, KY, 1988 (Physiology)

Post-doctoral Fellowship: University of Michigan Ann Arbor, MI, 1991 ( Renal Physiology )

Post-doctoral Fellowship: University of Cincinnati Cincinnati, OH, 1994 (Cell Physiology )

Grant: #P01 HL69779 Investigators:J. Robbins, PI 2007 -2012 NIH/NHLBI Signaling Processes Underlying Cardiovascular Function . Role:Co-Director, Core B Active Type:Grant

Grant: #R37 DK50594 Investigators:G.E. Shull, PI 2005 -2010 NIH/NIDDK Models for Genetic Disorders of Acid Base Transport. Role:Collaborator Active Type:Grant

Grant: #R01 HL61974 Investigators:G.E. Shull, PI 2004 -2009 NIH/NHLBI Mouse Models for Ion Transport Defects in Heart and Lung. Role:Collaborator Active Type:Grant

Grant: # R01 HL 028573-23 Investigators:J. Lingrel, PI 2006 -2011 NIH/NHLBI Na,K-ATPase: Role of Alpha Isoforms Role:Co-Investigator Active Type:Grant

Grant: #R01 HL66062 Investigators:J. Lingrel, PI 2005 -2010 NIH/NHLBI Functional Studies of the Na,K-ATPase. Role:Collaborator Active Type:Grant

Grant: #R01 DK57552 Investigators:Lorenz J, PI 2005 -2009 NIH/NHLBI Regulation of Sodium Excretion in Knockout Mice. Role:PI Type:Grant

Grant: #R01 DK084087 Investigators:Lorenz J. NIH/NIDDK Role of Na,K-ATPase in Renal Sodium Excretion. Role:PI Pending Type:Grant

Grant: #2 R01 HL028573 Investigators:Lingrel, Jerry; Lorenz, John 01-15-2007 -12-31-2013 National Heart, Lung and Blood Institute NA+K+ATPase: Role of Alpha Isoforms Role:Collaborator $1,950,000.00 Active Level:Federal

Grant: #R01 DK057552 Investigators:Lorenz, John 08-01-2005 -06-30-2010 National Inst of Diabetes and Digestive and Kidney Disease Regulation of Sodium Excretion in Knockout Mice Role:PI $883,346.00 Closed Level:Federal

Investigators:Lorenz, John 04-01-2004 -03-31-2005 National Heart, Lung and Blood Institute PTH Related Protein in Vascular Smooth Muscle Role:PI $40,971.00 Closed Level:Federal

Grant: #KFGC-33-01-A0-S0-E0 Investigators:Lorenz, John 12-10-1999 -02-28-2001 Kidney Foundation of Greater Cincinnati The Role of Parathyroid-Related Protein (PTHrP) in Renal Vascular Function Role:PI $25,000.00 Closed Level:Private Non-Profit

Grant: #UF07016 / R01 DK056245 Investigators:Lorenz, John; Soleimani, Manoocher 02-01-2007 -01-31-2010 National Inst of Diabetes and Digestive and Kidney Disease Oxalate Handling in PAT1 and DRA Knockout Mice Role:Collaborator $61,063.00 Closed Level:Federal

Grant: #5-R01-DK-57552-04-A0-S0-E0 Investigators:Lorenz, John 04-01-2000 -03-31-2005 National Inst of Diabetes and Digestive and Kidney Disease Regulation of Sodium Excretion in NHE3 Knock-out Mice Role:PI $918,000.00 Closed Level:Federal

Grant: #CHMC 105059 / P01HL069779 Investigators:Lorenz, John 01-11-2008 -12-31-2013 National Heart, Lung and Blood Institute Signaling Process Underlying Cardiovascular Function Role:PI $661,110.00 Active Level:Federal

Grant: #R01 HL092121 Investigators:Lorenz, John; McGraw, Dennis; Paul, Richard 09-01-2009 -06-30-2014 National Heart, Lung and Blood Institute The Role of Ga2 Signaling in Hypertension Role:Collaborator $1,566,075.00 Active Level:Federal

Grant: #2 R01 HL061974-10A1 Investigators:Lorenz, John; Shull, Gary; Wang, Hongsheng 09-01-2009 -08-31-2011 National Heart, Lung and Blood Institute Mouse Models for Ion Homeostasis Defects in Heart Role:Collaborator $1,111,765.00 Closed Level:Federal

Grant: #1 RC2 ES018765-01 Investigators:Belcher, Scott; Lorenz, John; Schultz, Jo El; Wang, Hongsheng 09-30-2009 -06-30-2013 National Institute of Environmental Health Sciences Defining the Impact of Dietary Bisphenol A on Heart Health in the C57BL/6 Mouse Role:Collaborator $1,428,319.00 Active Level:Federal

Grant: #R56 DK062809 Investigators:Amlal, Hassane; Lorenz, John; Soleimani, Manoocher 08-15-2009 -07-31-2010 National Inst of Diabetes and Digestive and Kidney Disease Apical Chloride/Bicarbonate Exchanges in Small Intestine and Kidney Role:Collaborator $460,826.00 Active Level:Federal

Grant: #R01 DK050594 Investigators:Lorenz, John; Shull, Gary; Soleimani, Manoocher; Worrell, Roger 06-01-2010 -03-31-2014 National Inst of Diabetes and Digestive and Kidney Disease Genetic Models for Disorders of Acid-Base Transport Role:Collaborator $1,916,619.00 Active Level:Federal

Grant: #133536 / P01HL069779 Investigators:Lorenz, John 09-01-2013 -05-31-2018 National Heart, Lung and Blood Institute Signaling Processes Underlying Cardiovascular Function Role:PI $253,706.00 Awarded Level:Federal

Grant: #R01 HL130356 Investigators:Lorenz, John; Sadayappan, Sakthivel 03-06-2017 -12-31-2019 National Heart, Lung and Blood Institute Molecular mechanism of hypertrophic cardiomyopathy in populations of South Asian descendants Role:Collaborator $405,408.00 Awarded Level:Federal

Grant: #R01 HL148451 Investigators:Haworth, Kevin; Holland, Christy; Lorenz, John 07-01-2019 -04-30-2024 National Heart, Lung and Blood Institute Ultrasound-mediated Controlled Hypoxemic Reperfusion for Inhibition of Reperfusion Injury Role:Collaborator $773,375.00 Awarded Level:Federal

Grant: #R25085 Investigators:Lorenz, John 05-01-2020 -04-30-2021 UC's URC Faculty Research Cost Support Awards Program Autonomic Dysfunction in Traumatic Brain Injury Role:PI $7,500.00 Active Level:Internal UC

Grant: #R01AR078001 Investigators:Heiny, Judith; Lorenz, John; Sadayappan, Sakthivel 08-15-2020 -07-31-2025 National Institute of Arthritis, Musculoskeletal and Skin Disease Slow myosin binding protein-C in skeletal muscle physiology Role:Collaborator $453,512.00 Active Level:Federal

