Eric S. Wohleb , PhD

Dr. Wohleb received his doctorate in Neuroscience from the Ohio State University in September 2013 under mentorship of Dr. Jonathan Godbout and Dr. John Sheridan at the Institute for Behavioral Medicine Research. Following graduate studies he completed postdoctoral studies in the laboratory of Dr. Ronald Duman at the Yale University School of Medicine from 2013 - 2016. Dr. Wohleb is currently an Assistant Professor in the Department of Pharmacology & Systems Physiology, with current research focused on the role of neuroimmune systems in shaping synaptic plasticity and behavior.

Bachelor's Degree: Saint John's University Collegeville, MN, 2008 (Mathematics; Psychology)

Doctoral Degree: The Ohio State University Columbus, Ohio, 2013 (Neuroscience; Neuroimmunology)

Postdoctoral Research Associate: Yale University New Haven, CT, 2015 ( )

Associate Research Scientist: Yale University New Haven, CT, 2016

Grant: #NARSAD Young Investigator Grant 01-15-2017 -01-14-2019 Brain & Behavior Research Foundation Microglia-mediated Synapse Elimination in Stress-induced Depressive-like Behavior Role:PI

Grant: #R21MH120614 Investigators:Wohleb, Eric 07-01-2019 -05-31-2021 National Institute of Mental Health Microglial brain-derived neurotrophic factor (BDNF) in stress and antidepressant responses Role:PI $200,625.00 Awarded Level:Federal

Grant: #R21DA049253 Investigators:Reyes, Teresa; Wohleb, Eric 09-01-2019 -08-31-2021 National Institute on Drug Abuse DAT18-09 Maternal opioid exposure and executive function evaluation in the mouse Role:Collaborator $240,750.00 Awarded Level:Federal

Grant: #R01NR019531 Investigators:Reyes, Teresa; Wohleb, Eric 09-07-2020 -06-30-2025 National Institute of Nursing Research Identification of causal factors underlying cognitive deficits in a mouse model of childhood leukemia survival Role:Collaborator $543,381.00 Awarded Level:Federal

Grant: #R01MH123545 Investigators:Davidson, Steve; Wohleb, Eric 05-06-2020 -02-28-2025 National Institute of Mental Health Defining neuron- and microglia-specific contributions to prefrontal cortex dysfunction in chronic stress Role:PI $422,347.00 Awarded Level:Federal

Grant: #VA IPA for Wohleb Investigators:Wohleb, Eric 02-01-2023 -01-31-2024 Department of Veterans Affairs IPA for Dr. Renu Sah's VA Merit Award Role:PI 8279.28 Hold Level:Federal

Grant: #R01MH130399 Investigators:; Wohleb, Eric 04-05-2023 -01-31-2028 National Institute of Mental Health The impact of stress-induced DNA breaks on chromatin structure, gene activity, and neuron function Role:PI 799766.00 Awarded Level:Federal

Peer Reviewed Publications

Horchar, Matthew J; Wohleb, Eric S (2019. ) Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress.Brain, Behavior, and Immunity, , More Information

Wohleb, Eric S; Terwilliger, Rosemarie; Duman, Catharine H; Duman, Ronald S (2018. ) Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior.Biological Psychiatry, , 83 (1 ) ,38-49 More Information

Wohleb, Eric S; Wu, Min; Gerhard, Danielle M; Taylor, Seth R; Picciotto, Marina R; Alreja, Meenakshi; Duman, Ronald S (2016. ) GABA interneurons mediate the rapid antidepressant-like effects of scopolamine.The Journal of Clinical Investigation, , 126 (7 ) ,2482-94 More Information

Smail, Marissa A; Smith, Brittany L; Shukla, Rammohan; Alganem, Khaled; Eby, Hunter M; Bollinger, Justin L; Parikh, Ria K; Chambers, James B; Reigle, James K; Moloney, Rachel D; Nawreen, Nawshaba; Wohleb, Eric S; Pantazopoulos, Harry; McCullumsmith, Robert E; Herman, James P (2023. ) Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix.Molecular psychiatry, , More Information

