Russell Patrick Sawyer , MD

MD: St. George's University Medical School Grenada, West Indies, 2013 (Medicine)

Bachelor of Science: University of California Davis Davis, CA, 2008 (Psychology, Minor-Neuroscience)

Residency: University of Cincinnati Medical Center Cincinnati, Ohio, 2016 (Neurology)

Fellowship: University of Cincinnati Medical Center Cincinnati, Ohio, 2017 (Behavioral Neurology)

American Board of Psychiatry and Neurology (Neurology) (Certification Date: 09-11-2017 )

United Council for Neurologic Subspecialties (Certification Date: 11-30-2018 )

Cognitive Aging

Cognitive Disorders

Internal Medicine

Neurology

Alzheimer's Disease

Amnesia

Aphasia

Chronic Traumatic Encephalopathy

Cognition Disorders

Dementia

Dysarthria

Early Anset Dementia

Epilepsy-Related Cognitive Dysfunction

Lewy Body Dementia

Lewy Body Disease

Mad Cow Disease (Creutzfeldt-Jakob disease)

Memory Disorders

Metabolic Brain Disease

Mild Cognitive Impairment

Multi-Infarct Dementia

Multiple System Atrophy (MSA)

Neuralgias

Neurogenic Inflammation

Neuropathic Facial Pain

Normal Pressure Hydrocephalus

Orthostatic Hypotension (Postural Hypotension)

Paraphasic Error

Paroxysmal Hemicrania

Pick's Disease (Frontotemporal dementia)

Posterior Cortical Atrophy

Postherpetic Neuralgia

Post-Traumatic Headache

Prion Disease

Pseudobulbar Palsy

Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)

Rare Cognitive Disorders

Stroke-Related Cognitive Dysfunction

Tauopathies

TDP-43 Proteinopathies

Vascular Cognitive Impairment

Vascular Dementia

Behavioral Neurology & Neuropsychiatry

Neurology

Dementia, Memory Disorder, Cognitive Behavioral

Grant: #R01AG072592 Investigators:Hyacinth, Hyacinth; Niu, Liang; Sawyer, Russell 09-15-2021 -05-31-2026 National Institute on Aging Cerebral small vessel disease burden and racial disparity in vascular cognitive impairment and Alzheimer's disease and its related dementias (transfer application) Role:Collaborator 1505134.00 Awarded Level:Federal

Grant: #AL002-2 (Invoke) 01-01-2023 -12-31-2025 PPD A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of AL002 in Participants with Early Alzheimer's Disease Role:PI 0.00 Hold Level:Industry

Grant: #AL002-2 (Invoke) 01-01-2023 -12-31-2025 PPD A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of AL002 in Participants with Early Alzheimer's Disease Role:PI 0.00 Hold Level:Industry

Grant: #Columbia; tba/tba Investigators:Sawyer, Russell 07-01-2023 -04-30-2026 National Institute on Aging Metformin in Alzheimer's dementia Prevention (MAP) Role:PI 244016.80 Hold Level:Federal

01-23-2024 -01-25-2027 PPD A Continuation Study of Latozinemab in Participants with Neurodegenerative Disease Role:PI 302631.81 Hold Level:Industry

01-23-2024 -01-25-2027 PPD A Continuation Study of Latozinemab in Participants with Neurodegenerative Disease Role:PI 302631.81 Hold Level:Industry

02-12-2024 -02-08-2027 IQVIA Clinical Trial Payments A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy, Safety, and Tolerability of BIIB080 in Subjects with Mild Cognitive Impairment Due to Alzheimer's Disease o Role:PI 372444.01 Active Level:Industry

02-12-2024 -02-08-2027 IQVIA Clinical Trial Payments A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy, Safety, and Tolerability of BIIB080 in Subjects with Mild Cognitive Impairment Due to Alzheimer's Disease o Role:PI 372444.01 Active Level:Industry

Grant: #1R01NS140155-01 Investigators:Demel, Stacie; Sawyer, Russell; Walsh, Kyle; Woo, Daniel -08-31-2028 National Institute of Neurological Disorders and Stroke Metabolomics of ICH recovery (METABOL-ICH) Role:Collaborator 0.00 Hold Level:Federal

Investigators:Sawyer, Russell 05-30-2024 -05-30-2028 PPD AL002: A Multicenter, Long Term Extension Study to Evaluate the safety, tolerability and efficacy of AL002 in Participants with Alzheimer's disease. Role:PI 111221.67 Hold Level:Industry