Grant: #U01DA039550 Investigators:Ball, William; Kirley, Terence; Lorenz, John; Norman, Andrew; Tsibulsky, Vladimir 08-01-2015 -05-31-2020 National Institute on Drug Abuse Advancing the Development of a Humanized Anti-cocaine Monoclonal Antibody Role:Collaborator 6259187.00 Closed Level:Federal

Investigators:Lorenz, John; Sadayappan, Sakthivel 09-01-2021 -01-31-2022 Novo Nordisk A/S Novonordisk Role:Collaborator 146894.22 Hold Level:Industry

Published Abstracts

Jagatheesan, G., S. Rajan, E.M. Schulz, R.P. Ahmed, N. Petrashevskaya, A. Schwartz, G.P. Boivin, G.M. Arteaga, T. Wang, Y.G. Wang, M. Ashraf, S.B. Liggett, J. Lorenz, R.J. Solaro, and D.F. Wieczorek. (2009. ) An internal domain of -tropomyosin increases myofilament Ca2+ sensitivity. Am J Physiol Heart Circ Physiol , (297(1) ) ,H181-90

Prasad, V., I. Bodi, J.W. Meyer, Y. Wang, M. Ashraf, S.J. Engle, T. Doetschman, K. Sisco, M.L. Nieman, M.L. Miller, J.N. Lorenz, and G.E. Shull. (2008. ) Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases. J Biol Chem (283(46) ) ,31303-14

Lorenz, J.N., E.L. Loreaux, I. Dostanic-Larson, V. Lasko, J.R. Schnetzer, R.J. Paul, and J.B. Lingrel. (2008. ) ACTH-induced hypertension is dependent on the ouabain-binding site of the 2-Na+-K+-ATPase subunit. .[Abstract]Am J Physiol Heart Circ Physiol , (295(1) ) , H273-80

Loreaux, E.L., B. Kaul, J.N. Lorenz, and J.B. Lingrel. (2008. ) Ouabain-sensitive 1 Na,K-ATPase enhances natriuretic response to saline load. .[Abstract]J Am Soc Nephrol , (19(10) ) ,1947-1954

Peer Reviewed Publications

Rubinstein, Jack; Lasko, Valerie M; Koch, Sheryl E; Singh, Vivek P; Carreira, Vinicius; Robbins, Nathan; Patel, Amit R; Jiang, Min; Bidwell, Philip; Kranias, Evangelia G; Jones, W Keith; Lorenz, John N (2014. ) Novel role of transient receptor potential vanilloid 2 in the regulation of cardiac performance.American journal of physiology. Heart and circulatory physiology, , 306 (4 ) ,H574-84 More Information

Gupta, Manish K; Gulick, James; James, Jeanne; Osinska, Hanna; Lorenz, John N; Robbins, Jeffrey (2013. ) Functional dissection of myosin binding protein C phosphorylation.Journal of molecular and cellular cardiology, , 64 ,39-50 More Information

Rindler, Tara N; Lasko, Valerie M; Nieman, Michelle L; Okada, Motoi; Lorenz, John N; Lingrel, Jerry B (2013. ) Knockout of the Na,K-ATPase ?2-isoform in cardiac myocytes delays pressure overload-induced cardiac dysfunction.American journal of physiology. Heart and circulatory physiology, , 304 (8 ) ,H1147-58 More Information

Auger-Messier, Mannix; Accornero, Federica; Goonasekera, Sanjeewa A; Bueno, Orlando F; Lorenz, John N; van Berlo, Jop H; Willette, Robert N; Molkentin, Jeffery D (2013. ) Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy.Circulation research, , 112 (1 ) ,48-56 More Information

Prasad, Vikram; Lorenz, John N; Lasko, Valerie M; Nieman, Michelle L; Al Moamen, Nabeel J; Shull, Gary E (2013. ) Loss of the AE3 Cl(-)/HCO(-) 3 exchanger in mice affects rate-dependent inotropy and stress-related AKT signaling in heart.Frontiers in physiology, , 4 ,399 More Information

Prasad, Vikram; Lorenz, John N; Miller, Marian L; Vairamani, Kanimozhi; Nieman, Michelle L; Wang, Yigang; Shull, Gary E (2013. ) Loss of NHE1 activity leads to reduced oxidative stress in heart and mitigates high-fat diet-induced myocardial stress.Journal of molecular and cellular cardiology, , 65 ,33-42 More Information

Singh, Vivek P; Rubinstein, Jack; Arvanitis, Demetrios A; Ren, Xiaoping; Gao, Xiaoqian; Haghighi, Kobra; Gilbert, Mark; Iyer, Venkat R; Kim, Do Han; Cho, Chunghee; Jones, Keith; Lorenz, John N; Armstrong, Clara F; Wang, Hong-Sheng; Gyorke, Sandor; Kranias, Evangelia G (2013. ) Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein.Journal of the American Heart Association, , 2 (5 ) ,e000460 More Information

Lorenz, John N; Oshiro, Naomi; Loreaux, Elizabeth L; Lingrel, Jerry B (2012. ) DOCA-salt hypertension does not require the ouabain-sensitive binding site of the ?2 Na,K-ATPase.American journal of hypertension, , 25 (4 ) ,421-9 More Information

Lorenz, John N (2012. ) Micropuncture of the kidney: a primer on techniques.Comprehensive Physiology, , 2 (1 ) ,621-37 More Information

Koch, Sheryl E; Gao, Xiaoqian; Haar, Lauren; Jiang, Min; Lasko, Valerie M; Robbins, Nathan; Cai, Wenfeng; Brokamp, Cole; Varma, Priyanka; Tranter, Michael; Liu, Yong; Ren, Xiaoping; Lorenz, John N; Wang, Hong-Sheng; Jones, W Keith; Rubinstein, Jack (2012. ) Probenecid: novel use as a non-injurious positive inotrope acting via cardiac TRPV2 stimulation.Journal of molecular and cellular cardiology, , 53 (1 ) ,134-44 More Information

Lynch, Jeffrey M; Maillet, Marjorie; Vanhoutte, Davy; Schloemer, Aryn; Sargent, Michelle A; Blair, N Scott; Lynch, Kaari A; Okada, Tetsuya; Aronow, Bruce J; Osinska, Hanna; Prywes, Ron; Lorenz, John N; Mori, Kazutoshi; Lawler, Jack; Robbins, Jeffrey; Molkentin, Jeffery D (2012. ) A thrombospondin-dependent pathway for a protective ER stress response.Cell, , 149 (6 ) ,1257-68 More Information

Lorenz, John N; Lasko, Valerie M; Nieman, Michelle L; Damhoff, Thomas; Prasad, Vikram; Beierwaltes, William H; Lingrel, Jerry B (2011. ) Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the ?1 or ?2 Na-K-ATPase ouabain-binding site.American journal of physiology. Renal physiology, , 301 (3 ) ,F615-21 More Information

Accornero, Federica; van Berlo, Jop H; Benard, Matthew J; Lorenz, John N; Carmeliet, Peter; Molkentin, Jeffery D (2011. ) Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism.Circulation research, , 109 (3 ) ,272-80 More Information

