Bruce Trapnell , MD

Bachelor's Degree: University of Maryland 1978 (Biochemistry)

Master's Degree: George Washington University and National Heart Lung and Blood Institute, National Institutes of Health 1981 (Genetics)

Medical Degree: University of Maryland School of Medicine 1984

Internship: The Ohio State Unviersity Hospitals 1985 (Medicine )

Residency : The Ohio State Unviersity Hospitals 1987 (Medicine)

Visiting Residency: The Brompton Chest Hospital 1987 (Medicine )

Fellowship: Warren Grant Magnuson Clinical Center, NHLBI, NIH 1989 (Pulmonary Medicine )

Pulmonary Innate Immunity, Cystic Fibrosis, PAP, Alpha-1.

1989 -1991 Staff Investigator, Pulmonary Branch, NHLBI, NIH,

1991 -1992 Senior Staff Investigator (NIH Special Volunteer), Pulmonary Branch, NHLBI, NIH,

1994 -1997 Assistant Professor (Adjunct), Department of Medicine, Georgetown University Medical Center, Washington, DC

1997 -2004 Associate Professor, Departments of Medicine and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

2004 -To Present Professor, Departments of Medicine and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

1997 -2012 Cystic Fibrosis TDN Center, DFF Therapeutics Development Center Role:Co-PI $564,166

Grant: #R01 HL085453-01A1 2007 -2011 NIH/NHLBI Role of Anti-GM-CSF Antibodies in Myeloid Cell Function & Innate Immunity Role:PI $1,000,000

Grant: #R01 HL086598-01A1 2007 -2012 NIH/NHLBI Epidermal Growth Factor Receptor Activation in Pulmonary Fibrosis Role:Co-I

Grant: #1UL1 RR026314-01 Investigators:Heubi, Tsevat 2010 -2011 Novel Translational Therapies for Congenital PAP Role:PI

Grant: #R21 HL106134-01 2010 -2012 NIH/NHLBI Macrophage-Based Gene Therapy for Hereditary PAP Role:PI

Peer Reviewed Publications

Trapnell, Bruce C; Strausbaugh, Steven D; Woo, Marlyn S; Tong, Shin-Yir; Silber, Steven A; Mulberg, Andrew E; Leitz, Gerhard (2011. ) Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, , More Information

Flotte, Terence R; Trapnell, Bruce C; Humphries, Margaret; Carey, Brenna; Calcedo, Roberto; Rouhani, Farshid; Campbell-Thompson, Martha; Yachnis, Anthony T; Sandhaus, Robert A; McElvaney, Noel G; Mueller, Christian; Messina, Louis M; Wilson, James M; Brantly, Mark; Knop, David R; Ye, Guo-Jie; Chulay, Jeffrey David (2011. ) Phase 2 Clinical Trial of a Recombinant Adeno-associated Virus Vector Expressing Alpha 1 Antitrypsin: Interim Results.Human gene therapy, , More Information

Nylund, Cade M; D'Mello, Sharon; Kim, Mi-Ok; Bonkowski, Erin; Däbritz, Jan; Foell, Dirk; Meddings, Jon; Trapnell, Bruce C; Denson, Lee A (2011. ) Granulocyte macrophage-colony-stimulating factor autoantibodies and increased intestinal permeability in Crohn disease.Journal of pediatric gastroenterology and nutrition, , 52 (5 ) ,542-8 More Information

Wu, Huixing; Suzuki, Takuji; Carey, Brenna; Trapnell, Bruce C; McCormack, Francis X (2011. ) Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophages.The Journal of biological chemistry, , 286 (17 ) ,14932-40 More Information

McCormack, Francis X; Inoue, Yoshikazu; Moss, Joel; Singer, Lianne G; Strange, Charlie; Nakata, Koh; Barker, Alan F; Chapman, Jeffrey T; Brantly, Mark L; Stocks, James M; Brown, Kevin K; Lynch, Joseph P; Goldberg, Hilary J; Young, Lisa R; Kinder, Brent W; Downey, Gregory P; Sullivan, Eugene J; Colby, Thomas V; McKay, Roy T; Cohen, Marsha M; Korbee, Leslie; Taveira-DaSilva, Angelo M; Lee, Hye-Seung; Krischer, Jeffrey P; Trapnell, Bruce C (2011. ) Efficacy and safety of sirolimus in lymphangioleiomyomatosis.The New England journal of medicine, , 364 (17 ) ,1595-606 More Information

Luisetti, Maurizio; Bruno, Pierdonato; Kadija, Zamir; Suzuki, Takuji; Raffa, Salvatore; Torrisi, Maria Rosaria; Campo, Ilaria; Mariani, Francesca; Pozzi, Ernesto; Trapnell, Bruce C; Mariotta, Salvatore (2011. ) Relationship Among Diffuse Pulmonary Fibrosis, Alveolar Proteinosis And Anti-GM-CSF Autoantibodies.Respiratory care, , More Information

Duvoix, Annelyse; Miranda, Elena; Perez, Juan; Sorensen, Grith L; Holmskov, Uffe; Trapnell, Bruce C; Madsen, Jens; Clark, Howard W; Edwards, Lisa D; Miller, Bruce E; Tal-Singer, Ruth M; Lomas, David A (2011. ) Evaluation of full-length, cleaved and nitrosylated serum surfactant protein D as biomarkers for COPD.COPD, , 8 (2 ) ,79-95 More Information

Samson, Charles M; Jurickova, Ingrid; Molden, Erin; Schreiner, William; Colliver, Joshua; Bonkowski, Erin; Han, Xiaonan; Trapnell, Bruce C; Denson, Lee A (2011. ) Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice.Inflammatory bowel diseases, , More Information

D'Mello, Sharon; Trauernicht, Anna; Ryan, Anne; Bonkowski, Erin; Willson, Tara; Trapnell, Bruce C; Frank, Stuart J; Kugasathan, Subra; Denson, Lee A (2011. ) Innate dysfunction promotes linear growth failure in pediatric Crohn's disease and growth hormone resistance in murine ileitis.Inflammatory bowel diseases, , More Information

Luisetti, Maurizio; Kroneberg, Philipp; Suzuki, Takuji; Kadija, Zamir; Muellinger, Bernhard; Campo, Ilaria; Gleske, Juliane; Rodi, Giuseppe; Zimlich, William C; Mariani, Francesca; Ferrari, Fabio; Frey, Manuel; Trapnell, Bruce C (2011. ) Physical properties, lung deposition modeling, and bioactivity of recombinant GM-CSF aerosolised with a highly efficient nebulizer.Pulmonary pharmacology & therapeutics, , 24 (1 ) ,123-7 More Information

Suzuki, Takuji; Sakagami, Takuro; Young, Lisa R; Carey, Brenna C; Wood, Robert E; Luisetti, Maurizio; Wert, Susan E; Rubin, Bruce K; Kevill, Katharine; Chalk, Claudia; Whitsett, Jeffrey A; Stevens, Carrie; Nogee, Lawrence M; Campo, Ilaria; Trapnell, Bruce C (2010. ) Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy.American journal of respiratory and critical care medicine, , 182 (10 ) ,1292-304 More Information

Young, Lisa R; Vandyke, Rhonda; Gulleman, Peter M; Inoue, Yoshikazu; Brown, Kevin K; Schmidt, Laura S; Linehan, W Marston; Hajjar, Fuad; Kinder, Brent W; Trapnell, Bruce C; Bissler, John J; Franz, David N; McCormack, Francis X (2010. ) Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases.Chest, , 138 (3 ) ,674-81 More Information

Watanabe, Masato; Uchida, Kanji; Nakagaki, Kazuhide; Trapnell, Bruce C; Nakata, Koh (2010. ) High avidity cytokine autoantibodies in health and disease: pathogenesis and mechanisms.Cytokine & growth factor reviews, , 21 (4 ) ,263-73 More Information

