Dorothy M. Supp , PHD

Areas of Specialization - bioengineering of human skin for improved wound healing, cutaneous gene therapy, molecular analysis of abnormal scarring, in vitro models for skin cancer research

Bachelor's Degree: Cornell University, College of Agriculture and Life Sciences Ithaca, New York,

Doctoral Degree: University of Cincinnati College of Medicine Cincinnati, Ohio, 1994 (Developmental Biology)

Fellowship: Childrens Hospital Research Foundation Cincinnnati, 1997 (Postdoctoral )

Fellowship: Shriners Hospitals for Children Cincinnati, OH , (Research Fellowship )

Wound healing, abnormal scarring (keloids, hypertrophic scars), cutaneous disease, skin tissue engineering.

2021 - Adjunct Professor, Department of Surgery, Division of Plastic, Reconstructive, and Hand Surgery/Burn Surgery, University of Cincinnati College of Medicine,

Grant: #R01 GM079542 Investigators:Bailey, John; Boyce, Steven; Kagan, Richard; Supp, Dorothy; Warner, Petra; Yakuboff, Kevin 09-04-2007 -08-31-2012 National Institute of General Medical Sciences Somatic Stem C ells in Engineered Human Skin Role:Collaborator $889,200.00 Active Level:Federal

Grant: #AFIRM Investigators:Boyce, Steven; Supp, Dorothy 03-10-2008 -06-30-2013 Department of the Army Medical Research and Materiel Command Armed Forces Institute For Regenerative Medicine (AFIRM) Role:Collaborator $1,224,151.00 Active Level:Federal

Grant: #TECH 09-006 Investigators:Boyce, Steven; Supp, Dorothy 08-01-2008 -06-30-2012 Ohio Department of Development Engineered Skin Substitutes Containing Mesenchymal Stem Cells Role:Collaborator $750,000.00 Active Level:State of Ohio

Grant: #R01 ES017561 Investigators:Abdelmalek, Zalfa; Kadekaro, Ana Luisa; Supp, Dorothy 07-20-2009 -04-30-2014 National Institute of Environmental Health Sciences Impact of MC 1R Functional Variants on the DNA Damage Response of Human Melanocytes Role:Collaborator $1,795,727.00 Active Level:Federal

Grant: #3 R01 GM079542-03S1 Investigators:Boyce, Steven; Supp, Dorothy 09-30-2009 -08-31-2012 National Institute of General Medical Sciences R01 GM79542 Somatic Stem Cells in Engineered Human Skin Administrative Supplement Role:Collaborator $246,973.00 Active Level:Federal

Grant: #URC Interdisciplinary Award AY2015-16 Investigators:Boyce, Steven; Supp, Dorothy; Zhang, Yuhang 05-01-2016 -04-30-2017 UC's University Research Council ENGINEERING HAIR FOLLICLE REGENERATION BY TARGETING DERMAL SHEATH CELLS Role:Collaborator $25,000.00 Active Level:Internal UC

Grant: #R21AR0173380 Investigators:Boyce, Steven; Supp, Dorothy; Zhang, Yuhang 04-01-2018 -03-31-2020 National Institute of Arthritis, Musculoskeletal and Skin Disease Reprogramming the dermal microenvironment to induce hair follicle neogenesis in engineered skin Role:Collaborator $211,043.00 Awarded Level:Federal

Grant: #VA IPA Supp Investigators:Supp, Dorothy 04-01-2020 -03-31-2021 Department of Veterans Affairs VA IPA Supp Role:PI $8,316.00 Active Level:Federal

Grant: #2020 Industry Sponsored Research Agreement Investigators:Supp, Dorothy 12-01-2020 -05-30-2021 Redx Pharma Plc Collaboration to determine efficacy of Redx Pharma proprietary agents as treatments for Keloids Role:PI $79,032.65 Awarded Level:Foreign Industry

Grant: #Shriners 72005-CIN-21 Investigators:Supp, Dorothy 01-01-2021 -12-31-2021 Shriners Hospitals for Children - Cincinnati The Role of Vitamin D and the Vitamin D Receptor in Fibrotic Wound Healing Role:PI $257,935.00 Awarded Level:Private Non-Profit

Grant: #Shriners Epidermolysis Investigators:Supp, Dorothy 01-01-2021 -12-31-2021 Shriners Hospital for Children - International Headquarters Correction of Epidermolysis Bullosa via Genome Editing and Tissue Engineering Role:PI $224,472.00 Active Level:Private Non-Profit

Grant: #Shriners 71012-CIN-20 Investigators:Supp, Dorothy 01-01-2021 -12-31-2021 Shriners Hospital for Children - International Headquarters Personalized Ablative Laser Therapy: A New Strategy for Effective Scar Reduction Role:PI $74,226.00 Active Level:Private Non-Profit

Grant: #PR221734P1 Investigators:Supp, Dorothy 09-01-2023 -08-31-2026 Department of the Army Medical Research Acquisition Activity Tissue Engineering for Cutaneous and Systemic Epidermolysis Bullosa Gene Therapy Role:PI 1558753.00 Hold Level:Federal

Grant: #R01AR077238 Investigators:Supp, Dorothy; Xie, Changchun; Zhang, Yuhang 02-04-2021 -11-30-2025 National Institute of Arthritis, Musculoskeletal and Skin Disease Multiscale modeling of an inductive hair follicle microenvironment in engineered skin substitute Role:Collaborator $364,613.00 Awarded Level:Federal