Kehat, Izhak; Davis, Jennifer; Tiburcy, Malte; Accornero, Federica; Saba-El-Leil, Marc K; Maillet, Marjorie; York, Allen J; Lorenz, John N; Zimmermann, Wolfram H; Meloche, Sylvain; Molkentin, Jeffery D (2011. ) Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth.Circulation research, , 108 (2 ) ,176-83 More Information

Rindler, Tara N; Dostanic, Iva; Lasko, Valerie M; Nieman, Michelle L; Neumann, Jonathan C; Lorenz, John N; Lingrel, Jerry B (2011. ) Knockout of the Na,K-ATPase ??-isoform in the cardiovascular system does not alter basal blood pressure but prevents ACTH-induced hypertension.American journal of physiology. Heart and circulatory physiology, , 301 (4 ) ,H1396-404 More Information

Wansapura, Arshani N; Lasko, Valerie M; Lingrel, Jerry B; Lorenz, John N (2011. ) Mice expressing ouabain-sensitive ?1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy.American journal of physiology. Heart and circulatory physiology, , 300 (1 ) ,H347-55 More Information

Al Moamen, Nabeel J; Prasad, Vikram; Bodi, Ilona; Miller, Marian L; Neiman, Michelle L; Lasko, Valerie M; Alper, Seth L; Wieczorek, David F; Lorenz, John N; Shull, Gary E (2011. ) Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.Journal of molecular and cellular cardiology, , 50 (1 ) ,137-46 More Information

Nakayama, Hiroyuki; Bodi, Ilona; Maillet, Marjorie; DeSantiago, Jaime; Domeier, Timothy L; Mikoshiba, Katsuhiko; Lorenz, John N; Blatter, Lothar A; Bers, Donald M; Molkentin, Jeffery D (2010. ) The IP3 receptor regulates cardiac hypertrophy in response to select stimuli.Circulation research, , 107 (5 ) ,659-66 More Information

Maillet, Marjorie; Davis, Jennifer; Auger-Messier, Mannix; York, Allen; Osinska, Hanna; Piquereau, Jérôme; Lorenz, John N; Robbins, Jeffrey; Ventura-Clapier, Renée; Molkentin, Jeffery D (2010. ) Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function.The Journal of biological chemistry, , 285 (9 ) ,6716-24 More Information

Bradford, Emily M; Miller, Marian L; Prasad, Vikram; Nieman, Michelle L; Gawenis, Lara R; Berryman, Mark; Lorenz, John N; Tso, Patrick; Shull, Gary E (2010. ) CLIC5 mutant mice are resistant to diet-induced obesity and exhibit gastric hemorrhaging and increased susceptibility to torpor.American journal of physiology. Regulatory, integrative and comparative physiology, , 298 (6 ) ,R1531-42 More Information

Liu, Qinghang; Chen, Xiongwen; Macdonnell, Scott M; Kranias, Evangelia G; Lorenz, John N; Leitges, Michael; Houser, Steven R; Molkentin, Jeffery D (2009. ) Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.Circulation research, , 105 (2 ) ,194-200 More Information

Sadayappan, Sakthivel; Gulick, James; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffery D; Robbins, Jeffrey (2009. ) Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background.Circulation, , 119 (9 ) ,1253-62 More Information

Wansapura, Arshani N; Lasko, Valerie; Xie, Zijian; Fedorova, Olga V; Bagrov, Alexei Y; Lingrel, Jerry B; Lorenz, John N (2009. ) Marinobufagenin enhances cardiac contractility in mice with ouabain-sensitive alpha1 Na+-K+-ATPase.American journal of physiology. Heart and circulatory physiology, , 296 (6 ) ,H1833-9 More Information

Maloyan, Alina; Osinska, Hanna; Lammerding, Jan; Lee, Richard T; Cingolani, Oscar H; Kass, David A; Lorenz, John N; Robbins, Jeffrey (2009. ) Biochemical and mechanical dysfunction in a mouse model of desmin-related myopathy.Circulation research, , 104 (8 ) ,1021-8 More Information

Prasad, Vikram; Bodi, Ilona; Meyer, Jamie W; Wang, Yigang; Ashraf, Muhammad; Engle, Sandra J; Doetschman, Thomas; Sisco, Karena; Nieman, Michelle L; Miller, Marian L; Lorenz, John N; Shull, Gary E (2008. ) Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.The Journal of biological chemistry, , 283 (46 ) ,31303-14 More Information

Lorenz, John N; Loreaux, Elizabeth L; Dostanic-Larson, Iva; Lasko, Valerie; Schnetzer, J Renee; Paul, Richard J; Lingrel, Jerry B (2008. ) ACTH-induced hypertension is dependent on the ouabain-binding site of the alpha2-Na+-K+-ATPase subunit.American journal of physiology. Heart and circulatory physiology, , 295 (1 ) ,H273-80 More Information

Sadayappan, Sakthivel; Finley, Natosha; Howarth, Jack W; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Rosevear, Paul R; Robbins, Jeffrey (2008. ) Role of the acidic N' region of cardiac troponin I in regulating myocardial function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 22 (4 ) ,1246-57 More Information

Diwan, Abhinav; Wansapura, Janaka; Syed, Faisal M; Matkovich, Scot J; Lorenz, John N; Dorn, Gerald W (2008. ) Nix-mediated apoptosis links myocardial fibrosis, cardiac remodeling, and hypertrophy decompensation.Circulation, , 117 (3 ) ,396-404 More Information

Loreaux, Elizabeth L; Kaul, Baksho; Lorenz, John N; Lingrel, Jerry B (2008. ) Ouabain-Sensitive alpha1 Na,K-ATPase enhances natriuretic response to saline load.Journal of the American Society of Nephrology : JASN, , 19 (10 ) ,1947-54 More Information

Pritchard, Tracy J; Parvatiyar, Michelle; Bullard, Daniel P; Lynch, Ronald M; Lorenz, John N; Paul, Richard J (2007. ) Transgenic mice expressing Na+-K+-ATPase in smooth muscle decreases blood pressure.American journal of physiology. Heart and circulatory physiology, , 293 (2 ) ,H1172-82 More Information

Hambleton, Michael; York, Allen; Sargent, Michelle A; Kaiser, Robert A; Lorenz, John N; Robbins, Jeffrey; Molkentin, Jeffery D (2007. ) Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure.American journal of physiology. Heart and circulatory physiology, , 293 (6 ) ,H3768-71 More Information

Gawenis, Lara R; Bradford, Emily M; Prasad, Vikram; Lorenz, John N; Simpson, Janet E; Clarke, Lane L; Woo, Alison L; Grisham, Christina; Sanford, L Philip; Doetschman, Thomas; Miller, Marian L; Shull, Gary E (2007. ) Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter.The Journal of biological chemistry, , 282 (12 ) ,9042-52 More Information

Kawedia, Jitesh D; Nieman, Michelle L; Boivin, Gregory P; Melvin, James E; Kikuchi, Ken-Ichiro; Hand, Arthur R; Lorenz, John N; Menon, Anil G (2007. ) Interaction between transcellular and paracellular water transport pathways through Aquaporin 5 and the tight junction complex.Proceedings of the National Academy of Sciences of the United States of America, , 104 (9 ) ,3621-6 More Information