Han, Xiaonan; Gilbert, Shila; Groschwitz, Katherine; Hogan, Simon; Jurickova, Ingrid; Trapnell, Bruce; Samson, Charles; Gully, Jonathan (2010. ) Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury.Gut, , 59 (8 ) ,1066-78 More Information

Luisetti, Maurizio; Kadija, Zamir; Mariani, Francesca; Rodi, Giuseppe; Campo, Ilaria; Trapnell, Bruce C (2010. ) Therapy options in pulmonary alveolar proteinosis.Therapeutic advances in respiratory disease, , 4 (4 ) ,239-48 More Information

Sakagami, Takuro; Beck, David; Uchida, Kanji; Suzuki, Takuji; Carey, Brenna C; Nakata, Koh; Keller, Gary; Wood, Robert E; Wert, Susan E; Ikegami, Machiko; Whitsett, Jeffrey A; Luisetti, Maurizio; Davies, Stella; Krischer, Jeffrey P; Brody, Alan; Ryckman, Fred; Trapnell, Bruce C (2010. ) Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates.American journal of respiratory and critical care medicine, , 182 (1 ) ,49-61 More Information

Tazawa, Ryushi; Trapnell, Bruce C; Inoue, Yoshikazu; Arai, Toru; Takada, Toshinori; Nasuhara, Yasuyuki; Hizawa, Nobuyuki; Kasahara, Yasunori; Tatsumi, Koichiro; Hojo, Masayuki; Ishii, Haruyuki; Yokoba, Masanori; Tanaka, Naohiko; Yamaguchi, Etsuro; Eda, Ryosuke; Tsuchihashi, Yoshiko; Morimoto, Konosuke; Akira, Masanori; Terada, Masaki; Otsuka, Junji; Ebina, Masahito; Kaneko, Chinatsu; Nukiwa, Toshihiro; Krischer, Jeffrey P; Akazawa, Kohei; Nakata, Koh (2010. ) Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis.American journal of respiratory and critical care medicine, , 181 (12 ) ,1345-54 More Information

Carey, Brenna; Trapnell, Bruce C (2010. ) The molecular basis of pulmonary alveolar proteinosis.Clinical immunology (Orlando, Fla.), , 135 (2 ) ,223-35 More Information

Uchida, Kanji; Carey, Brenna; Suzuki, Takuji; Nakata, Koh; Trapnell, Bruce (2010. ) Response: Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy persons.Blood, , 115 (2 ) ,431-3 More Information

Sakagami, Takuro; Uchida, Kanji; Suzuki, Takuji; Carey, Brenna C; Wood, Robert E; Wert, Susan E; Whitsett, Jeffrey A; Trapnell, Bruce C; Luisetti, Maurizio (2009. ) Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis.The New England journal of medicine, , 361 (27 ) ,2679-81 More Information

Trapnell, Bruce C; Maguiness, Karen; Graff, Gavin R; Boyd, David; Beckmann, Katrin; Caras, Steven (2009. ) Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, , 8 (6 ) ,370-7 More Information

Ishii, Haruyuki; Trapnell, Bruce C; Tazawa, Ryushi; Inoue, Yoshikazu; Akira, Masanori; Kogure, Yoshihito; Tomii, Keisuke; Takada, Toshinori; Hojo, Masayuki; Ichiwata, Toshio; Goto, Hajime; Nakata, Koh (2009. ) Comparative study of high-resolution CT findings between autoimmune and secondary pulmonary alveolar proteinosis.Chest, , 136 (5 ) ,1348-55 More Information

Trapnell, Bruce C (2009. ) A novel biomarker-guided immunomodulatory approach for the therapy of sepsis.American journal of respiratory and critical care medicine, , 180 (7 ) ,585-6 More Information

Trapnell, Bruce C; Carey, Brenna C; Uchida, Kanji; Suzuki, Takuji (2009. ) Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages.Current opinion in immunology, , 21 (5 ) ,514-21 More Information

Han, Xiaonan; Uchida, Kanji; Jurickova, Ingrid; Koch, Diana; Willson, Tara; Samson, Charles; Bonkowski, Erin; Trauernicht, Anna; Kim, Mi-Ok; Tomer, Gitit; Dubinsky, Marla; Plevy, Scott; Kugathsan, Subra; Trapnell, Bruce C; Denson, Lee A (2009. ) Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease.Gastroenterology, , 136 (4 ) ,1261-71, e1-3 More Information

Uchida, Kanji; Nakata, Koh; Suzuki, Takuji; Luisetti, Maurizio; Watanabe, Masato; Koch, Diana E; Stevens, Carrie A; Beck, David C; Denson, Lee A; Carey, Brenna C; Keicho, Naoto; Krischer, Jeffrey P; Yamada, Yoshitsugu; Trapnell, Bruce C (2009. ) Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects.Blood, , 113 (11 ) ,2547-56 More Information

Robinson, Terry E; Trapnell, Bruce C; Goris, Michael L; Quittell, Lynne M; Cornfield, David N (2009. ) Quantitative analysis of longitudinal response to aerosolized granulocyte-macrophage colony-stimulating factor in two adolescents with autoimmune pulmonary alveolar proteinosis.Chest, , 135 (3 ) ,842-8 More Information

Suzuki, Takuji; Sakagami, Takuro; Rubin, Bruce K; Nogee, Lawrence M; Wood, Robert E; Zimmerman, Sarah L; Smolarek, Teresa; Dishop, Megan K; Wert, Susan E; Whitsett, Jeffrey A; Grabowski, Gregory; Carey, Brenna C; Stevens, Carrie; van der Loo, Johannes C M; Trapnell, Bruce C (2008. ) Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.The Journal of experimental medicine, , 205 (12 ) ,2703-10 More Information

Uchida, Kanji; Nakata, Koh; Suzuki, Takuji; Luisetti, Maurizio; Watanabe, Masato; Koch, Diana E; Stevens, Carrie A; Beck, Dave C; Denson, Lee A; Carey, Brenna C; Keicho, Naoto; Krischer, Jeffrey P; Yamada, Yoshitsugu; Trapnell, Bruce C (2008. ) Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy individuals.Blood, , More Information

Sandhaus, Robert A; Turino, Gerard; Stocks, James; Strange, Charlie; Trapnell, Bruce C; Silverman, Edwin K; Everett, Sarah E; Stoller, James K (2008. ) alpha1-Antitrypsin augmentation therapy for PI*MZ heterozygotes: a cautionary note.Chest, , 134 (4 ) ,831-4 More Information

Spight, Donn; Trapnell, Bruce; Zhao, Bin; Berclaz, Pierre; Shanley, Thomas P (2008. ) Granulocyte-macrophage-colony-stimulating factor-dependent peritoneal macrophage responses determine survival in experimentally induced peritonitis and sepsis in mice.Shock (Augusta, Ga.), , 30 (4 ) ,434-42 More Information

Inoue, Yoshikazu; Trapnell, Bruce C; Tazawa, Ryushi; Arai, Toru; Takada, Toshinori; Hizawa, Nobuyuki; Kasahara, Yasunori; Tatsumi, Koichiro; Hojo, Masaaki; Ichiwata, Toshio; Tanaka, Naohiko; Yamaguchi, Etsuro; Eda, Ryosuke; Oishi, Kazunori; Tsuchihashi, Yoshiko; Kaneko, Chinatsu; Nukiwa, Toshihiro; Sakatani, Mitsunori; Krischer, Jeffrey P; Nakata, Koh (2008. ) Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan.American journal of respiratory and critical care medicine, , 177 (7 ) ,752-62 More Information

