Georg Weber

Dr. Georg F. Weber has made contributions to metastasis research by discovering the interaction between the molecules osteopontin and CD44 and by defining the physiologic role of metastasis genes as stress response genes. While he continues to address fundamental questions, he is researching new venues for diagnosis and therapy of cancer progression.

Cancers are increasingly classified on the molecular level (Weber 2007; Weber 2010a; Weber 2010b; Weber et al. 2012). Gain-of-function mutations of oncogenes or loss-of-function mutations of tumor suppressor genes underlie excessive cell division. Activation of senescence suppressor genes or inactivation of senescence genes underlies immortalization. While molecular studies have made their relation to the uncontrolled expansion of tumor cells obvious, it has not been clear why these defects also induce the ability to metastasize. Based on the phenotypes of knockout mice for various confirmed metastasis genes, we have identified the genetic basis of metastasis formation as aberrant expression or splicing of a unique set of developmentally non-essential genes (stress response genes) that physiologically mediate the homing of immune system cells. Metastasis genes encode homing receptors, their ligands, and extracellular matrix-degrading proteinases, which jointly cause invasion. The specific interaction of homing receptors on the tumor cell surface and their cognate cytokine ligands mediates migration and invasion. The organ preference of metastasis formation is determined by the particular identity of the homing receptors expressed on the tumor cell surface and their ligands (Weber/Ashkar 2000a,b; Ashkar et al. 2000; Weber 2008; Weber 2021). Metastases are generally characterized by a core program of gene expression that induces the oxidative metabolism, activates vascularization/tissue remodeling, silences extracellular matrix interactions, and alters ion homeostasis. This program distinguishes metastases from their originating primary tumors as well as from their target host tissues. Site-selectivity is accomplished through specific components that adjust to the target micro-environment (Hartung et al. 2017; Hartung et al. 2020; Fnu/Weber 2021).
 
Our laboratory has studied the cytokine osteopontin (Weber 2002; Weber 2018), which acts as a metastasis gene in multiple malignancies and is therefore a progression marker (Weber et al. 2010a; Weber et al. 2011; Weber 2011), which may act in conjunction with other molecules (Ramchandani/Weber 2015a,b). Based on the molecular mechanisms of osteopontin induction and function in cancer metastasis, we have established the following paradigms:
Osteopontin and variant CD44 interact. (Weber et al. 1996; Weber et al. 1997; Weber et al. 2002a; Weber et al. 1999; Weber et al. 2002b; Zhang et al. 2011).
Multiple osteopontin splice variants are expressed in invasive, but not in non-invasive, human tumor cells. (He et al. 2006; Shen/Weber 2014; Hartung/Weber 2013; An et al. 2023; Mirza et al. 2007; Sullivan et al. 2009; Tilli et al. 2011; Zduniak et al. 2015; Zduniak et al. 2016; Walasek et al. 2018; Ziolkowski et al. 2022; Weber 2023; AlSarkhi/Weber 2018).
Metastasis genes support anchorage-independence in an autocrine fashion. (Syed et al. 200; Weber 2016a; Weber 2016b; He et al. 2006; Wang et al. 2013; Shi et al. 2014a; Shi et al. 2014b; Fnu/Weber 2023; Weber et al. 1999; Unruh et al. 2016; Ramchandani et al. 2016).
Oncogenes induce distinct pathways to growth and invasiveness. (Zhang et al. 2003; Whalen et al. 2008; Mesa et al. 2006).
An osteopontin promoter polymorphism is associated with aggressiveness in breast cancer. (Ramchandani/Weber 2013; Briones-Orta et al. 2017a; Briones-Orta et al. 2017b).
 
In the context of our molecular analyses of carcinogenesis, we have investigated the cellular effects (Weber 2015a ; Weber et al. 1991; Weber/Nair 1992) and the metabolism of conventional anti-cancer drugs (LeBlanc et al. 1992; Weber/Waxman 1993a; Weber/Waxman 1993b; Chang et al. 1993; Weber 2013; Weber 2015b). We have also studied ways to selectively target metastasis with anti-cancer agents (Weber 2001; Weber 2005; Weber 2009; Weber 2012).