Bollinger, Justin L; Dadosky, David T; Flurer, James K; Rainer, Ivanka L; Woodburn, Samuel C; Wohleb, Eric S (2023. ) Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , 48 (9 ) ,1347-1357 More Information

Woodburn, Samuel C; Asrat, Helina S; Flurer, James K; Schwierling, Hana C; Bollinger, Justin L; Vollmer, Lauren L; Wohleb, Eric S (2023. ) Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress.Brain, behavior, and immunity, , 109 ,127-138 More Information

Morano, Rachel; Yates, Emily; Barnes, Rachel; Wohleb, Eric S; Perez-Tilve, Diego (2022. ) Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons.Neuroendocrinology, , 112 (3 ) ,287-297 More Information

Woodburn, Samuel C; Bollinger, Justin L; Wohleb, Eric S (2021. ) The semantics of microglia activation: neuroinflammation, homeostasis, and stress.Journal of neuroinflammation, , 18 (1 ) ,258 More Information

Koo, Ja Wook; Wohleb, Eric S (2021. ) How Stress Shapes Neuroimmune Function: Implications for the Neurobiology of Psychiatric Disorders.Biological psychiatry, , 90 (2 ) ,74-84 More Information

Wohleb, Eric S (2016. ) Neuron-Microglia Interactions in Mental Health Disorders: "For Better, and For Worse".Frontiers in Immunology, , 7 ,544 More Information

Woodburn, Samuel C; Bollinger, Justin L; Wohleb, Eric S (2021. ) Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy.Neurobiology of stress, , 14 ,100312 More Information

Bolyard, Chelsea; Meisen, W Hans; Banasavadi-Siddegowda, Yeshavanth; Hardcastle, Jayson; Yoo, Ji Young; Wohleb, Eric S; Wojton, Jeffrey; Yu, Jun-Ge; Dubin, Samuel; Khosla, Maninder; Xu, Bo; Smith, Jonathan; Alvarez-Breckenridge, Christopher; Pow-Anpongkul, Pete; Pichiorri, Flavia; Zhang, Jianying; Old, Matthew; Zhu, Dan; Van Meir, Erwin G; Godbout, Jonathan P; Caligiuri, Michael A; Yu, Jianhua; Kaur, Balveen (2017. ) BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy.Clinical cancer research : an official journal of the American Association for Cancer Research, , 23 (7 ) ,1809-1819 More Information

Wohleb, Eric S; Franklin, Tina; Iwata, Masaaki; Duman, Ronald S (2016. ) Integrating neuroimmune systems in the neurobiology of depression.Nature Reviews Neuroscience, , 17 (8 ) ,497-511 More Information

Hansen, Christopher N; Norden, Diana M; Faw, Timothy D; Deibert, Rochelle; Wohleb, Eric S; Sheridan, John F; Godbout, Jonathan P; Basso, D Michele (2016. ) Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury.Experimental neurology, , 282 ,86-98 More Information

Das, Amitava; Ghatak, Subhadip; Sinha, Mithun; Chaffee, Scott; Ahmed, Noha S; Parinandi, Narasimham L; Wohleb, Eric S; Sheridan, John F; Sen, Chandan K; Roy, Sashwati (2016. ) Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes.Journal of immunology (Baltimore, Md. : 1950), , 196 (12 ) ,5089-100 More Information

Dutheil, Sophie; Ota, Kristie T; Wohleb, Eric S; Rasmussen, Kurt; Duman, Ronald S (2016. ) High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , 41 (7 ) ,1874-87 More Information

McKim, Daniel B; Patterson, Jenna M; Wohleb, Eric S; Jarrett, Brant L; Reader, Brenda F; Godbout, Jonathan P; Sheridan, John F (2016. ) Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat.Biological psychiatry, , 79 (10 ) ,803-813 More Information