Grant: #TBD / R01AR080946 Investigators:Supp, Dorothy 08-15-2023 -06-30-2024 National Institute of Arthritis, Musculoskeletal and Skin Disease In Situ Skin Regeneration for Full Thickness Burn Injuries Role:PI 66465.77 Hold Level:Federal

Grant: #R01AR077238 Investigators:Supp, Dorothy; Xie, Changchun; Zhang, Yuhang 02-01-2021 -11-30-2025 National Institute of Arthritis, Musculoskeletal and Skin Disease Multiscale modeling of an inductive hair follicle microenvironment in engineered skin substitute Role:Collaborator $364,613.00 Awarded Level:Federal

Grant: #prepare reverse agreement_TECG20232883 Investigators:Supp, Dorothy 09-25-2023 -09-24-2024 Ohio Department of Development Development of LK 467, a tetrapeptide MC1R agonist, for sunless tanning Role:PI 120000.00 Hold Level:Ohio, State of

Grant: #R21AR078976 Investigators:Boyce, Steven; Supp, Dorothy; Zhang, Yuhang 04-12-2021 -03-31-2023 National Institute of Arthritis, Musculoskeletal and Skin Disease Reprogramming of human fibroblasts into inductive dermal papilla cells Role:Collaborator 213345.00 Awarded Level:Federal

Grant: #MC1R (R41AR083311) Investigators:Supp, Dorothy 09-22-2023 -08-14-2024 National Institute of Arthritis, Musculoskeletal and Skin Disease Vitiligo topical treatment applying a potent, highly selective MC1R agonist Role:PI 88777.00 Hold Level:Federal

Grant: #Shriners 71003 Investigators:Supp, Dorothy 01-01-2022 -12-31-2024 Shriners Hospital for Children - International Headquarters In Situ Skin Regeneration for Full Thickness Burn Injuries Role:PI 45581.00 Hold Level:Non Profit

Grant: #GR133079 Investigators:Supp, Dorothy 08-15-2023 -06-30-2028 National Institute of Arthritis, Musculoskeletal and Skin Disease In Situ Skin Regeneration for Full Thickness Burn Injuries Role:PI 61543.00 Hold Level:Federal

Grant: #R21NS130138 Investigators:Berta, Temugin; Davidson, Steve; Supp, Dorothy 09-08-2022 -08-31-2024 National Institute of Neurological Disorders and Stroke Genetic and physiological comparison of native human sensory neurons and induced pluripotent stem cells differentiated to sensory neurons Role:Collaborator 445500.00 Awarded Level:Federal

Investigators:Supp, Dorothy 10-01-2024 -01-31-2025 Procter & Gamble Digital Accelerator at UC P&G Digital Accelerator@UC: Category B; Pilot study to screen primary skin cells for genetic risk factors for atopic dermatitis Role:PI 21087.59 Hold Level:Industry

Grant: #79143-OHI-25 Investigators:Supp, Dorothy 01-01-2025 -12-31-2028 Shriners Hospitals for Children - Cincinnati Laser-Assisted Combination Drug Therapy for Excessive Post-Burn Scarring in Children Role:PI 117809.00 Hold Level:Non Profit

01-21-2025 -01-20-2027 Murdoch University Bespoke antisense oligomer-mediated splice modulating therapies for recessive dystrophic epidermolysis bullosa patients Role:PI 149402.15 Hold Level:Higher Education

01-21-2025 -01-20-2027 Murdoch University Bespoke antisense oligomer-mediated splice modulating therapies for recessive dystrophic epidermolysis bullosa patients Role:PI 149402.15 Hold Level:Higher Education

Peer Reviewed Publications

Kim, Jayne Y; Willard, James J; Supp, Dorothy M; Roy, Sashwati; Gordillo, Gayle M; Sen, Chandan K; Powell, Heather M (2015. ) Burn Scar Biomechanics Following Pressure Garment Therapy.Plastic and reconstructive surgery, , More Information

Kim, J. Y.; Dunham, D. M.; Supp, D. M.; Sen, C. K.; Powell, H. M. (2016. ) Novel burn device for rapid, reproducible burn wound generation .Plast Reconstr Surg Glob Open, , 42 (2 ) ,384-391

Alexander, J Wesley; Supp, Dorothy M (2014. ) Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection.Advances in wound care, , 3 (11 ) ,682-690 More Information

Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Supp, D. M. (2016. ) Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-á1 .Burns Trauma, , 4 (2 ) ,30

Boyce, Steven T; Zimmerman, Rachel L; Supp, Dorothy M (2014. ) Tumorigenicity Testing in Athymic Mice of Cultured Human Melanocytes for Transplantation in Engineered Skin Substitutes.Cell transplantation, , More Information

Supp, D. M.; Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Lee, K. S.; Inceoglu, B.; Wan, D.; Boyce, S. T.; Hammock, B. D. (2016. ) Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes .Plast Reconstr Surg Glob Open, , 4 (12 ) ,e1151

Supp, Dorothy M; Hahn, Jennifer M; McFarland, Kevin L; Glaser, Kathryn Inhibition of hyaluronan synthase 2 reduces the abnormal migration rate of keloid keratinocytes.Journal of burn care & research : official publication of the American Burn Association, , 35 (1 ) ,84-92 More Information