2004 -To Present College of Pharmacy, University of Cincinnati., Cincinnati,OH

2000 -2004 Graduate Program in Immunology, Sackler School of Graduate Biomedical Sciences,, Tufts University School of Medicine., Boston, MA

1999 -2004 Tufts-New England Medical Center., Boston, MA

1996 -2000 Department of Medicine, Dana-Farber Cancer Institute,, Harvard Medical School., Boston, MA

1993 -1996 Department of Pathology, Dana-Farber Cancer Institute,, Harvard Medical School., Boston, MA

2006 -To Present Graduate Program in Cell and Cancer Biology, University of Cincinnati, OH,

2004 -To Present Cancer Center, University of Cincinnati ,

2020 -To Present Professor, College of Pharmacy, University of Cincinnati,

Peer Reviewed Publications

Mirza M, Shaughnessy E, Hurley JK, Vanpatten KA, Pestano GA, He B, Weber GF (2008. ) Osteopontin-c is a highly selective marker for breast cancer .International Journal of Cancer , , 122 ,889-897

Whalen KA, Weber GF, Benjamin TL, Schaffhausen BS (2008. ) Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for migration of transformed cells .The Journal of Virology, , 82 ,4946-4954

Syed M, Fenoglio-Preiser C, Skau KA, Weber GF (2008. ) Acetylcholinesterase supports anchorage independence in colon cancer .Clinical and Experimental Metastasis, , 25 ,787-798

Sullivan J, Blair L, Alnajar A, Aziz T, Ng CY, Chipitsyna G, Gong Q, Witkiewicz A, Weber GF, Denhardt DT, Yeo CJ, Arafat HA. (2009. ) Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma .Surgery, , 146 ,232-240

Weber GF (2010. ) Molecular genetics and metastasis .Encyclopedia of Life Sciences, , DOI 10.1002/9780470015902.a0022447

Weber GF (2010. ) Toward a molecular classification of cancer .Biomarker Theme Issue of Toxicology, , 278 ,195-198

Weber GF, Lett GS, Haubein NC (2010. ) Osteopontin is a marker for cancer aggressiveness and patient survival .British Journal of Cancer , , 103 ,861-869

Tilli TM, Franco VF, Robbs BK, Wanderley JL, Silva F, Duarte de Mello K, Viola JPB, Weber GF, Gimba ERP (2011. ) Osteopontin-c splicing isoform contributes to ovarian cancer progression .Molecular Cancer Research , , 9 ,280-293

Shen H, Weber GF (2014. ) The osteopontin-c splice junction is important for anchorage-independent growth .Molecular Carcinogenesis, , 53 ,480-487

Shi Z, Mirza M, Wang B, Kennedy MA, Weber GF (2014. ) Osteopontin-a alters glucose homeostasis in anchorage-independent breast cancer cells .Cancer Letters, , 344 ,47-53

Weber GF (2011. ) The cancer biomarker Osteopontin: Combination with other markers .Cancer Genomics and Proteomics, , 8 ,263-288

Weber GF, Johnson BN, Yamamoto BK, Gudelsky GA (2014. ) Effects of stress and MDMA on hippocampal gene expression.BioMed Research International, , 2014 ,141396 More Information

Hartung F, Weber GF (2013. ) RNA blood levels of osteopontin splice variants are cancer markers .SpringerPlus, , 2 ,110

Wang B, Shi Z, Weber GF, Kennedy MA (2013. ) Introduction of a new critical p value correction method for statistical significance analysis of metabonomics data .Analytical and Bioanalytical Chemistry, , 405 ,8419-8429

Ramchandani D, Weber GF (2013. ) An osteopontin promoter polymorphism is associated with aggressiveness in breast cancer .Oncology Reports, , 30 ,1860-1868

