Bruce R. Yacyshyn , MD

Bachelor's Degree: University of Alberta 1980 (Medical Science )

Medical Degree: University of Alberta 1982

Chief Intern : Edmonton General Hospital 1982

Assistant Resident: University of Toronto, Toronto General Hospital 1984 (Medicine )

Assistant Resident: University of Toronto, Toronto General Hospital 1985 (Medicine )

Senior Resident: University of Toronto, Sunnybrook Medicine Centre 1986 (Medicine )

Clinical Fellowship: Washington University School of Medicine 1987 ( Gastroenterology )

Research Fellowship: Washington University School of Medicine 1989 (Gastroenterology )

American Board of Internal Medicine (Certification Date: 09-10-1986 )

Royal College of Physicians and Surgeons of Canada (Certification Date: 11-22-1989 )

Inflammatory Bowel Disease, Irritable Bowel Syndrome, General Gastroenterology.

2009 -To Present Professor of Clinical Medicine, Division of Digestive Diseases, University of Cincinnati, Cincinnati, OH

2006 -2009 Associate Clinical Professor of Medicine (volunteer track), University of Cincinnati, Cincinnati, OH

2004 -2005 Associate Professor, Department of Pathology, Case Western Reserve University, Cleveland, OH

2003 -2005 Staff PHysician, Louis Stokes VA Medical Center, Cleveland, OH

2002 -2005 Associate Professor of Medicine, Case Western Reserve University, Cleveland, OH

2002 -2005 Chief, Gastroenterology, Louis Stokes VA Medical Center, Cleveland, OH

1999 -2002 Medical Staff, Department of Medicine, Division of Gastroenterology, Grey Nuns Community Hospital & Health Centre, Caritas Health Group, Edmonton, Alberta, Canada

1995 -2002 Associate Professor, Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada

1995 -2002 Consultant Physician, Department of Medicine, Grey Nun's Hospital, Edmonton, Alberta, Canada

1989 -1994 Assistant Professor, Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, Canada

1989 -2002 Consultant Physician, Department of Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada

1987 -1989 Clinical Instructor of Medicine, Department of Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri

Investigators:BR Yacyshyn 01-1997 -12-1997 ISIS Pharmaceuticals Antisense in an animal model of intestinal inflammation $46,000

Investigators:BR Yacyshyn 10-1994 -10-1997 Crohn's & Colitis Foundation of Canada (Operating Grant) Multidrug resistance in inflammatory bowel disease $150,000

Investigators:BR Yacyshyn 01-1995 -01-1996 University of Alberta Central Research Fund IBD epithelium induction of integrins on isolated LPMC $8,000

Investigators:BR Yacyshyn 01-1996 -01-1997 UAH Special Services Research Committee MS patients have peripheral blood CD45RO B-cells and increased intestinal permeability $15,400

Investigators:BR Yacyshyn 11-1998 ISIS Pharmaceuticals Antisense to ICAM-1 in HLA-B27 transgenic rats $46,000

Investigators:BR Yacyshyn 12-1998 -12-2000 MSI Foundation CD45RO+ B-cells in inflammatory bowel disease $50,000

Investigators:BR Yacyshyn 01-2001 -12-2001 University Hospital Foundation Broad Medical Research Foundation MRP isoforms in inflammatory bowel disease Exposure to bacterial flora and gut permeability: a mechanistic correlation in the HLA-B27 animal model of IBD. $22,500

Investigators:BR Yacyshyn 01-2011 -01-2013 Merck Investigator Initiated Study Program (IISP) Cell mediated Immunity INCDAD $252,000

Grant: #IIS #38933 Investigators:Yacyshyn, Bruce 01-01-2011 -03-31-2014 Merck Sharp & Dohme Corp Cell Mediated Immunity in Recurrent Clostridium Difficile Infection Role:PI $252,894.00 Active Level:Industry

Grant: #T317401 / R01 DK087694 Investigators:Yacyshyn, Bruce 12-01-2014 -02-29-2016 National Inst of Diabetes and Digestive and Kidney Disease Gene discoveries in subjects with Crohn's disease of African descent (GENESIS) Role:PI $60,000.00 Active Level:Federal

