Ryan J White

My research and teaching interests lie at the intersection of nanoscience, electrochemistry and the biological interface. The research interests in our group focus on the development of new (bio)analytical methods to probe chemical and biological systems with unprecedented spatial and temporal resolutions afforded by working at the nanoscale. The scope of this research is quite broad, ranging from studies of fundamental chemical and biological phenomena to the development of applied sensor technologies. As such, students in the group can expect to gain valuable interdisciplinary laboratory experience.
 
Ryan J. White is Professor and Ohio Eminent Scholar in the Department of Chemistry with a complimenrary joint appointment in the Department of Electrical and Computer Engineering. He has served as Head of Chemistry since Fall 2022. Ryan received his bachelor’s degree in chemistry from the University of North Carolina (2003) and earned a Ph.D. in chemistry from the University of Utah (2007). He was an NIH NRSA Postdoctoral Fellow at the University of California Santa Barbara. Ryan started his academic career as an assistant professor in Chemistry and Biochemistry at UMBC in 2011, and was promoted to associate professor with tenure in 2016. Ryan joined UC in the fall of 2017. Ryan is also the recipient of the Royce W. Murray Young Investigator Award from the Society for Electroanalytical Chemistry. 
 

B.A.: University of North Carolina Chapel Hill, NC, 2003 (Chemistry)

Ph.D.: University of Utah Salt Lake City, UT, 2007 (Chemistry)

2007 -2011 NIH NRSA Postdoctoral Fellow, University of California Santa Barbara, Santa Barbara, CA

2011 -2016 Assistant Professor, Department of Chemistry and Biochemistry , University of Maryland Baltimore County (UMBC), Baltimore, MD

2016 -2017 Associate Professor, Department of Chemistry and Biochemistry, University of Maryland Baltimore County (UMBC), Baltimore, MD

2017 -To Present Associate Professor and Ohio Eminent Scholar , Department of Chemistry, University of Cincinnati , Cincinnati, OH

Grant: #R01 GM117159 Investigators:Ryan White (PI); Jennie Leach (Co-PI UMBC) 12-01-2015 -Bad Format: 20201131 NIH Aptamer-Hydrogel Hybrid Sensors for Continuous Therapeutic Drug Monitoring Role:PI $1,220,134 Active Type:Grant

Grant: #1608679 Investigators:Ryan White 06-01-2016 -05-31-2019 NSF Scanning Ion Conductance Microscopy Using Protein Channels Role:PI $360,000 Active Type:Grant

Grant: #1R21MH101692 Investigators:Ryan White 04-03-2014 -12-31-2016 NIH Nanoscale Sensors for Direct, Real-Time Monitoring of Gliotransmitter Release Role:PI $407,083 Completed Type:Grant

Investigators:Ryan White, NanoTerra Inc. 08-01-2016 -05-01-2017 DARPA Real-time Assessment of Antimicrobial Concentrations for Personalized Treatment of Infectious Diseases Role:Co-PI $40,000 Completed Type:Contract

Grant: #CHE-1753797 Investigators:White, Ryan 08-15-2017 -05-31-2019 National Science Foundation Scanning Ion Conductance Microscopy Using Protein Channels (TRANSFER of CHE-1608679) Role:PI $249,600.00

Grant: #R01GM117159 Investigators:White, Ryan 08-15-2017 -11-30-2020 National Institute of General Medical Sciences Aptamer-Hydrogel Hybrid Sensors for Continuous Therapeutic Drug Monitoring (transfer of NIH R01 GM117159) Role:PI $165,594.00 Active Level:Federal

Grant: #UC4DK11628 Investigators:Ryan White, NanoTerra Inc. 09-15-2017 -08-31-2021 NIH Modular monitoring of hormone release from human islets Role:Co-PI $1,981,404 Active Type:Grant

Grant: #DARPA D2-1980 Investigators:Ryan White 12-01-2017 -Bad Format: 20201131 DARPA Real-time Assessment of Antimicrobial Concentrations for Personalized Treatment of Infectious Diseases Role:Co-PI $301,512 Active

