Matthew Robson

Ph.D. : West Virginia University Morgantown, WV, 2013 (Pharmaceutical and Pharmacological Sciences)

B.S.: Canisius College Buffalo, NY, 2007 (Biochemistry)

Traumatic brain injuries (TBI) are a leading cause of disability in populations across the globe. Diverse environmental factors can lead to various forms of TBI, many of which result in the generation of chronic, neuropsychiatric comorbidities such as depression, anxiety and social withdrawal. Our current understanding of the neuronal and molecular mechanisms that contribute to the generation of these neuropsychiatric complications remains limited. The focus of the Robson Laboratory is to enhance our understanding of how TBI alters molecular signaling that leads to changes in neuronal signaling and behaviors. Specifically, the Robson Laboratory has a defined interest in understanding how serotonergic neurons and neurotransmission within the brain are altered by various mild forms of TBI. Further, we study how selectively targeting injury-induced changes in serotonergic neurotransmission may lead to promising therapeutics aimed at treating TBI-induced neuropsychiatric complications. It is our hope that a greater understanding of the molecular underpinnings of TBI will lead to better medical treatments for the detrimental effects of neurotrauma. 
 

2004 -2008 Research Assistant, DENT Neurologic Institute,

2013 -2016 Postdoctoral Fellow, Vanderbilt University ,

2016 -2017 Research Assistant Professor, Florida Atlantic University ,

2018 -2024 Assistant Professor, University of Cincinnati, Cincinnati, OH

Grant: #NS007491 NIH Role:Trainee Type:Fellowship

Grant: #NARSAD Young Investigator Grant 25230 Investigators:Robson, Matthew 01-01-2018 -07-14-2019 Brain & Behavior Research Foundation Regulation of SERT Activity by IL-1R1 Signaling in Serotonergic Neurons Role:PI $47,022.28 Active

Grant: #PhRMA 2019 Investigators:Robson, Matthew 03-01-2019 -02-28-2020 PhRMA Foundation Role of Sigma-1 Receptors in Traumatic Brain Injury Role:PI $100,000.00 Awarded Level:Private Non-Profit

Grant: #R25081 Investigators:Robson, Matthew 04-01-2019 -03-31-2020 UC's URC Faculty Research Cost Support Awards Program CO2- Induced Slosh Mitigation as a Strategy to Prevent Tramatic Brain Injury Role:PI $7,500.00 Active Level:Internal UC

Grant: #W81XWH-22-1-0849 Investigators:Gardner, Jason; Robson, Matthew 08-01-2022 -07-31-2024 Department of the Army Medical Research Acquisition Activity Targeting IL-1R1 Mediated Anemia in Complex Combat-Related Burns Role:Collaborator 600000.00 Active Level:Federal

Grant: #NINDS; 1R01NS137887-01 Investigators:Gudelsky, Gary; Ngwenya, Laura; Robson, Matthew -06-30-2029 National Institute of Neurological Disorders and Stroke No REST for 5-HT Neurons Following Traumatic Brain Injury Role:PI 0.00 Hold Level:Federal

Peer Reviewed Publications

Gengo, Fran; Westphal, Erica S; Rainka, Michelle M; Janda, Maria; Robson, Matthew J; Hourihane, J Maurice; Bates, Vernice (2016. ) Platelet response to increased aspirin dose in patients with persistent platelet aggregation while treated with aspirin 81?mg.Journal of clinical pharmacology, , 56 (4 ) ,414-21 More Information

Gengo, Francis M; Rainka, Michelle; Robson, Matthew; Gengo, Michael F; Forrest, Alan; Hourihane, Maurice; Bates, Vernice (2008. ) Prevalence of platelet nonresponsiveness to aspirin in patients treated for secondary stroke prophylaxis and in patients with recurrent ischemic events.Journal of clinical pharmacology, , 48 (3 ) ,335-43 More Information

Lucke-Wold, Brandon P; Turner, Ryan C; Logsdon, Aric F; Nguyen, Linda; Bailes, Julian E; Lee, John M; Robson, Matthew J; Omalu, Bennet I; Huber, Jason D; Rosen, Charles L (2016. ) Endoplasmic reticulum stress implicated in chronic traumatic encephalopathy.Journal of neurosurgery, , 124 (3 ) ,687-702 More Information

Turner, Ryan C; Lucke-Wold, Brandon P; Robson, Matthew J; Lee, John M; Bailes, Julian E (2016. ) Alzheimer's disease and chronic traumatic encephalopathy: Distinct but possibly overlapping disease entities.Brain injury, , 30 (11 ) ,1279-1292 More Information