Kleff, Veronika; Sorg, Ursula R; Bury, Carsten; Suzuki, Takuji; Rattmann, Ina; Jerabek-Willemsen, Moran; Poremba, Christopher; Flasshove, Michael; Opalka, Bertram; Trapnell, Bruce; Dirksen, Uta; Moritz, Thomas (2008. ) Gene therapy of beta(c)-deficient pulmonary alveolar proteinosis (beta(c)-PAP): studies in a murine in vivo model.Molecular therapy : the journal of the American Society of Gene Therapy, , 16 (4 ) ,757-64 More Information

Deutsch, Gail H; Young, Lisa R; Deterding, Robin R; Fan, Leland L; Dell, Sharon D; Bean, Judy A; Brody, Alan S; Nogee, Lawrence M; Trapnell, Bruce C; Langston, Claire ; Albright, Eric A; Askin, Frederic B; Baker, Peter; Chou, Pauline M; Cool, Carlyne M; Coventry, Susan C; Cutz, Ernest; Davis, Mary M; Dishop, Megan K; Galambos, Csaba; Patterson, Kathleen; Travis, William D; Wert, Susan E; White, Frances V (2007. ) Diffuse lung disease in young children: application of a novel classification scheme.American journal of respiratory and critical care medicine, , 176 (11 ) ,1120-8 More Information

Watanabe, Masato; Uchida, Kanji; Nakagaki, Kazuhide; Kanazawa, Hiroko; Trapnell, Bruce C; Hoshino, Yoshihiko; Kagamu, Hiroshi; Yoshizawa, Hirohisa; Keicho, Naoto; Goto, Hajime; Nakata, Koh (2007. ) Anti-cytokine autoantibodies are ubiquitous in healthy individuals.FEBS letters, , 581 (10 ) ,2017-21 More Information

Perlmutter, David H; Brodsky, Jeffrey L; Balistreri, William F; Trapnell, Bruce C (2007. ) Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review.Hepatology (Baltimore, Md.), , 45 (5 ) ,1313-23 More Information

Carey, Brenna; Staudt, Margaret K; Bonaminio, Dana; van der Loo, Johannes C M; Trapnell, Bruce C (2007. ) PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infection. Journal of immunology (Baltimore, Md. : 1950), , 178 (4 ) ,2440-7

Uchida, Kanji; Beck, David C; Yamamoto, Takashi; Berclaz, Pierre-Yves; Abe, Shuichi; Staudt, Margaret K; Carey, Brenna C; Filippi, Marie-Dominique; Wert, Susan E; Denson, Lee A; Puchalski, Jonathan T; Hauck, Diane M; Trapnell, Bruce C (2007. ) GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis.The New England journal of medicine, , 356 (6 ) ,567-79 More Information

Berclaz, Pierre-Yves; Carey, Brenna; Fillipi, Marie-Dominique; Wernke-Dollries, Kara; Geraci, Nick; Cush, Stephanie; Richardson, Terry; Kitzmiller, Joe; O'connor, Michael; Hermoyian, Christina; Korfhagen, Thomas; Whitsett, Jeffrey A; Trapnell, Bruce C (2007. ) GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS.American journal of respiratory cell and molecular biology, , 36 (1 ) ,114-21 More Information

Gonzalez-Juarrero, Mercedes; Hattle, Jessica M; Izzo, Angelo; Junqueira-Kipnis, Ana Paula; Shim, Tae S; Trapnell, Bruce C; Cooper, Andrea M; Orme, Ian M (2005. ) Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection.Journal of leukocyte biology, , 77 (6 ) ,914-22 More Information

Jennings, Kristi; Miyamae, Takako; Traister, Russell; Marinov, Anthony; Katakura, Shigeki; Sowders, Dawn; Trapnell, Bruce; Wilson, James M; Gao, Guangping; Hirsch, Raphael (2005. ) Proteasome inhibition enhances AAV-mediated transgene expression in human synoviocytes in vitro and in vivo.Molecular therapy : the journal of the American Society of Gene Therapy, , 11 (4 ) ,600-7 More Information

Whitsett, Jeffrey A; Wert, Susan E; Trapnell, Bruce C (2004. ) Genetic disorders influencing lung formation and function at birth.Human molecular genetics, , 13 Spec No 2 ,R207-15 More Information

Cheng, You-Hong; Aronow, Bruce J; Hossain, Shaikh; Trapnell, Bruce; Kong, Sue; Handwerger, Stuart (2004. ) Critical role for transcription factor AP-2alpha in human trophoblast differentiation.Physiological genomics, , 18 (1 ) ,99-107 More Information

Uchida, Kanji; Nakata, Koh; Trapnell, Bruce C; Terakawa, Takahiro; Hamano, Emi; Mikami, Ayako; Matsushita, Ikumi; Seymour, John F; Oh-Eda, Masayoshi; Ishige, Ikuo; Eishi, Yoshinobu; Kitamura, Takayuki; Yamada, Yoshitsugu; Hanaoka, Kazuo; Keicho, Naoto (2004. ) High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis.Blood, , 103 (3 ) ,1089-98 More Information

Katakura, Shigeki; Jennings, Kristi; Watanabe, Shohei; Adachi, Eijiroh; Thornton, Sherry; Gao, Guang-Ping; Wilson, James M; Burstein, Haim; Trapnell, Bruce; Hirsch, Raphael (2004. ) Recombinant adeno-associated virus preferentially transduces human, compared to mouse, synovium: implications for arthritis therapy.Modern rheumatology / the Japan Rheumatism Association, , 14 (1 ) ,18-24 More Information

Trapnell, Bruce C; Whitsett, Jeffrey A; Nakata, Koh (2003. ) Pulmonary alveolar proteinosis.The New England journal of medicine, , 349 (26 ) ,2527-39 More Information

Bonfield, Tracey L; Raychaudhuri, Baisakhi; Malur, Anagha; Abraham, Susamma; Trapnell, Bruce C; Kavuru, Mani S; Thomassen, Mary Jane (2003. ) PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor.American journal of physiology. Lung cellular and molecular physiology, , 285 (5 ) ,L1132-6 More Information

Hassett, Daniel J; Cuppoletti, John; Trapnell, Bruce; Lymar, Sergei V; Rowe, John J; Yoon, Sang Sun; Hilliard, George M; Parvatiyar, Kislay; Kamani, Moneesha C; Wozniak, Daniel J; Hwang, Sung Hei; McDermott, Timothy R; Ochsner, Urs A (2002. ) Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets. Advanced drug delivery reviews, , 54 (11 ) ,1425-43

Berclaz, Pierre-Yves; Shibata, Yoko; Whitsett, Jeffrey A; Trapnell, Bruce C (2002. ) GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lung.Blood, , 100 (12 ) ,4193-200 More Information

Berclaz, Pierre-Yves; Zsengellér, Zsuzsanna; Shibata, Yoko; Otake, Kazuhisa; Strasbaugh, Steven; Whitsett, Jeffrey A; Trapnell, Bruce C (2002. ) Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1. Journal of immunology (Baltimore, Md. : 1950), , 169 (11 ) ,6332-42

Trapnell, Bruce C (2002. ) Granulocyte macrophage-colony stimulating factor augmentation therapy in sepsis: is there a role? .American journal of respiratory and critical care medicine, , 166 (2 ) ,129-30

Trapnell, Bruce C; Whitsett, Jeffrey A (2002. ) Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense.Annual review of physiology, , 64 ,775-802 More Information

Kusakabe, Yoshiomi; Uchida, Kanji; Hiruma, Takahiro; Suzuki, Yoko; Totsu, Tokie; Suzuki, Takuji; Carey, Brenna C; Yamada, Yoshitsugu; Trapnell, Bruce C (2014. ) A standardized blood test for the routine clinical diagnosis of impaired GM-CSF signaling using flow cytometry.Journal of immunological methods, , More Information