Grant: #FSU R01952 sub UC4DK116283 Investigators:White, Ryan 09-15-2017 -08-31-2021 National Inst of Diabetes and Digestive and Kidney Disease Modular monitoring of hormone release from human islets Role:PI $590,568.00 Active

Grant: #012686 ISRA_Diamond Foun Investigators:Heikenfeld, Jason; White, Ryan 02-01-2020 -04-30-2020 Diamond Foundry, Inc. Diamond Electrode Biosensors Role:Collaborator $37,000.00 Awarded Level:Industry

Grant: #FA9550-20-1-0218 Investigators:Angelopoulos, Anastasios; Guliants, Vadim; Jha, Rashmi; Shanov, Vesselin; Shi, Jing; Smith, Leigh; Steiner, Matthew; Vasudevan, Vijay; White, Ryan; Zhang, Peng 09-01-2020 -08-31-2021 Air Force Office of Scientific Research Acquisition of an Analytical High-Resolution Scanning/Transmission Electron Microscope for Multidisciplinary Research and Education Role:Collaborator $500,000.00 Awarded Level:Federal

Grant: #AF 1677 Investigators:Angelopoulos, Anastasios; Guliants, Vadim; Jha, Rashmi; Shanov, Vesselin; Shi, Jing; Smith, Leigh; Steiner, Matthew; Vasudevan, Vijay; White, Ryan; Zhang, Peng 09-01-2020 -08-31-2021 Ohio Department of Higher Education Acquisition of an Analytical High-Resolution Scanning/Transmission Electron Microscope for Multidisciplinary Research and Education Role:Collaborator $237,500.00 Awarded Level:State of Ohio

Grant: #1015878 Investigators:Ryan White (Co-PI); Jason Heikenfeld (PI) The Diamond Foundry Diamond Electrode Biosensors 18,500

Grant: #CHE-2108368 Investigators:White, Ryan 04-01-2021 -03-31-2024 National Science Foundation Spatially-Resolved Chemical Detection with Maintained Single Protein Channel Recordings on Nanoneedle Probes Role:PI $270,000.00 Awarded Level:Federal

Grant: #CHE 2108368 Investigators:Ryan J White 04-2021 -03-2024 National Science Foundation Localized Chemical Detection with Maintained Single Protein Channel Recordings on Nanoneedle Probes Role:PI 405,000 Active Type:Grant

Grant: #R21EB033874 Investigators:Heikenfeld, Jason; White, Ryan 09-19-2022 -06-30-2025 National Institute of Biomedical Imaging and Bioengineering Breakthrough Blocking-Layer Stability for Broader Clinical Utility of Continuous Aptamer Biosensors Role:Collaborator 0.00 Awarded Level:Federal

Grant: #R01NS134365 Investigators:White, Ryan 06-15-2023 -05-31-2028 National Institute of Neurological Disorders and Stroke Developing Electrochemical Sensors to Enable Quantitative Measure of Gliotransmitter Release from Astrocytes Role:PI 392267.00 Awarded Level:Federal

Grant: #3-SRA-2024-1464-M-B Investigators:White, Ryan 10-01-2023 -09-30-2026 Juvenile Diabetes Research Foundation International Charting a Path for Continuous Insulin Monitoring Role:PI 261821.00 Hold Level:Non Profit

Grant: #CHE-2328176 Investigators:Angelopoulos, Anastasios; Sun, Yujie; Walla, Sarah; White, Ryan; Wu, Jingjie 01-01-2024 -12-31-2025 National Science Foundation MRI: Track 1 Acquisition of a high-performance X-ray photoelectron spectrometer for research and training (no cost share required per CHIPS And Science Act of 2022) Role:Collaborator 499997.00 Awarded Level:Federal

Grant: #CHE-2320116 Investigators:Angelopoulos, Anastasios; Sun, Yujie; Walla, Sarah; White, Ryan; Wu, Jingjie 09-01-2023 -08-31-2026 National Science Foundation MRI: Track 1 Acquisition of a high-performance X-ray photoelectron spectrometer for research and training (no cost share required per CHIPS And Science Act of 2022) Role:Collaborator 841753.00 Awarded Level:Federal