McKim, Daniel B; Niraula, Anzela; Tarr, Andrew J; Wohleb, Eric S; Sheridan, John F; Godbout, Jonathan P (2016. ) Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 36 (9 ) ,2590-604 More Information

Gerhard, Danielle M; Wohleb, Eric S; Duman, Ronald S (2016. ) Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity.Drug discovery today, , 21 (3 ) ,454-64 More Information

Navarria, Andrea; Wohleb, Eric S; Voleti, Bhavya; Ota, Kristie T; Dutheil, Sophie; Lepack, Ashley E; Dwyer, Jason M; Fuchikami, Manabu; Becker, Astrid; Drago, Filippo; Duman, Ronald S (2015. ) Rapid antidepressant actions of scopolamine: Role of medial prefrontal cortex and M1-subtype muscarinic acetylcholine receptors.Neurobiology of disease, , 82 ,254-261 More Information

Delpech, Jean-Christophe; Madore, Charlotte; Nadjar, Agnes; Joffre, Corinne; Wohleb, Eric S; Layé, Sophie (2015. ) Microglia in neuronal plasticity: Influence of stress.Neuropharmacology, , 96 (Pt A ) ,19-28 More Information

Sawicki, C M; McKim, D B; Wohleb, E S; Jarrett, B L; Reader, B F; Norden, D M; Godbout, J P; Sheridan, J F (2015. ) Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain.Neuroscience, , 302 ,151-64 More Information

Meisen, W Hans; Wohleb, Eric S; Jaime-Ramirez, Alena Cristina; Bolyard, Chelsea; Yoo, Ji Young; Russell, Luke; Hardcastle, Jayson; Dubin, Samuel; Muili, Kamaldeen; Yu, Jianhua; Caligiuri, Michael; Godbout, Jonathan; Kaur, Balveen (2015. ) The Impact of Macrophage- and Microglia-Secreted TNFα on Oncolytic HSV-1 Therapy in the Glioblastoma Tumor Microenvironment.Clinical cancer research : an official journal of the American Association for Cancer Research, , 21 (14 ) ,3274-85 More Information

Fuchikami, Manabu; Thomas, Alexandra; Liu, Rongjian; Wohleb, Eric S; Land, Benjamin B; DiLeone, Ralph J; Aghajanian, George K; Duman, Ronald S (2015. ) Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions.Proceedings of the National Academy of Sciences of the United States of America, , 112 (26 ) ,8106-11 More Information

Bollinger, Justin L; Horchar, Matthew J; Wohleb, Eric S (2020. ) Diazepam limits microglia-mediated neuronal remodeling in the prefrontal cortex and associated behavioral consequences following chronic unpredictable stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, , More Information

Reader, B F; Jarrett, B L; McKim, D B; Wohleb, E S; Godbout, J P; Sheridan, J F (2015. ) Peripheral and central effects of repeated social defeat stress: monocyte trafficking, microglial activation, and anxiety.Neuroscience, , 289 ,429-42 More Information

Gerhard, Danielle M; Pothula, Santosh; Liu, Rong-Jian; Wu, Min; Li, Xiao-Yuan; Girgenti, Matthew J; Taylor, Seth R; Duman, Catharine H; Delpire, Eric; Picciotto, Marina; Wohleb, Eric S; Duman, Ronald S (2020. ) GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.The Journal of clinical investigation, , 130 (3 ) ,1336-1349 More Information

Wohleb, Eric S; McKim, Daniel B; Sheridan, John F; Godbout, Jonathan P (2014. ) Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior.Frontiers in neuroscience, , 8 ,447 More Information

Girgenti, Matthew J; Wohleb, Eric S; Mehta, Sameet; Ghosal, Sriparna; Fogaca, Manoela V; Duman, Ronald S (2019. ) Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes.Translational psychiatry, , 9 (1 ) ,292 More Information