Suzuki, Takuji; Mayhew, Christopher; Sallese, Anthony; Chalk, Claudia; Carey, Brenna C; Malik, Punam; Wood, Robert E; Trapnell, Bruce C (2014. ) Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis.American journal of respiratory and critical care medicine, , 189 (2 ) ,183-93 More Information

Uchida, Kanji; Nakata, Koh; Carey, Brenna; Chalk, Claudia; Suzuki, Takuji; Sakagami, Takuro; Koch, Diana E; Stevens, Carrie; Inoue, Yoshikazu; Yamada, Yoshitsugu; Trapnell, Bruce C (2014. ) Standardized serum GM-CSF autoantibody testing for the routine clinical diagnosis of autoimmune pulmonary alveolar proteinosis.Journal of immunological methods, , 402 (1-2 ) ,57-70 More Information

Trapnell, Bruce C (2014. ) The dawn of protein-folding therapeutics.American journal of respiratory and critical care medicine, , 189 (1 ) ,1-3 More Information

Mueller, Christian; Chulay, Jeffrey D; Trapnell, Bruce C; Humphries, Margaret; Carey, Brenna; Sandhaus, Robert A; McElvaney, Noel G; Messina, Louis; Tang, Qiushi; Rouhani, Farshid N; Campbell-Thompson, Martha; Fu, Ann Dongtao; Yachnis, Anthony; Knop, David R; Ye, Guo-Jie; Brantly, Mark; Calcedo, Roberto; Somanathan, Suryanarayan; Richman, Lee P; Vonderheide, Robert H; Hulme, Maigan A; Brusko, Todd M; Wilson, James M; Flotte, Terence R (2013. ) Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.The Journal of clinical investigation, , 123 (12 ) ,5310-8 More Information

Däbritz, Jan; Bonkowski, Erin; Chalk, Claudia; Trapnell, Bruce C; Langhorst, Jost; Denson, Lee A; Foell, Dirk (2013. ) Granulocyte macrophage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease.The American journal of gastroenterology, , 108 (12 ) ,1901-10 More Information

Trapnell, Bruce C; Luisetti, Maurizio (2013. ) The parallel lives of alpha1-antitrypsin deficiency and pulmonary alveolar proteinosis.Orphanet journal of rare diseases, , 8 ,153 More Information

Dykes, Dana M H; Towbin, Alexander J; Bonkowski, Erin; Chalk, Claudia; Bezold, Ramona; Lake, Kathleen; Kim, Mi-Ok; Heubi, James E; Trapnell, Bruce C; Podberesky, Daniel J; Denson, Lee A (2013. ) Increased prevalence of luminal narrowing and stricturing identified by enterography in pediatric Crohn's disease patients with elevated granulocyte-macrophage colony stimulating factor autoantibodies.Inflammatory bowel diseases, , 19 (10 ) ,2146-54 More Information

Matthay, Michael A; Anversa, Piero; Bhattacharya, Jahar; Burnett, Bruce K; Chapman, Harold A; Hare, Joshua M; Hei, Derek J; Hoffman, Andrew M; Kourembanas, Stella; McKenna, David H; Ortiz, Luis A; Ott, Harald C; Tente, William; Thébaud, Bernard; Trapnell, Bruce C; Weiss, Daniel J; Yuan, Jason X-J; Blaisdell, Carol J (2013. ) Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012.American journal of respiratory and critical care medicine, , 188 (3 ) ,370-5 More Information

Young, Lisa; Lee, Hye-Seung; Inoue, Yoshikazu; Moss, Joel; Singer, Lianne G; Strange, Charlie; Nakata, Koh; Barker, Alan F; Chapman, Jeffrey T; Brantly, Mark L; Stocks, James M; Brown, Kevin K; Lynch, Joseph P; Goldberg, Hilary J; Downey, Gregory P; Swigris, Jeffrey J; Taveira-DaSilva, Angelo M; Krischer, Jeffrey P; Trapnell, Bruce C; McCormack, Francis X (2013. ) Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial.The Lancet. Respiratory medicine, , 1 (6 ) ,445-52 More Information

Gathungu, Grace; Kim, Mi-Ok; Ferguson, John P; Sharma, Yashoda; Zhang, Wei; Ng, Sok Meng E; Bonkowski, Erin; Ning, Kaida; Simms, Lisa A; Croft, Anthony R; Stempak, Joanne M; Walker, Nicole; Huang, Ning; Xiao, Yang; Silverberg, Mark S; Trapnell, Bruce; Cho, Judy H; Radford-Smith, Graham L; Denson, Lee A (2013. ) Granulocyte-macrophage colony-stimulating factor autoantibodies: a marker of aggressive Crohn's disease.Inflammatory bowel diseases, , 19 (8 ) ,1671-80 More Information

Campo, Ilaria; Mariani, Francesca; Rodi, Giuseppe; Paracchini, Elena; Tsana, Eric; Piloni, Davide; Nobili, Isabella; Kadija, Zamir; Corsico, Angelo; Cerveri, Isa; Chalk, Claudia; Trapnell, Bruce C; Braschi, Antonio; Tinelli, Carmine; Luisetti, Maurizio (2013. ) Assessment and management of pulmonary alveolar proteinosis in a reference center.Orphanet journal of rare diseases, , 8 ,40 More Information

Trapnell, Bruce C (2012. ) Induced sputum biomarkers for monitoring cystic fibrosis lung disease.American journal of respiratory and critical care medicine, , 186 (9 ) ,812-4 More Information

Cummings, Kristin J; Nakano, Makiko; Omae, Kazuyuki; Takeuchi, Koichiro; Chonan, Tatsuya; Xiao, Yong-long; Harley, Russell A; Roggli, Victor L; Hebisawa, Akira; Tallaksen, Robert J; Trapnell, Bruce C; Day, Gregory A; Saito, Rena; Stanton, Marcia L; Suarthana, Eva; Kreiss, Kathleen (2012. ) Indium lung disease.Chest, , 141 (6 ) ,1512-21 More Information

Luisetti, Maurizio; Balfour-Lynn, Ian M; Johnson, Simon R; Miravitlles, Marc; Strange, Charlie; Trapnell, Bruce C; van Bronswijk, Hans; Vogelmeier, Claus (2012. ) Perspectives for improving the evaluation and access of therapies for rare lung diseases in Europe.Respiratory medicine, , 106 (6 ) ,759-68 More Information

Trapnell, Bruce C (2012. ) Inhaled dry powder mannitol: a solution for cystic fibrosis.American journal of respiratory and critical care medicine, , 185 (6 ) ,596-8 More Information

Trapnell, Bruce C; McColley, Susanna A; Kissner, Dana G; Rolfe, Mark W; Rosen, Jonathan M; McKevitt, Matthew; Moorehead, Lisa; Montgomery, A Bruce; Geller, David E (2012. ) Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection.American journal of respiratory and critical care medicine, , 185 (2 ) ,171-8 More Information

Kugathasan, Subra; Denson, Lee A; Walters, Thomas D; Kim, Mi-Ok; Marigorta, Urko M; Schirmer, Melanie; Mondal, Kajari; Liu, Chunyan; Griffiths, Anne; Noe, Joshua D; Crandall, Wallace V; Snapper, Scott; Rabizadeh, Shervin; Rosh, Joel R; Shapiro, Jason M; Guthery, Stephen; Mack, David R; Kellermayer, Richard; Kappelman, Michael D; Steiner, Steven; Moulton, Dedrick E; Keljo, David; Cohen, Stanley; Oliva-Hemker, Maria; Heyman, Melvin B; Otley, Anthony R; Baker, Susan S; Evans, Jonathan S; Kirschner, Barbara S; Patel, Ashish S; Ziring, David; Trapnell, Bruce C; Sylvester, Francisco A; Stephens, Michael C; Baldassano, Robert N; Markowitz, James F; Cho, Judy; Xavier, Ramnik J; Huttenhower, Curtis; Aronow, Bruce J; Gibson, Greg; Hyams, Jeffrey S; Dubinsky, Marla C (2017. ) Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.Lancet (London, England), , 389 (10080 ) ,1710-1718 More Information