Grant: #RGA 53472 Investigators:Yacyshyn, Bruce; Yacyshyn, Mary Beth 08-04-2015 -02-28-2017 Cubist Pharmaceuticals, Inc. Phenotypic stratification of recurrent Clostridium difficile infected patients using circulating PBMC at point of initial infection. Role:PI $193,080.63 Awarded Level:Industry

Grant: #PCORI-PPRND-1507-31465 Investigators:Yacyshyn, Bruce 03-01-2017 -07-31-2019 Patient-Centered Outcomes Research Institute Comparative effectiveness of specific carbohydrate and Mediterranean diets to induce remission in patients with Crohn's disease Role:PI $8,600.00 Active Level:Private Non-Profit

Grant: #Emory T757471 sub R01DK087694 Investigators:Yacyshyn, Bruce 09-01-2016 -07-31-2021 National Inst of Diabetes and Digestive and Kidney Disease Gene discoveries in subjects with Crohn's disease of African descent (GENESIS) Role:PI $2,800.00 Active Level:Federal

Grant: #SPARC IBD Site Agreement Investigators:Yacyshyn, Bruce 07-13-2018 -07-12-2020 Crohn's & Colitis Foundation of American Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD) Role:PI $256,060.34 Awarded Level:Private Non-Profit

Peer Reviewed Publications

Yacyshyn, Bruce R (2008. ) Adhesion molecule therapeutics in IBD.Inflammatory bowel diseases, , 14 Suppl 2 ,S279-80 More Information

Mant, Michael J; Bain, Vincent G; Maguire, Conor G; Murland, Keith; Yacyshyn, Bruce R (2006. ) Prevalence of occult gastrointestinal bleeding in celiac disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, , 4 (4 ) ,451-4 More Information

Yacyshyn, B R; Schievella, A; Sewell, K L; Tami, J A (2005. ) Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical trial of antisense to ICAM-1.Clinical and experimental immunology, , 141 (1 ) ,141-7 More Information

Yacyshyn, Bruce R (2005. ) Antisense oligonucleotide treatment of inflammatory bowel diseases. Methods in molecular medicine, , 106 ,295-305

Yacyshyn, Bruce R; Pilarski, Linda M (2003. ) Discussion on the safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study. Gastroenterology, , 125 (5 ) ,1562; author reply 1

Yacyshyn, B R; Barish, C; Goff, J; Dalke, D; Gaspari, M; Yu, R; Tami, J; Dorr, F A; Sewell, K L (2002. ) Dose ranging pharmacokinetic trial of high-dose alicaforsen (intercellular adhesion molecule-1 antisense oligodeoxynucleotide) (ISIS 2302) in active Crohn's disease. Alimentary pharmacology & therapeutics, , 16 (10 ) ,1761-70

Bowen-Yacyshyn, Mary Beth; Bennett, C F; Nation, N; Rayner, D; Yacyshyn, B R (2002. ) Amelioration of chronic and spontaneous intestinal inflammation with an antisense oligonucleotide (ISIS 9125) to intracellular adhesion molecule-1 in the HLA-B27/beta2 microglobulin transgenic rat model.The Journal of pharmacology and experimental therapeutics, , 302 (3 ) ,908-17 More Information

Yacyshyn, B R; Chey, W Y; Goff, J; Salzberg, B; Baerg, R; Buchman, A L; Tami, J; Yu, R; Gibiansky, E; Shanahan, W R (2002. ) Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease. Gut, , 51 (1 ) ,30-6

Yacyshyn, B R; Thomson, A B R (2002. ) The clinical importance of proton pump inhibitor pharmacokinetics. Digestion, , 66 (2 ) ,67-78

Yacyshyn, B R; Crooke, S T (2001. ) The concept and application of antisense oligonucleotides. Diseases of the colon and rectum, , 44 (9 ) ,1241-3

Yacyshyn, B R; Thomson, A B (2000. ) Critical review of acid suppression in nonvariceal, acute, uppergastrointestinal bleeding. Digestive diseases (Basel, Switzerland), , 18 (3 ) ,117-28