Lucke-Wold, Brandon P; Naser, Zachary J; Logsdon, Aric F; Turner, Ryan C; Smith, Kelly E; Robson, Matthew J; Bailes, Julian E; Lee, John M; Rosen, Charles L; Huber, Jason D (2015. ) Amelioration of nicotinamide adenine dinucleotide phosphate-oxidase mediated stress reduces cell death after blast-induced traumatic brain injury.Translational research : the journal of laboratory and clinical medicine, , 166 (6 ) ,509-528.e1 More Information

Turner, Ryan C; Lucke-Wold, Brandon P; Logsdon, Aric F; Robson, Matthew J; Lee, John M; Bailes, Julian E; Dashnaw, Matthew L; Huber, Jason D; Petraglia, Anthony L; Rosen, Charles L (2015. ) Modeling Chronic Traumatic Encephalopathy: The Way Forward for Future Discovery.Frontiers in neurology, , 6 ,223 More Information

Turner, Ryan C; Lucke-Wold, Brandon P; Logsdon, Aric F; Robson, Matthew J; Dashnaw, Matthew L; Huang, Jason H; Smith, Kelly E; Huber, Jason D; Rosen, Charles L; Petraglia, Anthony L (2015. ) The Quest to Model Chronic Traumatic Encephalopathy: A Multiple Model and Injury Paradigm Experience.Frontiers in neurology, , 6 ,222 More Information

Nguyen, Linda; Lucke-Wold, Brandon P; Mookerjee, Shona A; Cavendish, John Z; Robson, Matthew J; Scandinaro, Anna L; Matsumoto, Rae R (2015. ) Role of sigma-1 receptors in neurodegenerative diseases.Journal of pharmacological sciences, , 127 (1 ) ,17-29 More Information

Logsdon, Aric Flint; Turner, Ryan Coddington; Lucke-Wold, Brandon Peter; Robson, Matthew James; Naser, Zachary James; Smith, Kelly Elizabeth; Matsumoto, Rae Reiko; Huber, Jason Delwyn; Rosen, Charles Lee (2014. ) Altering endoplasmic reticulum stress in a model of blast-induced traumatic brain injury controls cellular fate and ameliorates neuropsychiatric symptoms.Frontiers in cellular neuroscience, , 8 ,421 More Information

Nguyen, Linda; Kaushal, Nidhi; Robson, Matthew J; Matsumoto, Rae R (2014. ) Sigma receptors as potential therapeutic targets for neuroprotection.European journal of pharmacology, , 743 ,42-7 More Information

Matsumoto, Rae R; Seminerio, Michael J; Turner, Ryan C; Robson, Matthew J; Nguyen, Linda; Miller, Diane B; O'Callaghan, James P (2014. ) Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia.Pharmacology & therapeutics, , 144 (1 ) ,28-40 More Information

Robson, Matthew J; Turner, Ryan C; Naser, Zachary J; McCurdy, Christopher R; O'Callaghan, James P; Huber, Jason D; Matsumoto, Rae R (2014. ) SN79, a sigma receptor antagonist, attenuates methamphetamine-induced astrogliosis through a blockade of OSMR/gp130 signaling and STAT3 phosphorylation.Experimental neurology, , 254 ,180-9 More Information

Nguyen, Linda; Robson, Matthew J; Healy, Jason R; Scandinaro, Anna L; Matsumoto, Rae R (2014. ) Involvement of sigma-1 receptors in the antidepressant-like effects of dextromethorphan.PloS one, , 9 (2 ) ,e89985 More Information

Kaushal, Nidhi; Robson, Matthew J; Rosen, Abagail; McCurdy, Christopher R; Matsumoto, Rae R (2014. ) Neuroprotective targets through which 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a sigma receptor ligand, mitigates the effects of methamphetamine in vitro.European journal of pharmacology, , 724 ,193-203 More Information

Matsumoto, Rae R; Nguyen, Linda; Kaushal, Nidhi; Robson, Matthew J (2014. ) Sigma (?) receptors as potential therapeutic targets to mitigate psychostimulant effects.Advances in pharmacology (San Diego, Calif.), , 69 ,323-86 More Information

Turner, Ryan C; Naser, Zachary J; Logsdon, Aric F; DiPasquale, Kenneth H; Jackson, Garrett J; Robson, Matthew J; Gettens, Robert T T; Matsumoto, Rae R; Huber, Jason D; Rosen, Charles L (2013. ) Modeling clinically relevant blast parameters based on scaling principles produces functional & histological deficits in rats.Experimental neurology, , 248 ,520-9 More Information