Grant: #tba, 2RF1NS041588-22A1 Investigators:Flaherty, Matthew; Hyacinth, Hyacinth I.; Kissela, Brett; Robinson, David; Sawyer, Russell; Stanton, Robert 09-17-2024 -08-31-2026 National Institute of Neurological Disorders and Stroke Understanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic Transitions Role:Collaborator 582232.00 Hold Level:Federal

Grant: #Check No. 118 11-01-2024 -10-31-2026 Local Initiative for Excellence (L.I.F.E.) The Role of Small Non-Coding RNA in Frontotemporal Dementia Role:PI 50000.00 Awarded Level:Non Profit

Grant: #Check No. 118 11-01-2024 -10-31-2026 Local Initiative for Excellence (L.I.F.E.) The Role of Small Non-Coding RNA in Frontotemporal Dementia Role:PI 50000.00 Awarded Level:Non Profit

Grant: #ALZ NET Investigators:Sawyer, Russell; Shatz, Rhonna; Timmerman, Emerlee 03-01-2025 -02-08-2026 Alzheimer's Association ALZ-NET Registry Role:Collaborator 59548.53 Hold Level:Non Profit

Grant: #PA-24-254_5R01AG062624-05 (LOG) Investigators:Sawyer, Russell 07-01-2025 -04-30-2026 Johns Hopkins University Metformin In Alzheimer's Dementia Prevention (MAP) Role:PI 105172.00 Hold Level:Higher Education

Grant: #TRC-PAD Down Syndrome Investigators:Sawyer, Russell; Wang, Lauren 07-01-2025 -06-30-2030 University of Southern California Alzheimers Clinical Trial Consortium ACTC Master Agrement Role:PI 0.00 Hold Level:Higher Education

Investigators:Sawyer, Russell 08-15-2025 -08-15-2028 IQVIA Clinical Trial Payments A Phase II, 26-week, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacokinetics, and efficacy of ONO-2020 in patients with mild to moderate Alzheimer's Disease Role:PI 6.75 Active Level:Industry

Grant: #14 (GG015822-13) CR PRIME G20123 Investigators:Sawyer, Russell 05-01-2025 -04-30-2026 National Institute on Aging Metformin in Alzheimer's dementia Prevention (MAP) Role:PI 20932.00 Hold Level:Federal

Grant: #USC_5R33AG066543-05 Investigators:Sawyer, Russell; Wang, Lauren 09-01-2024 -08-31-2025 University of Southern California Clinical trials to prevent Alzheimer's Disease in Down Syndrome Role:PI 306000.00 Hold Level:Higher Education

Grant: #1R01NS147345-01 12-01-2025 -11-30-2030 National Institute of Neurological Disorders and Stroke Proteomics and Cognitive Decline Following Intracerebral Hemorrhage Role:PI 0.00 Hold Level:Federal

Grant: #1R01NS147345-01 12-01-2025 -11-30-2030 National Institute of Neurological Disorders and Stroke Proteomics and Cognitive Decline Following Intracerebral Hemorrhage Role:PI 0.00 Hold Level:Federal

Grant: #5R01AG063826 Investigators:Sawyer, Russell 05-01-2025 -04-30-2026 National Institute on Aging Allopregnanolone as Regenerative Therapeutic for Alzheimer's: Phase 2 Clinical Trial Role:PI 39233.35 Hold Level:Federal

Investigators:Sawyer, Russell 11-11-2025 -11-10-2030 Eli Lilly and Company A Randomized, Double-Blind, Placebo-Controlled, Phase 4 Dose-Escalation Study Evaluating the Safety, Tolerability, and Efficacy of Donanemab in adults with Down Syndrome Role:PI 195408.01 Hold Level:Industry

Peer Reviewed Publications

Sawyer, Russell P; Rodriguez-Porcel, Federico; Hagen, Matthew; Shatz, Rhonna; Espay, Alberto J (2017. ) Diagnosing the frontal variant of Alzheimer's disease: a clinician's yellow brick road.Journal of clinical movement disorders, , 4 ,2 More Information

Sawyer, Russell P; Sekar, Padmini; Osborne, Jennifer; Kittner, Steven J; Moomaw, Charles J; Flaherty, Matthew L; Langefeld, Carl D; Anderson, Christopher D; Rosand, Jonathan; Woo, Daniel (2018. ) Racial/ethnic variation of APOE alleles for lobar intracerebral hemorrhage.Neurology, , More Information