Investigators:Morehouse, Nathan; Tang, Ming; White, Ryan 08-01-2023 -05-31-2024 Procter & Gamble Digital Accelerator at UC P&G Digital Accelerator at UC: IRIS Institute for Research in Sensing Role:PI 16000.00 Hold Level:Industry

Grant: #015957 / TI-2335105 Investigators:Becker, Richard; Heikenfeld, Jason; White, Ryan 03-15-2024 -02-28-2026 National Science Foundation In-vivo validation of a volume-manufacturable and factory-calibrated continous NT-proBNP wearable monitoring system for heart-failure treatment. Role:Collaborator 135198.00 Hold Level:Federal

Grant: #Parent R21 Investigators:Heikenfeld, Jason; White, Ryan 09-01-2024 -08-31-2026 National Institute of Biomedical Imaging and Bioengineering Aptamer tagging with redox quenchers: a critical breakthrough in the sensitivity of continuous electrochemical protein monitoring Role:Collaborator 0.00 Hold Level:Federal

Peer Reviewed Publications

Wu, Yao, Belmonte, Israel, Sykes, Kiana S, Xiao, Yi, & White, Ryan J (2019). Perspective on the Future Role of Aptamers in Analytical Chemistry. Analytical chemistry, 91(24), 15335-15344.

Sykes, Kiana S, Oliveira, Luiz F L, Stan, George, & White, Ryan J (2019). Electrochemical Studies of Cation Condensation-Induced Collapse of Surface-Bound DNA. Langmuir : the ACS journal of surfaces and colloids, 35(40), 12962-12970.

Santos-Cancel, Mirelis, Simpson, Laura W, Leach, Jennie B, & White, Ryan J (2019). Direct, Real-Time Detection of Adenosine Triphosphate Release from Astrocytes in Three-Dimensional Culture Using an Integrated Electrochemical Aptamer-Based Sensor. ACS chemical neuroscience, 10(4), 2070-2079.

Y. Wu, B. Midinov* and R. J. White, "An Electrochemical Aptamer-Based Sensor for Real-Time Monitoring of Insulin," ACS Sens., 2019, 4, 498-503.

K. Shoji, R. Kawano and R. J. White, "Spatially Resolved Chemical Detection with a Nanoneedle-Probe-Supported Biological Nanopore," ACS Nano, 2019, 13, 2606-2614 

X. Zhang, R. Lazenby, Y. Wu, and R. J. White, "Electrochromic, Closed-Bipolar Electrodes Employing Aptamer-Based Recognition for Direct Colorimetric Sensing Visualization," Anal. Chem., 2019, 91, 11467-11473

P. Gupta, R. A. Lazenby, C. E. Rahm, W. R. Heineman, E. Buschbeck, R. J. White, N. T. Alvarez, “Electrochemistry of Controlled Diameter Carbon Nanotube Fibers at Cross Section and Sidewall,” ACS Appl. Energy Mater., 2019, 2, 8757.

Invited Presentations

Ryan J. White (01-16-2017. ) Developing Specific Electrochemical Sensing and Imaging Platforms .University , Virginia Commonwealth University . Level:University

Ryan J. White (04-10-2017. ) Developing Specific Electrochemical Sensing and Imaging Platforms .University , University of Utah. Level:University

Ryan J. White (08-24-2017. ) Collagen membranes with ribonuclease inhibitors for long-term stability of electrochemical, aptamer-based sensors employing RNA, .ACS National Meeting , Washington DC. Conference. . Level:National

Ryan J. White (10-10-2017. ) Developing Specific Electrochemical Sensing and Imaging Platforms .University, McGill University. Other Institution. . Level:International

Ryan J. White (11-09-2017. ) Using ion channels to detect single molecules with high spatial resolution .The Southeastern Regional Meeting of the American Chemical Society, Charlotte, NC. Level:Regional