Robson, Matthew J; Turner, Ryan C; Naser, Zachary J; McCurdy, Christopher R; Huber, Jason D; Matsumoto, Rae R (2013. ) SN79, a sigma receptor ligand, blocks methamphetamine-induced microglial activation and cytokine upregulation.Experimental neurology, , 247 ,134-42 More Information

Kaushal, Nidhi; Seminerio, Michael J; Robson, Matthew J; McCurdy, Christopher R; Matsumoto, Rae R (2013. ) Pharmacological evaluation of SN79, a sigma (?) receptor ligand, against methamphetamine-induced neurotoxicity in vivo.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, , 23 (8 ) ,960-71 More Information

Turner, Ryan C; Lucke-Wold, Brandon P; Robson, Matthew J; Omalu, Bennet I; Petraglia, Anthony L; Bailes, Julian E (2012. ) Repetitive traumatic brain injury and development of chronic traumatic encephalopathy: a potential role for biomarkers in diagnosis, prognosis, and treatment?.Frontiers in neurology, , 3 ,186 More Information

Robson, Matthew J; Seminerio, Michael J; McCurdy, Christopher R; Coop, Andrew; Matsumoto, Rae R (2013. ) ? Receptor antagonist attenuation of methamphetamine-induced neurotoxicity is correlated to body temperature modulation. Pharmacological reports : PR, , 65 (2 ) ,343-9

Seminerio, Michael J; Robson, Matthew J; McCurdy, Christopher R; Matsumoto, Rae R (2012. ) Sigma receptor antagonists attenuate acute methamphetamine-induced hyperthermia by a mechanism independent of IL-1? mRNA expression in the hypothalamus.European journal of pharmacology, , 691 (1-3 ) ,103-9 More Information

Robson, Matthew J; Elliott, Meenal; Seminerio, Michael J; Matsumoto, Rae R (2012. ) Evaluation of sigma (?) receptors in the antidepressant-like effects of ketamine in vitro and in vivo.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, , 22 (4 ) ,308-17 More Information

Seminerio, Michael J; Robson, Matthew J; Abdelazeem, Ahmed H; Mesangeau, Christophe; Jamalapuram, Seshulatha; Avery, Bonnie A; McCurdy, Christopher R; Matsumoto, Rae R (2012. ) Synthesis and pharmacological characterization of a novel sigma receptor ligand with improved metabolic stability and antagonistic effects against methamphetamine.The AAPS journal, , 14 (1 ) ,43-51 More Information

Kaushal, Nidhi; Elliott, Meenal; Robson, Matthew J; Iyer, Anand Krishnan V; Rojanasakul, Yon; Coop, Andrew; Matsumoto, Rae R (2012. ) AC927, a ? receptor ligand, blocks methamphetamine-induced release of dopamine and generation of reactive oxygen species in NG108-15 cells.Molecular pharmacology, , 81 (3 ) ,299-308 More Information

Xu, Yan-Tong; Robson, Matthew J; Szeszel-Fedorowicz, Wioletta; Patel, Divyen; Rooney, Robert; McCurdy, Christopher R; Matsumoto, Rae R (2012. ) CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain.Pharmacology, biochemistry, and behavior, , 101 (1 ) ,174-80 More Information

Robson, Matthew J; Noorbakhsh, Bahar; Seminerio, Michael J; Matsumoto, Rae R (2012. ) Sigma-1 receptors: potential targets for the treatment of substance abuse. Current pharmaceutical design, , 18 (7 ) ,902-19

Kaushal, Nidhi; Robson, Matthew J; Vinnakota, Harsha; Narayanan, Sanju; Avery, Bonnie A; McCurdy, Christopher R; Matsumoto, Rae R (2011. ) Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodents.The AAPS journal, , 13 (3 ) ,336-46 More Information

Fishback, James A; Robson, Matthew J; Xu, Yan-Tong; Matsumoto, Rae R (2010. ) Sigma receptors: potential targets for a new class of antidepressant drug.Pharmacology & therapeutics, , 127 (3 ) ,271-82 More Information

Robson, Matthew J; Quinlan, Meagan A; Blakely, Randy D (2017. ) Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery.ACS chemical neuroscience, , 8 (5 ) ,932-942 More Information

Robson, Matthew J; Zhu, Chong-Bin; Quinlan, Meagan A; Botschner, David A; Baganz, Nicole L; Lindler, Kathryn M; Thome, Jason G; Hewlett, William A; Blakely, Randy D (2016. ) Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1.PloS one, , 11 (3 ) ,e0150068 More Information