Weber GF (2013. ) Gene therapy--why can it fail? .Medical Hypotheses, , 80 ,613-616

Weber GF, Lett GS, Haubein NC (2011. ) Categorical meta-analysis of Osteopontin as a clinical cancer marker .Oncology Reports, , 25 ,433-441

Zhang R, Pan X, Huang Z, Weber GF, Zhang G (2011. ) Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines .PloS one, , 6 ,e23831

Weber GF (2008. ) Molecular mechanisms of metastasis .Cancer Letters, , 270 ,181-190

Milanowski P, Carter TJ, Weber GF (2013. ) Enzyme catalysis and the outcome of biochemical reactions .Journal of Proteomics and Bioinformatics , , 6 ,132-141

Weber GF (2013. ) Dynamic knowledge - a century of evolution .Sociology Mind , , 3 ,268-277

Weber GF, Warren J, Shoma H, Chen T, Halim A, Chakravarty G (2012. ) Biomarkers - A pot of gold or a can of worms? Meeting report from the 2nd world congress on biomarkers in clinical research, 2011, Baltimore, USA .Cancer Biology & Therapy , , 13 ,831-835

Shi Z, Wang B, Kennedy MA, Weber GF (2014. ) Metabolic skewing during anchorage independence. Induction by osteopontin-c .PlosOne, , 9 ,e105675

Mesa C Jr, Mirza M, Mitsutake N, Sartor M, Medvedovic M, Tomlinson C, Knauf JA, Weber GF, Fagin JA (2006. ) Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling .Cancer Research, , 66 ,6521-6529

Weber GF (2012. ) Why does cancer therapy lack effective anti-metastasis drugs? .Cancer Letters, , 328 ,207-211

Zduniak K, Ziolkowski P, Ahlin C, Agrawal A, Agrawal S, Blomqvist C, Fjällskog ML, Weber GF (2015. ) Nuclear Osteopontin-c is a marker for breast cancer prognosis .British Journal of Cancer , , 112 ,729-738

He B, Mirza M, Weber GF (2006. ) An osteopontin splice variant induces anchorage independence in human breast cancer cells .Oncogene, , 25 ,2192-2202

Weber GF (2015. ) Somnambulism and allergy .Clinical and Experimental Neuroimmunology , , 6 ,321

Weber GF (2015. ) Molecular analysis of a recurrent sarcoma identifies a mutation in FAF1 .Sarcoma, , 839182 ,doi:10.1155/2015/839182

Weber GF (2004. ) The absence of CD44 ameliorates Faslpr/lpr disease .Autoimmunity , , 37 ,1-8

Ramchandani D, Weber GF (2015. ) Interactions between OPN and VEGF in health and disease. Implications for cancer .BBA Reviews on Cancer, , 1855 ,202-222

He B, Weber GF (2004. ) Synergistic activation of the CMV promoter by NF-kB P50 and Cyclic GMP-Dependent Kinase .Biochemical and Biophysical Research Communications , , 321 ,13-20

Ramchandani D, Weber GF (2015. ) Interactions between OPN and VEGF in health and disease. Implications for the skeletal system .Bone, , 81 ,7-15

Craig-Mylius C, Weber GF, Coburn JL, Glickstein LG (2005. ) Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response .Journal of Leukocyte Biology, , 77 ,710-718

Weber GF (2009. ) Drug targets in cancer metastasis .American Association for Cancer Research 100th Annual Meeting Education Book, , 137-140

Weber GF (2016. ) Metabolism in cancer metastasis .International Journal of Cancer, ,

Unruh D, Ünlu B, Lewis CS, Qi X, Chu Z, Sturm R, Keil R, Ahmad SA, Sovershaev T, Adam M, Van Dreden P, Woodhams BJ, Ramchandani D, Weber GF, Rak JW, Wolberg AS, Mackman N, Versteeg HH, Bogdanov VY (2016. ) Antibody-based targeting of alternatively spliced Tissue Factor: a new approach to impede the primary growth and aggressiveness of pancreatic ductal adenocarcinoma. .Oncotarget, ,