Merola, Aristide; Sawyer, Russell P; Artusi, Carlo Alberto; Suri, Ritika; Berndt, Zoe; Lopez-Castellanos, Jose' Ricardo; Vaughan, Jennifer; Vizcarra, Joaquin A; Romagnolo, Alberto; Espay, Alberto J (2018. ) Orthostatic hypotension in Parkinson disease: Impact on health care utilization.Parkinsonism & related disorders, , 47 ,45-49 More Information

Kim, Daeeun; McInerney, Katelyn; Dagli, Chaitali; Armstrong, Nicole D; Cushman, Mary; Bennett, Aleena; Blue, Elizabeth E; Sofer, Tamar; Sawyer, Russell P; Yuan, Ya; Crowe, Michael; Judd, Suzanne E; Olson, Nels C; Irvin, Marguerite R; Raffield, Laura M (2026. ) Influence of Cardiometabolic and Alzheimer Disease Genetics on Cognitive-Related Outcomes in a Diverse Population.Neurology, , 107 (1 ) ,e218163 More Information

Bowers, Katherine; Bhoopathy, Krishna; Szczesniak, Rhonda; Sawyer, Russell P; Shah, Amy S; Ehrlich, Shelley; Dolan, Lawrence M; Summer, Suzanne; Smith, Emily; Altaye, Mekibib; Ollberding, Nicholas J; Catalano, Patrick; Khoury, Jane C (2026. ) Long-Term Effects of Maternal Glycemic Measures in Pregnancy and Offspring Adverse Glycemic Outcomes: Results from the TEAM Study.American journal of perinatology, , 43 (8 ) ,1082-1090 More Information

Sawyer, Russell P; Blair, Jessica; Judd, Suzanne E; Olson, Nels C; Howard, Virginia J; Armstrong, Nicole D; Long, D Leann; Hyacinth, Hyacinth I; Sargent, Lana; Manly, Jennifer J; Cushman, Mary (2026. ) Circulating Biomarkers of Neurodegeneration and All-Cause and Dementia-Specific Mortality.Neurology, , 106 (7 ) ,e214752 More Information

Sawyer, Russell P; Bennett, Aleena; Blair, Jessica; Judd, Suzanne E; Olson, Nels; Howard, Virginia J; Armstrong, Nicole D; Long, D Leann; Hyacinth, Hyacinth I; Manly, Jennifer J; Cushman, Mary (2025. ) Circulating Biomarkers of Neurodegeneration and Risk of Cognitive Impairment.Neurology, , 105 (4 ) ,e213935 More Information

Hill, Emily J; Marcucci, Samuel Blaise; DeLano, Kelly; Abanto, Jesus; Sawyer, Russell P; Marsili, Luca; Duque, Kevin R; Sun, Qin; Woo, Daniel; Langefeld, Carl D; Hall, Deborah A; Skirpan, Dawn; Paredes, Nathaly Chinchihualpa; Spikes, Cynthia; Bajaj, Deepa Agrawal; Gregor, Nathan; Stivers, Shea; Mahajan, Abhimanyu; Woo, Jessica G; Espay, Alberto J (2025. ) Community Disadvantage Is Associated With More Severe Motor Symptoms in Parkinson Disease.Neurology. Clinical practice, , 15 (4 ) ,e200506 More Information

DeLano, Kelly; Sprague, Alex C; Jandarov, Roman; Jackson, Brian P; Shatz, Rhonna; Langevin, Scott M; Sawyer, Russell P (2025. ) Association of plasma concentration of trace metals with frontotemporal degeneration.Frontiers in neurology, , 16 ,1593821 More Information

Thacker, Evan L; Karki, Reena; Gabor, Rachel; Blades, Natalie J; Sawyer, Russell P; Kouambo Beckodro, Cyrille N; Preece, Quinn; Prince, Samuel; Smith, McKay M; Gillett, Sarah R; Judd, Suzanne E; Kennedy, Richard E; Kizer, Jorge R; Levine, Deborah A; McClellan, William M; Kurella Tamura, Manjula; Unverzagt, Frederick W; Wadley, Virginia G; Cushman, Mary (2025. ) Leptin, adiponectin, body mass index, and incident cognitive impairment.Journal of Alzheimer's disease : JAD, , 105 (1 ) ,90-106 More Information