Wohleb, Eric S; McKim, Daniel B; Shea, Daniel T; Powell, Nicole D; Tarr, Andrew J; Sheridan, John F; Godbout, Jonathan P (2014. ) Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain.Biological psychiatry, , 75 (12 ) ,970-81 More Information

Bollinger, J L; Wohleb, E S (2019. ) The formative role of microglia in stress-induced synaptic deficits and associated behavioral consequences.Neuroscience letters, , 711 ,134369 More Information

Wohleb, Eric S; Patterson, Jenna M; Sharma, Vikram; Quan, Ning; Godbout, Jonathan P; Sheridan, John F (2014. ) Knockdown of interleukin-1 receptor type-1 on endothelial cells attenuated stress-induced neuroinflammation and prevented anxiety-like behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 34 (7 ) ,2583-91 More Information

Deyama, Satoshi; Bang, Eunyoung; Wohleb, Eric S; Li, Xiao-Yuan; Kato, Taro; Gerhard, Danielle M; Dutheil, Sophie; Dwyer, Jason M; Taylor, Seth R; Picciotto, Marina R; Duman, Ronald S (2019. ) Role of Neuronal VEGF Signaling in the Prefrontal Cortex in the Rapid Antidepressant Effects of Ketamine.The American journal of psychiatry, , 176 (5 ) ,388-400 More Information

Wohleb, Eric S; Powell, Nicole D; Godbout, Jonathan P; Sheridan, John F (2013. ) Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 33 (34 ) ,13820-33 More Information

Franklin, Tina C; Wohleb, Eric S; Zhang, Yi; Fogaça, Manoela; Hare, Brendan; Duman, Ronald S (2018. ) Persistent Increase in Microglial RAGE Contributes to Chronic Stress-Induced Priming of Depressive-like Behavior.Biological psychiatry, , 83 (1 ) ,50-60 More Information

Wohleb, Eric S; Godbout, Jonathan P (2013. ) Basic aspects of the immunology of neuroinflammation.Modern trends in pharmacopsychiatry, , 28 ,1-19 More Information

Wohleb, Eric S; Delpech, Jean-Christophe (2017. ) Dynamic cross-talk between microglia and peripheral monocytes underlies stress-induced neuroinflammation and behavioral consequences.Progress in neuro-psychopharmacology & biological psychiatry, , 79 (Pt A ) ,40-48 More Information

Voorhees, Jeffrey L; Tarr, Andrew J; Wohleb, Eric S; Godbout, Jonathan P; Mo, Xiaokui; Sheridan, John F; Eubank, Timothy D; Marsh, Clay B (2013. ) Prolonged restraint stress increases IL-6, reduces IL-10, and causes persistent depressive-like behavior that is reversed by recombinant IL-10.PloS one, , 8 (3 ) ,e58488 More Information

Bath, Kevin G; Russo, Scott J; Pleil, Kristen E; Wohleb, Eric S; Duman, Ronald S; Radley, Jason J (2017. ) Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development.Neurobiology of stress, , 7 ,137-151 More Information

Wohleb, Eric S; Fenn, Ashley M; Pacenta, Ann M; Powell, Nicole D; Sheridan, John F; Godbout, Jonathan P (2012. ) Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice.Psychoneuroendocrinology, , 37 (9 ) ,1491-505 More Information

Wohleb, Eric S; Hanke, Mark L; Corona, Angela W; Powell, Nicole D; Stiner, La'Tonia M; Bailey, Michael T; Nelson, Randy J; Godbout, Jonathan P; Sheridan, John F (2011. ) β-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 31 (17 ) ,6277-88 More Information

Wohleb, Eric S; Gerhard, Danielle; Thomas, Alex; Duman, Ronald S (2017. ) Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine.Current neuropharmacology, , 15 (1 ) ,11-20 More Information

Academic - Reading Campus
2120 East Galbraith Road
Cincinnati  Ohio, 45237
Phone: 513-558-6870
Fax: 513-297-0966
eric.wohleb@uc.edu