Alsarkhi, Lamyaa Kadhim; Weber, Georg F (2018. ) Anti?osteopontin autoantibodies in various types of cancer.Oncology reports, , 40 (6 ) ,3879-3889 More Information

Walaszek, Kinga; Lower, Elyse E; Ziolkowski, Piotr; Weber, Georg F (2018. ) Breast cancer risk in premalignant lesions: osteopontin splice variants indicate prognosis.British journal of cancer, , 119 (10 ) ,1259-1266 More Information

Weber, Georg F (2018. ) The Phylogeny of Osteopontin-Analysis of the Protein Sequence.International journal of molecular sciences, , 19 (9 ) , More Information

Hartung, Franz; Wang, Yunguan; Aronow, Bruce; Weber, Georg F (2017. ) A core program of gene expression characterizes cancer metastases.Oncotarget, , 8 (60 ) ,102161-102175 More Information

Briones-Orta, Marco Antonio; Avendaño-Vázquez, S Eréndira; Ivette Aparicio-Bautista, Diana; Coombes, Jason D; Weber, Georg F; Syn, Wing-Kin (2017. ) Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter.Data in brief, , 14 ,538-542 More Information

Briones-Orta, Marco Antonio; Avendaño-Vázquez, S Eréndira; Aparicio-Bautista, Diana Ivette; Coombes, Jason D; Weber, Georg F; Syn, Wing-Kin (2017. ) Osteopontin splice variants and polymorphisms in cancer progression and prognosis.Biochimica et biophysica acta. Reviews on cancer, , 1868 (1 ) ,93-108.A More Information

Weber, Georg F (2016. ) Time and Circumstances: Cancer Cell Metabolism at Various Stages of Disease Progression.Frontiers in oncology, , 6 ,257 More Information

Ramchandani, Divya; Unruh, Dusten; Lewis, Clayton S; Bogdanov, Vladimir Y; Weber, Georg F (2016. ) Activation of carbonic anhydrase IX by alternatively spliced tissue factor under late-stage tumor conditions.Laboratory investigation; a journal of technical methods and pathology, , 96 (12 ) ,1234-1245 More Information

Zduniak, Krzysztof; Agrawal, Anil; Agrawal, Siddarth; Hossain, Md Monir; Ziolkowski, Piotr; Weber, Georg F (2016. ) Osteopontin splice variants are differential predictors of breast cancer treatment responses.BMC cancer, , 16 ,441 More Information

Unruh, Dusten; Ünlü, Betül; Lewis, Clayton S; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Ramchandani, Divya; Weber, Georg F; Rak, Janusz W; Wolberg, Alisa S; Mackman, Nigel; Versteeg, Henri H; Bogdanov, Vladimir Y (2016. ) Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma.Oncotarget, , 7 (18 ) ,25264-75 More Information

Weber, Georg F (2016. ) Metabolism in cancer metastasis.International journal of cancer, , 138 (9 ) ,2061-6 More Information

Ramchandani, Divya; Weber, Georg F (2015. ) Interactions between osteopontin and vascular endothelial growth factor: Implications for skeletal disorders.Bone, , 81 ,7-15 More Information

Ramchandani, Divya; Weber, Georg F (2015. ) Interactions between osteopontin and vascular endothelial growth factor: Implications for cancer.Biochimica et biophysica acta, , 1855 (2 ) ,202-22 More Information

Zduniak, K; Ziolkowski, P; Ahlin, C; Agrawal, A; Agrawal, S; Blomqvist, C; Fjällskog, M-L; Weber, G F (2015. ) Nuclear osteopontin-c is a prognostic breast cancer marker.British journal of cancer, , 112 (4 ) ,729-38 More Information

Weber, Georg F (2015. ) Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1.Sarcoma, , 2015 ,839182 More Information

