Marlena Wosiski-Kuhn , MD,PhD

Bachelors Degree: Johns Hopkins University Baltimore, MD, (Neuroscience)

Graduate Degree: Wake Forest University Winston-Salem, NC, (Biomedical Research)

Medical Degree: Wake Forest University Winston-Salem, NC,

Grant: #EMF/EMRA Resident Research Grant Investigators:Wosiski-Kuhn, Marlena 07-01-2023 -06-30-2024 Emergency Medicine Foundation Central Nervous System Interleukin-6 (IL6) and Soluble IL6 Receptor in a Porcine Model of Traumatic Brain Injury Role:PI 6050.00 Hold Level:Non Profit

Peer Reviewed Publications

Milligan, Carol; Atassi, Nazem; Babu, Suma; Barohn, Richard J; Caress, James B; Cudkowicz, Merit E; Evora, Armineuza; Hawkins, Gregory A; Wosiski-Kuhn, Marlena; Macklin, Eric A; Shefner, Jeremy M; Simmons, Zachary; Bowser, Robert P; Ladha, Shafeeq S (2021. ) Tocilizumab is safe and tolerable and reduces C-reactive protein concentrations in the plasma and cerebrospinal fluid of ALS patients.Muscle & nerve, , More Information

Wosiski-Kuhn, Marlena; Caress, James B; Cartwright, Michael S; Hawkins, Gregory A; Milligan, Carol (2021. ) Interleukin 6 (IL6) level is a biomarker for functional disease progression within IL6R358Ala variant groups in amyotrophic lateral sclerosis patients.Amyotrophic lateral sclerosis & frontotemporal degeneration, , 22 (3-4 ) ,248-259 More Information

Wosiski-Kuhn, Marlena; Robinson, Mac; Strupe, Jane; Arounleut, Phonepasong; Martin, Matthew; Caress, James; Cartwright, Michael; Bowser, Robert; Cudkowicz, Merit; Langefeld, Carl; Hawkins, Gregory A; Milligan, Carol (2019. ) IL6 receptor358Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis.Neurology(R) neuroimmunology & neuroinflammation, , 6 (6 ) ,e631 More Information

Pathak, Sapna; Caress, James B; Wosiski-Kuhn, Marlena; Milligan, Carol; Williams, Delaney; Cartwright, Michael S (2019. ) A pilot study of neuromuscular ultrasound as a biomarker for amyotrophic lateral sclerosis.Muscle & nerve, , 59 (2 ) ,181-186 More Information

Wosiski-Kuhn, Marlena; Lyon, Miles S; Caress, James; Milligan, Carol (2019. ) Inflammation, immunity, and amyotrophic lateral sclerosis: II. immune-modulating therapies.Muscle & nerve, , 59 (1 ) ,23-33 More Information

Lyon, Miles S; Wosiski-Kuhn, Marlena; Gillespie, Rachel; Caress, James; Milligan, Carol (2019. ) Inflammation, Immunity, and amyotrophic lateral sclerosis: I. Etiology and pathology.Muscle & nerve, , 59 (1 ) ,10-22 More Information

Wosiski-Kuhn, Marlena; Bota, Mihail; Snider, Christina A; Wilson, Steven P; Venkataraju, Kannan U; Osten, Pavel; Stranahan, Alexis M (2018. ) Hippocampal brain-derived neurotrophic factor determines recruitment of anatomically connected networks after stress in diabetic mice.Hippocampus, , 28 (12 ) ,900-912 More Information

Dey, Aditi; Hao, Shuai; Wosiski-Kuhn, Marlena; Stranahan, Alexis M (2017. ) Glucocorticoid-mediated activation of GSK3? promotes tau phosphorylation and impairs memory in type 2 diabetes.Neurobiology of aging, , 57 ,75-83 More Information

McGee-Lawrence, Meghan E; Wenger, Karl H; Misra, Sudipta; Davis, Catherine L; Pollock, Norman K; Elsalanty, Mohammed; Ding, Kehong; Isales, Carlos M; Hamrick, Mark W; Wosiski-Kuhn, Marlena; Arounleut, Phonepasong; Mattson, Mark P; Cutler, Roy G; Yu, Jack C; Stranahan, Alexis M (2017. ) Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice.Endocrinology, , 158 (5 ) ,1160-1171 More Information

Dey, Aditi; Hao, Shuai; Erion, Joanna R; Wosiski-Kuhn, Marlena; Stranahan, Alexis M (2014. ) Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes.Journal of neuroimmunology, , 269 (1-2 ) ,20-27 More Information

Wosiski-Kuhn, Marlena; Erion, Joanna R; Gomez-Sanchez, Elise P; Gomez-Sanchez, Celso E; Stranahan, Alexis M (2014. ) Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice.Psychoneuroendocrinology, , 42 ,165-77 More Information

Erion, Joanna R; Wosiski-Kuhn, Marlena; Dey, Aditi; Hao, Shuai; Davis, Catherine L; Pollock, Norman K; Stranahan, Alexis M (2014. ) Obesity elicits interleukin 1-mediated deficits in hippocampal synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience, , 34 (7 ) ,2618-31 More Information

Wosiski-Kuhn, Marlena; Stranahan, Alexis M (2013. ) From pattern separation to mood regulation: multiple roles for developmental signals in the adult dentate gyrus.Frontiers in cellular neuroscience, , 7 ,96 More Information

Stranahan, Alexis M; Erion, Joanna R; Wosiski-Kuhn, Marlena (2013. ) Reelin signaling in development, maintenance, and plasticity of neural networks.Ageing research reviews, , 12 (3 ) ,815-22 More Information

Sherwood, Andrew; Wosiski-Kuhn, Marlena; Nguyen, Truc; Holland, Peter C; Lakaye, Bernard; Adamantidis, Antoine; Johnson, Alexander W (2012. ) The role of melanin-concentrating hormone in conditioned reward learning.The European journal of neuroscience, , 36 (8 ) ,3126-33 More Information

Wosiski-Kuhn, Marlena; Stranahan, Alexis M (2012. ) Opposing effects of positive and negative stress on hippocampal plasticity over the lifespan.Ageing research reviews, , 11 (3 ) ,399-403 More Information

Wosiski-Kuhn, Marlena; Stranahan, Alexis M (2012. ) Transient increases in dendritic spine density contribute to dentate gyrus long-term potentiation.Synapse (New York, N.Y.), , 66 (7 ) ,661-4 More Information

Johnson, A W; Sherwood, A; Smith, D R; Wosiski-Kuhn, M; Gallagher, M; Holland, P C (2010. ) An analysis of licking microstructure in three strains of mice.Appetite, , 54 (2 ) ,320-30 More Information

Academic - University of Cincinnati College of Medicine
Department of Emergency Medicine
Cincinnati, OH  Ohio, 45267-0769
Phone: 513-558-8114
Fax: 513-558-5791
Marlena.Wosiski-Kuhn@uc.edu