Mueller, Christian; Gernoux, Gwladys; Gruntman, Alisha M; Borel, Florie; Reeves, Emer P; Calcedo, Roberto; Rouhani, Farshid N; Yachnis, Anthony; Humphries, Margaret; Campbell-Thompson, Martha; Messina, Louis; Chulay, Jeffrey D; Trapnell, Bruce; Wilson, James M; McElvaney, Noel G; Flotte, Terence R (2017. ) 5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency.Molecular therapy : the journal of the American Society of Gene Therapy, , More Information

Young, Lisa R; Trapnell, Bruce C; Mandl, Kenneth D; Swarr, Daniel T; Wambach, Jennifer A; Blaisdell, Carol J (2016. ) Accelerating Scientific Advancement for Pediatric Rare Lung Disease Research. Report from a National Institutes of Health-NHLBI Workshop, September 3 and 4, 2015.Annals of the American Thoracic Society, , 13 (12 ) ,385-393 More Information

Suzuki, Takuji; Trapnell, Bruce C (2016. ) Pulmonary Alveolar Proteinosis Syndrome.Clinics in chest medicine, , 37 (3 ) ,431-40 More Information

Campo, Ilaria; Luisetti, Maurizio; Griese, Matthias; Trapnell, Bruce C; Bonella, Francesco; Grutters, Jan; Nakata, Koh; Van Moorsel, Coline H M; Costabel, Ulrich; Cottin, Vincent; Ichiwata, Toshio; Inoue, Yoshikazu; Braschi, Antonio; Bonizzoni, Giacomo; Iotti, Giorgio A; Tinelli, Carmine; Rodi, Giuseppe (2016. ) Whole lung lavage therapy for pulmonary alveolar proteinosis: a global survey of current practices and procedures.Orphanet journal of rare diseases, , 11 (1 ) ,115 More Information

Mucci, Adele; Kunkiel, Jessica; Suzuki, Takuji; Brennig, Sebastian; Glage, Silke; Kühnel, Mark P; Ackermann, Mania; Happle, Christine; Kuhn, Alexandra; Schambach, Axel; Trapnell, Bruce C; Hansen, Gesine; Moritz, Thomas; Lachmann, Nico (2016. ) Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.Stem cell reports, , 7 (2 ) ,292-305 More Information

Cummings, Kristin J; Virji, M Abbas; Park, Ji Young; Stanton, Marcia L; Edwards, Nicole T; Trapnell, Bruce C; Carey, Brenna; Stefaniak, Aleksandr B; Kreiss, Kathleen (2016. ) Respirable indium exposures, plasma indium, and respiratory health among indium-tin oxide (ITO) workers.American journal of industrial medicine, , 59 (7 ) ,522-31 More Information

Campo, Ilaria; Luisetti, Maurizio; Griese, Matthias; Trapnell, Bruce C; Bonella, Francesco; Grutters, Jan C; Nakata, Koh; Van Moorsel, Coline H M; Costabel, Ulrich; Cottin, Vincent; Ichiwata, Toshio; Inoue, Yoshikazu; Braschi, Antonio; Bonizzoni, Giacomo; Iotti, Giorgio A; Tinelli, Carmine; Rodi, Giuseppe (2016. ) A Global Survey on Whole Lung Lavage in Pulmonary Alveolar Proteinosis.Chest, , 150 (1 ) ,251-3 More Information

Schnepp, Bruce C; Chulay, Jeffrey D; Ye, Guo-Jie; Flotte, Terence R; Trapnell, Bruce C; Johnson, Philip R (2016. ) Recombinant Adeno-Associated Virus Vector Genomes Take the Form of Long-Lived, Transcriptionally Competent Episomes in Human Muscle.Human gene therapy, , 27 (1 ) ,32-42 More Information

Fan, Leland L; Dishop, Megan K; Galambos, Csaba; Askin, Frederic B; White, Frances V; Langston, Claire; Liptzin, Deborah R; Kroehl, Miranda E; Deutsch, Gail H; Young, Lisa R; Kurland, Geoffrey; Hagood, James; Dell, Sharon; Trapnell, Bruce C; Deterding, Robin R (2015. ) Diffuse Lung Disease in Biopsied Children 2 to 18 Years of Age. Application of the chILD Classification Scheme.Annals of the American Thoracic Society, , 12 (10 ) ,1498-505 More Information

Trapnell, Bruce C (2015. ) A lymphocyte-mediated cause of secondary PAP.Blood, , 125 (2 ) ,215-6 More Information

Cummings, Kristin J; Virji, M Abbas; Trapnell, Bruce C; Carey, Brenna; Healey, Terrance; Kreiss, Kathleen (2014. ) Early changes in clinical, functional, and laboratory biomarkers in workers at risk of indium lung disease.Annals of the American Thoracic Society, , 11 (9 ) ,1395-403 More Information

Suzuki, Takuji; Arumugam, Paritha; Sakagami, Takuro; Lachmann, Nico; Chalk, Claudia; Sallese, Anthony; Abe, Shuichi; Trapnell, Cole; Carey, Brenna; Moritz, Thomas; Malik, Punam; Lutzko, Carolyn; Wood, Robert E; Trapnell, Bruce C (2014. ) Pulmonary macrophage transplantation therapy.Nature, , 514 (7523 ) ,450-4 More Information

Kleff, Veronika; Sorg, Ursula R; Bury, Carsten; Suzuki, Takuji; Rattmann, Ina; Jerabek-Willemsen, Moran; Poremba, Christopher; Flasshove, Michael; Opalka, Bertram; Trapnell, Bruce; Dirksen, Uta; Moritz, Thomas (2008. ) Gene Therapy of ?c-Deficient Pulmonary Alveolar Proteinosis (?c-PAP): Studies in a Murine in vivo Model.Molecular therapy : the journal of the American Society of Gene Therapy, , 16 (4 ) ,757-764 More Information

Acciani, T H; Suzuki, T; Trapnell, B C; Le Cras, T D (2016. ) Epidermal growth factor receptor signalling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, , 46 (2 ) ,317-28 More Information

Jurickova, I; Collins, M H; Chalk, C; Seese, A; Bezold, R; Lake, K; von Allmen, D; Frischer, J S; Falcone, R A; Trapnell, B C; Denson, L A (2013. ) Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity.Clinical and experimental immunology, , 172 (3 ) ,455-65 More Information

Ishii, H; Tazawa, R; Kaneko, C; Saraya, T; Inoue, Y; Hamano, E; Kogure, Y; Tomii, K; Terada, M; Takada, T; Hojo, M; Nishida, A; Ichiwata, T; Trapnell, B C; Goto, H; Nakata, K (2011. ) Clinical features of secondary pulmonary alveolar proteinosis: pre-mortem cases in Japan.The European respiratory journal, , 37 (2 ) ,465-8 More Information

Suzuki, T; Maranda, B; Sakagami, T; Catellier, P; Couture, C-Y; Carey, B C; Chalk, C; Trapnell, B C (2011. ) Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations.The European respiratory journal, , 37 (1 ) ,201-4 More Information

Luisetti, M; Rodi, G; Perotti, C; Campo, I; Mariani, F; Pozzi, E; Trapnell, B C (2009. ) Plasmapheresis for treatment of pulmonary alveolar proteinosis.The European respiratory journal, , 33 (5 ) ,1220-2 More Information