Shi, Zhanquan; Wang, Bo; Chihanga, Tafadzwa; Kennedy, Michael A; Weber, Georg F (2014. ) Energy metabolism during anchorage-independence. Induction by osteopontin-c.PloS one, , 9 (8 ) ,e105675 More Information

Weber, Georg F (2013. ) Why does cancer therapy lack effective anti-metastasis drugs?.Cancer letters, , 328 (2 ) ,207-11 More Information

Weber, Georg F The cancer biomarker osteopontin: combination with other markers. Cancer genomics & proteomics, , 8 (6 ) ,263-88

Tilli, Tatiana M; Franco, Vanessa Ferreira; Robbs, Bruno Kaufmann; Wanderley, João Luiz Mendes; da Silva, Fabrício Ribeiro de Azevedo; de Mello, Kivvi Duarte; Viola, João P B; Weber, Georg F; Gimba, Etel R (2011. ) Osteopontin-c splicing isoform contributes to ovarian cancer progression.Molecular cancer research : MCR, , 9 (3 ) ,280-93 More Information

Weber, Georg F (2010. ) Toward a molecular classification of cancer.Toxicology, , 278 (2 ) ,195-8 More Information

Weber, G F; Lett, G S; Haubein, N C (2010. ) Osteopontin is a marker for cancer aggressiveness and patient survival.British journal of cancer, , 103 (6 ) ,861-9 More Information

Sullivan, Jennifer; Blair, Laurel; Alnajar, Amer; Aziz, Tamer; Ng, Chee Yuan; Chipitsyna, Galina; Gong, Qiaoke; Witkiewicz, Agnes; Weber, Georg F; Denhardt, David T; Yeo, Charles J; Arafat, Hwyda A (2009. ) Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma.Surgery, , 146 (2 ) ,232-40 More Information

Whalen, Kerry A; Weber, Georg F; Benjamin, Thomas L; Schaffhausen, Brian S (2008. ) Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells.Journal of virology, , 82 (10 ) ,4946-54 More Information

Mirza, Mana; Shaughnessy, Elizabeth; Hurley, John K; Vanpatten, Kristie A; Pestano, Gary A; He, Bin; Weber, Georg F (2008. ) Osteopontin-c is a selective marker of breast cancer.International journal of cancer, , 122 (4 ) ,889-97 More Information

Syed, Moyeenuddin; Fenoglio-Preiser, Cecilia; Skau, Kenneth A; Weber, Georg F (2008. ) Acetylcholinesterase supports anchorage independence in colon cancer.Clinical & experimental metastasis, , 25 (7 ) ,787-98 More Information

Fnu, Gulimirerouzi; Weber, Georg F (2023. ) Osteopontin induces mitochondrial biogenesis in deadherent cancer cells.Oncotarget, , 14 ,957-969 More Information

Weber, Georg F (2023. ) Crossroads: the role of biomarkers in the management of lumps in the breast.Oncotarget, , 14 ,358-362 More Information

An, Yu; Fnu, Gulimirerouzi; Xie, Changchun; Weber, Georg F (2023. ) Meta-analysis of Osteopontin splice variants in cancer.BMC cancer, , 23 (1 ) ,373 More Information

Fnu, Gulimirerouzi; Hudock, Kristin; Powers-Fletcher, Margaret; Huang, Ruo-Pan; Weber, Georg F (2022. ) Induction of a cytokine storm involves suppression of the Osteopontin-dependent TH1 response.Immunology, , 167 (2 ) ,165-180 More Information

Ziółkowski, Piotr; Woźniak, Marta; Mansour, Ahmad; An, Yu; Weber, Georg F (2022. ) Breast cancer risk in papilloma patients: Osteopontin splice variants indicate prognosis.Breast cancer research : BCR, , 24 (1 ) ,64 More Information

Fnu, Gulimirerouzi; Weber, Georg F (2021. ) Alterations of Ion Homeostasis in Cancer Metastasis: Implications for Treatment.Frontiers in oncology, , 11 ,765329 More Information