Lorenz, John N; Arend, Lois J; Robitz, Rachel; Paul, Richard J; MacLennan, A John (2007. ) Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice.American journal of physiology. Regulatory, integrative and comparative physiology, , 292 (1 ) ,R440-6 More Information

Sadayappan, Sakthivel; Osinska, Hanna; Klevitsky, Raisa; Lorenz, John N; Sargent, Michelle; Molkentin, Jeffrey D; Seidman, Christine E; Seidman, Jonathan G; Robbins, Jeffrey (2006. ) Cardiac myosin binding protein C phosphorylation is cardioprotective.Proceedings of the National Academy of Sciences of the United States of America, , 103 (45 ) ,16918-23 More Information

Adhami, Faisal; Liao, Guanghong; Morozov, Yury M; Schloemer, Aryn; Schmithorst, Vincent J; Lorenz, John N; Dunn, R Scott; Vorhees, Charles V; Wills-Karp, Marsha; Degen, Jay L; Davis, Roger J; Mizushima, Noboru; Rakic, Pasko; Dardzinski, Bernard J; Holland, Scott K; Sharp, Frank R; Kuan, Chia-Yi (2006. ) Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.The American journal of pathology, , 169 (2 ) ,566-83 More Information

Dostanic-Larson, Iva; Lorenz, John N; Van Huysse, James W; Neumann, Jon C; Moseley, Amy E; Lingrel, Jerry B (2006. ) Physiological role of the alpha1- and alpha2-isoforms of the Na+-K+-ATPase and biological significance of their cardiac glycoside binding site.American journal of physiology. Regulatory, integrative and comparative physiology, , 290 (3 ) ,R524-8 More Information

Xu, Jian; Kimball, Thomas R; Lorenz, John N; Brown, David A; Bauskin, Asne R; Klevitsky, Raisa; Hewett, Timothy E; Breit, Samuel N; Molkentin, Jeffery D (2006. ) GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation.Circulation research, , 98 (3 ) ,342-50 More Information

Lorenz, John N; Dostanic-Larson, Iva; Shull, Gary E; Lingrel, Jerry B (2006. ) Ouabain inhibits tubuloglomerular feedback in mutant mice with ouabain-sensitive alpha1 Na,K-ATPase.Journal of the American Society of Nephrology : JASN, , 17 (9 ) ,2457-63 More Information

Elitsur, Noeet; Lorenz, John N; Hawkins, Jennifer A; Rudolph, Jeffrey A; Witte, David; Yang, Li E; McDonough, Alicia A; Cohen, Mitchell B (2006. ) The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response.Journal of pediatric gastroenterology and nutrition, , 43 Suppl 1 ,S74-81 More Information

Pathak, Anand; del Monte, Federica; Zhao, Wen; Schultz, Jo-El; Lorenz, John N; Bodi, Ilona; Weiser, Doug; Hahn, Harvey; Carr, Andrew N; Syed, Faisal; Mavila, Nirmala; Jha, Leena; Qian, Jiang; Marreez, Yehia; Chen, Guoli; McGraw, Dennis W; Heist, E Kevin; Guerrero, J Luis; DePaoli-Roach, Anna A; Hajjar, Roger J; Kranias, Evangelia G (2005. ) Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1.Circulation research, , 96 (7 ) ,756-66 More Information

Dostanic-Larson, Iva; Van Huysse, James W; Lorenz, John N; Lingrel, Jerry B (2005. ) The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation.Proceedings of the National Academy of Sciences of the United States of America, , 102 (44 ) ,15845-50 More Information

Wang, Zhaohui; Wang, Tong; Petrovic, Snezana; Tuo, Biguang; Riederer, Brigitte; Barone, Sharon; Lorenz, John N; Seidler, Ursula; Aronson, Peter S; Soleimani, Manoocher (2005. ) Renal and intestinal transport defects in Slc26a6-null mice.American journal of physiology. Cell physiology, , 288 (4 ) ,C957-65 More Information

Noonan, William T; Woo, Alison L; Nieman, Michelle L; Prasad, Vikram; Schultheis, Patrick J; Shull, Gary E; Lorenz, John N (2005. ) Blood pressure maintenance in NHE3-deficient mice with transgenic expression of NHE3 in small intestine.American journal of physiology. Regulatory, integrative and comparative physiology, , 288 (3 ) ,R685-91 More Information

Dostanic, Iva; Paul, Richard J; Lorenz, John N; Theriault, Steven; Van Huysse, James W; Lingrel, Jerry B (2005. ) The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.American journal of physiology. Heart and circulatory physiology, , 288 (2 ) ,H477-85 More Information

Sakthivel, Sadayappan; Finley, Natosha L; Rosevear, Paul R; Lorenz, John N; Gulick, James; Kim, Scott; VanBuren, Peter; Martin, Lisa A; Robbins, Jeffrey (2005. ) In vivo and in vitro analysis of cardiac troponin I phosphorylation.The Journal of biological chemistry, , 280 (1 ) ,703-14 More Information

Dostanic, Iva; Schultz, Jo El J; Lorenz, John N; Lingrel, Jerry B (2004. ) The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart.The Journal of biological chemistry, , 279 (52 ) ,54053-61 More Information

Kumar, A; Crawford, K; Flick, R; Klevitsky, R; Lorenz, J N; Bove, K E; Robbins, J; Lessard, J L (2004. ) Transgenic overexpression of cardiac actin in the mouse heart suggests coregulation of cardiac, skeletal and vascular actin expression. Transgenic research, , 13 (6 ) ,531-40

Quinlan, John G; Hahn, Harvey S; Wong, Brenda L; Lorenz, John N; Wenisch, Alexandra S; Levin, Linda S (2004. ) Evolution of the mdx mouse cardiomyopathy: physiological and morphological findings.Neuromuscular disorders : NMD, , 14 (8-9 ) ,491-6 More Information

Braz, Julian C; Gregory, Kimberly; Pathak, Anand; Zhao, Wen; Sahin, Bogachan; Klevitsky, Raisa; Kimball, Thomas F; Lorenz, John N; Nairn, Angus C; Liggett, Stephen B; Bodi, Ilona; Wang, Su; Schwartz, Arnold; Lakatta, Edward G; DePaoli-Roach, Anna A; Robbins, Jeffrey; Hewett, Timothy E; Bibb, James A; Westfall, Margaret V; Kranias, Evangelia G; Molkentin, Jeffery D (2004. ) PKC-alpha regulates cardiac contractility and propensity toward heart failure.Nature medicine, , 10 (3 ) ,248-54 More Information

Ji, Yong; Li, Bailing; Reed, Thomas D; Lorenz, John N; Kaetzel, Marcia A; Dedman, John R (2003. ) Targeted inhibition of Ca2+/calmodulin-dependent protein kinase II in cardiac longitudinal sarcoplasmic reticulum results in decreased phospholamban phosphorylation at threonine 17.The Journal of biological chemistry, , 278 (27 ) ,25063-71 More Information