Griggs, Robert C; Batshaw, Mark; Dunkle, Mary; Gopal-Srivastava, Rashmi; Kaye, Edward; Krischer, Jeffrey; Nguyen, Tan; Paulus, Kathleen; Merkel, Peter A (2009. ) Clinical research for rare disease: opportunities, challenges, and solutions.Molecular genetics and metabolism, , 96 (1 ) ,20-6 More Information

Shibata, Y; Zsengeller, Z; Otake, K; Palaniyar, N; Trapnell, B C (2001. ) Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema. Blood, , 98 (9 ) ,2845-52

Shibata, Y; Berclaz, P Y; Chroneos, Z C; Yoshida, M; Whitsett, J A; Trapnell, B C (2001. ) GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity, , 15 (4 ) ,557-67

Zsengellér, Z K; Ross, G F; Trapnell, B C; Szabó, C; Whitsett, J A (2001. ) Adenovirus infection increases iNOS and peroxynitrite production in the lung. American journal of physiology. Lung cellular and molecular physiology, , 280 (3 ) ,L503-11

Zsengellér, Z; Otake, K; Hossain, S A; Berclaz, P Y; Trapnell, B C (2000. ) Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection. Journal of virology, , 74 (20 ) ,9655-67

Harrod, K S; Trapnell, B C; Otake, K; Korfhagen, T R; Whitsett, J A (1999. ) SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection. The American journal of physiology, , 277 (3 Pt 1 ) ,L580-8

Schwarz, Y A; Amin, R S; Stark, J M; Trapnell, B C; Wilmott, R W (1999. ) Interleukin-1 receptor antagonist inhibits interleukin-8 expression in A549 respiratory epithelial cells infected in vitro with a replication-deficient recombinant adenovirus vector.American journal of respiratory cell and molecular biology, , 21 (3 ) ,388-94 More Information

March, K L; Woody, M; Mehdi, K; Zipes, D P; Brantly, M; Trapnell, B C (1999. ) Efficient in vivo catheter-based pericardial gene transfer mediated by adenoviral vectors. Clinical cardiology, , 22 (1 Suppl 1 ) ,I23-9

Iwamoto, H S; Trapnell, B C; McConnell, C J; Daugherty, C; Whitsett, J A (1999. ) Pulmonary inflammation associated with repeated, prenatal exposure to an E1, E3-deleted adenoviral vector in sheep.Gene therapy, , 6 (1 ) ,98-106 More Information

Otake, K; Ennist, D L; Harrod, K; Trapnell, B C (1998. ) Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses.Human gene therapy, , 9 (15 ) ,2207-22 More Information

Harrod, K S; Hermiston, T W; Trapnell, B C; Wold, W S; Whitsett, J A (1998. ) Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector-mediated lung inflammation and enhances transgene expression.Human gene therapy, , 9 (13 ) ,1885-98 More Information

Connelly, S; Andrews, J L; Gallo, A M; Kayda, D B; Qian, J; Hoyer, L; Kadan, M J; Gorziglia, M I; Trapnell, B C; McClelland, A; Kaleko, M (1998. ) Sustained phenotypic correction of murine hemophilia A by in vivo gene therapy. Blood, , 91 (9 ) ,3273-81

Czubayko, F; Downing, S G; Hsieh, S S; Goldstein, D J; Lu, P Y; Trapnell, B C; Wellstein, A (1997. ) Adenovirus-mediated transduction of ribozymes abrogates HER-2/neu and pleiotrophin expression and inhibits tumor cell proliferation.Gene therapy, , 4 (9 ) ,943-9 More Information

Zsengellér, Z K; Wert, S E; Bachurski, C J; Kirwin, K L; Trapnell, B C; Whitsett, J A (1997. ) Recombinant adenoviral vector disrupts surfactant homeostasis in mouse lung.Human gene therapy, , 8 (11 ) ,1331-44 More Information

Zsengellér, Z K; Boivin, G P; Sawchuk, S S; Trapnell, B C; Whitsett, J A; Hirsch, R (1997. ) Anti-T cell receptor antibody prolongs transgene expression and reduces lung inflammation after adenovirus-mediated gene transfer.Human gene therapy, , 8 (8 ) ,935-41 More Information

Mittereder, N; March, K L; Trapnell, B C (1996. ) Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. Journal of virology, , 70 (11 ) ,7498-509

Stark, J M; Amin, R S; Trapnell, B C (1996. ) Infection of A549 cells with a recombinant adenovirus vector induces ICAM-1 expression and increased CD-18-dependent adhesion of activated neutrophils.Human gene therapy, , 7 (14 ) ,1669-81 More Information

Jobe, A H; Ueda, T; Whitsett, J A; Trapnell, B C; Ikegami, M (1996. ) Surfactant enhances adenovirus-mediated gene expression in rabbit lungs. Gene therapy, , 3 (9 ) ,775-9

Gorziglia, M I; Kadan, M J; Yei, S; Lim, J; Lee, G M; Luthra, R; Trapnell, B C (1996. ) Elimination of both E1 and E2 from adenovirus vectors further improves prospects for in vivo human gene therapy. Journal of virology, , 70 (6 ) ,4173-8

Wilmott, R W; Amin, R S; Perez, C R; Wert, S E; Keller, G; Boivin, G P; Hirsch, R; De Inocencio, J; Lu, P; Reising, S F; Yei, S; Whitsett, J A; Trapnell, B C (1996. ) Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates.Human gene therapy, , 7 (3 ) ,301-18 More Information

Holzinger, A; Trapnell, B C; Weaver, T E; Whitsett, J A; Iwamoto, H S (1995. ) Intraamniotic administration of an adenoviral vector for gene transfer to fetal sheep and mouse tissues.Pediatric research, , 38 (6 ) ,844-50 More Information

Vincent, M C; Trapnell, B C; Baughman, R P; Wert, S E; Whitsett, J A; Iwamoto, H S (1995. ) Adenovirus-mediated gene transfer to the respiratory tract of fetal sheep in utero.Human gene therapy, , 6 (8 ) ,1019-28 More Information

Clayman, G L; Trapnell, B C; Mittereder, N; Liu, T J; Eicher, S; Zhang, S; Shillitoe, E J (1995. ) Transduction of normal and malignant oral epithelium by an adenovirus vector: the effect of dose and treatment time on transduction efficiency and tissue penetration. Cancer gene therapy, , 2 (2 ) ,105-11

Zsengeller, Z K; Wert, S E; Hull, W M; Hu, X; Yei, S; Trapnell, B C; Whitsett, J A (1995. ) Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice.Human gene therapy, , 6 (4 ) ,457-67 More Information

March, K L; Madison, J E; Trapnell, B C (1995. ) Pharmacokinetics of adenoviral vector-mediated gene delivery to vascular smooth muscle cells: modulation by poloxamer 407 and implications for cardiovascular gene therapy.Human gene therapy, , 6 (1 ) ,41-53 More Information

Trapnell, B C; Gorziglia, M (1994. ) Gene therapy using adenoviral vectors. Current opinion in biotechnology, , 5 (6 ) ,617-25

Yei, S; Bachurski, C J; Weaver, T E; Wert, S E; Trapnell, B C; Whitsett, J A (1994. ) Adenoviral-mediated gene transfer of human surfactant protein B to respiratory epithelial cells.American journal of respiratory cell and molecular biology, , 11 (3 ) ,329-36 More Information

Yei, S; Mittereder, N; Wert, S; Whitsett, J A; Wilmott, R W; Trapnell, B C (1994. ) In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung.Human gene therapy, , 5 (6 ) ,731-44 More Information

