Chenran Wang , PhD

Ph.D.: Peking University

PostDoc training: University of Michigan

My research interests include selective autophagy, mTORC1 activation, and lipid metabolisms in development and neurogenesis of postnatal neural stem cells; glial micro-environment for cancer metastasis to brain; functions of autophagy in neurodegenerative diseases, e.g. Alzheimer’s disease.

Grant: #R03NS097887 Investigators:Guan, Jun-lin; Wang, Chenran 07-01-2016 -06-30-2018 National Institute of Neurological Disorders and Stroke Mechanisms of autophagy in TSC1-deficient neural stem cells Role:PI $79,000.00 Awarded Level:Federal

Grant: #R01NS103981 Investigators:Guan, Jun-lin; Wang, Chenran 07-15-2018 -06-30-2023 National Institute of Neurological Disorders and Stroke Regulation of lipid catabolism by autophagy in neural stem cell of tuberous sclerosis complex Role:PI $350,000.00 Active Level:Federal

Grant: #305627 sub 3R01AG053498-02S1 Investigators:Wang, Chenran 09-06-2018 -02-28-2019 National Institute on Aging Administrative supplement to metabolic alterations in age-associated dendritic cell function Role:PI $8,533.96 Active Level:Federal

Grant: #2019 Award Investigators:Wang, Chenran 01-01-2020 -12-31-2021 Local Initiative for Excellence (L.I.F.E.) Mechanisms of enhanced autophagy protecting healthy aging of neural stem cells Role:PI $50,000.00 Awarded Level:Private Non-Profit

Grant: #R01NS094144 Investigators:Guan, Jun-lin; Wang, Chenran 09-01-2020 -06-30-2025 National Institute of Neurological Disorders and Stroke Regulation of neural stem cells and neurogenesis by autophagy genes Role:Collaborator $396,034.00 Awarded Level:Federal

Grant: #AARG-NTF-21-849207 Investigators:Wang, Chenran 10-01-2021 -09-30-2024 Alzheimer's Association Functions of microglial autophagy in neurogenesis of Alzheimer's disease Role:PI 0.00 Awarded Level:Non Profit

Grant: #R01CA273586 Investigators:Guan, Jun-lin; Wang, Chenran 04-01-2023 -03-31-2028 National Cancer Institute Roles of Glial Autophagy in Breast Cancer Brain Metastasis Role:PI 402424.00 Awarded Level:Federal

Peer Reviewed Publications

Yeo, Syn Kok; Paul, Ritama; Haas, Michael; Wang, Chenran; Guan, Jun-Lin (2018. ) Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer.Autophagy, , 14 (7 ) ,1214-1225 More Information

Wang, Chenran; Yeo, Syn; Haas, Michael A; Guan, Jun-Lin (2017. ) Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia.The Journal of cell biology, , 216 (8 ) ,2581-2596 More Information

Chen, Song; Wang, Chenran; Yeo, Syn; Liang, Chun-Chi; Okamoto, Takako; Sun, Shaogang; Wen, Jian; Guan, Jun-Lin (2016. ) Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.Genes & development, , 30 (7 ) ,856-69 More Information

Wang, Chenran; Chen, Song; Yeo, Syn; Karsli-Uzunbas, Gizem; White, Eileen; Mizushima, Noboru; Virgin, Herbert W; Guan, Jun-Lin (2016. ) Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide.The Journal of cell biology, , 212 (5 ) ,545-60 More Information

Wen, Jian; Yeo, Syn; Wang, Chenran; Chen, Song; Sun, Shaogang; Haas, Michael A; Tu, Wei; Jin, Feng; Guan, Jun-Lin (2015. ) Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis.Breast cancer research and treatment, , 149 (3 ) ,619-29 More Information

Kim, Edward; Wang, Yuan; Kim, Sun-Jung; Bornhorst, Miriam; Jecrois, Emmanuelle S; Anthony, Todd E; Wang, Chenran; Li, Yi E; Guan, Jun-Lin; Murphy, Geoffrey G; Zhu, Yuan (2014. ) Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1.eLife, , 3 , More Information

Wei, Huijun; Wang, Chenran; Croce, Carlo M; Guan, Jun-Lin (2014. ) p62/SQSTM1 synergizes with autophagy for tumor growth in vivo.Genes & development, , 28 (11 ) ,1204-16 More Information

Wang, Chenran; Haas, Michael A., Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R.; Guan, Jun-Lin (11-11-2019. ) Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells .Nature Metabolism, , 1, ,1127–1140

Deng, Shan; Essandoh, Kobina; Wang, Xiaohong; Li, Yutian; Huang, Wei; Chen, Jing; Peng, Jiangtong; Jiang, Ding-Sheng; Mu, Xingjiang; Wang, Chenran; Peng, Tianqing; Guan, Jun-Lin; Wang, Yigang; Jegga, Anil; Huang, Kai; Fan, Guo-Chang (2020. ) Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage.Redox biology, , 101453 More Information