Wang, Xia; Weber, Georg F (2021. ) Quantitative Analysis of Protein Evolution: The Phylogeny of Osteopontin.Frontiers in genetics, , 12 ,700789 More Information

Fnu, Gulimirerouzi; Agrawal, Palak; Kundu, Gopal C; Weber, Georg F (2021. ) Structural Constraint of Osteopontin Facilitates Efficient Binding to CD44.Biomolecules, , 11 (6 ) , More Information

Butti, Ramesh; Nimma, Ramakrishna; Kundu, Gautam; Bulbule, Anuradha; Kumar, Totakura V S; Gunasekaran, Vinoth Prasanna; Tomar, Deepti; Kumar, Dhiraj; Mane, Anupama; Gill, Satyajit S; Patil, Tushar; Weber, Georg F; Kundu, Gopal C (2021. ) Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression.Oncogene, , 40 (11 ) ,2002-2017 More Information

Weber, Georg F (2020. ) Cancer research - can the entity be bigger than the sum of its parts?.Oncoscience, , 7 (3-4 ) ,17-18 More Information

Hartung, Franz; Patil, Aditya; Meshram, Rohan J; Weber, Georg F (2020. ) Gene expression signatures of site-specificity in cancer metastases.Clinical & experimental metastasis, , 37 (1 ) ,159-171 More Information

Craig-Mylius, Kathleen; Weber, Georg F; Coburn, Jenifer; Glickstein, Lisa (2005. ) Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response.Journal of leukocyte biology, , 77 (5 ) ,710-8 More Information

Weber, Georg F (2004. ) The absence of CD44 ameliorates Fas(lpr/lpr) disease.Autoimmunity, , 37 (1 ) ,1-8 More Information

Zhang, Guoxin; He, Bin; Weber, Georg F (2003. ) Growth factor signaling induces metastasis genes in transformed cells: molecular connection between Akt kinase and osteopontin in breast cancer.Molecular and cellular biology, , 23 (18 ) ,6507-19 More Information

He, Bin; Weber, Georg F (2003. ) Phosphorylation of NF-kappaB proteins by cyclic GMP-dependent kinase. A noncanonical pathway to NF-kappaB activation.European journal of biochemistry, , 270 (10 ) ,2174-85 More Information

Weber, Georg F; Zawaideh, Samer; Hikita, Sherry; Kumar, Vikram A; Cantor, Harvey; Ashkar, Samy (2002. ) Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. Journal of leukocyte biology, , 72 (4 ) ,752-61

Weber, Georg F; Bronson, Roderick T; Ilagan, John; Cantor, Harvey; Schmits, Rudolf; Mak, Tak W (2002. ) Absence of the CD44 gene prevents sarcoma metastasis. Cancer research, , 62 (8 ) ,2281-6

Ashkar, S; Weber, G F; Panoutsakopoulou, V; Sanchirico, M E; Jansson, M; Zawaideh, S; Rittling, S R; Denhardt, D T; Glimcher, M J; Cantor, H (2000. ) Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity.Science (New York, N.Y.), , 287 (5454 ) ,860-4 More Information

Weber, G F; Ashkar, S (2000. ) Stress response genes: the genes that make cancer metastasize.Journal of molecular medicine (Berlin, Germany), , 78 (8 ) ,404-8 More Information

Weber, G F (1999. ) Final common pathways in neurodegenerative diseases: regulatory role of the glutathione cycle.Neuroscience and biobehavioral reviews, , 23 (8 ) ,1079-86 More Information

Pestano, G A; Zhou, Y; Trimble, L A; Daley, J; Weber, G F; Cantor, H (1999. ) Inactivation of misselected CD8 T cells by CD8 gene methylation and cell death.Science (New York, N.Y.), , 284 (5417 ) ,1187-91 More Information

Weber, G F; Mirza, N M; Yunis, E J; Dubey, D; Cantor, H (1997. ) Localization and treatment of an oxidation-sensitive defect within the TCR-coupled signalling pathway that is associated with normal and premature immunologic aging. Growth, development, and aging : GDA, , 61 (3-4 ) ,191-207