Mittereder, N; Yei, S; Bachurski, C; Cuppoletti, J; Whitsett, J A; Tolstoshev, P; Trapnell, B C (1994. ) Evaluation of the efficacy and safety of in vitro, adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA.Human gene therapy, , 5 (6 ) ,717-29 More Information

Yei, S; Mittereder, N; Tang, K; O'Sullivan, C; Trapnell, B C (1994. ) Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung. Gene therapy, , 1 (3 ) ,192-200

Smith, T A; Mehaffey, M G; Kayda, D B; Saunders, J M; Yei, S; Trapnell, B C; McClelland, A; Kaleko, M (1993. ) Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice.Nature genetics, , 5 (4 ) ,397-402 More Information

Lee, S W; Trapnell, B C; Rade, J J; Virmani, R; Dichek, D A (1993. ) In vivo adenoviral vector-mediated gene transfer into balloon-injured rat carotid arteries. Circulation research, , 73 (5 ) ,797-807

Erzurum, S C; Danel, C; Gillissen, A; Chu, C S; Trapnell, B C; Crystal, R G (1993. ) In vivo antioxidant gene expression in human airway epithelium of normal individuals exposed to 100% O2. Journal of applied physiology (Bethesda, Md. : 1985), , 75 (3 ) ,1256-62

Trapnell, B C (1993. ) Quantitative evaluation of gene expression in freshly isolated human respiratory epithelial cells. The American journal of physiology, , 264 (3 Pt 1 ) ,L199-212

Chu, C S; Trapnell, B C; Curristin, S; Cutting, G R; Crystal, R G (1993. ) Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA.Nature genetics, , 3 (2 ) ,151-6 More Information

Nakamura, H; Yoshimura, K; Bajocchi, G; Trapnell, B C; Pavirani, A; Crystal, R G (1992. ) Tumor necrosis factor modulation of expression of the cystic fibrosis transmembrane conductance regulator gene. FEBS letters, , 314 (3 ) ,366-70

Chu, C S; Trapnell, B C; Curristin, S M; Cutting, G R; Crystal, R G (1992. ) Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manifestations of cystic fibrosis.The Journal of clinical investigation, , 90 (3 ) ,785-90 More Information

Bargon, J; Trapnell, B C; Yoshimura, K; Dalemans, W; Pavirani, A; Lecocq, J P; Crystal, R G (1992. ) Expression of the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C. The Journal of biological chemistry, , 267 (23 ) ,16056-60

Bargon, J; Trapnell, B C; Chu, C S; Rosenthal, E R; Yoshimura, K; Guggino, W B; Dalemans, W; Pavirani, A; Lecocq, J P; Crystal, R G (1992. ) Down-regulation of cystic fibrosis transmembrane conductance regulator gene expression by agents that modulate intracellular divalent cations. Molecular and cellular biology, , 12 (4 ) ,1872-8

Rosenfeld, M A; Yoshimura, K; Trapnell, B C; Yoneyama, K; Rosenthal, E R; Dalemans, W; Fukayama, M; Bargon, J; Stier, L E; Stratford-Perricaudet, L (1992. ) In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell, , 68 (1 ) ,143-55

Hamosh, A; Trapnell, B C; Zeitlin, P L; Montrose-Rafizadeh, C; Rosenstein, B J; Crystal, R G; Cutting, G R (1991. ) Severe deficiency of cystic fibrosis transmembrane conductance regulator messenger RNA carrying nonsense mutations R553X and W1316X in respiratory epithelial cells of patients with cystic fibrosis.The Journal of clinical investigation, , 88 (6 ) ,1880-5 More Information

Yoshimura, K; Nakamura, H; Trapnell, B C; Chu, C S; Dalemans, W; Pavirani, A; Lecocq, J P; Crystal, R G (1991. ) Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin. Nucleic acids research, , 19 (19 ) ,5417-23

Trapnell, B C; Chu, C S; Paakko, P K; Banks, T C; Yoshimura, K; Ferrans, V J; Chernick, M S; Crystal, R G (1991. ) Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. Proceedings of the National Academy of Sciences of the United States of America, , 88 (15 ) ,6565-9

Trapnell, B C; Zeitlin, P L; Chu, C S; Yoshimura, K; Nakamura, H; Guggino, W B; Bargon, J; Banks, T C; Dalemans, W; Pavirani, A (1991. ) Down-regulation of cystic fibrosis gene mRNA transcript levels and induction of the cystic fibrosis chloride secretory phenotype in epithelial cells by phorbol ester. The Journal of biological chemistry, , 266 (16 ) ,10319-23

Chu, C S; Trapnell, B C; Murtagh, J J; Moss, J; Dalemans, W; Jallat, S; Mercenier, A; Pavirani, A; Lecocq, J P; Cutting, G R (1991. ) Variable deletion of exon 9 coding sequences in cystic fibrosis transmembrane conductance regulator gene mRNA transcripts in normal bronchial epithelium. The EMBO journal, , 10 (6 ) ,1355-63

Abe, T; Kobayashi, N; Yoshimura, K; Trapnell, B C; Kim, H; Hubbard, R C; Brewer, M T; Thompson, R C; Crystal, R G (1991. ) Expression of the secretory leukoprotease inhibitor gene in epithelial cells.The Journal of clinical investigation, , 87 (6 ) ,2207-15 More Information

Yoshimura, K; Nakamura, H; Trapnell, B C; Dalemans, W; Pavirani, A; Lecocq, J P; Crystal, R G (1991. ) The cystic fibrosis gene has a "housekeeping"-type promoter and is expressed at low levels in cells of epithelial origin. The Journal of biological chemistry, , 266 (14 ) ,9140-4

Nagaoka, I; Trapnell, B C; Crystal, R G (1990. ) Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis.The Journal of clinical investigation, , 85 (6 ) ,2023-7 More Information

Saltini, C; Kirby, M; Trapnell, B C; Tamura, N; Crystal, R G (1990. ) Biased accumulation of T lymphocytes with "memory"-type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung. The Journal of experimental medicine, , 171 (4 ) ,1123-40

Nagaoka, I; Trapnell, B C; Crystal, R G (1990. ) Regulation of insulin-like growth factor I gene expression in the human macrophage-like cell line U937.The Journal of clinical investigation, , 85 (2 ) ,448-55 More Information

Rom, W N; Basset, P; Fells, G A; Nukiwa, T; Trapnell, B C; Crysal, R G (1988. ) Alveolar macrophages release an insulin-like growth factor I-type molecule.The Journal of clinical investigation, , 82 (5 ) ,1685-93 More Information

Trapnell, B C; Mavko, L E; Birskovich, L M; Falko, J M (1986. ) Metoclopramide suppositories in the treatment of diabetic gastroparesis. Archives of internal medicine, , 146 (11 ) ,2278-9

Dalgleish, R; Trapnell, B C; Crystal, R G; Tolstoshev, P (1982. ) Copy number of a human type I alpha 2 collagen gene. The Journal of biological chemistry, , 257 (22 ) ,13816-22

Tolstoshev, P; Haber, R; Trapnell, B C; Crystal, R G (1981. ) Procollagen messenger RNA levels and activity and collagen synthesis during the fetal development of sheep lung, tendon, and skin. The Journal of biological chemistry, , 256 (18 ) ,9672-9

Tolstoshev, P; Berg, R A; Rennard, S I; Bradley, K H; Trapnell, B C; Crystal, R G (1981. ) Procollagen production and procollagen messenger RNA levels and activity in human lung fibroblasts during periods of rapid and stationary growth. The Journal of biological chemistry, , 256 (6 ) ,3135-40

Trapnell, B C; Tolstoshev, P; Crystal, R G (1980. ) Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors. Nucleic acids research, , 8 (16 ) ,3659-72