Woo, Alison L; Noonan, William T; Schultheis, Patrick J; Neumann, Jonathan C; Manning, Patrice A; Lorenz, John N; Shull, Gary E (2003. ) Renal function in NHE3-deficient mice with transgenic rescue of small intestinal absorptive defect.American journal of physiology. Renal physiology, , 284 (6 ) ,F1190-8 More Information

Noonan, William T; Lorenz, John N (2003. ) Clearance studies in genetically altered mice.Methods in molecular medicine, , 86 ,315-27 More Information

Dostanic, Iva; Lorenz, John N; Schultz, Jo El J; Grupp, Ingrid L; Neumann, Jonathan C; Wani, Maqsood A; Lingrel, Jerry B (2003. ) The alpha2 isoform of Na,K-ATPase mediates ouabain-induced cardiac inotropy in mice.The Journal of biological chemistry, , 278 (52 ) ,53026-34 More Information

Noonan, William T; Qian, Jin; Stuart, William D; Clemens, Thomas L; Lorenz, John N (2003. ) Altered renal hemodynamics in mice overexpressing the parathyroid hormone (PTH)/PTH-related peptide type 1 receptor in smooth muscle.Endocrinology, , 144 (11 ) ,4931-8 More Information

Lorenz, John N; Nieman, Michelle; Sabo, Jenine; Sanford, L Philip; Hawkins, Jennifer A; Elitsur, Noeet; Gawenis, Lara R; Clarke, Lane L; Cohen, Mitchell B (2003. ) Uroguanylin knockout mice have increased blood pressure and impaired natriuretic response to enteral NaCl load.The Journal of clinical investigation, , 112 (8 ) ,1244-54 More Information

Krenz, Maike; Sanbe, Atsushi; Bouyer-Dalloz, Florence; Gulick, James; Klevitsky, Raisa; Hewett, Timothy E; Osinska, Hanna E; Lorenz, John N; Brosseau, Christine; Federico, Andrea; Alpert, Norman R; Warshaw, David M; Perryman, M Benjamin; Helmke, Steve M; Robbins, Jeffrey (2003. ) Analysis of myosin heavy chain functionality in the heart.The Journal of biological chemistry, , 278 (19 ) ,17466-74 More Information

Shull, Gary E; Okunade, Gbolahan; Liu, Lynne H; Kozel, Peter; Periasamy, Muthu; Lorenz, John N; Prasad, Vikram (2003. ) Physiological functions of plasma membrane and intracellular Ca2+ pumps revealed by analysis of null mutants. Annals of the New York Academy of Sciences, , 986 ,453-60

Meyer, Jamie W; Flagella, Michael; Sutliff, Roy L; Lorenz, John N; Nieman, Michelle L; Weber, Craig S; Paul, Richard J; Shull, Gary E (2002. ) Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter.American journal of physiology. Heart and circulatory physiology, , 283 (5 ) ,H1846-55 More Information

Schmidt, Albrecht G; Zhai, Jing; Carr, Andrew N; Gerst, Mike J; Lorenz, John N; Pollesello, Piero; Annila, Arto; Hoit, Brian D; Kranias, Evangelia G (2002. ) Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure. Cardiovascular research, , 56 (2 ) ,248-59

Pieples, Kathy; Arteaga, Grace; Solaro, R John; Grupp, Ingrid; Lorenz, John N; Boivin, Greg P; Jagatheesan, Ganapathy; Labitzke, Erin; DeTombe, Pieter P; Konhilas, John P; Irving, Thomas C; Wieczorek, David F (2002. ) Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.American journal of physiology. Heart and circulatory physiology, , 283 (4 ) ,H1344-53 More Information

Yussman, Martin G; Toyokawa, Tsuyoshi; Odley, Amy; Lynch, Roy A; Wu, Guangyu; Colbert, Melissa C; Aronow, Bruce J; Lorenz, John N; Dorn, Gerald W (2002. ) Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy.Nature medicine, , 8 (7 ) ,725-30 More Information

Lorenz, John N (2002. ) A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice.American journal of physiology. Regulatory, integrative and comparative physiology, , 282 (6 ) ,R1565-82 More Information

Bueno, Orlando F; Wilkins, Benjamin J; Tymitz, Kevin M; Glascock, Betty J; Kimball, Thomas F; Lorenz, John N; Molkentin, Jeffery D (2002. ) Impaired cardiac hypertrophic response in Calcineurin Abeta -deficient mice.Proceedings of the National Academy of Sciences of the United States of America, , 99 (7 ) ,4586-91 More Information

Lorenz, John N; Baird, Nancy R; Judd, Louise M; Noonan, William T; Andringa, Anastasia; Doetschman, Thomas; Manning, Patrice A; Liu, Lynne H; Miller, Marian L; Shull, Gary E (2002. ) Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome.The Journal of biological chemistry, , 277 (40 ) ,37871-80 More Information

Ledoussal, C; Lorenz, J N; Nieman, M L; Soleimani, M; Schultheis, P J; Shull, G E (2001. ) Renal salt wasting in mice lacking NHE3 Na+/H+ exchanger but not in mice lacking NHE2. American journal of physiology. Renal physiology, , 281 (4 ) ,F718-27

Fortner, C N; Lorenz, J N; Paul, R J (2001. ) Chloride channel function is linked to epithelium-dependent airway relaxation. American journal of physiology. Lung cellular and molecular physiology, , 280 (2 ) ,L334-41

Dalton, T P; Kerzee, J K; Wang, B; Miller, M; Dieter, M Z; Lorenz, J N; Shertzer, H G; Nerbert, D W; Puga, A (2001. ) Dioxin exposure is an environmental risk factor for ischemic heart disease. Cardiovascular toxicology, , 1 (4 ) ,285-98

Krane, C M; Fortner, C N; Hand, A R; McGraw, D W; Lorenz, J N; Wert, S E; Towne, J E; Paul, R J; Whitsett, J A; Menon, A G (2001. ) Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation.Proceedings of the National Academy of Sciences of the United States of America, , 98 (24 ) ,14114-9 More Information

Wang, X; Osinska, H; Dorn, G W; Nieman, M; Lorenz, J N; Gerdes, A M; Witt, S; Kimball, T; Gulick, J; Robbins, J (2001. ) Mouse model of desmin-related cardiomyopathy. Circulation, , 103 (19 ) ,2402-7

Lorenz, J N (2001. ) Considerations for the evaluation of renal function in genetically engineered mice. Current opinion in nephrology and hypertension, , 10 (1 ) ,65-9

Liggett, S B; Tepe, N M; Lorenz, J N; Canning, A M; Jantz, T D; Mitarai, S; Yatani, A; Dorn, G W (2000. ) Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation, , 101 (14 ) ,1707-14

Tepe, N M; Lorenz, J N; Yatani, A; Dash, R; Kranias, E G; Dorn, G W; Liggett, S B (1999. ) Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling. Biochemistry, , 38 (50 ) ,16706-13

Dorn, G W; Souroujon, M C; Liron, T; Chen, C H; Gray, M O; Zhou, H Z; Csukai, M; Wu, G; Lorenz, J N; Mochly-Rosen, D (1999. ) Sustained in vivo cardiac protection by a rationally designed peptide that causes epsilon protein kinase C translocation. Proceedings of the National Academy of Sciences of the United States of America, , 96 (22 ) ,12798-803