Hahn, J. M.; Supp, D. M. (2017. ) Abnormal expression of the vitamin D receptor in keloid scars .Acta Biomater, , 43 (7 ) ,1506-1515

Osterburg, Andrew R; Hexley, Philip; Supp, Dorothy M; Robinson, Chad T; Noel, Greg; Ogle, Cora; Boyce, Steven T; Aronow, Bruce J; Babcock, George F (2013. ) Concerns over interspecies transcriptional comparisons in mice and humans after trauma.Proceedings of the National Academy of Sciences of the United States of America, , 110 (36 ) ,E3370 More Information

DeBruler, D. M.; Blackstone, B. N.; Baumann, M. E.; McFarland, K. L.; Wulff, B. C.; Wilgus, T. A.; Bailey, J. K.; Supp, D. M.; Powell, H. M. (2017. ) Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO2 laser treatment of scars .Acta Biomater, , 49 (7 ) ,675-685

Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Aronow, Bruce J; Boyce, Steven T; Supp, Dorothy M Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , 21 (4 ) ,530-44 More Information

Boyce, S. T.; Lloyd, C. M.; Kleiner, M. C.; Swope, V. B.; Abdel-Malek, Z.; Supp, D. M. (2017. ) Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in dermal-epidermal engineered skin substitutes .Acta Biomater, , 30 (6 ) ,531-540

Sriwiriyanont, Penkanok; Lynch, Kaari A; McFarland, Kevin L; Supp, Dorothy M; Boyce, Steven T (2013. ) Characterization of hair follicle development in engineered skin substitutes.PloS one, , 8 (6 ) ,e65664 More Information

Blackstone, B. N.; Kim, J. Y.; McFarland, K. L.; Sen, C. K.; Supp, D. M.; Bailey, J. K.; Powell, H. M. (2017. ) Scar formation following excisional and burn injuries in a red Duroc pig model .Wound Repair Regen., , 25 (4 ) ,618-631

Sriwiriyanont, Penkanok; Lynch, Kaari A; Maier, Elizabeth A; Hahn, Jennifer M; Supp, Dorothy M; Boyce, Steven T (2012. ) Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells.Experimental dermatology, , 21 (10 ) ,783-5 More Information

Sethuraman, S. A.; Gottschlich, M. M.; Supp, D. M.; Khoury, J.; Kagan, R. J. (2017. ) Vitamin D biomarkers associated with abnormal scar formation in pediatric burn patients .Acta Biomater, , 1 (1 ) ,78-87

Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A (2012. ) Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3.The Journal of investigative dermatology, , 132 (9 ) ,2255-62 More Information

DeBruler, D. M.; Zbinden, J. C.; Baumann, M. E.; Blackstone, B. N.; Malara, M. M.; Bailey, J. K.; Supp, D. M.; Powell, H. M. (2018. ) Early cessation of pressure garment therapy results in scar contraction and thickening .J Burn Care Res, , 13 (6 ) ,e0197558

Boyce, Steven T; Rice, Rachel K; Lynch, Kaari A; Supp, Andrew P; Swope, Viki B; Kagan, Richard J; Supp, Dorothy M Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , 20 (4 ) ,544-51 More Information

DeBruler, D. M.; Blackstone, B. N.; McFarland, K. L.; Baumann, M. E.; Supp, D. M.; Bailey, J. K.; Powell, H. M. (2018. ) Effect of skin graft thickness on scar development in a porcine burn model .J Burn Care Res, , 13 (17 ) ,10

Supp, Dorothy M; Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Boyce, Steven T (2012. ) Deep and superficial keloid fibroblasts contribute differentially to tissue phenotype in a novel in vivo model of keloid scar.Plastic and reconstructive surgery, , 129 (6 ) ,1259-71 More Information

Bailey, J. K.; Blackstone, B. N.; DeBruler, D. M.; Kim, J. Y.; Baumann, M. E.; McFarland, K. L.; Imeokparia, F. O.; Supp, D. M.; Powell, H. M. (2018. ) Effects of early combinatorial treatment of autologous split-thickness skin grafts in red duroc pig model using pulsed dye laser and fractional CO2 laser .Acta Biomater, , 50 (1 ) ,78-87

Supp, Dorothy M (2012. ) Genomic Reprogramming and Skin-Like Maturation of Engineered Human Skin Substitutes.Advances in wound care, , 1 (2 ) ,63-68 More Information

Blackstone, B. N.; Hahn, J. M.; McFarland, K. L.; DeBruler, D. M.; Supp, D. M.; Powell, H. M. (2018. ) Inflammatory response and biomechanical properties of coaxial scaffolds for engineered skin in vitro and post-grafting .Acta Biomater, , 80 (17 ) ,247-257

Supp, Dorothy M; Glaser, Kathryn; Hahn, Jennifer M; McFarland, Kevin L; Boyce, Steven T (2012. ) LETTER TO THE EDITOR Abnormal Responses of Keloid Tissue to Wounding Identified Using In Vitro Model System. Eplasty, , 12 ,e19

Malara, M. M.; Kim, J. Y.; Clark, J. A.; Blackstone, B. N.; Ruegsegger, M. A.; Bailey, J. K.; Supp, D. M.; Powell, H. M. (2018. ) Structural, Chemical, and Mechanical Properties of Pressure Garments as a Function of Simulated Use and Repeated Laundering .J Burn Care Res, , 39 (4 ) ,562-571