Boyd, C D; Tolstoshev, P; Schafer, M P; Trapnell, B C; Coon, H C; Kretschmer, P J; Nienhuis, A W; Crystal, R G (1980. ) Isolation and characterization of a 15-kilobase genomic sequence coding for part of the Pro alpha 2 chain of sheep type I collagen. The Journal of biological chemistry, , 255 (7 ) ,3212-20

Gupta, Nishant; Lee, Hye-Seung; Young, Lisa R; Strange, Charlie; Moss, Joel; Singer, Lianne G; Nakata, Koh; Barker, Alan F; Chapman, Jeffrey T; Brantly, Mark L; Stocks, James M; Brown, Kevin K; Lynch, Joseph P; Goldberg, Hilary J; Downey, Gregory P; Taveira-DaSilva, Angelo M; Krischer, Jeffrey P; Setchell, Kenneth; Trapnell, Bruce C; Inoue, Yoshikazu; McCormack, Francis X (2019. ) Analysis of the MILES cohort reveals determinants of disease progression and treatment response in lymphangioleiomyomatosis.The European respiratory journal, , 53 (4 ) , More Information

Trapnell, Bruce C; Nakata, Koh; Bonella, Francesco; Campo, Ilaria; Griese, Matthias; Hamilton, John; Wang, Tisha; Morgan, Cliff; Cottin, Vincent; McCarthy, Cormac (2019. ) Pulmonary alveolar proteinosis.Nature reviews. Disease primers, , 5 (1 ) ,16 More Information

McCarthy, Cormac; Bartholmai, Brian J; Woods, Jason C; McCormack, Francis X; Trapnell, Bruce C (2019. ) Automated Parenchymal Pattern Analysis of Treatment Responses in Pulmonary Alveolar Proteinosis.American journal of respiratory and critical care medicine, , More Information

McCarthy, Cormac; Carey, Brenna; Trapnell, Bruce C (2019. ) Blood Testing for Differential Diagnosis of Pulmonary Alveolar Proteinosis Syndrome.Chest, , 155 (2 ) ,450-452 More Information

McCarthy, Cormac; Carey, Brenna; Trapnell, Bruce C (2018. ) Blood testing in the diagnosis of pulmonary alveolar proteinosis.The Lancet. Respiratory medicine, , 6 (11 ) ,e54 More Information

McCarthy, Cormac; Lee, Elinor; Bridges, James P; Sallese, Anthony; Suzuki, Takuji; Woods, Jason C; Bartholmai, Brian J; Wang, Tisha; Chalk, Claudia; Carey, Brenna C; Arumugam, Paritha; Shima, Kenjiro; Tarling, Elizabeth J; Trapnell, Bruce C (2018. ) Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis.Nature communications, , 9 (1 ) ,3127 More Information

McCarthy, Cormac; Avetisyan, Ruzan; Carey, Brenna C; Chalk, Claudia; Trapnell, Bruce C (2018. ) Prevalence and healthcare burden of pulmonary alveolar proteinosis.Orphanet journal of rare diseases, , 13 (1 ) ,129 More Information

Hiruma, Takahiro; Tsuyuzaki, Hitoshi; Uchida, Kanji; Trapnell, Bruce C; Yamamura, Yoshiro; Kusakabe, Yoshiomi; Totsu, Tokie; Suzuki, Takuji; Morita, Shigeki; Doi, Kent; Noiri, Eisei; Nakamura, Kensuke; Nakajima, Susumu; Yahagi, Naoki; Morimura, Naoto; Chang, Kyungho; Yamada, Yoshitsugu (2018. ) IFN-? Improves Sepsis-related Alveolar Macrophage Dysfunction and Postseptic Acute Respiratory Distress Syndrome-related Mortality.American journal of respiratory cell and molecular biology, , 59 (1 ) ,45-55 More Information

McCarthy, Cormac; Brewington, John J; Harkness, Beth; Clancy, John P; Trapnell, Bruce C (2018. ) Personalised CFTR pharmacotherapeutic response testing and therapy of cystic fibrosis.The European respiratory journal, , 51 (6 ) , More Information

Wright, Sandra S; Trauernicht, Anna; Bonkowski, Erin; McCall, Courtney A; Maier, Elizabeth A; Bezold, Ramona; Lake, Kathleen; Chalk, Claudia; Trapnell, Bruce C; Kim, Mi-Ok; Kugathasan, Subra; Denson, Lee A (2018. ) Familial Association of Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition, , 66 (5 ) ,767-772 More Information

Aoki, Ami; Sakagami, Takuro; Yoshizawa, Kazutaka; Shima, Kenjiro; Toyama, Mio; Tanabe, Yoshinari; Moro, Hiroshi; Aoki, Nobumasa; Watanabe, Satoshi; Koya, Toshiyuki; Hasegawa, Takashi; Morimoto, Kozo; Kurashima, Atsuyuki; Hoshino, Yoshihiko; Trapnell, Bruce C; Kikuchi, Toshiaki (2018. ) Clinical Significance of Interferon-? Neutralizing Autoantibodies Against Disseminated Nontuberculous Mycobacterial Disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, , 66 (8 ) ,1239-1245 More Information

Hetzel, Miriam; Suzuki, Takuji; Hashtchin, Anna Rafiei; Arumugam, Paritha; Carey, Brenna; Schwabbauer, Marc; Kuhn, Alexandra; Meyer, Johann; Schambach, Axel; Van Der Loo, Johannes; Moritz, Thomas; Trapnell, Bruce C; Lachmann, Nico (2017. ) Function and Safety of Lentivirus-Mediated Gene Transfer for CSF2RA-Deficiency.Human gene therapy methods, , 28 (6 ) ,318-329 More Information

Trapnell, Bruce C; Bridges, James (2017. ) Does Granulocyte-Macrophage Colony-Stimulating Factor Coordinate a Hepatopulmonary Axis of Lipid Metabolism?.American journal of respiratory cell and molecular biology, , 57 (4 ) ,383-385 More Information

Sallese, Anthony; Suzuki, Takuji; McCarthy, Cormac; Bridges, James; Filuta, Alyssa; Arumugam, Paritha; Shima, Kenjiro; Ma, Yan; Wessendarp, Matthew; Black, Diane; Chalk, Claudia; Carey, Brenna; Trapnell, Bruce C (2017. ) Targeting cholesterol homeostasis in lung diseases.Scientific reports, , 7 (1 ) ,10211 More Information

Kristof, Arnold S; Petrof, Basil J; Hamid, Qutayba; Kolb, Martin; Landry, Jennifer S; MacKenzie, Alex; McCormack, Francis X; Murawski, Inga J; Moss, Joel; Rauch, Frank; Rosas, Ivan O; Shapiro, Adam J; Smith, Benjamin M; Thomas, David Y; Trapnell, Bruce C; Young, Lisa R; Zariwala, Maimoona A (2017. ) An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases.Annals of the American Thoracic Society, , 14 (8 ) ,1239-1247 More Information

McCarthy, Cormac; Lara Gallego, Beatriz; Trapnell, Bruce C; McCormack, Francis X (2017. ) Epidemiology of Rare Lung Diseases: The Challenges and Opportunities to Improve Research and Knowledge.Advances in experimental medicine and biology, , 1031 ,419-442 More Information

lung, respiratory, pulmonology

Academic - Internal Medicine
Medical Sciences Building Room 6065
Cincinnati  Ohio, 45267
Phone: 513-558-4831
Fax: 513-558-4858
bruce.trapnell@cchmc.org

Practice - MAB
222 Piedmont Ave, Suite 4000
Cincinnati  Ohio, 45219
Phone: 513-475-8523
bruce.trapnell@cchmc.org