Lorenz, J N; Schultheis, P J; Traynor, T; Shull, G E; Schnermann, J (1999. ) Micropuncture analysis of single-nephron function in NHE3-deficient mice. The American journal of physiology, , 277 (3 Pt 2 ) ,F447-53

Dorn, G W; Tepe, N M; Lorenz, J N; Koch, W J; Liggett, S B (1999. ) Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proceedings of the National Academy of Sciences of the United States of America, , 96 (11 ) ,6400-5

Flagella, M; Clarke, L L; Miller, M L; Erway, L C; Giannella, R A; Andringa, A; Gawenis, L R; Kramer, J; Duffy, J J; Doetschman, T; Lorenz, J N; Yamoah, E N; Cardell, E L; Shull, G E (1999. ) Mice lacking the basolateral Na-K-2Cl cotransporter have impaired epithelial chloride secretion and are profoundly deaf. The Journal of biological chemistry, , 274 (38 ) ,26946-55

Schultz, J E; Witt, S A; Nieman, M L; Reiser, P J; Engle, S J; Zhou, M; Pawlowski, S A; Lorenz, J N; Kimball, T R; Doetschman, T (1999. ) Fibroblast growth factor-2 mediates pressure-induced hypertrophic response.The Journal of clinical investigation, , 104 (6 ) ,709-19 More Information

Qian, J; Lorenz, J N; Maeda, S; Sutliff, R L; Weber, C; Nakayama, T; Colbert, M C; Paul, R J; Fagin, J A; Clemens, T L (1999. ) Reduced blood pressure and increased sensitivity of the vasculature to parathyroid hormone-related protein (PTHrP) in transgenic mice overexpressing the PTH/PTHrP receptor in vascular smooth muscle.Endocrinology, , 140 (4 ) ,1826-33 More Information

Maeda, S; Sutliff, R L; Qian, J; Lorenz, J N; Wang, J; Tang, H; Nakayama, T; Weber, C; Witte, D; Strauch, A R; Paul, R J; Fagin, J A; Clemens, T L (1999. ) Targeted overexpression of parathyroid hormone-related protein (PTHrP) to vascular smooth muscle in transgenic mice lowers blood pressure and alters vascular contractility.Endocrinology, , 140 (4 ) ,1815-25 More Information

Periasamy, M; Reed, T D; Liu, L H; Ji, Y; Loukianov, E; Paul, R J; Nieman, M L; Riddle, T; Duffy, J J; Doetschman, T; Lorenz, J N; Shull, G E (1999. ) Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. The Journal of biological chemistry, , 274 (4 ) ,2556-62

Lorenz, J N; Gruenstein, E (1999. ) A simple, nonradioactive method for evaluating single-nephron filtration rate using FITC-inulin. The American journal of physiology, , 276 (1 Pt 2 ) ,F172-7

Schultheis, P J; Lorenz, J N; Meneton, P; Nieman, M L; Riddle, T M; Flagella, M; Duffy, J J; Doetschman, T; Miller, M L; Shull, G E (1998. ) Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule. The Journal of biological chemistry, , 273 (44 ) ,29150-5

Grupp, I L; Lorenz, J N; Walsh, R A; Boivin, G P; Rindt, H (1998. ) Overexpression of alpha1B-adrenergic receptor induces left ventricular dysfunction in the absence of hypertrophy. The American journal of physiology, , 275 (4 Pt 2 ) ,H1338-50

Williams, R V; Lorenz, J N; Witt, S A; Hellard, D T; Khoury, P R; Kimball, T R (1998. ) End-systolic stress-velocity and pressure-dimension relationships by transthoracic echocardiography in mice. The American journal of physiology, , 274 (5 Pt 2 ) ,H1828-35

Zhou, M; Sutliff, R L; Paul, R J; Lorenz, J N; Hoying, J B; Haudenschild, C C; Yin, M; Coffin, J D; Kong, L; Kranias, E G; Luo, W; Boivin, G P; Duffy, J J; Pawlowski, S A; Doetschman, T (1998. ) Fibroblast growth factor 2 control of vascular tone. Nature medicine, , 4 (2 ) ,201-7

Stockelman, M G; Lorenz, J N; Smith, F N; Boivin, G P; Sahota, A; Tischfield, J A; Stambrook, P J (1998. ) Chronic renal failure in a mouse model of human adenine phosphoribosyltransferase deficiency. The American journal of physiology, , 275 (1 Pt 2 ) ,F154-63

Schultheis, P J; Clarke, L L; Meneton, P; Miller, M L; Soleimani, M; Gawenis, L R; Riddle, T M; Duffy, J J; Doetschman, T; Wang, T; Giebisch, G; Aronson, P S; Lorenz, J N; Shull, G E (1998. ) Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger.Nature genetics, , 19 (3 ) ,282-5 More Information

Meneton, P; Schultheis, P J; Greeb, J; Nieman, M L; Liu, L H; Clarke, L L; Duffy, J J; Doetschman, T; Lorenz, J N; Shull, G E (1998. ) Increased sensitivity to K+ deprivation in colonic H,K-ATPase-deficient mice.The Journal of clinical investigation, , 101 (3 ) ,536-42 More Information

Lorenz, J N; Kranias, E G (1997. ) Regulatory effects of phospholamban on cardiac function in intact mice. The American journal of physiology, , 273 (6 Pt 2 ) ,H2826-31

D'Angelo, D D; Sakata, Y; Lorenz, J N; Boivin, G P; Walsh, R A; Liggett, S B; Dorn, G W (1997. ) Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proceedings of the National Academy of Sciences of the United States of America, , 94 (15 ) ,8121-6

Lorenz, J N; Robbins, J (1997. ) Measurement of intraventricular pressure and cardiac performance in the intact closed-chest anesthetized mouse. The American journal of physiology, , 272 (3 Pt 2 ) ,H1137-46

Lorenz, J N; Paul, R J (1997. ) Dependence of Ca2+ channel currents on endogenous and exogenous sources of ATP in portal vein smooth muscle. The American journal of physiology, , 272 (2 Pt 2 ) ,H987-94

Liu, L H; Paul, R J; Sutliff, R L; Miller, M L; Lorenz, J N; Pun, R Y; Duffy, J J; Doetschman, T; Kimura, Y; MacLennan, D H; Hoying, J B; Shull, G E (1997. ) Defective endothelium-dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+-ATPase isoform 3. The Journal of biological chemistry, , 272 (48 ) ,30538-45

Colbert, M C; Hall, D G; Kimball, T R; Witt, S A; Lorenz, J N; Kirby, M L; Hewett, T E; Klevitsky, R; Robbins, J (1997. ) Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice.The Journal of clinical investigation, , 100 (8 ) ,1958-68 More Information

Tam, E S; Ferguson, D G; Bielefeld, D R; Lorenz, J N; Cohen, R M; Pun, R Y (1997. ) Norepinephrine-mediated calcium signaling is altered in vascular smooth muscle of diabetic rat. Cell calcium, , 21 (2 ) ,143-50