Baganz, N L; Lindler, K M; Zhu, C B; Smith, J T; Robson, M J; Iwamoto, H; Deneris, E S; Hewlett, W A; Blakely, R D (2015. ) A requirement of serotonergic p38? mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors.Translational psychiatry, , 5 ,e671 More Information

Robson, Matthew J; Quinlan, Meagan A; Margolis, Kara Gross; Gajewski-Kurdziel, Paula A; Veenstra-VanderWeele, Jeremy; Gershon, Michael D; Watterson, D Martin; Blakely, Randy D (2018. ) p38a MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.Proceedings of the National Academy of Sciences of the United States of America, , More Information

Burke, Susan J; Batdorf, Heidi M; Burk, David H; Martin, Thomas M; Mendoza, Tamra; Stadler, Krisztian; Alami, Wateen; Karlstad, Michael D; Robson, Matthew J; Blakely, Randy D; Mynatt, Randall L; Collier, J Jason (2018. ) Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet B-cell de-differentiation.Molecular metabolism, , More Information

Quinlan, Meagan A; Krout, Danielle; Katamish, Rania; Robson, Matthew J; Nettesheim, Catherine; Gresch, Paul J; Mash, Deborah; Henry, Keith; Blakely, Randy D (2019. ) Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences.ACS chemical neuroscience, , More Information

Liu, Xiaoyu; Nemeth, Daniel P; McKim, Daniel B; Zhu, Ling; DiSabato, Damon J; Berdysz, Olimpia; Gorantla, Gowthami; Oliver, Braedan; Witcher, Kristina G; Wang, Yufen; Negray, Christina E; Vegesna, Rekha S; Sheridan, John F; Godbout, Jonathan P; Robson, Matthew J; Blakely, Randy D; Popovich, Phillip G; Bilbo, Staci D; Quan, Ning (2019. ) Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.Immunity, , More Information

Chen, Yanting; Lu, Xiaohan; Whitney, Raeann L; Li, Yu; Robson, Matthew J; Blakely, Randy D; Chi, Jen-Tsan; Crowley, Steven D; Privratsky, Jamie R (2024. ) Novel anti-inflammatory effects of the IL-1 receptor in kidney myeloid cells following ischemic AKI.Frontiers in molecular biosciences, , 11 ,1366259 More Information

O'Connell, Christopher J; Reeder, Evan L; Hymore, Jacob A; Brown, Ryan S; Notorgiacomo, Gabrielle A; Collins, Sean M; Gudelsky, Gary A; Robson, Matthew J (2024. ) Transcriptomic dynamics governing serotonergic dysregulation in the dorsal raphe nucleus following mild traumatic brain injury.Experimental neurology, , 374 ,114695 More Information

Hetzer, S M; O'Connell, C; Lallo, V; Robson, M; Evanson, N K (2024. ) Model matters: Differential outcomes in traumatic optic neuropathy pathophysiology between blunt and blast-wave mediated head injuries.Experimental neurology, , 372 ,114613 More Information

O'Connell, Christopher J; Brown, Ryan S; Peach, Taylor M; Traubert, Owen D; Schwierling, Hana C; Notorgiacomo, Gabrielle A; Robson, Matthew J (2024. ) Strain in the Midbrain: Impact of Traumatic Brain Injury on the Central Serotonin System.Brain sciences, , 14 (1 ) , More Information

Ren, Jiafa; Liu, Kang; Wu, Buyun; Lu, Xiaohan; Sun, Lianqin; Privratsky, Jamie R; Xing, Changying; Robson, Matthew J; Mao, Huijuan; Blakely, Randy D; Abe, Koki; Souma, Tomokazu; Crowley, Steven D (2023. ) Divergent Actions of Renal Tubular and Endothelial Type 1 IL-1 Receptor Signaling in Toxin-Induced AKI.Journal of the American Society of Nephrology : JASN, , 34 (10 ) ,1629-1646 More Information

Luis, Tiago C; Barkas, Nikolaos; Carrelha, Joana; Giustacchini, Alice; Mazzi, Stefania; Norfo, Ruggiero; Wu, Bishan; Aliouat, Affaf; Guerrero, Jose A; Rodriguez-Meira, Alba; Bouriez-Jones, Tiphaine; Macaulay, Iain C; Jasztal, Maria; Zhu, Guangheng; Ni, Heyu; Robson, Matthew J; Blakely, Randy D; Mead, Adam J; Nerlov, Claus; Ghevaert, Cedric; Jacobsen, Sten Eirik W (2023. ) Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner.Nature communications, , 14 (1 ) ,6062 More Information