McFarland, Kevin L; Glaser, Kathryn; Hahn, Jennifer M; Boyce, Steven T; Supp, Dorothy M Culture medium and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts.Journal of burn care & research : official publication of the American Burn Association, , 32 (4 ) ,498-508 More Information

Supp, D. M. (2019. ) Animal Models for Studies of Keloid Scarring .Adv Wound Care (New Rochelle), , 8 (2 ) ,77-89

Powell, Heather M; McFarland, Kevin L; Butler, David L; Supp, Dorothy M; Boyce, Steven T (2010. ) Uniaxial strain regulates morphogenesis, gene expression, and tissue strength in engineered skin.Tissue engineering. Part A, , 16 (3 ) ,1083-92 More Information

Supp, D. M.; Hahn, J. M.; Combs, K. A.; McFarland, K. L.; Schwentker, A.; Boissy, R. E.; Boyce, S. T.; Powell, H. M.; Lucky, A. W. (2019. ) Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Formation in Bilayer Engineered Skin Substitutes .Burns, , 28 (9-10 ) ,1242-1256

Klingenberg, Jennifer M; McFarland, Kevin L; Friedman, Aaron J; Boyce, Steven T; Aronow, Bruce J; Supp, Dorothy M (2010. ) Engineered human skin substitutes undergo large-scale genomic reprogramming and normal skin-like maturation after transplantation to athymic mice.The Journal of investigative dermatology, , 130 (2 ) ,587-601 More Information

Hahn, J. M.; Combs, K. A.; Lloyd, C. M.; McFarland, K. L.; Boyce, S. T.; Supp, D. M. (2019. ) Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting to full thickness wounds .PLoS One, , 14 (3 ) ,e0213325

Supp, Dorothy M; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N (2009. ) Antibiotic resistance in clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to human beta defensin 4.Burns : journal of the International Society for Burn Injuries, , 35 (7 ) ,949-55 More Information

DeBruler, D. M.; Baumann, M. E.; Blackstone, B. N.; Zbinden, J. C.; McFarland, K. L.; Bailey, J. K.; Supp, D. M.; Powell, H. M. (2019. ) Role of Early Application of Pressure Garments following Burn Injury and Autografting .Plast Reconstr Surg, , 143 (2 ) ,310e-321e

McFarland, Kevin L; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M Expression of genes encoding antimicrobial proteins and members of the toll-like receptor/nuclear factor-kappaB pathways in engineered human skin.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , 16 (4 ) ,534-41 More Information

Malara, M. M.; Blackstone, B. N.; Baumann, M. E.; Bailey, J. K.; Supp, D. M.; Powell, H. M. (2020. ) Cultured Epithelial Autograft Combined with Micropatterned Dermal Template Forms Rete Ridges In Vivo .Tissue Eng Part A, , 26 (21-22 ) ,1138-1146

Kalyanaraman, Balaji; Supp, Dorothy M; Boyce, Steven T (2008. ) Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusion culture.Tissue engineering. Part A, , 14 (5 ) ,583-93 More Information

Baumann, M. E.; DeBruler, D. M.; Blackstone, B. N.; Coffey, R. A.; Boyce, S. T.; Supp, D. M.; Bailey, J. K.; Powell, H. M. (2020. ) Direct comparison of reproducibility and reliability in quantitative assessments of burn scar properties .Burns, , 102 (3-4 ) ,287-297

Powell, Heather M; Supp, Dorothy M; Boyce, Steven T (2008. ) Influence of electrospun collagen on wound contraction of engineered skin substitutes.Biomaterials, , 29 (7 ) ,834-43 More Information

Boyce, S. T.; Supp, D. M.; Lloyd, C. M. (2020. ) Exogenous Keratinocyte Growth Factor Is Not Required for Pigmentation of Skin Substitutes with Three Isogeneic Cell Types .Tissue Eng Part A, , 26 (3-4 ) ,214-224

Fang, Cheng-Hui; Li, Bingguo; James, J Howard; Yahya, Ayesha; Kadeer, Nijiati; Guo, Xialing; Xiao, Chun; Supp, Dorothy M; Kagan, Richard J; Hasselgren, Per-Olof; Sheriff, Sulaiman (2007. ) GSK-3beta activity is increased in skeletal muscle after burn injury in rats.American journal of physiology. Regulatory, integrative and comparative physiology, , 293 (4 ) ,R1545-51 More Information

Blackstone, B. N.; Malara, M. M.; Baumann, M. E.; McFarland, K. L.; Supp, D. M.; Powell, H. M. (2020. ) Fractional CO2 laser micropatterning of cell-seeded electrospun collagen scaffolds enables rete ridge formation in 3D engineered skin .Acta Biomater, , 102 (3-4 ) ,287-297

Supp, Dorothy M (2007. ) Gene therapy to fight infection in skin transplants.Pharmacogenomics, , 8 (5 ) ,483-6 More Information

DeBruler, D. M.; Baumann, M. E.; Zbinden, J. C.; Blackstone, B. N.; Bailey, J. K.; Supp, D. M.; Powell, H. M. (2020. ) Improved Scar Outcomes with Increased Daily Duration of Pressure Garment Therapy .Adv Wound Care (New Rochelle), , 9 (8 ) ,453-61