Behymer, Tyler P; Sekar, Padmini; Demel, Stacie L; Aziz, Yasmin N; Coleman, Elisheva R; Williamson, Brady J; Stanton, Robert J; Sawyer, Russell P; Turner, Ashby C; Vagal, Vaibhav S; Osborne, Jennifer; Gilkerson, Lee A; Comeau, Mary E; Flaherty, Matthew L; Langefeld, Carl D; Woo, Daniel (2025. ) Psychosocial Stress and Risk for Intracerebral Hemorrhage in the ERICH (Ethnic/Racial Variations of Intracerebral Hemorrhage) Study.Journal of the American Heart Association, , 14 (6 ) ,e024457 More Information

Del Bene, Victor A; Howard, George; Gropen, Toby I; Lyerly, Michael J; Howard, Virginia J; Sawyer, Russell P; Lazar, Ronald M (2025. ) Cognitive Decline After First-Time Transient Ischemic Attack.JAMA neurology, , 82 (4 ) ,323-32 More Information

Khatri, Pooja; Sucharew, Heidi; Sawyer, Russell P; Khandwala, Vivek; Wang, Lily Li-Li; Cornelius, Rebecca; Gaskill-Shipley, Mary; Tomsick, Thomas A; Wang, David; Gangatirkar, Shantala; Williamson, Brady Jamal; Maloney, Thomas; Horn, Paul; Carrozzella, Janice; Alwell, Kathleen; Haverbusch, Mary; Kissela, Brett M; Vagal, Achala (2025. ) Assessing Population-Based Radiological Brain Health in Stroke Epidemiology: Rationale and Design.Cerebrovascular diseases (Basel, Switzerland), , 54 (6 ) ,901-909 More Information

Sawyer, Russell P; Blair, Jessica; Shatz, Rhonna; Manly, Jennifer J; Judd, Suzanne E (2024. ) Association of Adherence to a MIND-Style Diet With the Risk of Cognitive Impairment and Decline in the REGARDS Cohort.Neurology, , 103 (8 ) ,e209817 More Information

Karkoska, Kristine A; Gollamudi, Jahnavi; Sawyer, Russell P; Woo, Daniel; Hyacinth, Hyacinth I (2024. ) Quantifying dilated perivascular spaces in children with sickle cell disease.Pediatric blood & cancer, , 71 (9 ) ,e31150 More Information

Doran, Sarah J; Sawyer, Russell P (2024. ) Risk factors in developing amyloid related imaging abnormalities (ARIA) and clinical implications.Frontiers in neuroscience, , 18 ,1326784 More Information

Sawyer, Russell P; Bennett, Aleena; Blair, Jessica; Molano, Jennifer; Timmerman, Emerlee; Foster, Forrest; Karkoska, Kristine; Hyacinth, Hyacinth I; Manly, Jennifer J; Howard, Virginia J; Petrov, Megan E; Hoffmann, Coles M; Yu, Fang; Demel, Stacie L; Aziz, Yasmin; Hooper, Destiny; Hill, Emily J; Johnson, Jamelle; Pounders, Johnson; Shatz, Rhonna (2023. ) History of obstructive sleep apnea associated with incident cognitive impairment in white but not black individuals in a US national cohort study.Sleep medicine, , 112 ,1-8 More Information

Sawyer, Russell P; Worrall, Bradford B; Howard, Virginia J; Crowe, Michael G; Howard, George; Hyacinth, Hyacinth I (2023. ) Methods of a Study to Assess the Contribution of Cerebral Small Vessel Disease and Dementia Risk Alleles to Racial Disparities in Vascular Cognitive Impairment and Dementia.Journal of the American Heart Association, , 12 (17 ) ,e030925 More Information

Hill, Emily J; Sharma, Jennifer; Wissel, Benjamin; Sawyer, Russell P; Jiang, Megan; Marsili, Luca; Duque, Kevin; Botsford, Vanesa; Wood, Christopher; DeLano, Kelly; Sun, Qin; Kissela, Brett; Espay, Alberto J (2023. ) Parkinson's disease diagnosis codes are insufficiently accurate for electronic health record research and differ by race.Parkinsonism & related disorders, , 114 ,105764 More Information