Weber, G F; Daley, J; Kraeft, S K; Chen, L B; Cantor, H (1997. ) Measurement of apoptosis in heterogenous cell populations.Cytometry, , 27 (2 ) ,136-44 More Information

Weber, G F; Ashkar, S; Cantor, H (1997. ) Interaction between CD44 and osteopontin as a potential basis for metastasis formation. Proceedings of the Association of American Physicians, , 109 (1 ) ,1-9

Weber, G F; Cantor, H (1996. ) The immunology of Eta-1/osteopontin.Cytokine & growth factor reviews, , 7 (3 ) ,241-8 More Information

Weber, G F; Ashkar, S; Glimcher, M J; Cantor, H (1996. ) Receptor-ligand interaction between CD44 and osteopontin (Eta-1).Science (New York, N.Y.), , 271 (5248 ) ,509-12 More Information

Weber, G F; Abromson-Leeman, S; Cantor, H (1995. ) A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death.Immunity, , 2 (4 ) ,363-72 More Information

Weber, G F (1994. ) The pathophysiology of reactive oxygen intermediates in the central nervous system.Medical hypotheses, , 43 (4 ) ,223-30 More Information

Weber, G F; Cantor, H (1994. ) Phosphatidylinositol synthesis is a proximal event in intracellular signaling coupled to T cell receptor ligation. Differential induction by conventional antigen and retroviral superantigen. Journal of immunology (Baltimore, Md. : 1950), , 152 (9 ) ,4433-43

Weber, G F; Waxman, D J (1993. ) Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases.Archives of biochemistry and biophysics, , 307 (2 ) ,369-78 More Information

Chang, T K; Weber, G F; Crespi, C L; Waxman, D J (1993. ) Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer research, , 53 (23 ) ,5629-37

Weber, G F; Waxman, D J (1993. ) Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes.Biochemical pharmacology, , 45 (8 ) ,1685-94 More Information

Weber, G F; Bruch, H P (1993. ) Hydroxyethyl starch and diseases mediated by free radicals.Free radical biology & medicine, , 14 (1 ) ,96-7 More Information

Weber, G F; Bruch, H P (1992. ) [The pharmacology of superoxide dismutase]. Die Pharmazie, , 47 (3 ) ,159-67

LeBlanc, G A; Sundseth, S S; Weber, G F; Waxman, D J (1992. ) Platinum anticancer drugs modulate P-450 mRNA levels and differentially alter hepatic drug and steroid hormone metabolism in male and female rats. Cancer research, , 52 (3 ) ,540-7

Weber, G F; Nair, M G (1992. ) Inhibition of the neutrophil NADPH oxidase by folic acid and antagonists of the folic acid metabolism.Immunopharmacology and immunotoxicology, , 14 (3 ) ,523-38 More Information

Weber, G F; Nair, M G; McCord, J M (1991. ) The antifolate 10-deazaaminopterin inhibits neutrophil chemotaxis and superoxide generation.Immunopharmacology and immunotoxicology, , 13 (3 ) ,379-93 More Information

Published Books

Georg F. Weber (2005. ) Cancer Therapy: Molecular Targets in Tumor-Host Interactions .Wymondham , Horizon Press

Georg F. Weber (2007. ) Molecular Mechanisms of Malignancy in Cancer .Dordrecht , Springer

Georg F. Weber (2015. ) Molecular Therapies of Cancer .Switzerland , Springer

cancer, metastasis, cytokines, biomarkers

Academic - UC College of Pharmacy
231 Albert Sabin Way, MSB
Cincinnati  Ohio, 45267
Phone: 513-558-0947
Georg.Weber@uc.edu

Research - Weber's Lab
231 Albert Sabin Way
Cincinnati  Ohio, 45229
Phone: 513-558-8369
http://pharmacy.uc.edu/weber