Turki, J; Lorenz, J N; Green, S A; Donnelly, E T; Jacinto, M; Liggett, S B (1996. ) Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America, , 93 (19 ) ,10483-8

Lorenz, J N; Bielefeld, D R; Sperelakis, N (1994. ) Regulation of calcium channel current in A7r5 vascular smooth muscle cells by cyclic nucleotides. The American journal of physiology, , 266 (6 Pt 1 ) ,C1656-63

Prasad, Vikram; Lorenz, John N; Lasko, Valerie M; Nieman, Michelle L; Huang, Wei; Wang, Yigang; Wieczorek, David W; Shull, Gary E (2015. ) SERCA2 Haploinsufficiency in a Mouse Model of Darier Disease Causes a Selective Predisposition to Heart Failure.BioMed research international, , 2015 ,251598 More Information

Prasad, Vikram; Lorenz, John N; Lasko, Valerie M; Nieman, Michelle L; Jiang, Min; Gao, Xu; Rubinstein, Jack; Wieczorek, David F; Shull, Gary E (2014. ) Ablation of plasma membrane Ca(2+)-ATPase isoform 4 prevents development of hypertrophy in a model of hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology, , 77 ,53-63 More Information

Kirschner, Akiva; Koch, Sheryl E; Robbins, Nathan; Karthik, Felix; Mudigonda, Parvathi; Ramasubramanian, Ranjani; Nieman, Michelle L; Lorenz, John N; Rubinstein, Jack (2021. ) Pharmacologic Inhibition of Pain Response to Incomplete Vascular Occlusion Blunts Cardiovascular Preconditioning Response.Cardiovascular toxicology, , 21 (11 ) ,889-900 More Information

Lynch, Thomas L; Kumar, Mohit; McNamara, James W; Kuster, Diederik W D; Sivaguru, Mayandi; Singh, Rohit R; Previs, Michael J; Lee, Kyoung Hwan; Kuffel, Gina; Zilliox, Michael J; Lin, Brian Leei; Ma, Weikang; Gibson, Aaron M; Blaxall, Burns C; Nieman, Michelle L; Lorenz, John N; Leichter, Dana M; Leary, Owen P; Janssen, Paul M L; de Tombe, Pieter P; Gilbert, Richard J; Craig, Roger; Irving, Thomas; Warshaw, David M; Sadayappan, Sakthivel (2021. ) Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility.Journal of molecular and cellular cardiology, , 156 ,33-44 More Information

Song, Taejeong; McNamara, James W; Ma, Weikang; Landim-Vieira, Maicon; Lee, Kyoung Hwan; Martin, Lisa A; Heiny, Judith A; Lorenz, John N; Craig, Roger; Pinto, Jose Renato; Irving, Thomas; Sadayappan, Sakthivel (2021. ) Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction.Proceedings of the National Academy of Sciences of the United States of America, , 118 (17 ) , More Information

Khalid, Fatima; Yang, George L; McGuire, Jennifer L; Robson, Matthew J; Foreman, Brandon; Ngwenya, Laura B; Lorenz, John N (2019. ) Autonomic dysfunction following traumatic brain injury: translational insights.Neurosurgical focus, , 47 (5 ) ,E8 More Information

Mercado-Shekhar, Karla P; Su, Haili; Kalaikadal, Deepak S; Lorenz, John N; Manglik, Raj M; Holland, Christy K; Redington, Andrew N; Haworth, Kevin J (2019. ) Acoustic droplet vaporization-mediated dissolved oxygen scavenging in blood-mimicking fluids, plasma, and blood.Ultrasonics sonochemistry, , 56 ,114-124 More Information

Jensen, Victoria N; Seedle, Kari; Turner, Sarah M; Lorenz, John N; Crone, Steven A (2019. ) V2a Neurons Constrain Extradiaphragmatic Respiratory Muscle Activity at Rest.eNeuro, , 6 (4 ) , More Information

Barefield, David Y; McNamara, James W; Lynch, Thomas L; Kuster, Diederik W D; Govindan, Suresh; Haar, Lauren; Wang, Yang; Taylor, Erik N; Lorenz, John N; Nieman, Michelle L; Zhu, Guangshuo; Luther, Pradeep K; Varró, Andras; Dobrev, Dobromir; Ai, Xun; Janssen, Paul M L; Kass, David A; Jones, Walter Keith; Gilbert, Richard J; Sadayappan, Sakthivel (2019. ) Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.Journal of molecular and cellular cardiology, , 129 ,236-246 More Information

Green, Lisa C; Anthony, Sarah R; Slone, Samuel; Lanzillotta, Lindsey; Nieman, Michelle L; Wu, Xiaoqing; Robbins, Nathan; Jones, Shannon M; Roy, Sudeshna; Owens, A Phillip; Aube, Jeffrey; Xu, Liang; Lorenz, John N; Blaxall, Burns C; Rubinstein, Jack; Benoit, Joshua B; Tranter, Michael (2019. ) Human antigen R as a therapeutic target in pathological cardiac hypertrophy.JCI insight, , 4 (4 ) , More Information

Abdullah, Chowdhury S; Alam, Shafiul; Aishwarya, Richa; Miriyala, Sumitra; Panchatcharam, Manikandan; Bhuiyan, Mohammad Alfrad Nobel; Peretik, Jonette M; Orr, A Wayne; James, Jeanne; Osinska, Hanna; Robbins, Jeffrey; Lorenz, John N; Bhuiyan, Md Shenuarin (2018. ) Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics.Journal of the American Heart Association, , 7 (20 ) ,e009775 More Information

Vairamani, Kanimozhi; Prasad, Vikram; Wang, Yigang; Huang, Wei; Chen, Yinhua; Medvedovic, Mario; Lorenz, John N; Shull, Gary E (2018. ) NBCe1 Na+-HCO3- cotransporter ablation causes reduced apoptosis following cardiac ischemia-reperfusion injury in vivo.World journal of cardiology, , 10 (9 ) ,97-109 More Information

Valiente-Alandi, Iñigo; Potter, Sarah J; Salvador, Ane M; Schafer, Allison E; Schips, Tobias; Carrillo-Salinas, Francisco; Gibson, Aaron M; Nieman, Michelle L; Perkins, Charles; Sargent, Michelle A; Huo, Jiuzhou; Lorenz, John N; DeFalco, Tony; Molkentin, Jeffery D; Alcaide, Pilar; Blaxall, Burns C (2018. ) Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure.Circulation, , 138 (12 ) ,1236-1252 More Information

Koch, Sheryl E; Nieman, Michelle L; Robbins, Nathan; Slone, Samuel; Worley, Mariah; Green, Lisa C; Chen, Yamei; Barlow, Alexandria; Tranter, Michael; Wang, HongSheng; Lorenz, John N; Rubinstein, Jack (2018. ) Tranilast Blunts the Hypertrophic and Fibrotic Response to Increased Afterload Independent of Cardiomyocyte Transient Receptor Potential Vanilloid 2 Channels.Journal of cardiovascular pharmacology, , 72 (1 ) ,40-48 More Information