Ryan J. White (10-14-2017. ) Developing Specific Electrochemical Sensing and Imaging Platforms .UMBC Undergraduate Research Symposium, Baltimore, MD. Level:National

Ryan J. White (11-17-2017. ) Developing Specific Electrochemical Sensing and Imaging Platforms .University, Florida International University . Level:University

Ryan J. White (01-05-2018. ) Developing Specific Electrochemical Sensors and Imaging Platforms .Sensors Retreat. UC. . Level:Regional

Ryan J. White (02-06-2018. ) Developing Specific Electrochemical Sensors and Imaging Platforms .Wayne State University, Detroit, MI. Other Institution. . Level:University

Ryan J. White (08-21-2018. ) Rapid, 2 ms Interrogation of Electrochemical Aptamer Based Sensors .American Chemical Society National Meeting, Boston, MA. Level:National

Ryan J. White (11-20-2018. ) Ion Channel Probes for Chemical Detection and Imaging .Tokyo University of Agriculture and Technology, Tokyo, Japan. Level:International

flyer

Ryan J. White (12-07-2018. ) Pushing the Limits of Specific Electrochemical Sensors .Univerity of Akron, Akron, OH. Level:University

Ryan J. White (07-20-2018. ) Pushing the Limits of Specific Electrochemical Sensors .Air Force Research Laboratory, Dayton, OH. Level:National

Ryan J. White (02-15-2019. ) Developing Specific Chemical Sensing Platforms .Purdue University Fort Wayne, Indianapolis, IN. Level:University

Ryan J. White (02-28-2019. ) Developing Specific Chemical Sensing Platforms .University of Miami, Oxford, OH. Level:University

Ryan J. White (09-20-2019. ) Dynamic Molecular Monitoring with Electrochemistry .NC State University, Raleigh, NC. Level:University

Ryan J. White (11-13-2019. ) Dynamic Molecular Monitoring with Electrochemistry .IUPUI, Indianapolis, IN. Level:University

Ryan J. White (03-18-2019. ) Developing Specific Chemical Sensing Platforms .University of Bordeaux, Bordeaux, France. Level:International

Ryan J. White (08-22-2019. ) Antifouling electrochemical aptamer-based sensor and moving towards flexible, naked-eye detection .American Chemical Society National Meeting, San Diego, CA. Level:National

Ryan White (10-19-2020. ) Exploiting the Dynamics of Surface Bound DNA For Analytical Sensor Performance .University of Utah, Virtual. Other Institution. . Level:National

Ryan white (11-23-2020. ) Exploiting the Dynamics of Surface Bound DNA For Analytical Sensor Performance .Illinois Institute of Tecnology, Virtual. Level:National

Ryan J. White (11-2021. ) Exploiting the Dynamics of Surface Bound DNA For Analytical Sensor Performance .Illinois Institute of Technology, IL. Other Institution. . Level:National

Ryan J White (03-2021. ) Pushing the Spatiotemporal Resolution of Electrochemical Sensors .Pittcon, Conference. . Level:International

Poster Presentations

Kiana Sykes (03-2019. ) Electrochemical Studies of DNA Cation Condensation and Collapse of Surface Bound DNA. .Naff Symposium, University of Kentucky. . Other Institution. . Level:University

Kiana Sykes (09-2019. ) Electrochemically Monitoring and Quantifying Surface-Bound ssDNA Collapse and dsDNA Collapse. Oesper Symposium, University of Cincinnati. . UC. . Level:University

Hope Kumakli (09-2019. ) Real-time Formation and Studies of Self Assembled Monolayer on Gold Electrode Surface Using Scanning Electrochemical Cell Microscopy (SECCM) .Oesper Symposium, University of Cincinnati. . UC. . Level:University

Israel Belmonte (03-2019. ) lectrochemical Reduction of Diazonium Salts onto Glassy Carbon Electrodes for a more Robust Electrochemical Aptamer-Based Sensor. Naff Symposium, University of Kentucky. . Other Institution. . Level:University