Chen, Qixin; Shao, Xintian; Hao, Mingang; Fang, Hongbao; Guan, Ruilin; Tian, Zhiqi; Li, Miaoling; Wang, Chenran; Ji, Liangnian; Chao, Hui; Guan, Jun-Lin; Diao, Jiajie (2020. ) Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy.Biomaterials, , 250 ,120059 More Information

Yang, Fuchun; Sun, Shaogang; Wang, Chenran; Haas, Michael; Yeo, Syn; Guan, Jun-Lin (2020. ) Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation.British journal of cancer, , More Information

Yeo, Syn Kok; Wang, Chenran; Guan, Jun-Lin (2020. ) Role of FIP200 in inflammatory processes beyond its canonical autophagy function.Biochemical Society transactions, , More Information

Wang, Chenran; Haas, Michael A; Yang, Fuchun; Yeo, Syn; Okamoto, Takako; Chen, Song; Wen, Jian; Sarma, Pranjal; Plas, David R; Guan, Jun-Lin (2019. ) Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells.Nature metabolism, , 1 (11 ) ,1127-1140 More Information

Tang, Xin; Angst, Gabrielle; Haas, Michael; Yang, Fuchun; Wang, Chenran (2021. ) The Characterization of a Subependymal Giant Astrocytoma-Like Cell Line from Murine Astrocyte with mTORC1 Hyperactivation.International journal of molecular sciences, , 22 (8 ) , More Information

Wang, Chenran; Haas, Michael A; Yeo, Syn Kok; Paul, Ritama; Yang, Fuchun; Vallabhapurapu, Subrahmanya; Qi, Xiaoyang; Plas, David R; Guan, Jun-Lin (2021. ) Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis.British journal of cancer, , More Information

Wang, Chenran; Haas, Michael; Yeo, Syn Kok; Sebti, Salwa; Fernández, Álvaro F; Zou, Zhongju; Levine, Beth; Guan, Jun-Lin (2021. ) Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction.Autophagy, , 1-14 More Information

Wang, Chenran; Haas, Michael; Yeo, Syn Kok; Sebti, Salwa; Fernández, Álvaro F; Zou, Zhongju; Levine, Beth; Guan, Jun-Lin (2021. ) Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction.Autophagy, , 1-14 More Information

Liu, Hang; Wang, Chenran; Yi, Fei; Yeo, Syn; Haas, Michael; Tang, Xin; Guan, Jun-Lin (2021. ) Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation.Scientific reports, , 11 (1 ) ,23907 More Information

Nagayach, Aarti; Wang, Chenran (2024. ) Autophagy in neural stem cells and glia for brain health and diseases.Neural regeneration research, , 19 (4 ) ,729-736 More Information

Tang, Xin; Walter, Ellen; Wohleb, Eric; Fan, Yanbo; Wang, Chenran (2023. ) ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease.Autophagy, , 1-16 More Information

Angst, Gabrielle; Tang, Xin; Wang, Chenran (2023. ) Functional Analysis of a Novel Immortalized Murine Microglia Cell Line in 3D Spheroid Model.Neurochemical research, , 48 (9 ) ,2857-2869 More Information

Ren, Lu; Du, Wa; Song, Dan; Lu, Haocheng; Hamblin, Milton H; Wang, Chenran; Du, Chunying; Fan, Guo-Chang; Becker, Richard C; Fan, Yanbo (2023. ) Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice.iScience, , 26 (1 ) ,105769 More Information

Pounders, Jonathan; Hill, Emily J; Hooper, Destiny; Zhang, Xiang; Biesiada, Jacek; Kuhnell, Damaris; Greenland, Hannah L; Esfandiari, Leyla; Timmerman, Emerlee; Foster, Forrest; Wang, Chenran; Walsh, Kyle B; Shatz, Rhonna; Woo, Daniel; Medvedovic, Mario; Langevin, Scott; Sawyer, Russell P (2022. ) MicroRNA expression within neuronal-derived small extracellular vesicles in frontotemporal degeneration.Medicine, , 101 (40 ) ,e30854 More Information

Chen, Qixin; Jin, Chengzhi; Shao, Xintian; Guan, Ruilin; Tian, Zhiqi; Wang, Chenran; Liu, Fei; Ling, Peixue; Guan, Jun-Lin; Ji, Liangnian; Wang, Fengshan; Chao, Hui; Diao, Jiajie (2018. ) Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore.Small (Weinheim an der Bergstrasse, Germany), , 14 (41 ) ,e1802166 More Information

Academic - Vontz Center for Molecular Studies
Room 3316
Cincinnati  Ohio, 45267
Phone: (513) 558-4816
chenran.wang@uc.edu