Smiley, Andrea K; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N; Supp, Dorothy M Expression of human beta defensin 4 in genetically modified keratinocytes enhances antimicrobial activity.Journal of burn care & research : official publication of the American Burn Association, , 28 (1 ) ,127-32 More Information

Supp, D. M.; Hahn, J. M.; Lloyd, C. M.; Combs, K. A.; Swope, V. B.; Abdel-Malek, Z.; Boyce, S. T. (2020. ) Light or Dark Pigmentation of Engineered Skin Substitutes Containing Melanocytes Protects Against Ultraviolet Light-Induced DNA Damage In Vivo .J Burn Care Res, , 41 (4 ) ,751-760

Smiley, Andrea K; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M (2006. ) Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting.Burns : journal of the International Society for Burn Injuries, , 32 (2 ) ,135-8 More Information

Satish, L.; Evdokiou, A.; Geletu, E.; Hahn, J. M.; Supp, D. M. (2020. ) Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes .Burns Trauma, , 8 (4 ) ,tkz007

Smiley, Andrea K; Klingenberg, Jennifer M; Aronow, Bruce J; Boyce, Steven T; Kitzmiller, W John; Supp, Dorothy M (2005. ) Microarray analysis of gene expression in cultured skin substitutes compared with native human skin.The Journal of investigative dermatology, , 125 (6 ) ,1286-301 More Information

Hahn, J. M.; McFarland, K. L.; Combs, K. A.; Anness, M. C.; Supp, D. M. (2021. ) Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin .Wound Repair Regen, , 29 (5 ) ,777-791

Supp, Dorothy M; Boyce, Steven T Engineered skin substitutes: practices and potentials.Clinics in dermatology, , 23 (4 ) ,403-12 More Information

Gibson, A. L. F.; Carney, B. C.; Cuttle, L.; Andrews, C. J.; Kowalczewski, C. J.; Liu, A.; Powell, H. M.; Stone, R.; Supp, D. M.; Singer, A. J.; Shupp, J. W.; Stalter, L.; Moffatt, L. T. (2021. ) Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models? .J Burn Care Res, , 42 (1 ) ,98-109

Supp, Andrew P; Neely, Alice N; Supp, Dorothy M; Warden, Glenn D; Boyce, Steven T Evaluation of cytotoxicity and antimicrobial activity of Acticoat Burn Dressing for management of microbial contamination in cultured skin substitutes grafted to athymic mice. The Journal of burn care & rehabilitation, , 26 (3 ) ,238-46

Ruiz-Torres, S.; Brusadelli, M. G.; Witte, D. P.; Wikenheiser-Brokamp, K. A.; Sauter, S.; Nelson, A. S.; Sertorio, M.; Chlon, T. M.; Lane, A.; Mehta, P. A.; Myers, K. C.; Bedard, M. C.; Pal, B.; Supp, D. M.; Lambert, P. F.; Komurov, K.; Kovacic, M. B.; Davies, S. M.; Wells, S. I. (2021. ) Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin .Cell Stem Cell, , 28 (3 ) ,424-435.e6

Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T (2004. ) Expression of human beta-defensins HBD-1, HBD-2, and HBD-3 in cultured keratinocytes and skin substitutes.Burns : journal of the International Society for Burn Injuries, , 30 (7 ) ,643-8 More Information

Supp, D. M.; Hahn, J. M.; Combs, K. A.; McFarland, K. L.; Powell, H. M. (2022. ) Isolation and feeder-free primary culture of four cell types from a single human skin sample .STAR Protoc, , 3 (1 ) ,101172

Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T Vascular endothelial growth factor overexpression increases vascularization by murine but not human endothelial cells in cultured skin substitutes grafted to athymic mice. The Journal of burn care & rehabilitation, , 25 (4 ) ,337-45

Bergmann, C. B.; McReynolds, C. B.; Wan, D.; Singh, N.; Goetzman, H.; Caldwell, C. C.; Supp, D. M.; Hammock, B. D. (2022. ) sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury .Proc Natl Acad Sci U S A, , 119 (13 ) ,e2120691119

Supp, Dorothy M; Wilson-Landy, Kaila; Boyce, Steven T (2002. ) Human dermal microvascular endothelial cells form vascular analogs in cultured skin substitutes after grafting to athymic mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology, , 16 (8 ) ,797-804 More Information

Supp, Dorothy M; Boyce, Steven T Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes. The Journal of burn care & rehabilitation, , 23 (1 ) ,10-20

Supp, D M; Supp, A P; Bell, S M; Boyce, S T (2000. ) Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor.The Journal of investigative dermatology, , 114 (1 ) ,5-13 More Information

Supp, D M; Bell, S M; Morgan, J R; Boyce, S T Genetic modification of cultured skin substitutes by transduction of human keratinocytes and fibroblasts with platelet-derived growth factor-A. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , 8 (1 ) ,26-35

Boyce S.T.;Supp D.M.;Lloyd C.M. (02-01-2020. ) Exogenous Keratinocyte Growth Factor Is Not Required for Pigmentation of Skin Substitutes with Three.Tissue Engineering - Part A, , 26 (3-4 ) ,214-224 More Information

Blackstone B.;Malara M.;Baumann M.;McFarland K.;Supp D.;Powell H. (01-15-2020. ) Fractional CO2 laser micropatterning of cell-seeded electrospun collagen scaf.Acta Biomaterialia, , 102 ,287-297 More Information