Travers, Joshua G; Kamal, Fadia A; Valiente-Alandi, Iñigo; Nieman, Michelle L; Sargent, Michelle A; Lorenz, John N; Molkentin, Jeffery D; Blaxall, Burns C (2017. ) Pharmacological and Activated Fibroblast Targeting of Gβγ-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression.Journal of the American College of Cardiology, , 70 (8 ) ,958-971 More Information

Vairamani, Kanimozhi; Wang, Hong-Sheng; Medvedovic, Mario; Lorenz, John N; Shull, Gary E (2017. ) RNA SEQ Analysis Indicates that the AE3 Cl-/HCO3- Exchanger Contributes to Active Transport-Mediated CO2 Disposal in Heart.Scientific reports, , 7 (1 ) ,7264 More Information

Alshahrani, Saeed; Rapoport, Robert M; Zahedi, Kamyar; Jiang, Min; Nieman, Michelle; Barone, Sharon; Meredith, Andrea L; Lorenz, John N; Rubinstein, Jack; Soleimani, Manoocher (2017. ) The non-diuretic hypotensive effects of thiazides are enhanced during volume depletion states.PloS one, , 12 (7 ) ,e0181376 More Information

Koch, Sheryl E; Mann, Adrien; Jones, Shannon; Robbins, Nathan; Alkhattabi, Abdullah; Worley, Mariah C; Gao, Xu; Lasko-Roiniotis, Valerie M; Karani, Rajiv; Fulford, Logan; Jiang, Min; Nieman, Michelle; Lorenz, John N; Rubinstein, Jack (2017. ) Transient receptor potential vanilloid 2 function regulates cardiac hypertrophy via stretch-induced activation.Journal of hypertension, , 35 (3 ) ,602-611 More Information

Bhuiyan, Md Shenuarin; McLendon, Patrick; James, Jeanne; Osinska, Hanna; Gulick, James; Bhandary, Bidur; Lorenz, John N; Robbins, Jeffrey (2016. ) In vivo definition of cardiac myosin-binding protein C's critical interactions with myosin.Pflugers Archiv : European journal of physiology, , 468 (10 ) ,1685-95 More Information

Bakeer, Nihal; James, Jeanne; Roy, Swarnava; Wansapura, Janaka; Shanmukhappa, Shiva Kumar; Lorenz, John N; Osinska, Hanna; Backer, Kurt; Huby, Anne-Cecile; Shrestha, Archana; Niss, Omar; Fleck, Robert; Quinn, Charles T; Taylor, Michael D; Purevjav, Enkhsaikhan; Aronow, Bruce J; Towbin, Jeffrey A; Malik, Punam (2016. ) Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology.Proceedings of the National Academy of Sciences of the United States of America, , 113 (35 ) ,E5182-91 More Information

Book Chapter

Schnermann,J., Lorenz,J. N., Briggs,J. P. (2008 ) Cardiorenal Physiology of the Mouse: From Loss of Genome to Gain of Phenome Molecular and Genetic Basis of Renal Disease .(pp. 15 -39).Philadelphia, W.B. Saunders

Noonan,W. T., Lorenz,J. N. (2003 ) Clearance studies in genetically altered mice Renal Disease: Techniques and Protocols .(pp. 315 -327).Totowa, Humana

Paul,R. J., Lorenz,J. N. (1996 ) Metabolic modulation of excitation-contraction coupling in smooth muscle Smooth Muscle Excitation. (pp. 315 -323).London, Academic Press

Sperelakis,N., Xiong,Z., Lorenz,J. N. (1994 ) Regulation of Ca2+ channels in vascular smooth muscle cells by cyclic nucleotides and by G-protein gating Membrane Physiopathology .(pp. 155 -172).Boston, Kluwer Academic Publishers

Sperelakis,N., Xiong,Z., Inoue,Y., Ohya,Y., Shimamura,K., Bielefeld,D. R., Lorenz,J. N. (1993 ) Fast Na+ current and Ca2+ currents in smooth muscles Ion Flux in Pulmonary Vascular control .(pp. 77 -104).New York, Plenum Press

Crystal Fancher (Master ) Student Thesis Preceptor Status:Completed 2009

Ryan Heaney (Master ) Status:Completed 2009

Arshani Wansapura Status:In Progress

Elise Demitrack (Doctoral ) Committee Member Status:Completed 06-2010

Nabeel Al Moamen (Doctoral ) Committee Member

Emily Bradford (Doctoral ) Committee Member

Dheer Vyas (Doctoral ) Lab Rotation Preceptor

(Shared Space and Facilities Committee ) Committee Member Type:Departmental Service Level:Department

(Medical Education Committee ) Committee Member Type:Departmental Service Level:Department

(Academic Reappointment, Promotion and Tenure Committee ) Committee Member Type:Departmental Service Level:Department

(Admissions Committee, Medical Masters Program. ) Committee Member Type:Departmental Service Level:Department

(Admissions Committee, Systems Biology and Physiology Doctoral Program ) Committee Member Type:Departmental Service Level:Department

(Pre-Qualifying Advisor and Chair, Qualifying Exam Committee ) Committee Member Type:Departmental Service Level:Department

(Physician Scientist Promotion Board ) Member Type:University/College Service Level:College

(Faculty Forum Executive Committee ) Committee Member Type:University/College Service Level:College

(Academic Reappointment, Promotion and Tenure Committee ) Committee Member Type:University/College Service Level:College

(Institutional Animal Care and Use Committee ) Committee Member Type:University/College Service Level:University

American Journal of Physiology: Renal Physiology Editorial Board Member Type:Editorial Service Level:National

American Journal of Physiology: Reg, Int and Comp Physiology. Reviewer Type:Editorial Service Level:National

American Journal of Physiology: Heart and Circulatory Physiology Reviewer Type:Editorial Service Level:National

Experimental Physiology Reviewer Type:Editorial Service Level:National

Journal of Applied Physiology Reviewer Type:Editorial Service Level:National

American Journal of Hypertension Reviewer Type:Editorial Service Level:National

Hypertension Reviewer Type:Editorial Service Level:National

Kidney International Reviewer Type:Editorial Service Level:International

Journal of the American Society of Nephrology Reviewer Type:Editorial Service Level:National

Cardiovascular Research Reviewer Type:Editorial Service Level:National

American Heart Association (Great Lakes Affiliate (Cardiorenal section) ) Co-Chair Type:Public Level:National

National Institutes of Health (NCAM Special Emphasis Panel ) Member Type:Public Level:National -03-2009

National Institutes of Health (CMBK Study Section ) Member Type:Public Level:National -04-2009

Cardiovascular Physiology,Murine Physiology,Renal Physiology,Pulmonary Physiology

26-MCP-848 SPECIAL TOPICS PHYS Medical Physiology Level:Graduate

Medical Physiology: Physiology of the Circulation. Level:Graduate

26-MCP-848 SPECIAL TOPICS PHYS Human Systems Physiology I - Cardiovascular Physiology Level:Graduate

26-MCP-848 SPECIAL TOPICS PHYS Human Systems Physiology I, Cardiovascular Physiology Level:Graduate

26-MCP-970 INTRO TO RESEARCH Statistical Methods in Physiology Level:Graduate