Chang, Q; Soper, B D; Yacyshyn, B R; Tepperman, B L (2000. ) Alterations in protein kinase C isoforms in experimentally-induced colitis in the rat. Inflammation research : official journal of the European Histamine Research Society ... [et al.], , 49 (1 ) ,27-35

Yacyshyn, B R; Shanahan, W R (1999. ) Making sense of antisense. Canadian journal of gastroenterology = Journal canadien de gastroenterologie, , 13 (9 ) ,745-51

Marcusson, E G; Yacyshyn, B R; Shanahan, W R; Dean, N M (1999. ) Preclinical and clinical pharmacology of antisense oligonucleotides.Molecular biotechnology, , 12 (1 ) ,1-11 More Information

Vaile, J H; Meddings, J B; Yacyshyn, B R; Russell, A S; Maksymowych, W P (1999. ) Bowel permeability and CD45RO expression on circulating CD20+ B cells in patients with ankylosing spondylitis and their relatives. The Journal of rheumatology, , 26 (1 ) ,128-35

Yacyshyn, B R (1998. ) New biotechnological therapies for Crohn's disease: where are we now? .BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, , 10 (4 ) ,301-16

Yacyshyn, B R (1998. ) Drug treatment for Crohn's disease.Lancet, , 352 (9129 ) ,743 More Information

Yacyshyn, B R; Bowen-Yacyshyn, M B; Jewell, L; Tami, J A; Bennett, C F; Kisner, D L; Shanahan, W R (1998. ) A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease. Gastroenterology, , 114 (6 ) ,1133-42

Yacyshyn, B R; Bowen-Yacyshyn, M B; Pilarski, L M (1996. ) Inhibition by rapamycin of P-glycoprotein 170-mediated export from normal lymphocytes. Scandinavian journal of immunology, , 43 (4 ) ,449-55

Yacyshyn, B R; Meddings, J B (1995. ) CD45RO expression on circulating CD19+ B cells in Crohn's disease correlates with intestinal permeability. Gastroenterology, , 108 (1 ) ,132-7

Yacyshyn, B R; Lazarovits, A; Tsai, V; Matejko, K (1994. ) Crohn's disease, ulcerative colitis, and normal intestinal lymphocytes express integrins in dissimilar patterns. Gastroenterology, , 107 (5 ) ,1364-71

Pilarski, L M; Yacyshyn, B R; Lazarovits, A I (1994. ) Analysis of peripheral blood lymphocyte populations and immune function from children exposed to cyclosporine or to azathioprine in utero. Transplantation, , 57 (1 ) ,133-44

Yacyshyn, B R; Pilarski, L M (1993. ) Expression of CD45RO on circulating CD19+ B-cells in Crohn's disease. Gut, , 34 (12 ) ,1698-704

Yacyshyn, B R (1993. ) Activated CD19+ B cell lamina propria lymphocytes in ulcerative colitis.Immunology and cell biology, , 71 ( Pt 4) ,265-74 More Information

Jensen, G S; Belch, A R; Mant, M J; Ruether, B A; Yacyshyn, B R; Pilarski, L M (1993. ) Expression of multiple beta 1 integrins on circulating monoclonal B cells in patients with multiple myeloma. American journal of hematology, , 43 (1 ) ,29-36

Pilarski, L M; Yacyshyn, B R; Jensen, G S; Pruski, E; Pabst, H F (1991. ) Beta 1 integrin (CD29) expression on human postnatal T cell subsets defined by selective CD45 isoform expression. Journal of immunology (Baltimore, Md. : 1950), , 147 (3 ) ,830-7

Matthis, Andrea L; Zhang, Bin; Denson, Lee A; Yacyshyn, Bruce R; Aihara, Eitaro; Montrose, Marshall H (2016. ) Importance of the Evaluation of N-Acetyltransferase Enzyme Activity Prior to 5-Aminosalicylic Acid Medication for Ulcerative Colitis.Inflammatory bowel diseases, , 22 (8 ) ,1793-802 More Information