Singer, Kathleen E; McGlone, Emily D; Collins, Sean M; Wallen, Taylor E; Morris, Mackenzie C; Schuster, Rebecca M; England, Lisa G; Robson, Matthew J; Goodman, Michael D (2023. ) Propranolol Reduces p-tau Accumulation and Improves Behavior Outcomes in a Polytrauma Murine Model.The Journal of surgical research, , 282 ,183-190 More Information

Reeder, Evan L; O'Connell, Christopher J; Collins, Sean M; Traubert, Owen D; Norman, Sophia V; Cáceres, Román A; Sah, Renu; Smith, David W; Robson, Matthew J (2023. ) Increased Carbon Dioxide Respiration Prevents the Effects of Acceleration/Deceleration Elicited Mild Traumatic Brain Injury.Neuroscience, , 509 ,20-35 More Information

Reeder, Evan L; Liber, Mei-Ling; Traubert, Owen D; O'Connell, Christopher J; Turner, Ryan C; Robson, Matthew J (2022. ) Effect of driver gas composition on production of scaled Friedlander waveforms in an open-ended shock tube model.Biomedical physics & engineering express, , 8 (6 ) , More Information

O'Connell, Christopher J; Reeder, Evan L; Collins, Sean M; Lungani, Kainat; Norman, Sophia V; Robson, Matthew J (2022. ) Mild traumatic brain injury elicits time- and region-specific reductions in serotonin transporter protein expression and uptake capacity.Neuroreport, , 33 (14 ) ,612-616 More Information

Collins, Sean M; O'Connell, Christopher J; Reeder, Evan L; Norman, Sophia V; Lungani, Kainat; Gopalan, Poornima; Gudelsky, Gary A; Robson, Matthew J (2022. ) Altered Serotonin 2A (5-HT2A) Receptor Signaling Underlies Mild TBI-Elicited Deficits in Social Dominance.Frontiers in pharmacology, , 13 ,930346 More Information

Ren, Jiafa; Lu, Xiaohan; Hall, Gentzon; Privratsky, Jamie R; Robson, Matthew J; Blakely, Randy D; Crowley, Steven D (2022. ) IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.American journal of physiology. Renal physiology, , 322 (2 ) ,F164-F174 More Information

Logsdon, Aric F; Lucke-Wold, Brandon P; Turner, Ryan C; Collins, Sean M; Reeder, Evan L; Huber, Jason D; Rosen, Charles L; Robson, Matthew J; Plattner, Florian (2020. ) Low-intensity Blast Wave Model for Preclinical Assessment of Closed-head Mild Traumatic Brain Injury in Rodents.Journal of visualized experiments : JoVE, , (165 ) , More Information

Sturchio, Andrea; Marsili, Luca; Vizcarra, Joaquin A; Dwivedi, Alok K; Kauffman, Marcelo A; Duker, Andrew P; Lu, Peixin; Pauciulo, Michael W; Wissel, Benjamin D; Hill, Emily J; Stecher, Benjamin; Keeling, Elizabeth G; Vagal, Achala S; Wang, Lily; Haslam, David B; Robson, Matthew J; Tanner, Caroline M; Hagey, Daniel W; El Andaloussi, Samir; Ezzat, Kariem; Fleming, Ronan M T; Lu, Long J; Little, Max A; Espay, Alberto J (2020. ) Phenotype-Agnostic Molecular Subtyping of Neurodegenerative Disorders: The Cincinnati Cohort Biomarker Program (CCBP).Frontiers in aging neuroscience, , 12 ,553635 More Information

Quinlan, Meagan A; Robson, Matthew J; Ye, Ran; Rose, Kristie L; Schey, Kevin L; Blakely, Randy D (2020. ) Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.Frontiers in molecular neuroscience, , 13 ,89 More Information

Thome, Jason G; Reeder, Evan L; Collins, Sean M; Gopalan, Poornima; Robson, Matthew J (2019. ) Contributions of Interleukin-1 Receptor Signaling in Traumatic Brain Injury.Frontiers in behavioral neuroscience, , 13 ,287 More Information

Khalid, Fatima; Yang, George L; McGuire, Jennifer L; Robson, Matthew J; Foreman, Brandon; Ngwenya, Laura B; Lorenz, John N (2019. ) Autonomic dysfunction following traumatic brain injury: translational insights.Neurosurgical focus, , 47 (5 ) ,E8 More Information

231 Albert Sabin Way
Cincinnati  Ohio, 45267-0514
Phone: 513-558-0333
Matthew.Robson@UC.edu

Research - Robson's Lab
231 Albert Sabin Way
Cincinnati  Ohio, 45229
http://pharmacy.uc.edu/research/robson_laboratory