Bonham, Luke W; Geier, Ethan G; Sirkis, Daniel W; Leong, Josiah K; Ramos, Eliana Marisa; Wang, Qing; Karydas, Anna; Lee, Suzee E; Sturm, Virginia E; Sawyer, Russell P; Friedberg, Adit; Ichida, Justin K; Gitler, Aaron D; Sugrue, Leo; Cordingley, Michael; Bee, Walter; Weber, Eckard; Kramer, Joel H; Rankin, Katherine P; Rosen, Howard J; Boxer, Adam L; Seeley, William W; Ravits, John; Miller, Bruce L; Yokoyama, Jennifer S (2023. ) Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 43 (2 ) ,333-345 More Information

Sawyer, Russell P; Pun, Sirjana; Karkoska, Kristine A; Clendinen, Cherita A; DeBaun, Michael R; Gutmark, Ephraim; Barrile, Riccardo; Hyacinth, Hyacinth I (2022. ) Effect of Blood Transfusion on Cerebral Hemodynamics and Vascular Topology Described by Computational Fluid Dynamics in Sickle Cell Disease Patients.Brain sciences, , 12 (10 ) , More Information

Sawyer, Russell P; Stone, Hillarey K; Salim, Hanan; Lu, Xiaoming; Weirauch, Matthew T; Kottyan, Leah (2022. ) Frontotemporal degeneration genetic risk loci and transcription regulation as a possible mechanistic link to disease risk.Medicine, , 101 (41 ) ,e31078 More Information

Pounders, Jonathan; Hill, Emily J; Hooper, Destiny; Zhang, Xiang; Biesiada, Jacek; Kuhnell, Damaris; Greenland, Hannah L; Esfandiari, Leyla; Timmerman, Emerlee; Foster, Forrest; Wang, Chenran; Walsh, Kyle B; Shatz, Rhonna; Woo, Daniel; Medvedovic, Mario; Langevin, Scott; Sawyer, Russell P (2022. ) MicroRNA expression within neuronal-derived small extracellular vesicles in frontotemporal degeneration.Medicine, , 101 (40 ) ,e30854 More Information

Sawyer, Russell P; Demel, Stacie L; Comeau, Mary E; Marion, Miranda; Rosand, Jonathan; Langefeld, Carl D; Woo, Daniel (2022. ) Alzheimer's disease related single nucleotide polymorphisms and correlation with intracerebral hemorrhage incidence.Medicine, , 101 (39 ) ,e30782 More Information

Boyne, Pierce; Doren, Sarah; Scholl, Victoria; Staggs, Emily; Whitesel, Dustyn; Carl, Daniel; Shatz, Rhonna; Sawyer, Russell; Awosika, Oluwole O; Reisman, Darcy S; Billinger, Sandra A; Kissela, Brett; Vannest, Jennifer; Dunning, Kari (2022. ) Preliminary Outcomes of Combined Treadmill and Overground High-Intensity Interval Training in Ambulatory Chronic Stroke.Frontiers in neurology, , 13 ,812875 More Information

Sawyer, Russell P; Hill, Emily J; Yokoyama, Jennifer; Medvedovic, Mario; Ren, Yan; Zhang, Xiang; Choubey, Divaker; Shatz, Rhonna S; Miller, Bruce; Woo, Daniel (2022. ) Differences in peripheral immune system gene expression in frontotemporal degeneration.Medicine, , 101 (3 ) ,e28645 More Information

Sawyer, Russell P; Yim, Eunji; Coleman, Elisheva; Demel, Stacie L; Sekar, Padmini; Woo, Daniel (2021. ) Impact of Preexisting Cognitive Impairment and Race/Ethnicity on Functional Outcomes Following Intracerebral Hemorrhage.Stroke, , 52 (2 ) ,603-610 More Information

Vagal, Vaibhav; Venema, Simone U; Behymer, Tyler P; Mistry, Eva A; Sekar, Padmini; Sawyer, Russell P; Gilkerson, Lee; Moomaw, Charles J; Haverbusch, Mary; Coleman, Elisheva R; Flaherty, Matthew L; Van Sanford, Carson; Stanton, Robert J; Anderson, Christopher; Rosand, Jonathan; Woo, Daniel (2020. ) White Matter Lesion Severity is Associated with Intraventricular Hemorrhage in Spontaneous Intracerebral Hemorrhage.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, , 29 (5 ) ,104661 More Information

Academic - Stetson Building
Suite 2300
Cincinnati  Ohio, 45219
Phone: 513-558-2968
russell.sawyer@uc.edu