Travis, Simon P L; Schnell, Dan; Feagan, Brian G; Abreu, Maria T; Altman, Douglas G; Hanauer, Stephen B; Krzeski, Piotr; Lichtenstein, Gary R; Marteau, Philippe R; Mary, Jean-Yves; Reinisch, Walter; Sands, Bruce E; Schnell, Patrick; Yacyshyn, Bruce R; Colombel, Jean-Frédéric; Bernhardt, Christian A; Sandborn, William J (2015. ) The Impact of Clinical Information on the Assessment of Endoscopic Activity: Characteristics of the Ulcerative Colitis Endoscopic Index Of Severity [UCEIS].Journal of Crohn's & colitis, , 9 (8 ) ,607-16 More Information

Engevik, Melinda A; Yacyshyn, Mary Beth; Engevik, Kristen A; Wang, Jiang; Darien, Benjamin; Hassett, Daniel J; Yacyshyn, Bruce R; Worrell, Roger T (2015. ) Human Clostridium difficile infection: altered mucus production and composition.American journal of physiology. Gastrointestinal and liver physiology, , 308 (6 ) ,G510-24 More Information

Engevik, Melinda A; Engevik, Kristen A; Yacyshyn, Mary Beth; Wang, Jiang; Hassett, Daniel J; Darien, Benjamin; Yacyshyn, Bruce R; Worrell, Roger T (2015. ) Human Clostridium difficile infection: inhibition of NHE3 and microbiota profile.American journal of physiology. Gastrointestinal and liver physiology, , 308 (6 ) ,G497-509 More Information

Winter, Harland S; Krzeski, Piotr; Heyman, Melvin B; Ibarguen-Secchia, Eduardo; Iwanczak, Barbara; Kaczmarski, Maciej; Kierkus, Jaroslaw; Kola?ek, Sanja; Osuntokun, Bankole; Quiros, J Antonio; Shah, Manoj; Yacyshyn, Bruce; Dunnmon, Preston M (2014. ) High- and low-dose oral delayed-release mesalamine in children with mild-to-moderately active ulcerative colitis.Journal of pediatric gastroenterology and nutrition, , 59 (6 ) ,767-72 More Information

Yacyshyn, Mary B; Reddy, Tara N; Plageman, Lauren R; Wu, Jiang; Hollar, Amy R; Yacyshyn, Bruce R (2014. ) Clostridium difficile recurrence is characterized by pro-inflammatory peripheral blood mononuclear cell (PBMC) phenotype.Journal of medical microbiology, , 63 (Pt 10 ) ,1260-73 More Information

1996 Finalist Canada's Top 40 under 40

1989 American Gastroenterological Association Senior Fellowship Research Award

1987 -1989 Research Fellow Alberta Heritage Foundation for Medical Research

1981 Alberta Heritage Foundation for Medical Research Studentship

1980 Dorothy Jean Usher Memorial Summer Research Award

1979 Faculty of Medicine Student Research Competition (First Place)

1980 Faculty of Medicine Student Research Competition (First Place)

1979 Ciba-Geigy Summer Research Scholarship

1977 Province of Alberta Undergraduate Scholarship

1978 Province of Alberta Undergraduate Scholarship

1976 Edmonton Civic Trust Scholarship

1976 Province of Alberta Undergraduate Scholarship

digestive diseases, gastroenterology, inflammatory bowel disease, ulcerative colitis

Academic - Medical Sciences Building, 7th Floor
231 Albert Sabin Way
Cincinnati  Ohio, 670595
Phone: 513-558-5244
Fax: 513-558-1744
bruce.yacyshyn@uc.edu

Clinical - UC Health Physicians Office - Clifton
222 Piedmont Ave., 6th Floor
Cincinnati  Ohio, 45219
Phone: 513-475-7505
Fax: 513-475-7355
bruce.yacyshyn@uc.edu

Clinical - UC Health Physicians Office - Montgomery
9275 Montgomery Rd.
Cincinnati  Ohio, 45242
Phone: 513-475-7505
Fax: 513-475-7723
bruce.yacyshyn@uc.edu