Israel Belmonte (09-2019. ) Quantitatively Measuring Gliotransmitter Release from Astrocytes in a 3-D Collagen Culture using an E-AB Sensor .Oesper Symposium, University of Cincinnati. . UC. . Level:University

Tatiana Ilina (09-2019. ) Development of Calibration-Free Biosensors Using Intermittent Pulse Amperometry .Oesper Symposium, University of Cincinnati. . UC. . Level:University

Yao Wu (03-2019. ) A Generalizable Electrocatalytic Mechanism between DNA Tethered Methylene Blue and Ferricyanide .Naff Symposium, University of Kentucky. . Other Institution. . Level:University

Yao Wu (09-2019. ) Electrocatalysis in Differentiating DNA Polymorphisms .Oesper Symposium, University of Cincinnati. . UC. . Level:University

Spencer Hendickson (09-2019. ) evelopment of Bio-fouling-resistant Electrochemical Aptamer-based Sensors for Use in Complex Media .Oesper Symposium, University of Cincinnati. . UC. . Level:University

Paper Presentations

Ryan J White (03-09-2017. ) Quantitative, Simultaneous Stochastic Sensing with Multiple Protein Channels .Chicago, IL. Conference. Level:International

Ryan J. White (02-27-2018. ) Rapid, 2 ms Interrogation of Electrochemical Aptamer Based Sensors .Orlando, FL. Conference.

Kiana Sykes (03-2019. ) Electrochemical Studies of DNA Cation Condensation and Collapse of Surface Bound DNA .Philadelphia, PA. Conference. Level:International

Israel Belmonte (02-2019. ) Aryl Modified Surfaces for the Fabrication of Electrochemical Aptamer-Based Sensors on Glassy Carbon .Philadelphia, PA. Conference. Level:International

Yao Wu (03-2019. ) A Generalizable Electrocatalytic Mechanism between DNA Tethered Methylene Blue and Ferricyanide .Philadelphia, PA. Conference. Level:International

Event Organized

SEAC: A student session in electroanalysis. Symposium Pittcon 2018 - Orlando, FL Level:International

Electrochemistry Gordon Conference - Session Chair Electroanalytical Chemistry Conference Ventura California Level:International

2016 SEAC Royce W. Murray Young Investigator Award Society for Electroanalytical Chemistry Status:Recipient Level:International

Mirelis Santos Cancel (Doctoral ) Chair Status:In Progress

Sierra Mize (Undergrad ) Advisor Status:In Progress

Catherine Peterson (Undergrad ) Advisor Status:In Progress

Eli Seidman-Deutsch (Undergrad ) Advisor Status:Completed 12-18-2017

Dr. Robert Lazenby (Postdoctoral ) Advisor Status:In Progress

Dr. Kan Shoji (Postdoctoral ) Advisor Status:In Progress

Inayah Entzminger (Undergrad ) Advisor Status:Completed 08-15-2017

Nick Vaccaro (Undergrad ) Advisor Status:Completed 08-15-2017

Justine Lottermoser (Undergrad ) Advisor Status:Completed 08-15-2017

Department of Chemistry (Sustainable Chemistry Faculty Search Committee ) Committee Chair Type:Departmental Service 08-20-2017 -01-31-2018

Deparmtent of Electrical Engineering and Computer Science (Faculty Search Committee ) Committee Member Type:Departmental Service 09-01-2017 -02-01-2018

Department of Chemistry (Awards Committee ) Committee Member Type:Departmental Service 09-01-2017

Department of Electrical Engineering and Computer Science (ERC Cleanroom Operation Committee ) Committee Member Type:Departmental Service 09-01-2017

Pittcon 2018 (The Student Session in Electroanalysis. ) Co-Chair Type:Service to Professional Associations Level:International 02-27-2018 -02-27-2018

National Institutes of Health (ISD ) Member Type:Grant Panel Level:National 04-05-2018 -04-06-2018

National Institutes of Health (EBIT ) Member Type:Grant Panel Level:National 09-04-2018 -09-05-2018

Department of Chemistry (Awards Committee ) Member Type:Departmental Service Level:Department 01-01-2018