Supp D.M.;Hahn J.M.;Combs K.A.;McFarland K.L.;Schwentker A.;Boissy R.E.;Boyce S.T.;Powell H.M.;Lucky A.W. (09-01-2019. ) Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Forma.Cell Transplantation, , 28 (9-10 ) ,1242-1256 More Information

Hahn J.M.;Combs K.A.;Lloyd C.M.;McFarland K.L.;Boyce S.T.;Supp D.M. (03-01-2019. ) Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting.PLoS ONE, , 14 (3 ) , More Information

Supp D. (02-01-2019. ) Animal Models for Studies of Keloid Scarring.Advances in Wound Care, , 8 (2 ) ,77-89 More Information

Debruler D.;Baumann M.;Blackstone B.;Zbinden J.;McFarland K.;Bailey J.;Supp D.;Powell H. (02-01-2019. ) Role of Early Application of Pressure Garments following Burn Injury and Autografting.Plastic and Reconstructive Surgery, , 143 (2 ) ,310e-321e More Information

Baumann M.E.;Blackstone B.N.;Malara M.M.;Clairmonte I.A.;Supp D.M.;Bailey J.K.;Powell H.M. (01-01-2019. ) Fractional CO2 laser ablation of porcine burn scars after grafting: Is deeper.Burns, , More Information

Blackstone B.;Hahn J.;McFarland K.;DeBruler D.;Supp D.;Powell H. (10-15-2018. ) Inflammatory response and biomechanical properties of coaxial scaffolds for engineered skin in vitro.Acta Biomaterialia, , 80 ,247-257 More Information

Malara M.;Kim J.;Clark J.;Blackstone B.;Ruegsegger M.;Bailey J.;Supp D.;Powell H. (06-13-2018. ) Structural, Chemical, and Mechanical Properties of Pressure Garments as a Function of Simulated Use .Journal of Burn Care and Research, , 39 (4 ) ,562-571 More Information

DeBruler D.;Blackstone B.;McFarland K.;Baumann M.;Supp D.;Bailey J.;Powell H. (06-01-2018. ) Effect of skin graft thickness on scar development in a porcine burn model.Burns, , 44 (4 ) ,917-930 More Information

DeBruler D.;Zbinden J.;Baumann M.;Blackstone B.;Malara M.;Bailey J.;Supp D.;Powell H. (06-01-2018. ) Early cessation of pressure garment therapy results in scar contraction and thickening.PLoS ONE, , 13 (6 ) , More Information

Bailey J.;Blackstone B.;DeBruler D.;Kim J.;Baumann M.;McFarland K.;Imeokparia F.;Supp D.;Powell H. (01-01-2018. ) Effects of early combinatorial treatment of autologous split-thickness skin grafts in red duroc pig .Lasers in Surgery and Medicine, , 50 (1 ) ,78-87 More Information

Hahn J.;Supp D. (11-01-2017. ) Abnormal expression of the vitamin D receptor in keloid scars.Burns, , 43 (7 ) ,1506-1515 More Information

Boyce S.;Lloyd C.;Kleiner M.;Swope V.;Abdel-Malek Z.;Supp D. (11-01-2017. ) Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in d.Pigment Cell and Melanoma Research, , 30 (6 ) ,531-540 More Information

Lander J.;Supp D.;He H.;Martin L.;Chen X.;Weirauch M.;Boyce S.;Kopan R. (09-01-2017. ) Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensi.PLoS ONE, , 12 (9 ) , More Information

DeBruler D.;Blackstone B.;Baumann M.;McFarland K.;Wulff B.;Wilgus T.;Bailey J.;Supp D.;Powell H. (09-01-2017. ) Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO2&.Lasers in Surgery and Medicine, , 49 (7 ) ,675-685 More Information

Blackstone B.;Kim J.;McFarland K.;Sen C.;Supp D.;Bailey J.;Powell H. (07-01-2017. ) Scar formation following excisional and burn injuries in a red Duroc pig model.Wound Repair and Regeneration, , 25 (4 ) ,618-631 More Information

Supp D.;Boyce S. (04-19-2016. ) Bioengineering of human skin substitutes .Tissue Engineering and Artificial Organs, , 715-731

Kim J.;Dunham D.;Supp D.;Sen C.;Powell H. (03-01-2016. ) Novel burn device for rapid, reproducible burn wound generation.Burns, , 42 (2 ) ,384-391 More Information

Boyce S.;Supp D. (01-01-2016. ) Biologic Skin Substitutes.Skin Tissue Engineering and Regenerative Medicine, , 211-238 More Information

Supp D.M.;Hahn J.M.;McFarland K.L.;Combs K.A.;Lee K.S.S.;Inceoglu B.;Wan D.;Boyce S.T.;Hammock B.D. (01-01-2016. ) Soluble epoxide hydrolase inhibition and epoxyeicosatrienoic acid treatment improve vascularization .Plastic and Reconstructive Surgery - Global Open, , 4 (12 ) , More Information

Swope V.B.;Jameson J.A.;McFarland K.L.;Supp D.M.;Miller W.E.;McGraw D.W.;Patel M.A.;Nix M.A.;Millhauser G.L.;Babcock G.F.;Abdel-Malek Z.A. (01-01-2012. ) Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti s.Journal of Investigative Dermatology, , 132 (9 ) ,2255-2262 More Information