University of Cincinnati (Urban Futures Institute Planning Committee ) Member Type:University/College Service Level:University 01-01-2018

University of Cincinnati (Data Task Force Committee ) Member Type:University/College Service Level:University 11-09-2018

Department of Chemistry (Center for Chemical Sensors and Biosensors ) Director Type:Departmental Service Level:Department 08-01-2018

Sensing our Digital Future (Sensing our Digital Future ) Other Type:University/College Service Level:University 12-01-2019

NIH (EBIT ) Member Type:Grant Panel Level:National 10-01-2019

(Search Committee ) Committee Chair Type:Departmental Service Level:Department 08-01-2019

(BME Head Search Committee ) Member Type:University/College Service Level:National 04-01-2019

(Equity and Inclusion Taskforce ) Committee Chair Type:Departmental Service Level:National 10-01-2019

(Institute for Research in Sensing (IRiS) ) Co-Coordinator Type:University/College Service Level:National 09-01-2019

Journal Reviewer Type:Service to Professional Associations Level:International

Institute for Research in Sensing (IRiS) (Leadership Team ) Committee Member Type:University/College Service Level:University

Department of Chemistru (Diversity, Equity, and Inclusion Task Force ) Committee Chair Type:Departmental Service Level:Department

A&S (21st Century Task Force - Entrepreneurial Growth Sub Group ) Co-Chair Type:University/College Service Level:College

(Analytical Chemistry Diversity Colloquium Series ) Co-Chair Type:Service to Professional Associations Level:National

National Institutes of Health (EBIT Review Panel ) Other Type:Grant Panel Level:National

Analytical Chemistry (Features Panel Advisory Board ) Member Type:Editorial Service Level:International

Analytica Chimica Acta (Editorial Advisory Board ) Member Type:Editorial Service Level:International

(Faculty Search Committee ) Committee Chair Type:Departmental Service Level:Department

Biological/Bioanalytical/Bioinorganic/Biophysical

2017: NSF Review Panel Member National Science Foundation, Washington, DC

2017: NIH Review Panel Member Enabling Biotechnologies Study Section National Institutes of Health , Washington, DC

2017: NIH Review Panel Member Instrumentation and Systems Development Study Section National Institutes of Health , Washington, DC

2017: Journal Reviewer Analytical Chemistry, Journal of the American Chemical Society, Angewandte Chemie, Nature Chemistry, Langmuir, Chemical Communications, ACS Sensors, Analyst, Journal of Physical Chemistry,

2017: NSF Graduate Research Fellowship Review Panel National Science Foundation,

2016 -2021: Society for Electroanalytical Chemistry Board of Directors Member

2017: Member of Features Panel for Analytical Chemistry Features Panel Member for the ACS journal Analytical Chemistry

-CHEM-3030 ANALYTICAL II Level:Undergraduate

Literature Research Level:Graduate

Undergraduate Research Level:Undergraduate

-CHEM-3030 ANALYTICAL II Level:Undergraduate

-CHEM 8027 Chemical Sensors I Level:Both

CHEM 5030 Tackling Global Problems Through International Collaboration

Survey of Biochemistry II Level:Undergraduate

Chemical Sensors Level:Graduate

Introduction to Sensors Level:Both

Electroanalytical Chemistry Level:Graduate

CREATIVITY IN SCIENCE RESEARCH Level:Graduate

2022-043 Single waveform, Conitinous Squarewave Voltammetry for Optimal Calibration Free Sensing

2022-015 APTAMER SENSORS WITH TEMPERATURE CORRECTION

2021-138 Silver Nanoneedles for Sustained DC Current Single Nanopore Measurements

2021-64 SOLUTE-PHASE ELECTROCHEMICAL APTAMER ARCHITECTURES

2021-19 HIGHLY CHEMICALLY STABLE APTAMER SENSORS

Participated in radio interview with respect to Sensors at UC. WVXU Cincinnati.,

Audio File

Academic - 418S Rieveschl
Cincinnati  Ohio, Phone: 513-556-4369
ryan.white@uc.edu