Supp D. (04-01-2011. ) Skin substitutes for burn wound healing: Current and future approaches.Expert Review of Dermatology, , 6 (2 ) ,217-227 More Information

Forouzandeh F.;Jalili R.;Hartwell R.;Allan S.;Boyce S.;Supp D.;Ghahary A. (11-01-2010. ) Local expression of indoleamine 2,3-dioxygenase suppresses T-cell-mediated rejection of an engineere.Wound Repair and Regeneration, , 18 (6 ) ,614-623 More Information

Kadekaro A.L.;Leachman S.;Kavanagh R.J.;Swope V.;Cassidy P.;Supp D.;Sartor M.;Schwemberger S.;Babcock G.;Wakamatsu K.;Ito S.;Koshoffer A.;Boissy R.E.;Manga P.;Sturm R.A.;Abdel-Malek Z.A. (01-01-2010. ) Melanocortin 1 receptor genotype: An important determinant of the damage response of melanocytes to .FASEB Journal, , 24 (10 ) ,3850-3860 More Information

Kalyanaraman B.;Supp D.;Boyce S. (05-01-2008. ) Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusio.Tissue Engineering - Part A., , 14 (5 ) ,583-593 More Information

Abdel-Malek Z.;Supp D. (02-01-2008. ) ?-Defensin 3: A novel and unexpected key that unlocks the melanocortin 1 receptor.Pigment Cell and Melanoma Research, , 21 (1 ) ,7-8 More Information

Supp D.;Neely A. (02-01-2008. ) Cutaneous antimicrobial gene therapy: Engineering human skin replacements to combat wound infection.Expert Review of Dermatology, , 3 (1 ) ,73-84 More Information

Supp D.;Boyce S. (01-01-2007. ) Bioengineering of human skin substitutes .Tissue Engineering, , 275-291

Hahn, Jennifer M; Combs, Kelly A; Powell, Heather M; Supp, Dorothy M (2023. ) A Role for Vitamin D and the Vitamin D Receptor in Keloid Disorder.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , More Information

Carney, Bonnie C; Bailey, John K; Powell, Heather M; Supp, Dorothy M; Travis, Taryn E (2023. ) Scar Management and Dyschromia: A Summary Report from the 2021 American Burn Association State of the Science Meeting.Journal of burn care & research : official publication of the American Burn Association, , 44 (3 ) ,535-545 More Information

Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Powell, Heather M; Supp, Dorothy M (2022. ) Myofibroblasts Are Not Characteristic Features of Keloid Lesions.Plastic and reconstructive surgery. Global open, , 10 (11 ) ,e4680 More Information

Burmeister, David M; Supp, Dorothy M; Clark, Richard A; Tredget, Edward E; Powell, Heather M; Enkhbaatar, Perenlei; Bohannon, Julia K; Cancio, Leopoldo C; Hill, David M; Nygaard, Rachel M (2022. ) Advantages and Disadvantages of Using Small and Large Animals in Burn Research: Proceedings of the 2021 Research Special Interest Group.Journal of burn care & research : official publication of the American Burn Association, , 43 (5 ) ,1032-1041 More Information

Bergmann, Christian B; McReynolds, Cindy B; Wan, Debin; Singh, Nalin; Goetzman, Holly; Caldwell, Charles C; Supp, Dorothy M; Hammock, Bruce D (2022. ) sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury.Proceedings of the National Academy of Sciences of the United States of America, , 119 (13 ) ,e2120691119 More Information

Supp, Dorothy M; Hahn, Jennifer M; Combs, Kelly A; McFarland, Kevin L; Powell, Heather M (2022. ) Isolation and feeder-free primary culture of four cell types from a single human skin sample.STAR protocols, , 3 (1 ) ,101172 More Information

Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Anness, Meridith C; Supp, Dorothy M (2021. ) Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , 29 (5 ) ,777-791 More Information

Bergmann, Christian B; Hammock, Bruce D; Wan, Debin; Gogolla, Falk; Goetzman, Holly; Caldwell, Charles C; Supp, Dorothy M (2021. ) TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function.Scientific reports, , 11 (1 ) ,16555 More Information

Ruiz-Torres, Sonya; Brusadelli, Marion G; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Sauter, Sharon; Nelson, Adam S; Sertorio, Mathieu; Chlon, Timothy M; Lane, Adam; Mehta, Parinda A; Myers, Kasiani C; Bedard, Mary C; Pal, Bidisha; Supp, Dorothy M; Lambert, Paul F; Komurov, Kakajan; Kovacic, Melinda Butsch; Davies, Stella M; Wells, Susanne I (2021. ) Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin.Cell stem cell, , 28 (3 ) ,424-435.e6 More Information

Powell, Heather M; Supp, Dorothy M; Bailey, J Kevin; Baumann, Molly E (2021. ) Response to the Letter to the Editor: Fractional CO2 laser ablation of porcine burn scars after grafting: Is deeper better?.Burns : journal of the International Society for Burn Injuries, , 47 (2 ) ,494-495 More Information

Baumann, Molly E; DeBruler, Danielle M; Blackstone, Britani N; Coffey, Rebecca A; Boyce, Steven T; Supp, Dorothy M; Bailey, J Kevin; Powell, Heather M (2021. ) Direct comparison of reproducibility and reliability in quantitative assessments of burn scar properties.Burns : journal of the International Society for Burn Injuries, , 47 (2 ) ,466-478 More Information

Gibson, Angela L F; Carney, Bonnie C; Cuttle, Leila; Andrews, Christine J; Kowalczewski, Christine J; Liu, Aiping; Powell, Heather M; Stone, Randolph; Supp, Dorothy M; Singer, Adam J; Shupp, Jeffrey W; Stalter, Lily; Moffatt, Lauren T (2021. ) Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models?.Journal of burn care & research : official publication of the American Burn Association, , 42 (1 ) ,98-109 More Information

Malara, Megan M; Blackstone, Britani N; Baumann, Molly E; Bailey, J Kevin; Supp, Dorothy M; Powell, Heather M (2020. ) Cultured Epithelial Autograft Combined with Micropatterned Dermal Template Forms Rete Ridges In Vivo.Tissue engineering. Part A, , 26 (21-22 ) ,1138-1146 More Information

Stevens, Mariana L; Zhang, Zhonghua; Johansson, Elisabet; Ray, Samriddha; Jagpal, Amrita; Ruff, Brandy P; Kothari, Arjun; He, Hua; Martin, Lisa J; Ji, Hong; Wikenheiser-Brokamp, Kathryn; Weirauch, Matthew T; Supp, Dorothy M; Biagini Myers, Jocelyn M; Khurana Hershey, Gurjit K (2020. ) Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.Nature communications, , 11 (1 ) ,4092 More Information

DeBruler, Danielle M; Baumann, Molly E; Zbinden, Jacob C; Blackstone, Britani N; Bailey, John Kevin; Supp, Dorothy M; Powell, Heather M (2020. ) Improved Scar Outcomes with Increased Daily Duration of Pressure Garment Therapy.Advances in wound care, , 9 (8 ) ,453-461 More Information

Supp, Dorothy M; Hahn, Jennifer M; Lloyd, Christopher M; Combs, Kelly A; Swope, Viki B; Abdel-Malek, Zalfa; Boyce, Steven T (2020. ) Light or Dark Pigmentation of Engineered Skin Substitutes Containing Melanocytes Protects Against Ultraviolet Light-Induced DNA Damage In Vivo.Journal of burn care & research : official publication of the American Burn Association, , 41 (4 ) ,751-760 More Information

Satish, Latha; Evdokiou, Alexander; Geletu, Eleni; Hahn, Jennifer M; Supp, Dorothy M (2020. ) Pirfenidone inhibits epithelial-mesenchymal transition in keloid keratinocytes.Burns & trauma, , 8 ,tkz007 More Information

Supp, Dorothy M (2019. ) Animal Models for Studies of Keloid Scarring.Advances in wound care, , 8 (2 ) ,77-89 More Information

Supp, Dorothy M; Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Lee, Kin Sing Stephen; Inceoglu, Bora; Wan, Debin; Boyce, Steven T; Hammock, Bruce D (2016. ) Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes.Plastic and reconstructive surgery. Global open, , 4 (12 ) ,e1151 More Information

Hahn, Jennifer M; McFarland, Kevin L; Combs, Kelly A; Supp, Dorothy M (2016. ) Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1.Burns & trauma, , 4 (1 ) ,30 More Information

Blackstone, Britani N; Malara, Megan M; Baumann, Molly E; McFarland, Kevin L; Supp, Dorothy M; Powell, Heather M (2023. ) Laser Micropatterning Promotes Rete Ridge Formation and Enhanced Engineered Skin Strength without Increased Inflammation.Bioengineering (Basel, Switzerland), , 10 (7 ) , More Information

Hahn, Jennifer M; Combs, Kelly A; Phillips, Caitlin M; Warner, Petra M; Qazi, Uzair A; Powell, Heather M; Supp, Dorothy M (2025. ) CYP24A1 is overexpressed in keloid keratinocytes and its inhibition alters profibrotic gene expression.Burns & trauma, , 13 ,tkae063 More Information

James, Andrew J; Torres-Guzman, Ricardo A; Chaker, Sara C; Sigel, Matthew E; Perdikis, Galen; Supp, Dorothy M; Dale Slater, Elizabeth L (2024. ) Global insights into keloid formation: An international systematic review of regional genetic risk factors and commonalities.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, , 32 (5 ) ,746-757 More Information

DeVore, Stanley B; Schuetz, Matthew; Alvey, Lauren; Lujan, Henry; Ochayon, David E; Williams, Lindsey; Chang, Wan Chi; Filuta, Alyssa; Ruff, Brandy; Kothari, Arjun; Hahn, Jennifer M; Brandt, Eric; Satish, Latha; Roskin, Krishna; Herr, Andrew B; Biagini, Jocelyn M; Martin, Lisa J; Cagdas, Deniz; Keles, Sevgi; Milner, Joshua D; Supp, Dorothy M; Khurana Hershey, Gurjit K (2024. ) Regulation of MYC by CARD14 in human epithelium is a determinant of epidermal homeostasis and disease.Cell reports, , 43 (8 ) ,114589 More Information

Cultured Skin Substitutes, Tissue Engineering, Gene Therapy, Wound Healing

Academic - University of Cincinnati College of Medicine
Department of Surgery
Cincinnati  Ohio, 45267
Phone: 5135584617
dorothy.supp@uc.edu